公开(公告)号：WO2013090407A2

公开(公告)日：2013-06-20

申请号：PCT/US2012/069209

申请日：2012-12-12

Applicant: STEP AHEAD INNOVATIONS, INC.

Inventor： CLARK, James, E.

IPC: G01N21/31 ,  G01N21/55 ,  G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N21/84

CPC classification number: G01N21/77 ,  A01K63/04 ,  C02F1/008 ,  C02F2103/42 ,  C02F2209/005 ,  C02F2209/006 ,  C02F2209/008 ,  C02F2209/06 ,  C02F2209/14 ,  C02F2209/15 ,  C02F2209/18 ,  G01N21/15 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8507 ,  G01N21/88 ,  G01N31/22 ,  G01N33/18 ,  G01N2021/758 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2201/127 ,  G02B6/0001 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/12 ,  Y10T436/173076 ,  Y10T436/173845 ,  Y10T436/174614 ,  Y10T436/175383 ,  Y10T436/193333 ,  Y10T436/207497 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Monitoring and dosing systems for dosing additives to water in aquatic environments, such as aquariums, swimming pools, hot tubs, and ponds, to maintain the quality of the water within tolerances and/or to control other aspect of the aquatic environment, such as controlling the growth rates of flora and/or fauna in the aquatic environment. Some monitoring systems disclosed include chemical indicator apparatuses submerged in the water and having multiple immobilized-dye-based chemical indicators for detecting the levels of multiple constituents of the water that contribute to water quality. Corresponding monitoring/measuring units include one or more optical readers for acquiring readings of the chemical indicators. Dosing can be performed automatedly and/or in an assisted manner via a dosing calculator and appropriate support systems. A variety of robustness features are also disclosed that can be used to assist the systems in ensuring that measurement readings are as accurate as possible to avoid improper dosing.

Abstract translation: 监测和给药系统，用于在水生环境中如水族箱，游泳池，热水浴缸​​和池塘中的水添加添加剂，以将水的质量保持在公差内和/或控制水生环境的其他方面，例如控制 水生环境中植物群和/或动物群的增长率。 公开的一些监测系统包括淹没在水中的化学指示器，并具有多个固定染料的化学指示剂，用于检测有助于水质的水的多种成分的含量。 相应的监测/测量单元包括一个或多个光学读取器，用于获取化学指示物的读数。 剂量可以通过计量计算器和适当的支持系统自动执行和/或以辅助方式进行。 还公开了各种鲁棒性特征，其可以用于帮助系统确保测量读数尽可能准确以避免不适当的给药。

公开(公告)号：WO2006008531A1

公开(公告)日：2006-01-26

申请号：PCT/GB2005/002861

申请日：2005-07-19

Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTD. ,  LOWE, Christopher, Robin ,  BLYTH, Jeffrey ,  JAMES, Anthony, Peter

Inventor： LOWE, Christopher, Robin ,  BLYTH, Jeffrey ,  JAMES, Anthony, Peter

IPC: G03H1/18

CPC classification number: G01N21/75 ,  G01N21/4788 ,  G01N2021/758 ,  G03H2001/0044

Abstract: A sensing method, which comprises subjecting a holographic sensor to an external physical interaction to which the sensor is sensitive, and observing a change in the holographic image.

Abstract translation: 一种感测方法，其包括使全息传感器经受传感器敏感的外部物理相互作用，并观察全息图像的变化。

公开(公告)号：WO2016108396A1

公开(公告)日：2016-07-07

申请号：PCT/KR2015/009557

申请日：2015-09-11

Applicant: 한국세라믹기술원

Inventor： 구은회 ,  김현철

IPC: G01N21/64 ,  G01N21/76 ,  C09K11/06

CPC classification number: G01N31/222 ,  G01N21/64 ,  G01N21/643 ,  G01N21/76 ,  G01N21/78 ,  G01N33/00 ,  G01N2021/758 ,  G01N2021/7786 ,  G01N2033/0078

Abstract: 본 발명에서는 칼세인, 칼세인 아세톡시메틸 에스테르 (Calcein acetoxymethyl ester, Calcein-AM) 및 칼세인 블루(Calcein blue)로 구성된 군으로부터 선택되는 하나 이상의 수분민감성 화합물을 포함하는 수분검출 센서, 결함 검출 센서 및 그를 이용한 센서 어레이를 제공한다. 본 발명의 수분검출 및 결함검출 센서는 공존가스의 방해를 받지 않고 수분만을 정확하게 정량할 수 있는 선택성이 우수하고, 가역적이어서 계속적으로 재사용이 가능하여 소요 비용이 절감되고 수분의 농도 변화를 효과적으로 모니터링할 수 있어, 수분차단 특성 또는 수분투과 특성을 측정할 수 있다. 또한, 민감도가 우수하여 정밀한 검출이 가능하고, 응답속도가 매우 빠른 장점이 있다. 또한 결함을 통하여 수분이 쉽게 침투하고 형광 강도가 증가함으로 이를 이용하여 결함을 용이하게 모니터링할 수 있다.

Abstract translation: 本发明提供了一种水分检测传感器，缺陷检测传感器和使用该水分检测传感器的传感器阵列，所述水分检测器传感器包括至少一种选自钙黄绿素，钙黄绿素乙酰氧基甲酯，钙黄绿素AM和钙黄绿素 蓝色。 本发明的水分检测传感器和缺陷检测传感器具有优异的选择性，因此能够仅在不受共存气体影响的情况下精确地量化湿度，并且是可逆的，使得水分检测传感器和缺陷检测传感器可以被重新 连续使用，从而可以降低所需成本并有效监测水分浓度的变化。 因此，水分检测传感器和缺陷检测传感器可以测量防潮性或水蒸汽透过性。 此外，水分检测传感器和缺陷检测传感器具有由于灵敏度优异并且响应速度非常快而精确地检测水分的优点。 此外，本发明可以通过利用水分容易地通过缺陷渗透到缺陷检测传感器中并因此荧光强度增加的现象来容易地监测缺陷。

公开(公告)号：WO2006008524A1

公开(公告)日：2006-01-26

申请号：PCT/GB2005/002846

申请日：2005-07-19

Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTD ,  LOWE, Christopher, Robin ,  JAMES, Anthony, Peter ,  RAYNE, Edward ,  KABILAN, Satymoorthy ,  MARSHALL, Alexander, James

Inventor： LOWE, Christopher, Robin ,  JAMES, Anthony, Peter ,  RAYNE, Edward ,  KABILAN, Satymoorthy ,  MARSHALL, Alexander, James

IPC: G01N21/47

CPC classification number: G01N21/4788 ,  G01N21/75 ,  G01N2021/758 ,  G03H1/0011 ,  G03H1/0248 ,  G03H2001/0044 ,  G03H2260/12

Abstract: A sensor which comprises a support medium and a hologram disposed therein, wherein an optical characteristic of the medium varies as a result of a change of a property of the medium, and wherein the medium is heterogeneous such that the change of property is heterogeneous.

Abstract translation: 一种包括支撑介质和设置在其中的全息图的传感器，其中介质的光学特性由于介质性质的改变而变化，并且其中介质是异质的，使得性质的变化是异质的。

公开(公告)号：WO2005041746A3

公开(公告)日：2006-01-12

申请号：PCT/US0324153

申请日：2003-07-30

Applicant: TREX ENTPR CORP ,  MARTIN PETER ,  DANCIL KEIKI ANA ,  MORSELL ARTHUR LEE ,  TIGLI HUS

Inventor： MARTIN PETER ,  DANCIL KEIKI ANA ,  MORSELL ARTHUR LEE ,  TIGLI HUS

IPC: B01L3/00 ,  G01N21/84 ,  G01N33/552 ,  G01N35/00 ,  C12M3/00

CPC classification number: B01L3/502753 ,  B01L3/5023 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N21/77 ,  G01N33/552 ,  G01N2021/752 ,  G01N2021/755 ,  G01N2021/757 ,  G01N2021/758 ,  G01N2021/7779 ,  G01N2021/7796 ,  G01N2035/0097 ,  Y10S435/808

Abstract: Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules.In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules duffuse closely enough to the ligands to become bounds. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.

Abstract translation: 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供了分子的动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。在优选实施方案中，配体固定在硅衬底中产生的多孔硅相互作用区域的孔内， 之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子达到配体足够接近成为界限时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选的实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。

公开(公告)号：WO2002075294A1

公开(公告)日：2002-09-26

申请号：PCT/US2001/032265

申请日：2001-10-17

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor： ABBOTT, Nicholas ,  SHAH, Rahul

IPC: G01N21/75

CPC classification number: B82Y15/00 ,  B82Y30/00 ,  G01N21/21 ,  G01N21/75 ,  G01N2021/758 ,  G02F1/133719 ,  Y10S436/805

Abstract: A device for detecting a compound in a sample includes a substrate and a self-assembled monolayer. The substrate includes a support with a metallized top surface, and the self-assembled monolayer includes an alkanethiol attached to the metallized top surface of the substrate and having a functional group that reversibly or irreversibly interacts with the compound. A liquid crystal is disposed on the self-assembled monolayer opposite the side of the self-assembled monolayer attached to the metallized top surface of the substrate. The liquid crystal includes a moiety that interacts with the functional group of the alkanethiol. When the compound is present in a sample that that contacts the self-assembled monolayer, the orientation of the liquid crystal is altered.

Abstract translation: 用于检测样品中化合物的装置包括基底和自组装单层。 衬底包括具有金属化顶表面的支撑体，并且自组装单层包括连接到衬底的金属化顶表面的链烷硫醇并具有与化合物可逆地或不可逆地相互作用的官能团。 将液晶设置在与组装在衬底的金属化顶表面上的自组装单层相对的自组装单层上。 液晶包括与烷硫醇的官能团相互作用的部分。 当化合物存在于与自组装单层接触的样品中时，液晶的取向发生变化。

公开(公告)号：WO2015082412A1

公开(公告)日：2015-06-11

申请号：PCT/EP2014/076133

申请日：2014-12-01

Applicant: UNIVERSITÉ DE MONS ,  MATERIA NOVA

Inventor： BUENO MARTINEZ, Antonio ,  CAUCHETEUR, Christophe ,  DEBLIQUY, Marc ,  LAHEM, Driss ,  MEGRET, Patrice ,  OLIVIER, Marie-Georges

IPC: G01N21/78 ,  G01N21/77

CPC classification number: G01N21/783 ,  G01N21/7703 ,  G01N33/0018 ,  G01N33/0037 ,  G01N2021/758 ,  G01N2021/7709 ,  G01N2021/773 ,  G01N2021/7773 ,  G01N2201/08 ,  Y02A50/245

Abstract: The present invention relates to gas sensors, in particular, to an optical fibre sensor for measuring the presence and/or quantity of one of more gasses, the gas sensor comprising an optical fibre, and a gas sensitive detection material at a portion of the surface of the optical fibre, said gas sensitive detection material comprising a gas sensitive reactant and a porous matrix, wherein the gas sensitive detection material undergoes a reversible change of reflectance and/or absorbance at a detection wavelength when subjected to a gas to be detected.

Abstract translation: 气体传感器技术领域本发明涉及气体传感器，特别涉及一种用于测量更多气体中存在和/或数量的光纤传感器，该气体传感器包括光纤，以及在表面的一部分处的气体敏感检测材料 所述气体敏感性检测材料包括气体敏感性反应物和多孔基质，其中气体敏感性检测材料经受待检测气体的检测波长的反射率和/或吸光度的可逆变化。

公开(公告)号：WO2010024456A1

公开(公告)日：2010-03-04

申请号：PCT/JP2009/065372

申请日：2009-08-27

Applicant: SHARP KABUSHIKI KAISHA ,  JORDAN, Pamela Ann

Inventor： JORDAN, Pamela Ann

IPC: G01N21/27 ,  G01N21/64

CPC classification number: G01N21/75 ,  G01N21/21 ,  G01N33/54373 ,  G01N2021/758

Abstract: The present invention relates to a liquid crystal device for detecting interactions between a surface and an analyte. Specifically it provides a device for detecting interactions between a surface and an analyte, said device comprising a first substrate having an active surface supporting one or more first analyte(s), a second substrate, and a liquid crystal disposed on the active surface between the first substrate and second substrate, wherein the liquid crystal has a cross-section of varying thickness, wherein the cross-section of the liquid crystal has a first thickness and second thickness that is different to the first thickness, whereby the interaction between the active surface and the first analyte causes the orientation of the liquid crystal to change at a first critical thickness that is between the first and second thicknesses of the liquid crystal.

Abstract translation: 本发明涉及一种用于检测表面和分析物之间的相互作用的液晶装置。 具体地说，它提供了一种用于检测表面和分析物之间的相互作用的装置，所述装置包括第一衬底，其具有支撑一个或多个第一分析物的活性表面，第二衬底和布置在有源表面之间的液晶 第一基板和第二基板，其中所述液晶具有不同厚度的横截面，其中所述液晶的横截面具有与所述第一厚度不同的第一厚度和第二厚度，由此所述有源表面 并且第一分析物导致液晶的取向在液晶的第一和第二厚度之间的第一临界厚度处变化。

公开(公告)号：WO2006120426A1

公开(公告)日：2006-11-16

申请号：PCT/GB2006/001691

申请日：2006-05-09

Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTD. ,  KABILAN, Satyamoorthy ,  BLYTH, Jeffrey

Inventor： KABILAN, Satyamoorthy ,  BLYTH, Jeffrey

IPC: G01N21/47 ,  G03H1/18

CPC classification number: G01N21/75 ,  G01N21/4788 ,  G01N2021/758 ,  G01N2021/7723 ,  G01N2021/773 ,  G03H2001/0044 ,  G03H2260/12

Abstract: A sensor for the detection of an analyte, comprises a medium and, disposed therein, a hologram, wherein an optical characteristic of the medium changes as a result of a variation of a physical property of the medium, wherein the medium comprises a first polymer interpenetrated by a second, different polymer, and wherein the hologram is recorded in the first polymer and said variation arises as a result of interaction between the second polymer and the analyte.

Abstract translation: 用于检测分析物的传感器包括介质，并且在其中设置全息图，其中介质的光学特性由于介质的物理性质的变化而改变，其中介质包括第一聚合物互穿的 通过第二种不同的聚合物，并且其中全息图被记录在第一聚合物中，并且由于第二聚合物和分析物之间的相互作用而产生所述变化。

公开(公告)号：WO2005041746A2

公开(公告)日：2005-05-12

申请号：PCT/US2003/024153

申请日：2003-07-30

Applicant: TREX ENTERPRISES CORPORATION ,  MARTIN, PETER ,  DANCIL, Keiki Ana ,  MORSELL, Arthur Lee ,  TIGLI, Hus

Inventor： MARTIN, PETER ,  DANCIL, Keiki Ana ,  MORSELL, Arthur Lee ,  TIGLI, Hus

IPC: A61B

CPC classification number: B01L3/502753 ,  B01L3/5023 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N21/77 ,  G01N33/552 ,  G01N2021/752 ,  G01N2021/755 ,  G01N2021/757 ,  G01N2021/758 ,  G01N2021/7779 ,  G01N2021/7796 ,  G01N2035/0097 ,  Y10S435/808

Abstract: Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules.In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules duffuse closely enough to the ligands to become bounds. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.

Abstract translation: 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供了分子的动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。在优选实施方案中，配体固定在硅衬底中产生的多孔硅相互作用区域的孔内， 之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子达到配体足够接近成为界限时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选的实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。