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    ATOMISING DEVICE, ATOMISING BODY AND METHOD OF MANUFACTURING THE SAME
    2.
    发明申请
    ATOMISING DEVICE, ATOMISING BODY AND METHOD OF MANUFACTURING THE SAME 审中-公开
    原型装置，原型装置及其制造方法

    公开(公告)号：WO2009002178A2

    公开(公告)日：2008-12-31

    申请号：PCT/NL2008/050438

    申请日：2008-06-30

    Applicant: MEDSPRAY XMEMS B.V. ,  WISSINK, Jeroen Mathijn ,  HESKAMP, Iwan Rutger ,  DE KRUIJF, Wilhelmus Petrus Johannes ,  NIJDAM, Wietze ,  VAN RIJN, Cornelis Johannes Maria

    Inventor： WISSINK, Jeroen Mathijn ,  HESKAMP, Iwan Rutger ,  DE KRUIJF, Wilhelmus Petrus Johannes ,  NIJDAM, Wietze ,  VAN RIJN, Cornelis Johannes Maria

    IPC: B05B1/08 ,  B05B1/26 ,  B29C65/14

    CPC classification number: B05B1/08 ,  B05B1/26

    Abstract: An atomizing device, comprising an atomizing body (1 ) with an inlet (16) for receiving a fluid under increased pressure, and with at least one set of outflow ports (18) for allowing the fluid to escape on a delivery side with forming of a vapour. Imaginary central axes of the outflow ports directed in a flow direction herein enclose a mutual angle (α) in order to intersect each other at an intersection (S). The atomizing body comprises a roof (21) and a bottom (11) which extend over at least a first distance (dl) beyond the set of outflow ports (18) and bound a vaporizing space (17) on either side. The intersection (S) of the imaginary central axes of the outflow ports lies at a second distance (d2) from the set of outflow ports, wherein the second distance (d2) is greater than the first distance (dl) and extends beyond the vaporizing space (17). In a further aspect of the invention the atomizing body is able and adapted to capture supplied radiation, thus forming heat. In a further aspect the atomizing body is in an envelope which at least on a boundary layer is adhered with a boundary layer to the atomizing body.

    Abstract translation: 一种雾化装置，包括具有用于在增加的压力下接收流体的入口（16）的雾化体（1）和至少一组用于允许流体在输送侧逸出的至少一组流出端口（18），形成 蒸气 沿流动方向引导的流出口的虚拟中心轴在这里封闭相互的角度（a），以在交叉点（S）彼此相交。 雾化体包括在至少第一距离（d1）上延伸超出该组流出端口（18）并且限定任一侧上的汽化空间（17）的屋顶（21）和底部（11）。 流出端口的假想中心轴线的交点（S）位于距离该组流出端口的第二距离（d2）处，其中第二距离（d2）大于第一距离（d1）并且延伸超出蒸发 空间（17）。 在本发明的另一方面，雾化体能够并适于捕获供应的辐射，从而形成热量。 在另一方面，雾化体是在至少在边界层上附着有边界层至雾化体的外壳。

    ELECTROFORMING METHOD, ELECTROFORMING MANDREL AND ELECTROFORMED PRODUCT
    4.
    发明申请
    ELECTROFORMING METHOD, ELECTROFORMING MANDREL AND ELECTROFORMED PRODUCT 审中-公开
    电镀方法，电镀和电镀产品

    公开(公告)号：WO1997040213A1

    公开(公告)日：1997-10-30

    申请号：PCT/NL1997000203

    申请日：1997-04-18

    Applicant: STORK VECO B.V. ,  AQUAMARIJN MICRO FILTRATION B.V. ,  KNOL, Harm, Gerrit ,  KRUITHOF, Cornelis, Johannes ,  VAN RIJN, Cornelis, Johannes, Maria ,  NIJDAM, Wietze

    Inventor： STORK VECO B.V. ,  AQUAMARIJN MICRO FILTRATION B.V.

    IPC: C25D01/10

    CPC classification number: C25D1/10 ,  C25D1/08

    Abstract: In an electroforming method for making metal products (10) having a pattern of openings (9) separated by dykes (8) using a mandrel in an electroplating bath, metal from the bath is deposited on at least two electrically mutually insulated regions. Said regions comprise at least one main pattern (3) for product dykes (8) to be formed, which main pattern (3) is electrically insulated from at least one ancillary pattern (5) for a reinforcement (7) to be formed. In the method according to the invention, first the ancillary pattern (5) is connected to a current source in order to form reinforcement (7) thereon and in order to effect an electrical connection between the ancillary pattern (5) and the main pattern (3) by means of the growing metal. During the continuation of the method, reinforcement (7) is thickened and the product dykes (8) are formed. A strong product having different thicknesses is therefore obtained in one step. A mandrel suitable for use in the method is also described.

    Abstract translation: 在用于在电镀浴中使用心轴制造具有由堤（8）分开的开口（9）图案的金属制品（10）的电铸方法中，来自浴的金属沉积在至少两个电互相绝缘的区域上。 所述区域包括用于要形成的产品堤坝（8）的至少一个主图案（3），该主图案（3）与要形成的加强件（7）的至少一个辅助图案（5）电绝缘。 在根据本发明的方法中，首先，辅助图案（5）连接到电流源以在其上形成加强件（7），并且为了实现辅助图案（5）和主图案（5）之间的电连接 3）通过生长的金属。 在该方法的继续期间，钢筋（7）变厚并形成产品（8）。 因此，在一个步骤中获得具有不同厚度的强力产品。 还描述了适用于该方法的心轴。

    DEVICE FOR GENERATING MICROSPHERES FROM A FLUID, METHOD OF INJECTING AT LEAST ONE FIRST FLUID INTO A SECOND FLUID, AND AN INJECTION PLATE
    5.
    发明申请
    DEVICE FOR GENERATING MICROSPHERES FROM A FLUID, METHOD OF INJECTING AT LEAST ONE FIRST FLUID INTO A SECOND FLUID, AND AN INJECTION PLATE 审中-公开
    用于从流体产生微生物的装置，将至少一个第一流体注入第二流体的方法和注射板

    公开(公告)号：WO2005115599A1

    公开(公告)日：2005-12-08

    申请号：PCT/NL2005/000385

    申请日：2005-05-25

    Applicant: NANOMI B.V. ,  WISSINK, Jeroen Mathijn ,  VAN RIJN, Cornelis Johannes Maria ,  NIJDAM, Wietze ,  GOETING, Christiaan, Haldir ,  HESKAMP, Iwan Rutger ,  VELDHUIS, Gerrit Jan

    Inventor： WISSINK, Jeroen Mathijn ,  VAN RIJN, Cornelis Johannes Maria ,  NIJDAM, Wietze ,  GOETING, Christiaan, Haldir ,  HESKAMP, Iwan Rutger ,  VELDHUIS, Gerrit Jan

    IPC: B01F3/08

    CPC classification number: B01F3/0807 ,  B01F5/0475 ,  B01F5/0476 ,  B01F5/0485 ,  B01F13/0059 ,  B01F2215/0427 ,  B01F2215/0431 ,  Y10T137/0357 ,  Y10T137/212

    Abstract: A device for generating micro spheres from a fluid (13) comprises an injection plate (6) which comprises at least one defined injection channel (1) having on an inlet side an inflow opening for receiving the fluid and on an outlet side an outflow opening for delivering micro spheres (12) formed from the fluid. The device is provided with feed means for carrying the fluid through the injection channel and is in open communication, on a side wall thereof, with at least one secondary channel (10) at least at the position of a break-up point where at least during operation a flow of the fluid in the injection channel breaks up into separate parts. The secondary channel is intended and adapted to comprise an auxiliary fluid at least during operation and at least at the position of a break-up point. For at least a part of the first fluid an inflow resistance of the secondary channel is greater than an inflow resistance of the injection channel. Such a device is employed in a method for injecting a first fluid into a second fluid and a cross-flow of a second fluid is guided over an outlet side of the injection plate.

    Abstract translation: 用于从流体（13）产生微球的装置包括注射板（6），其包括至少一个限定的注入通道（1），所述注入通道在入口侧具有用于接收流体的流入开口，在出口侧具有流出开口 用于递送由流体形成的微球体（12）。 该装置设置有用于通过注入通道运送流体的进料装置，并且在其侧壁上与至少一个次要通道（10）开放连通，至少在分解点的位置至少 在操作期间，注入通道中的流体流分解成单独的部分。 次级通道旨在并适于至少在操作期间和至少在分解点的位置处包括辅助流体。 对于第一流体的至少一部分，次通道的流入阻力大于注入通道的流入阻力。 这种装置用于将第一流体注入第二流体的方法，并且第二流体的横流被引导到注射板的出口侧。

    MEMBRANE FILTER AND A METHOD OF MANUFACTURING THE SAME AS WELL AS A MEMBRANE
    6.
    发明申请
    MEMBRANE FILTER AND A METHOD OF MANUFACTURING THE SAME AS WELL AS A MEMBRANE 审中-公开
    膜过滤器及其制造方法作为膜

    公开(公告)号：WO1995013860A1

    公开(公告)日：1995-05-26

    申请号：PCT/EP1994003783

    申请日：1994-11-14

    Applicant: VAN RIJN, Cornelis, Johannes, Maria

    IPC: B01D69/02

    CPC classification number: B01D67/0062 ,  B01D39/1692 ,  B01D67/0058 ,  B01D67/0072 ,  B01D69/02 ,  B01D69/10 ,  B01D69/12 ,  B01D71/02 ,  B01D2325/04 ,  B01J35/065 ,  G03F7/12 ,  Y10S55/05

    Abstract: A membrane filter comprises a membrane provided with pores with a pore size between 5 nm and 50 mu m. The membrane may easily and reliably be processed with use of silicon micromachining through depositing a relatively thin membrane layer on a support, by means of a suitable vapour deposition or spincoating technique, after which perforations are made in the thin membrane layer, for example by means of etching with aid of photo-lithography or an imprint technique. Such a membrane is very well applicable for the separation of biological cells. A membrane with a thickness smaller than the diameter of the perforations is in particular suited for the separation of vulnerable cells and may be used as a leucocyte filter or as a blood plasma separator of blood concentrates. A microfiltration membrane according to the invention may very well be applied as a support for the deposition of a separation layer for ultrafiltration, gas separation or catalysis.

    Abstract translation: 膜过滤器包括具有孔径在5nm和50μm之间的孔的膜。 通过使用合适的气相沉积或旋涂技术，通过在载体上沉积相对薄的薄膜层，可以容易且可靠地使用硅微加工来加工薄膜，之后在薄膜层中例如通过方法 通过光刻或压印技术进行蚀刻。 这样的膜非常适用于分离生物细胞。 具有小于穿孔直径的膜的膜特别适用于分离易受伤害的细胞，并且可以用作白细胞过滤器或血浓缩物的血浆分离器。 根据本发明的微滤膜可以非常好地用作用于沉积用于超滤，气体分离或催化的分离层的载体。

    METHODS, SYSTEMS AND DEVICES FOR SEPARATING TUMOR CELLS
    7.
    发明申请
    METHODS, SYSTEMS AND DEVICES FOR SEPARATING TUMOR CELLS 审中-公开
    用于分离肿瘤细胞的方法，系统和装置

    公开(公告)号：WO2011123655A1

    公开(公告)日：2011-10-06

    申请号：PCT/US2011/030741

    申请日：2011-03-31

    Applicant: VIATAR LLC ,  VAN RIJN, Cornelis, Johannes, Maria ,  BAGGERMAN, Jacob ,  REICH, Ilan

    Inventor： VAN RIJN, Cornelis, Johannes, Maria ,  BAGGERMAN, Jacob ,  REICH, Ilan

    IPC: G01N33/49 ,  G01N33/50 ,  A61M1/36 ,  B01D71/02 ,  B01D67/00

    CPC classification number: A61M1/34 ,  A61M1/3403 ,  A61M1/3633 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50 ,  B01D63/087 ,  B01D67/0034 ,  B01D2325/021 ,  B01D2325/04 ,  G01N33/491 ,  G01N33/57492

    Abstract: Embodiments of the present disclosure are directed to the separation/capture of specific cells and/or contaminants, as well as the determination, monitoring, and treatment of cancer. Moreover, some embodiments are directed to methods, systems and devices for removing cancer, stem and/or tumor cells in vivo or in vitro from a bodily fluid to prevent or impede the proliferation of a cancer. Some embodiments provide a blood-compatible filter comprising, for example, a membrane provided with a number of openings (preferably precise) which yield minimal detrimental effect both quantitatively and qualitatively on cells present in the bodily fluid during the separation process. For example, in some embodiments, a majority percentage of circulating tumor cells are captured by a filter while a majority percentage of leukocytes, for example, are allowed to pass, where the passed leukocytes retain their vitality.

    Abstract translation: 本公开的实施方案涉及分离/捕获特定细胞和/或污染物，以及癌症的测定，监测和治疗。 此外，一些实施方案涉及用于从体液或体外从体液中除去癌症，干细胞和/或肿瘤细胞以防止或阻碍癌细胞增殖的方法，系统和装置。 一些实施方案提供血液兼容过滤器，其包括例如具有多个开口（优选精确的）的膜，其在分离过程期间对存在于体液中的细胞进行定量和定性的产生最小的有害影响。 例如，在一些实施方案中，通过过滤器捕获大部分百分比的循环肿瘤细胞，而允许例如白细胞的多数百分比通过，其中通过的白细胞保持其活力。

    FLUID HANDLING SYSTEM AND USES THEREOF
    8.
    发明申请
    FLUID HANDLING SYSTEM AND USES THEREOF 审中-公开
    流体处理系统及其用途

    公开(公告)号：WO2010136602A1

    公开(公告)日：2010-12-02

    申请号：PCT/EP2010/057539

    申请日：2010-05-31

    Applicant: NOVOFLOW GMBH ,  VAN RIJN, Cornelis, Johannes, Maria ,  LIEBERMANN, Franz

    Inventor： VAN RIJN, Cornelis, Johannes, Maria ,  LIEBERMANN, Franz

    IPC: B01F3/08 ,  B01D29/74 ,  B01D33/21

    CPC classification number: B01D29/74 ,  B01D33/21 ,  B01D33/56

    Abstract: The present invention discloses a fluid handling system comprising at least one membrane provided with pores, a housing and means to rotate the membrane in the housing. The membrane is a membrane filter with a low flow resistance, in particular a microsieve. Further the invention relates to uses of the fluid handling system, namely for atomization, in particular emulsification, and for filtration.

    Abstract translation: 本发明公开了一种流体处理系统，其包括至少一个设置有孔的膜，壳体以及使膜在壳体中旋转的装置。 膜是具有低流动阻力的膜过滤器，特别是微筛。 此外，本发明涉及流体处理系统的用途，即用于雾化，特别是乳化和过滤。

    INORGANIC MEMBRANE FOR MICROFILTRATION, AND A PROCESS FOR PRODUCTION OF SUCH AN INORGANIC MEMBRANE
    9.
    发明申请
    INORGANIC MEMBRANE FOR MICROFILTRATION, AND A PROCESS FOR PRODUCTION OF SUCH AN INORGANIC MEMBRANE 审中-公开
    用于微滤膜的无机膜及其生产这种无机膜的方法

    公开(公告)号：WO1993023154A1

    公开(公告)日：1993-11-25

    申请号：PCT/EP1993001280

    申请日：1993-05-19

    Applicant: VAN RIJN, Cornelis, Johannes, Maria

    IPC: B01D71/02

    CPC classification number: B01D67/0072 ,  B01D67/0093 ,  B01D71/02 ,  B01D2325/02 ,  B01D2325/04 ,  C04B38/0051 ,  C04B41/009 ,  C04B41/4582 ,  C04B41/52 ,  C04B41/81 ,  C04B41/89 ,  C04B2111/00801 ,  C04B2111/00836 ,  G03F7/0015 ,  C04B35/00 ,  C04B38/04 ,  C04B41/4529 ,  C04B41/4562 ,  C04B41/459 ,  C04B41/5025 ,  C04B41/5338 ,  C04B41/51 ,  C04B41/45 ,  C04B35/515

    Abstract: The inorganic membrane consists of a macroporous inorganic support and an inorganic membrane layer. The membrane layer is formed through depositing an inorganic layer by "Chemical Vapour Deposition" or "sputtering" on the macroporous support, onto this inorganic layer a photo-lacquer layer is formed, this photo-lacquer layer being exposed to a regular mask pattern with the use of a suitable source, this lacquer layer being developed, and in the inorganic layer the mask pattern is etched by a suitable etchant, thus forming the membrane layer. The pattern of the membrane layer may be given any particularly design, practically with a repetition rate in the range 0.1-10 mu m. It is thus conceivable to separate not only particles according to their size, but also to their shape. The membrane layer can be deposited very thinly in comparison to the dimension of the pore size, enabling a large flux, a reduced clogging and a minimal damage to particles or cells.

    Abstract translation: 无机膜由大孔无机载体和无机膜层组成。 通过在大孔载体上通过“化学气相沉积”或“溅射”沉积无机层而形成膜层，在该无机层上形成光漆层，该光漆层暴露于规则的掩模图案， 使用合适的来源，这个漆层被开发，并且在无机层中，通过合适的蚀刻剂蚀刻掩模图案，从而形成膜层。 膜层的图案可以给出任何特别设计，实际上具有在0.1-10μm的范围内的重复率。 因此，可以想到，不仅根据颗粒尺寸分离颗粒，而且分离其形状。 与孔尺寸相比，膜层可以非常薄地沉积，使得能够获得大的通量，减少堵塞和对颗粒或细胞的最小的损伤。

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