公开(公告)号：WO2006012778A1

公开(公告)日：2006-02-09

申请号：PCT/CN2004/000906

申请日：2004-08-06

IPC分类号： C07C43/243

CPC分类号： C07C43/253 ,  C07C41/36 ,  C07C43/243 ,  C07C2602/26

摘要： This invention relates to extracts of Pholidota Chinesis Lindl. the preparation methods and pharrriaceutical use thereof. The methods of extracting active compound from Pholidota Chinesis Lindl. incudes the following steps: 1) extracting the Pholidota Chinesis Lindl. by ethanol, concentrating at reduced pressure to make extractive; 2) ectracting the extractive in turn of n-butane, ethyl acetate, n-butanol; 3) directing the extractive of ethyl acetate through chromatography column, eluting by methanol;4) separating and purifying the elent collected in step 3) by high pressure liquid chromatography to get active compounds. The formula of the extracted active compound (3-10) is: (I); active compound (1) is: (II); active compound (2) is: (III). The compound or its salts, enantiomers, racemes, tautomers and physiologic functional derivates extracted from the Pholidota Chinesis Lindl. Are useful in production of the medicament for the treatment or prevention of inflammatory disease.

公开(公告)号：WO01016064A1

公开(公告)日：2001-03-08

申请号：PCT/US2000/023717

申请日：2000-08-29

IPC分类号： B01J31/02 ,  B01J31/06 ,  C07B61/00 ,  C07C37/14 ,  C07C39/12 ,  C07C39/23 ,  C07C41/05 ,  C07C41/06 ,  C07C43/243 ,  C07C43/174 ,  B01J21/02 ,  B01J21/08 ,  B01J21/12 ,  B01J21/14 ,  C07C2/08 ,  C07C2/14 ,  C07C37/11 ,  C08L61/06 ,  C08L61/10

CPC分类号： B01J31/0227 ,  B01J31/0237 ,  B01J31/0247 ,  B01J31/06 ,  B01J2231/323 ,  C07C37/14 ,  C07C37/88 ,  C07C41/06 ,  C07C2601/16 ,  C07C2603/68 ,  C07C39/23 ,  C07C39/17 ,  C07C43/243

摘要： A catalyst composition comprising trifluoromethanesulfonic acid (also referred to as triflic acid) and a sufficient quantity of a substance (also referred to as a retarder) to decrease but not eliminate the catalytic activity of the acid is disclosed. Also disclosed, is a method and composition for condensing a hydroxyaryl with a diene by use of the catalyst composition. The method is capable of producing condensates having: a mole ratio of 1 mole of the diene to one mole of the hydroxyaryl; one mole of diene to two moles of the hydroxyaryl as well as higher molecular weight products such as resins by changes in temperature, time of reaction, type and quantity of retarder and other variables.

摘要翻译： 公开了一种催化剂组合物，其包含三氟甲磺酸（也称为三氟甲磺酸）和足量的物质（也称为缓凝剂）以减少但不消除酸的催化活性。 还公开了通过使用催化剂组合物将羟基芳基与二烯缩合的方法和组合物。 该方法能够产生具有以下摩尔比的缩合物：1摩尔二烯与1摩尔羟基芳基的摩尔比; 1摩尔二烯与2摩尔羟基芳基以及较高分子量产物如树脂的温度变化，反应时间，缓凝剂的种类和数量等变量。

公开(公告)号：WO2008145528A1

公开(公告)日：2008-12-04

申请号：PCT/EP2008/055951

申请日：2008-05-15

申请人： Agfa Graphics NV ,  VENNEMAN, Jan ,  HENDRIKX, Peter ,  CALLANT, Paul ,  WILLIAMSON, Alexander

发明人： VENNEMAN, Jan ,  HENDRIKX, Peter ,  CALLANT, Paul ,  WILLIAMSON, Alexander

IPC分类号： G03F7/029 ,  G03F7/031 ,  C07C41/30 ,  C08F2/50

CPC分类号： G03F7/031 ,  C07C41/30 ,  C07C43/215 ,  C07C43/23 ,  C07C43/243 ,  C07C2601/08 ,  C07C2601/14 ,  C08F2/50 ,  G03F7/029

摘要： A lithographic printing plate precursor comprising an image- recording layer, said image -recording layer being photopolymerizable upon exposure to light having a wavelength of from 300 to 500 nm and containing a mixture of sensitizers.

摘要翻译： 包括图像记录层的平版印刷版原版，所述图像记录层在暴露于波长为300-500nm的光并且含有敏化剂的混合物时可光聚合。

公开(公告)号：WO1994027947A1

公开(公告)日：1994-12-08

申请号：PCT/GB1994001189

申请日：1994-06-01

申请人： RHONE-POULENC RORER LTD. ,  FENTON, Garry ,  MASON, Jonathan, Stephen ,  PALFREYMAN, Malcom, Norman ,  RATCLIFFE, Andrew, James

发明人： RHONE-POULENC RORER LTD.

IPC分类号： C07C47/47

CPC分类号： C07C311/07 ,  C07C43/235 ,  C07C43/243 ,  C07C43/253 ,  C07C45/71 ,  C07C47/47 ,  C07C47/575 ,  C07C49/577 ,  C07C62/12 ,  C07C69/007 ,  C07C225/20 ,  C07C233/23 ,  C07C235/40 ,  C07C251/42 ,  C07C259/08 ,  C07C271/24 ,  C07C271/28 ,  C07C275/34 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/06 ,  C07C2601/08

摘要： This invention relates to substituted phenylcyclopropane derivatives, which carry various substituents on the cyclopropane ring, to processes for their preparation, to pharmaceutical compositions containing them, and to methods for their use in the treatment of disease states, for example disease states associated with proteins that mediate cellular activity, for example by inhibiting tumour necrosis factor and/or by inhibiting cyclic AMP phosphodiesterase.

摘要翻译： 本发明涉及在环丙烷环上携带各种取代基的取代的苯基环丙烷衍生物，其制备方法，含有它们的药物组合物及其用于治疗疾病状态的方法，例如与蛋白质相关的疾病状态 介导细胞活性，例如通过抑制肿瘤坏死因子和/或抑制环AMP磷酸二酯酶。

公开(公告)号：WO2006012778A8

公开(公告)日：2007-05-10

申请号：PCT/CN2004000906

申请日：2004-08-06

申请人： UNIV NIHON ,  WANG JUE ,  KITANAKA SUSUMU

发明人： WANG JUE ,  KITANAKA SUSUMU

IPC分类号： C07C43/243 ,  C07C41/36 ,  C07C43/253

CPC分类号： C07C43/253 ,  C07C41/36 ,  C07C43/243 ,  C07C2602/26

摘要： This invention relates to extracts of Pholidota Chinesis Lindl. the preparation methods and pharrriaceutical use thereof. The methods of extracting active compound from Pholidota Chinesis Lindl. incudes the following steps: 1) extracting the Pholidota Chinesis Lindl. by ethanol, concentrating at reduced pressure to make extractive; 2) ectracting the extractive in turn of n-butane, ethyl acetate, n-butanol; 3) directing the extractive of ethyl acetate through chromatography column, eluting by methanol;4) separating and purifying the elent collected in step 3) by high pressure liquid chromatography to get active compounds. The formula of the extracted active compound (3-10) is: (I); active compound (1) is: (II); active compound (2) is: (III). The compound or its salts, enantiomers, racemes, tautomers and physiologic functional derivates extracted from the Pholidota Chinesis Lindl. Are useful in production of the medicament for the treatment or prevention of inflammatory disease.

摘要翻译： 本发明涉及中华百草枯提取物。 其制备方法和药物用途。 从Pholidota Chinesis Lindl提取活性化合物的方法。 包括以下步骤：1）提取Pholidota Chinesis Lindl。 用乙醇浓缩，减压浓缩; 2）将正丁醇，乙酸乙酯，正丁醇依次取出; 3）通过色谱柱引导乙酸乙酯萃取，用甲醇洗脱; 4）通过高压液相色谱法分离纯化步骤3）中收集的洗脱液，得到活性化合物。 提取的活性化合物（3-10）的配方为：（I）; 活性化合物（1）为：（II）; 活性化合物（2）为：（III）。 从PholidotaChinesis Lindl提取的化合物或其盐，对映异构体，总状花序，互变异构体和生理功能衍生物。 可用于生产用于治疗或预防炎性疾病的药物。

公开(公告)号：WO1996020162A1

公开(公告)日：1996-07-04

申请号：PCT/US1995013322

申请日：1995-10-10

申请人： SMITHKLINE BEECHAM CORPORATION ,  CHRISTENSEN, Siegfried, B., IV ,  KARPINSKI, Joseph, M.

发明人： SMITHKLINE BEECHAM CORPORATION

IPC分类号： C07C229/00

CPC分类号： C07C43/243 ,  C07C309/65 ,  C07C2601/08 ,  C07C2601/16

摘要： This invention relates to certain 1,4,4-(trisubstituted)cyclohex-1-ene dimers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).

摘要翻译： 本发明涉及可用于治疗过敏性和炎性疾病和抑制肿瘤坏死因子（TNF）产生的某些1,4,4-（三取代）环己-1-烯二聚体和相关化合物。

公开(公告)号：WO1992005131A1

公开(公告)日：1992-04-02

申请号：PCT/JP1991001228

申请日：1991-09-17

申请人： IDEMITSU KOSAN CO., LTD. ,  HIGASHI, Hisahiro ,  HOSOKAWA, Chishio ,  TOKAILIN, Hiroshi

发明人： IDEMITSU KOSAN CO., LTD.

IPC分类号： C07C13/28

CPC分类号： C07D213/30 ,  C07C13/28 ,  C07C15/52 ,  C07C43/215 ,  C07C43/243 ,  C07C43/285 ,  C07C45/004 ,  C07C45/513 ,  C07C47/548 ,  C07C47/575 ,  C07C49/782 ,  C07C49/813 ,  C07C49/84 ,  C07C2601/14 ,  C07D209/86 ,  C07D215/04 ,  C07D215/14 ,  C07D241/12 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C09K11/06 ,  H01L51/005 ,  H01L51/5012 ,  H05B33/14 ,  Y10S428/917 ,  Y10T428/31678 ,  C07C47/546

摘要： An organic electroluminescent element comprising a dimeric stryryl compound represented by general formula (I) as the luminescent material, wherein D, D', E, E', F, F', G, G' and Q are each as defined in the specification. The dimeric styryl compound used is one prepared by bonding two molecules of a compound having a good luminescence efficiency and a desirable luminescence wavelength to each other via a divalent group which breaks a conjugated system without impairing the abilities of the compound to thereby increase the molecular weight (to dimerize) and improve the properties as thin film. Therefore this element is widely applicable as various display materials.

公开(公告)号：WO2008145529A1

公开(公告)日：2008-12-04

申请号：PCT/EP2008/055952

申请日：2008-05-15

申请人： AGFA GRAPHICS NV ,  VENNEMAN, Jan ,  HENDRIKX, Peter ,  CALLANT, Paul ,  WILLIAMSON, Alexander

发明人： VENNEMAN, Jan ,  HENDRIKX, Peter ,  CALLANT, Paul ,  WILLIAMSON, Alexander

IPC分类号： G03F7/031 ,  C08F2/50 ,  C07C41/30 ,  C07C43/215 ,  C07C43/23 ,  C07C43/243

CPC分类号： C07C41/30 ,  C07C43/215 ,  C07C43/23 ,  C07C43/243 ,  C07C2601/14 ,  C08F2/50 ,  G03F7/031

摘要： A lithographic printing plate precursor comprising an image- recording layer, said image -recording layer being photopolymerizable upon exposure to light having a wavelenght of from 300 to 500 nm and containing a mixture of sensitizers.

摘要翻译： 包括图像记录层的平版印刷版原版，所述图像记录层在暴露于波长为300-500nm的光并且含有敏化剂的混合物时可光聚合。

公开(公告)号：WO1998006692A1

公开(公告)日：1998-02-19

申请号：PCT/US1997014098

申请日：1997-08-11

申请人： CELGENE CORPORATION ,  MULLER, George, W. ,  SHIRE, Mary

发明人： CELGENE CORPORATION

IPC分类号： C07C255/37

CPC分类号： C07D317/60 ,  C07C43/215 ,  C07C43/235 ,  C07C43/243 ,  C07C45/00 ,  C07C45/46 ,  C07C45/69 ,  C07C49/255 ,  C07C67/343 ,  C07C69/734 ,  C07C205/45 ,  C07C225/22 ,  C07C235/34 ,  C07C255/34 ,  C07C255/37 ,  C07C2601/08 ,  C07D213/57 ,  C07D307/54 ,  C07C49/84 ,  C07C49/784 ,  C07C69/616

摘要： Cyano and carboxy derivatives of substituted styrenes of formula (I), in which Y is -COZ, -CN, or lower alkyl of 1 to 5 carbon atoms; Z is -OH, -NR R , -R , or -OR ; X, R , R , R , R , R , R , and R have the values given in the description are inhibitors of tumor necrosis factor alpha , nuclear factor kappa B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3,3-bis-(3,4-dimethoxyphenyl)acrylonitrile.

摘要翻译： 式（I）的取代苯乙烯的氰基和羧基衍生物，其中Y是-COZ，-CN或1-5个碳原子的低级烷基; Z是-OH，-NR 6 R 6，-R 7或-OR 7; X，R 1，R 2，R 3，R 4，R 5，R 6和R 7具有在本说明书中给出的值是肿瘤坏死因子的抑制剂 α，核因子κB和磷酸二酯酶，可用于抵抗恶病质，内毒素性休克，逆转录病毒复制，哮喘和炎症状态。 典型的实施方案是3,3-双 - （3,4-二甲氧基苯基）丙烯腈。

公开(公告)号：WO1994014800A1

公开(公告)日：1994-07-07

申请号：PCT/GB1993002627

申请日：1993-12-22

申请人： CELLTECH LIMITED

发明人： CELLTECH LIMITED ,  WARRELLOW, Graham, John ,  BOYD, Ewan, Campbell ,  ALEXANDER, Rikki, Peter

IPC分类号： C07D405/06

CPC分类号： C07D213/30 ,  C07C43/243 ,  C07C43/247 ,  C07C43/253 ,  C07C65/26 ,  C07C69/94 ,  C07D213/36 ,  C07D213/38 ,  C07D213/40 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D405/06

摘要： Compounds of general formula (1) are described, wherein Y is a halogen atom or a group -OR , wherein R is an optionally substituted alkyl group; X is -O-, -S- or -N(R )-, where R is a hydrogen atom or an alkyl group; R is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R and R , which may be the same or different, is each a group -(CH2)nAr, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1, 2 or 3; R is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are potent, selective and orally active PDE IV inhibitors and are useful in the prophylaxis and treatment of asthma and other diseases.

摘要翻译： 描述通式（1）的化合物，其中Y是卤素原子或-OR 1基团，其中R 1是任选取代的烷基; X是-O - ， - S-或-N（R 6） - ，其中R 6是氢原子或烷基; R 2是任选取代的烷基，烯基，环烷基或环烯基; R 3和R 4可以相同或不同，各自为 - （CH 2）nAr基团，其中Ar是任选含有一个或多个选自氧，硫或氮的杂原子的单环或双环芳基 原子和n为零或整数1,2或3; R 5是氢原子或任选取代的烷基; 及其盐，溶剂合物，水合物和N-氧化物。 根据本发明的化合物是有效的，选择性和口服活性的PDE IV抑制剂，并且可用于预防和治疗哮喘和其它疾病。