公开(公告)号：WO2022146758A2

公开(公告)日：2022-07-07

申请号：PCT/US2021/064487

申请日：2021-12-21

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： MALHOTRA, Atul ,  DI STEFANI, Gianni

IPC: B65B3/00 ,  B65B3/04 ,  B65B3/12 ,  B65B39/00 ,  B65B51/14 ,  B65B55/12 ,  B65B51/22 ,  B65B57/04 ,  B65B61/06 ,  B65B65/00 ,  G01N1/14 ,  B29C65/00 ,  A61J1/10 ,  B29C66/929 ,  B29C66/97 ,  B65B2210/06 ,  B65B3/003 ,  B65B3/045 ,  B65B39/001 ,  B65B51/142 ,  B65B65/006

Abstract: A method for producing sterile solution-filled containers includes positioning a cartridge onto a filling machine. The cartridge includes a plurality of containers (26), a filter assembly (34), and a connection line 46 in fluid communication with the filter assembly. Each of the plurality of containers includes a volume and a stem in fluid communication with the volume and in fluid communication with the connection line. The method includes coupling the cartridge to a feed line in fluid communication with a mix tank, activating a pump coupled to the feed line, and at least partially filling one or more of the volumes associated with the plurality of containers by pumping fluid through the feed line, the filter assembly, and the connection line to create one or more at least partially filled containers. Further, the method includes sealing and separating each of the filled and sealed containers from the connection line.

公开(公告)号：WO2020013725A1

公开(公告)日：2020-01-16

申请号：PCT/RU2018/000460

申请日：2018-07-12

Applicant: ARSHINTSEVA, Elena Valentinovna ,  PUSHKIN, Sergei Yurevich

Inventor： ARSHINTSEVA, Elena Valentinovna ,  PUSHKIN, Sergei Yurevich

IPC: A61L2/07 ,  B65B55/12

Abstract: The invention relates to chemical and pharmaceutical industry, in particular to technologies of obtaining sterile drugs, drug substances and cosmetic products used in the form of solutions or emulsions, and comprising poloxamer. The thermal method for sterilizing aqueous poloxamer solutions is provided, the method including: dissolving a poloxamer in water for injection; performing the sterilizing filtration of the aqueous poloxamer solution simultaneously with filling sterile containers with the filtered poloxamer solution; sealing the containers containing the poloxamer solution; applying a thermal sterilization with steam under pressure to the containers containing the poloxamer solution, and cooling them, wherein the thermal sterilization of the containers containing the poloxamer solution with steam under pressure is performed under the pressure between 82.4 and 107.8 kPa.

公开(公告)号：WO2019200249A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/027206

申请日：2019-04-12

Applicant: NQV8 LLC

Inventor： KUENZI, John ,  SPURGEON, Eric ,  AHLVERS, Cole

IPC: A23L3/00 ,  A23L3/01 ,  A23L3/28 ,  A23L3/3409 ,  B65B55/12

Abstract: A method and apparatus for reducing pathogens in successive pre-measured units of a flowable food product without substantially increasing the head height requirement of a feed production system. A plurality of containers are moved about a path within a housing. The path has a plurality of stations, such as a receiving station, one or more sanitizing stations, and a dispensing station, and a container cleaning station. A pre-measured unit of the flowable food product is received at the receiving station into a container. The pre-measured unit of the flowable food product is exposed to one or more sanitizing agents at one or more sanitizing stations. The pre-measured unit of the flowable food product is dispensed into the packaging device at the dispensing station. The containers are then cleaned at the container cleaning station to prepare each container to receive a subsequent pre-quantified unit of the flowable feed product.

公开(公告)号：WO2017098331A1

公开(公告)日：2017-06-15

申请号：PCT/IB2016/001958

申请日：2016-12-09

Applicant: VANRX PHARMASYSTEMS INC

Inventor： PROCYSHYN, Chris ,  CICHY, Marcin

IPC: B65B3/04 ,  A61J1/14 ,  A61J1/20 ,  B25J9/18 ,  B65B55/12

CPC classification number: G01N35/10 ,  A61J1/14 ,  A61J1/20 ,  B01L3/02 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/0609 ,  B65B3/003 ,  B65B3/04 ,  B65B55/12 ,  G01N35/00029 ,  G01N35/0099 ,  G01N2035/00148 ,  G01N2035/00277

Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

Abstract translation: 受控环境外壳包括机器人手臂操纵系统，该机器人手臂操纵系统用于保护和解除受保护环境外壳内的流体路径和拭子。 该设备允许流体路径在受控环境外壳被净化之前防止危险的净化蒸气和化学物质。 该设备允许流体路径在没有使用手套或其他手段的情况下不受保护，这在完成去污时会降低受控环境外壳的完整性。 该设备和方法允许保护，解除保护和去污染序列的自动化。 在一些实施例中，流体路径包括填充针，填充针可以用一次性单片注塑聚合物填充针护套可移除地和无菌地密封。 该设备和方法还允许使用置于拭子支架中的拭子，该拭子无菌且可去除地密封于拭子帽以保护拭子免受去污蒸气的侵害。

公开(公告)号：WO2016103188A1

公开(公告)日：2016-06-30

申请号：PCT/IB2015/059896

申请日：2015-12-22

Applicant: BRONNER, Laurent, Robert ,  SPORS, Antje ,  LIEBERMANN, Franz ,  VAN RIJN, Cornelis Johannes Maria

Inventor： BRONNER, Laurent, Robert ,  SPORS, Antje ,  LIEBERMANN, Franz ,  VAN RIJN, Cornelis Johannes Maria

IPC: A23L2/02 ,  B01D63/16 ,  B65B55/12

CPC classification number: B65B55/02 ,  A01J11/06 ,  A23C3/005 ,  A23C7/02 ,  A23C2210/208 ,  A23L2/02 ,  A23L2/42 ,  A23L2/74 ,  B01D63/16 ,  B65B3/00 ,  B65B25/001 ,  B65B2210/08 ,  B65B2210/10

Abstract: A system for packaging a low acid Liquid is provided herein, The system includes feeding unit configured to feed the low acid liquid into a filtration unit. The filtration unit is configured to filter the low acid liquid by using a number or pores provided on a micro sieve membrane. Further, the filtered low acid liquid is provided to an aseptic buffer unit configured to fill the aseptic filtered low acid liquid into packaging containers. The system further includes an automatic cleaning in place unit configured to automatically clean the feeding unit, the filtration unit and the aseptic buffer unit by decontamination using a decontaminating material.

Abstract translation: 本文提供了一种用于包装低酸液体的系统。该系统包括被配置为将低酸液体进料到过滤单元中的进料单元。 过滤单元被配置为通过使用设置在微筛膜上的数量或孔来过滤低酸液体。 此外，过滤的低酸液体被提供到无菌缓冲单元，其构造成将无菌过滤的低酸液体填充到包装容器中。 该系统还包括一个自动清洗就位单元，其被配置为通过使用净化材料的去污来自动清洁进料单元，过滤单元和无菌缓冲单元。

公开(公告)号：WO2007055595A1

公开(公告)日：2007-05-18

申请号：PCT/NZ2006/000268

申请日：2006-10-20

Applicant: MERCER TECHNOLOGIES LIMITED ,  KEMP, Terry, Dean ,  DE KLERK, Christo, Andre

Inventor： KEMP, Terry, Dean ,  DE KLERK, Christo, Andre

IPC: B65B55/12 ,  B65B31/06 ,  B65D33/16 ,  A61L2/07 ,  B65B51/30 ,  B65D81/20 ,  A61L2/24 ,  B65D33/01

CPC classification number: A61L2/24 ,  A61L2/07 ,  B65B31/024 ,  B65B31/06 ,  B65B55/18

Abstract: A method and apparatus for sterilization in which items to be sterilized are placed in an impervious sealable package and the sterilization process is carried out within the package. The apparatus (10) includes a cabinet (18) in which a package (P) preferably with a carrier (11) located within, can be positioned. A snorkel (17) is inserted into the package (P) and via connector (23) vacuum, pressure and sterilant can be applied to the interior of the package (P). A sealing arrangement (14b, 22b) can seal the package closed after the sterilization process has been completed.

Abstract translation: 一种用于灭菌的方法和装置，其中待灭菌的物品被放置在不可渗透的可密封包装中，并且灭菌过程在包装内进行。 装置（10）包括一个机箱（18），其中优选地具有位于其内的载体（11）的包装（P）可以被定位。 将一个通气管（17）插入到包装（P）中并通过连接器（23）插入真空中，压力和灭菌剂可以施加到包装（P）的内部。 密封装置（14b，22b）可以在灭菌处理完成之后密封封装。

公开(公告)号：WO99018815A1

公开(公告)日：1999-04-22

申请号：PCT/US1998/021019

申请日：1998-10-02

IPC: A23L3/22 ,  A23L23/00 ,  B65B55/12

CPC classification number: A23L3/225 ,  A23L3/22 ,  A23L23/00 ,  B65B55/12

Abstract: A method and apparatus for producing a heterogeneous food in a continuous aseptic thermal process is disclosed herein. The invention involves the combining of two streams of aseptically processed components of a final heterogeneous food product such as potato soup, yogurt or the like. One of the streams is a homogeneous component of the final product and the other stream is a heterogeneous component. The invention involves aseptically processing both streams, then using the homogeneous component or carrier fluid, to partially cool the heterogeneous food product. The invention allows for the holding of the heterogeneous component for a predetermined residence time at a predetermined temperature as set by FDA regulations. The final product may be packaged on an aseptic packaging machine.

Abstract translation: 本文公开了在连续无菌热处理中生产异质食物的方法和装置。 本发明涉及将最终的异质食品如马铃薯汤，酸奶等的无菌加工成分的两股混合。 其中一个流是最终产品的均匀组件，另一个流是异构组件。 本发明涉及无菌处理两种物流，然后使用均相成分或载体流体来部分冷却异质食品。 本发明允许在由FDA规定设定的预定温度下保持异相组分达预定的停留时间。 最终产品可以包装在无菌包装机上。

公开(公告)号：WO2022112853A1

公开(公告)日：2022-06-02

申请号：PCT/IB2021/054302

申请日：2021-05-19

Applicant: DELTAPAK S.R.L.

Inventor： BENEDETTI, Claudio

IPC: B65B57/00 ,  B65B65/00 ,  B65B59/04 ,  G05B19/042 ,  B65B55/02 ,  B65B59/00 ,  B65B59/02 ,  B65B7/16 ,  B65B7/28 ,  B65B55/12

Abstract: The system (1) of activation of packaging machines, comprising: - at least one packaging machine (2) provided with packaging means (7, 8, 9, 10) adapted to package at least one product (3) and command means (4) configured to control the operation of the packaging means (7, 8, 9, 10) to package the product (3); - activation means (5, 6, 11, 12, 13) of the command means (4) between at least one home configuration, in which the command means (4) are deactivated, thus preventing the operation of the packaging means (7, 8, 9, 10) and at least one working configuration, in which the command means (4) are activated, thus allowing the operation of the packaging means (7, 8, 9, 10); wherein the activation means (5, 6, 11, 12, 13) comprise at least one activation device (5) connectable in a removable manner to the packaging machine (2) to activate the command means (4) between the home configuration and the working configuration.

公开(公告)号：WO2019204627A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/028156

申请日：2019-04-18

Applicant: XENON CORPORATION

Inventor： HATHAWAY, Ryan ,  WILLIAMS, Roger ,  AHMED, Saad

IPC: A01G5/06 ,  A01G22/05 ,  A23L3/28 ,  A61L2/10 ,  A61L2/28 ,  A23B7/015 ,  B65B55/12

Abstract: Systems and methods for treating unwashed fruit with fruit bloom that provide a first ultraviolet (UV) energy with one or more flashes using a first set of one or more flash lamps to a first surface of each of a plurality of blueberries and provide a second UV energy with one or more flashes using a second set of one or more flash lamps to a second surface of each of the plurality of blueberries. The system determines a fruit bloom level associated with the plurality of blueberries after provision of the first and second UV energies and determines an adjustment to a parameter of at least one of the first and second UV energies based on the fruit bloom level. The system provides UV energy with the adjusted parameter to a subsequent set of blueberries to remove microorganisms from the blueberries while retaining fruit bloom.

公开(公告)号：WO2018049516A1

公开(公告)日：2018-03-22

申请号：PCT/CA2017/051071

申请日：2017-09-12

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： NAING, Juvenal ,  GOFMAN, Yakov ,  CICHY, Marcin ,  SENGER, John ,  GUERRERO, Carlos Alberto Diaz

IPC: B65B55/12 ,  A61J1/00 ,  A61L2/24 ,  B65B3/04

CPC classification number: A61L2/24 ,  A61J1/00 ,  A61L2/07 ,  A61L2/202 ,  A61L2/206 ,  A61L2/208 ,  A61L2202/122 ,  A61L2202/14 ,  A61L2202/21 ,  B65B3/003 ,  B65B43/60 ,  B65B55/027

Abstract: The system of the invention involves monitoring and controlling in a sterilizable environment the peeling of a cover from a tub sealed by the cover. The system and associated method employs a platform having a fiducial source locating structure for holding the tub, a cover removal station disposed to engage with the cover and to peel the cover from the tub. The container assembly for holding nested pharmaceutical container parts comprises a bottom, a top lip that provides a horizontal top sealing surface that has a peripheral outline, and sidewalls located between the bottom and the top lip, a peelable container cover consisting of a sheet of flexible material sealed to the sealing surface of the top lip of the rectangular container to seal the contents of the container, and a cover removal fixture on the container cover.

Abstract translation: 本发明的系统涉及在可消毒的环境中监测和控制盖子从被盖子密封的桶中剥离。 该系统和相关方法采用具有用于保持桶的基准源定位结构的平台，设置用于与盖接合并将盖从桶中剥离的盖移除台。 用于保持嵌套的药物容器部件的容器组件包括底部，顶部唇缘，其提供具有周边轮廓的水平顶部密封表面以及位于底部和顶部唇缘之间的侧壁，可剥离容器盖由柔性片 材料密封到矩形容器的上唇的密封表面以密封容器的内容物，以及容器盖上的盖移除夹具。