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    A TECHNIQUE FOR SIMULTANEOUSLY SORTING AND ALIGNING A BIOLOGICAL ENTITY IN A FLOW CELL
    1.
    发明申请
    A TECHNIQUE FOR SIMULTANEOUSLY SORTING AND ALIGNING A BIOLOGICAL ENTITY IN A FLOW CELL 审中-公开
    一种在流动细胞中同时排列和排列生物实体的技术

    公开(公告)号：WO2017157445A1

    公开(公告)日：2017-09-21

    申请号：PCT/EP2016/055794

    申请日：2016-03-17

    申请人： SIEMENS HEALTHCARE GMBH

    发明人： HAYDEN, Oliver ,  RICHTER, Lukas ,  UGELE, Matthias ,  KÜHN, Daniela ,  STANZEL, Manfred

    IPC分类号： G01N15/14 ,  B01L3/00 ,  G01N15/02

    摘要： A technique is presented for simultaneously sorting a first biological entity from a second biological entity and aligning the first biological entity, in a desired region within a flow chamber of a flow cell. The flow chamber has a rectangular cross-section. A bottom flow input module, a top flow input module and a sample input module provide a first fluid, a second fluid, and the sample, respectively, to the flow chamber. The sample laminarly flows sandwiched between the first and the second fluids. By controlling flow rate of the first and/or the second fluid the sample flow is aligned adjacent to but distinct from the desired region. An acoustic transducer generates a standing acoustic wave having pressure node linearly arranged along an axis passing through the desired region thus moving, i.e. sorting, and simultaneously orienting, the first biological entity from the sample flow into the desired region.

    摘要翻译： 提出了一种用于同时从第二生物实体分拣第一生物实体并将第一生物实体排列在流动池的流动室内的期望区域中的技术。 流动室具有矩形横截面。 底部流动输入模块，顶部流动输入模块和样本输入模块分别向流动室提供第一流体，第二流体和样本。 样品层流地夹在第一流体和第二流体之间。 通过控制第一流体和/或第二流体的流速，样品流被排列成与所需区域相邻但不同。 声学换能器产生具有沿着穿过期望区域的轴线线性布置的压力节点的驻声波，因此将第一生物实体从样品流动移动，即分选和同时定向到期望区域。

    AN INTERFEROMETRIC MICROSCOPY ARRANGEMENT WITH A POINT-LIKE BEAM SPLITTING LAYER
    3.
    发明申请
    AN INTERFEROMETRIC MICROSCOPY ARRANGEMENT WITH A POINT-LIKE BEAM SPLITTING LAYER 审中-公开
    具有点状束分裂层的干涉仪显微镜安排

    公开(公告)号：WO2018007101A1

    公开(公告)日：2018-01-11

    申请号：PCT/EP2017/064213

    申请日：2017-06-12

    申请人： SIEMENS HEALTHCARE GMBH

    发明人： SCHICK, Anton ,  HAYDEN, Oliver ,  SCHMIDT, Oliver

    IPC分类号： G03H1/04 ,  G01B9/021 ,  G01B9/02 ,  G01N21/45 ,  G02B21/36 ,  G02B21/00 ,  G01B9/04 ,  G03H1/00

    CPC分类号： G01B9/04 ,  G01B9/02001 ,  G01B9/02034 ,  G02B21/0056 ,  G02B21/361 ,  G02B27/108 ,  G03H1/0443 ,  G03H1/0493 ,  G03H2001/005 ,  G03H2001/0445

    摘要： An interfere) metric microscopy arrangement (1) is presented having an objective lens (20) that receives a light beam (9) emerging after sample interaction, wherefrom the light beam (9) is received by a beam splitter unit (30), positioned at a focal length (22) of the objective lens (20), the beam splitter unit (30) having a transparent substrate (32) and a point-like beam-splitting layer (34) that splits a part of the light beam (9) into a spatially filtered reference beam (40) and an object beam (50). Thereafter, a reference beam tube lens (60) and an object beam tube lens (70) receive the reference (40) and the object (50) beams, respectively. A beam combiner unit (80) having a transparent substrate (82) and a beam-combining layer (84) receives the reference (40) and the object (50) beams from the reference (60) and the object (70) beam tube lenses, respectively, and combines the reference (40) and the object (50) beams to form pattern-generating beam (99) directed towards the optical detector (90) to form an interference pattern thereon.

    摘要翻译： 提供具有物镜（20）的干涉）度量显微镜装置（1），所述物镜（20）接收在样品相互作用之后出现的光束（9），其中光束（9） （30），所述分束器单元（30）具有透明衬底（32）和点状分束层（34），所述点分束器单元（30）位于所述物镜（20）的焦距（22） 将光束（9）的一部分分成空间滤波的参考光束（40）和物体光束（50）。 之后，参考光束管透镜（60）和物镜光管透镜（70）分别接收参考光束（40）和物体（50）光束。 具有透明衬底（82）和光束组合层（84）的光束组合器单元（80）接收来自参考（60）和物体（70）光束管的参考物体（40）和物体（50） （40）和物体（50）光束组合以形成指向光学检测器（90）的图案生成光束（99）以在其上形成干涉图案。

    ALIGNING A NON-SPHERICAL BIOLOGICAL ENTITY IN A SAMPLE FLOW USING AMBIENT VISCOELASTIC FLUID FLOWS
    4.
    发明申请
    ALIGNING A NON-SPHERICAL BIOLOGICAL ENTITY IN A SAMPLE FLOW USING AMBIENT VISCOELASTIC FLUID FLOWS 审中-公开
    使用环境粘弹性流体流动来排列样品流中的非球形生物实体

    公开(公告)号：WO2017167361A1

    公开(公告)日：2017-10-05

    申请号：PCT/EP2016/056955

    申请日：2016-03-30

    申请人： SIEMENS HEALTHCARE GMBH

    发明人： HAYDEN, Oliver ,  RICHTER, Lukas ,  UGELE, Matthias

    IPC分类号： G01N15/14 ,  B01L3/00

    摘要： A technique is presented for aligning, in a desired region within a flow chamber of a flow cell, a non-spherical biological entity carried in a sample. The flow chamber has a rectangular cross-section. A bottom flow input module, a top flow input module and a sample input module provide a viscoelastic first fluid, a second viscoelastic fluid, and the sample, respectively, to the flow chamber. The first and the second viscoelastic fluids laminarly flow along a bottom and a top wall of the flow chamber and the sample laminarly flows sandwiched between them. By controlling rate of flow of the first and/or the second viscoelastic fluids the sample flow, and thus the non-spherical biological entity, is focused in the desired region. A gradient of sheer within the sample flow set up due to the first and second viscoelastic fluids orients the non-spherical biological entity in the desired region.

    摘要翻译： 提出了一种技术，用于在流动池的流动室内的期望区域中对准样品中携带的非球形生物实体。 流动室具有矩形横截面。 底部流动输入模块，顶部流动输入模块和样本输入模块分别向流动室提供粘弹性第一流体，第二粘弹性流体和样本。 第一和第二粘弹性流体沿流动室的底部和顶壁分层流动，并且样品层流地夹在它们之间。 通过控制第一和/或第二粘弹性流体的流动速率，样品流动并且因此非球形生物实体被聚焦在期望的区域中。 由于第一和第二粘弹性流体而建立的样品流内的陡度梯度将非球形生物实体定向在期望区域中。

    AN INTERFEROMETRIC MICROSCOPY ARRANGEMENT WITH A POINT-LIKE BEAM SPLITTING LAYER
    6.
    发明申请
    AN INTERFEROMETRIC MICROSCOPY ARRANGEMENT WITH A POINT-LIKE BEAM SPLITTING LAYER 审中-公开

    公开(公告)号：WO2018007101A8

    公开(公告)日：2018-01-11

    申请号：PCT/EP2017/064213

    申请日：2017-06-12

    申请人： SIEMENS HEALTHCARE GMBH

    发明人： SCHICK, Anton ,  HAYDEN, Oliver ,  SCHMIDT, Oliver

    IPC分类号： G03H1/04 ,  G01B9/021 ,  G01B9/02 ,  G01N21/45 ,  G02B21/36 ,  G02B21/00 ,  G01B9/04 ,  G03H1/00

    摘要： An interferometric microscopy arrangement (1) is presented having an objective lens (20) that receives a light beam (9) emerging after sample interaction, wherefrom the light beam (9) is received by a beam splitter unit (30), positioned at a focal length (22) of the objective lens (20), the beam splitter unit (30) having a transparent substrate (32) and a point-like beam-splitting layer (34) that splits a part of the light beam (9) into a spatially filtered reference beam (40) and an object beam (50). Thereafter, a reference beam tube lens (60) and an object beam tube lens (70) receive the reference (40) and the object (50) beams, respectively. A beam combiner unit (80) having a transparent substrate (82) and a beam-combining layer (84) receives the reference (40) and the object (50) beams from the reference (60) and the object (70) beam tube lenses, respectively, and combines the reference (40) and the object (50) beams to form pattern-generating beam (99) directed towards the optical detector (90) to form an interference pattern thereon.

    ARRANGEMENT AND METHOD FOR PROVIDING A SAMPLE FOR INSPECTION BY AN IMAGING DEVICE
    8.
    发明申请
    ARRANGEMENT AND METHOD FOR PROVIDING A SAMPLE FOR INSPECTION BY AN IMAGING DEVICE 审中-公开
    用于通过成像装置提供样品进行检查的装置和方法

    公开(公告)号：WO2017045712A1

    公开(公告)日：2017-03-23

    申请号：PCT/EP2015/071244

    申请日：2015-09-16

    申请人： SIEMENS HEALTHCARE GMBH

    发明人： HAYDEN, Oliver ,  RICHTER, Lukas ,  SCHMIDT, Oliver ,  TEDDE, Sandro Francesco

    IPC分类号： G01N1/28 ,  G02B21/34 ,  G01N35/00 ,  G01N21/03

    CPC分类号： G01N35/00009 ,  G01N1/2813 ,  G01N21/03 ,  G01N2021/0353 ,  G01N2021/0357 ,  G01N2021/0364 ,  G02B21/34

    摘要： An arrangement, a system and a method for providing a sample for investigation by an imaging device are presented. The arrangement includes a substrate and a capillary forming part. The substrate includes a sample receiving region and a capillary forming region on a surface of the substrate. The sample receiving region receives the sample. The sample receiving region is adjacent to the capillary forming region. The capillary forming part includes a coverslip and a spacer. The coverslip is positioned over the capillary forming region of the surface of the substrate such that the coverslip covers the capillary forming region. The coverslip is transparent and is positioned in a Field of View of the imaging device. The spacer is positioned in between the substrate and the coverslip such that a capillary volume is formed between the coverslip, the spacer and the capillary forming region of the surface.

    摘要翻译： 提出了一种用于提供用于由成像装置进行调查的样本的装置，系统和方法。 该装置包括基底和毛细管形成部分。 衬底包括在衬底的表面上的样品接收区域和毛细管形成区域。 样品接收区域接收样品。 样品接收区域与毛细管形成区域相邻。 毛细管形成部分包括盖玻片和间隔物。 盖玻片位于衬底表面的毛细管形成区域上方，使得盖玻片覆盖毛细管形成区域。 盖玻片是透明的，并且位于成像装置的视场中。 间隔物定位在基片和盖玻片之间，使得在盖片，间隔物和表面的毛细管形成区域之间形成毛细管体积。

    AN INTERFEROMETRIC MICROSCOPY ARRANGEMENT FOR INSPECTING A SAMPLE USING TWO ILLUMINATION SOURCES
    9.
    发明申请
    AN INTERFEROMETRIC MICROSCOPY ARRANGEMENT FOR INSPECTING A SAMPLE USING TWO ILLUMINATION SOURCES 审中-公开
    用于使用两个照明源检查样品的干涉显微镜装置

    公开(公告)号：WO2017041841A1

    公开(公告)日：2017-03-16

    申请号：PCT/EP2015/070627

    申请日：2015-09-09

    申请人： SIEMENS HEALTHCARE GMBH

    发明人： SCHICK, Anton ,  HAYDEN, Oliver ,  SCHMIDT, Oliver

    IPC分类号： G02B21/16 ,  G02B21/18 ,  G01B9/02

    CPC分类号： G02B21/18 ,  G01B9/02007 ,  G01B9/02024 ,  G01B9/02027 ,  G01B9/02097 ,  G02B21/16

    摘要： An interferometric microscopy arrangement for inspecting a sample includes a first illumination source providing a collimated first light beam, a second illumination source providing a second light beam focused onto the sample, a selection filter, an interferometric unit and an optical detector system. The selection filter directs the first and the second light beam towards the sample. The first and the second light beams after sample interaction are received by the interferometric unit. The interferometric unit generates from the first light beam a first object beam and a first reference beam, filters out object information from the first reference beam. The interferometric unit directs the first object beam, the first reference beam, and the second light beam towards the optical detector system. The optical detector assembly detects an interference pattern formed from the first light beam and also detects an optical pattern formed from the second light beam.

    摘要翻译： 用于检查样本的干涉式显微镜装置包括提供准直的第一光束的第一照明源，提供聚焦到样本上的第二光束的第二照明源，选择滤光器，干涉测量单元和光学检测器系统。 选择滤波器将第一和第二光束导向样品。 样品相互作用后的第一和第二光束被干涉仪接收。 该干涉单元从第一光束产生第一物体光束和第一参考光束，从第一参考光束滤出物体信息。 干涉测量单元将第一物体光束，第一参考光束和第二光束引导到光学检测器系统。 光检测器组件检测由第一光束形成的干涉图案，并且还检测由第二光束形成的光学图案。

    AN INTERFEROMETRIC MICROSCOPY TECHNIQUE FOR INSPECTING A SAMPLE SIMULTANEOUSLY AT DIFFERENT DEPTHS OF THE SAMPLE
    10.
    发明申请
    AN INTERFEROMETRIC MICROSCOPY TECHNIQUE FOR INSPECTING A SAMPLE SIMULTANEOUSLY AT DIFFERENT DEPTHS OF THE SAMPLE 审中-公开
    用于在样品不同深度同时检测样品的干涉显微技术

    公开(公告)号：WO2017041840A1

    公开(公告)日：2017-03-16

    申请号：PCT/EP2015/070626

    申请日：2015-09-09

    申请人： SIEMENS HEALTHCARE GMBH

    发明人： HAYDEN, Oliver ,  SCHICK, Anton ,  SCHMIDT, Oliver

    IPC分类号： G02B21/14 ,  G02B21/36 ,  G02B27/14 ,  G01B9/02

    CPC分类号： G02B21/14 ,  G01B9/02024 ,  G02B21/367 ,  G02B27/0075 ,  G02B27/146

    摘要： An interferometric microscopy arrangement for inspecting a sample simultaneously along different depths of the sample is presented. The arrangement includes an interferometric unit and a sensor assembly. The interferometric unit generates an object beam and a reference beam. The sensor assembly includes a primary beam splitter and a plurality of sensors having a first sensor and a second sensor located at different positions with respect to the primary beam splitter. The interferometric unit directs the object beam and the reference beam to form an interference pattern forming beam directed towards the sensor assembly. The primary beam splitter of the sensor assembly receives and splits the interference pattern forming beam into at least a first and a second part. The primary beam splitter then directs the first part towards the first sensor and the second part towards the second sensor.

    摘要翻译： 提出了一种用于在样品的不同深度同时检测样品的干涉显微镜装置。 该装置包括干涉仪和传感器组件。 干涉单元产生物体光束和参考光束。 传感器组件包括主分束器和多个传感器，其具有位于相对于主分束器的不同位置的第一传感器和第二传感器。 干涉测量单元引导物体光束和参考光束以形成指向传感器组件的干涉图案形成光束。 传感器组件的主分束器接收并将干涉图形形成光束分成至少第一和第二部分。 主分束器然后将第一部分朝着第一传感器引导，第二部分朝向第二传感器。