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1.发明申请HIGH-THROUGHPUT HYPERSPECTRAL IMAGING WITH SUPERIOR RESOLUTION AND OPTICAL SECTIONING 审中-公开高分辨率高分辨率高分辨率成像和光学分割
公开(公告)号：WO2016115018A1
公开(公告)日：2016-07-21
申请号：PCT/US2016/012815
申请日：2016-01-11
Applicant: VERILY LIFE SCIENCES LLC
Inventor： ACOSTA, Victor, Marcel , BACKER, Adam , PERREAULT, John, D. , PIPONI, Daniele, Paolo
CPC classification number: G02B21/0064 , G01J3/0205 , G01J3/021 , G01J3/0229 , G01J3/0237 , G01J3/18 , G01J3/502 , G01J2003/1278 , G01J2003/468 , G01N21/255 , G01N21/27 , G01N2201/06113 , G01N2201/0675 , G02B5/1828 , G02B6/2931 , G02B21/06 , G02B21/361 , G02B26/0808 , G02F1/133553 , G02F1/23 , G02F1/292 , G06T7/11 , G06T7/90 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064 , G06T2207/30004 , H04N5/2256 , H04N5/332
Abstract: An imaging system includes a light source configured to illuminate a target and a camera configured to image light responsively emitted from the target and reflected from a spatial light modulator (SLM). The imaging system is configured to generate high-resolution, hyperspectral images of the target. The SLM includes a refractive layer that is chromatically dispersive and that has a refractive index that is controllable. The refractive index of the refractive layer can be controlled to vary according to a gradient such that light reflected from the SLM is chromatically dispersed and spectrographs information about the target can be captured using the camera. Such a system could be operated confocally, e.g., by incorporating a micromirror device configured to control a spatial pattern of illumination of the target and to modulate the transmission of light from the target to the camera via the SLM according to a corresponding spatial pattern.
Abstract translation: 成像系统包括被配置为照亮目标的光源和被配置为对从目标发射的并且从空间光调制器（SLM）反射的光进行成像的照相机。 成像系统被配置为产生目标的高分辨率，高光谱图像。 SLM包括色度分散的折射层并具有可控制的折射率。 折射层的折射率可以根据梯度来变化，使得从SLM反射的光被色散地分散，并且可以使用照相机捕获关于目标的信息。 这样的系统可以例如通过结合配置成控制目标的照明的空间模式的微镜装置并且经由SLM根据对应的空间模式来调制从目标到照相机的光的传输。
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公开(公告)号：WO2006021903A9
公开(公告)日：2007-06-14
申请号：PCT/IB2005052558
申请日：2005-07-29
Applicant: KONINKL PHILIPS ELECTRONICS NV , SCHUURMANS FRANCK JEROEN PIETE , VAN BEEK MICHAEL CORNELIS , VAN DER VOORT MARJOLEIN
CPC classification number: G01J3/28 , G01J3/04 , G01J3/36 , G01J2003/047 , G01J2003/1278
Abstract: The present invention provides an autonomous calibration of a multivariate based spectroscopic system that is preferably implemented as a multivariate based spectrometer. The spectroscopic system is based on a multivariate optical element that provides a spectral weighting of an incident optical signal. Spectral weighting is performed on the basis of spatial separation of spectral components and subsequent spatial filtering by means of a spatial light modulator. Calibration of the spectroscopic system is based on a dedicated calibration segment of the spatial light modulator, whose position corresponds to a characteristic calibration or reference wavelength of the incident optical signal. Preferably, the calibration or reference wavelength is given by the wavelength of the excitation radiation generated by the optical source that serves to induce scattering processes in a volume of interest.
Abstract translation: 本发明提供了基于多变量的光谱仪的多变量光谱系统的自主校准，其优选地被实现为基于多变量的光谱仪。 光谱系统基于提供入射光信号的光谱加权的多元光学元件。 基于光谱分量的空间分离和随后的空间光调制器的空间滤波进行光谱加权。 光谱系统的校准基于空间光调制器的专用校准段，其位置对应于入射光信号的特征校准或参考波长。 优选地，校准或参考波长由用于感兴趣的体积中的散射过程的光源产生的激发辐射的波长给出。
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公开(公告)号：WO2006021926A1
公开(公告)日：2006-03-02
申请号：PCT/IB2005/052760
申请日：2005-08-23
Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. , RENSEN, Wouter
Inventor： RENSEN, Wouter
CPC classification number: G01J3/36 , G01J3/04 , G01J2003/047 , G01J2003/1278
Abstract: The present invention provides an optical analysis system for determining an amplitude of a principal component of an optical signal. The principle component is indicative of the concentration of a particular compound of various compounds of a substance that is subject to spectroscopic analysis. The optical signal is subject to a wavelength selective weighting. Spectral weighting is preferably performed by means of spatial light manipulation means in combination with a dispersive optical element. The inventive calibration mechanism and method effectively allows for an accurate positioning of the spatial light manipulation means. Calibration is based on a calibration segment on the spatial light manipulation means in combination with a reference light source and a detector.
Abstract translation: 本发明提供了一种用于确定光信号的主分量的幅度的光学分析系统。 主要组分表示受光谱分析的物质的各种化合物的特定化合物的浓度。 光信号经受波长选择加权。 光谱加权优选地通过与分散光学元件组合的空间光操纵装置来执行。 本发明的校准机构和方法有效地允许空间光操纵装置的精确定位。 校准基于与参考光源和检测器组合的空间光操纵装置上的校准段。
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Patent Agency Ranking
公开(公告)号：WO99063385A1
公开(公告)日：1999-12-09
申请号：PCT/US1999/012523
申请日：1999-06-04
CPC classification number: G03F7/70375 , B01J19/0046 , B01J2219/00439 , B01J2219/00527 , B01J2219/00529 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B40/06 , G01J2003/1278 , G02B26/0833 , G03F7/2002 , G03F7/2053 , G03F7/70291
Abstract: An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redirected light (14) catalyzes a chemical reaction proximate a substrate (24), is disclosed. A computer (18) is connected to, and controls, the positioning of mirrors within the micromirror (16) to specifically redirect light to specific portions of a substrate. The substrate (24) can be placed in a reaction chamber (50), wherein the light (14) that is redirected by the micromirror (16) catalyzes a chemical reaction proximate a substrate (24).
Abstract translation: 一种用于在衬底（24）上催化反应的装置和方法，包括光源（12），微反射镜（16），其定位成将光（14）从光源（12）重新定向到衬底（24），其中 公开了重定向的光（14）催化邻近衬底（24）的化学反应。 计算机（18）连接到并且控制微镜（16）内的反射镜的定位，以将光特异性地重定向到衬底的特定部分。 衬底（24）可以放置在反应室（50）中，其中由微反射镜（16）重定向的光（14）催化邻近衬底（24）的化学反应。
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公开(公告)号：WO2006021903A1
公开(公告)日：2006-03-02
申请号：PCT/IB2005/052558
申请日：2005-07-29
Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHUURMANS, Franck, Jeroen, Pieter , VAN BEEK, Michael, Cornelis , VAN DER VOORT, Marjolein
Inventor： SCHUURMANS, Franck, Jeroen, Pieter , VAN BEEK, Michael, Cornelis , VAN DER VOORT, Marjolein
CPC classification number: G01J3/28 , G01J3/04 , G01J3/36 , G01J2003/047 , G01J2003/1278
Abstract: The present invention provides an autonomous calibration of a multivariate based spectroscopic system that is preferably implemented as a multivariate based spectrometer. The spectroscopic system is based on a multivariate optical element that provides a spectral weighting of an incident optical signal. Spectral weighting is performed on the basis of spatial separation of spectral components and subsequent spatial filtering by means of a spatial light modulator. Calibration of the spectroscopic system is based on a dedicated calibration segment of the spatial light modulator, whose position corresponds to a characteristic calibration or reference wavelength of the incident optical signal. Preferably, the calibration or reference wavelength is given by the wavelength of the excitation radiation generated by the optical source that serves to induce scattering processes in a volume of interest.
Abstract translation: 本发明提供了一种基于多变量的光谱仪的多变量光谱系统的自主校准，其优选地被实现为基于多变量的光谱仪。 光谱系统基于提供入射光信号的光谱加权的多元光学元件。 基于光谱分量的空间分离和随后的空间光调制器的空间滤波进行光谱加权。 分光系统的校准基于空间光调制器的专用校准段，其位置对应于入射光信号的特征校准或参考波长。 优选地，校准或参考波长由用于感兴趣的体积中的散射过程的光源产生的激发辐射的波长给出。
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公开(公告)号：WO2002103309A1
公开(公告)日：2002-12-27
申请号：PCT/DK2002/000414
申请日：2002-06-19
Applicant: DELTA DANSK ELEKTRONIK, LYS & AKUSTIK , FABRICIUS, Henrik , HANSEN, Jan, H. , JENSEN, Jens, Jørgen , NIELSEN, Hans, Ole
Inventor： FABRICIUS, Henrik , HANSEN, Jan, H. , JENSEN, Jens, Jørgen , NIELSEN, Hans, Ole
IPC: G01J3/51
CPC classification number: G01J3/51 , G01J3/0208 , G01J3/0251 , G01J3/465 , G01J3/506 , G01J3/524 , G01J2003/1213 , G01J2003/1278 , G01J2003/1282 , G01J2003/467 , H04N17/02 , H04N17/04
Abstract: A combination of a response adapting filter (11, 12, 13) and a detector (14), the detector having a predetermined spectral response function to electromagnetic radiation, a method of its preparation, a camera (11, 12, 13, 14, 15) comprising such a response filter and detector combination, and use thereof in e.g. colour measurements in combination with an integrating cavity and a vision inspection system of natural and/or a synthetic material surfaces; also a display and detector combination, a method of displaying optical information, a colour display and monitor system, and a method of controlling colour display, said combination, systems and methods comprising such combination of a response adapting filter and a detector.
Abstract translation: 响应适应滤波器（11,12,13）和检测器（14）的组合，所述检测器具有对电磁辐射的预定光谱响应函数，其准备方法，相机（11,12,13,14， 15），其包括这样的响应滤波器和检测器组合，以及其在例如 颜色测量结合积分腔和天然和/或合成材料表面的视觉检查系统; 显示和检测器组合，显示光学信息的方法，彩色显示和监视系统以及控制彩色显示的方法，所述组合，系统和方法包括响应适配滤波器和检测器的组合。
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公开(公告)号：WO01088434A1
公开(公告)日：2001-11-22
申请号：PCT/US2001/015538
申请日：2001-05-15
CPC classification number: F21S10/02 , F21S8/006 , F21V9/40 , F21V23/0442 , F21V23/0457 , G01J2003/1278
Abstract: An apparatus for generating artificial light that closely simulates the intensity and spectrum of natural light and other dynamic light conditions. The apparatus includes a collection of light sources (1) of various colors which are controlled by a computer (3). Attached to the computer (3) is a sensor (4) that measures the spectral qualities of the light produced by the light sources (1). The sensor (4) sends this information to the computer (3) which then adjusts the light sources (1) to generate the desired light conditions.
Abstract translation: 一种用于产生人造光的装置，其紧密地模拟自然光和其他动态光条件的强度和光谱。 该装置包括由计算机（3）控制的各种颜色的光源（1）的集合。 连接到计算机（3）的是传感器（4），其测量由光源（1）产生的光的光谱质量。 传感器（4）将该信息发送到计算机（3），然后调整光源（1）以产生期望的光条件。
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公开(公告)号：WO1992007239A1
公开(公告)日：1992-04-30
申请号：PCT/US1991007721
申请日：1991-10-15
Applicant: PHOTON TECHNOLOGY INTERNATIONAL INC.
Inventor： PHOTON TECHNOLOGY INTERNATIONAL INC. , MARIANIK, Charles, G., J. , ZARATE, Carlos, E. , LEVY, Gilbert, M.
IPC: G01J03/04
CPC classification number: G01J3/02 , G01J3/0232 , G01J3/0256 , G01J3/12 , G01J2003/1278 , G01J2003/1286 , G01N2201/067
Abstract: A random access monochromator (10) is disclosed. This device has no mechanical parts and eliminates the need to scan sequentially the wavelengths of light contained in a light spectrum to select a desired wavelength or wavelengths from the spectrum. The device has high speed switching means (16), permits one to select multiple wavelengths and bandwidths at the same time, and has the ability to correct for non-linearity in prisms caused by their nonlinear or second order dispersion of light.
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