-
公开(公告)号：EP2054388A1
公开(公告)日：2009-05-06
申请号：EP07785026.1
申请日：2007-08-06
发明人： BEAULIEU, Pierre L , COULOMBE, René , FAZAL, Gulrez , GOULET, Sylvie , POIRIER, Martin , RANCOURT, Jean , STAMMERS, Timothy , THAVONEKHAM, Bounkham
IPC分类号： C07D213/62 , A61K31/351 , A61K31/381 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4439 , A61K31/497 , A61K31/5377 , A61P31/14 , C07D231/18 , C07D235/12 , C07D309/12 , C07D333/32 , C07D401/06 , C07D401/12 , C07D413/04 , C07D413/06 , C07D417/06
CPC分类号： C07D213/68 , C07D213/70 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/85 , C07D213/89 , C07D215/227 , C07D217/24 , C07D231/18 , C07D235/08 , C07D235/12 , C07D237/14 , C07D239/34 , C07D239/56 , C07D241/20 , C07D241/24 , C07D307/20 , C07D309/12 , C07D333/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04
摘要： Compounds of formula (I) : wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
-
公开(公告)号：EP1625154B1
公开(公告)日：2014-01-08
申请号：EP04731118.8
申请日：2004-05-05
发明人： COULOMBE, René , BEAULIEU, Pierre, Louis , JOLICOEUR, Eric , KUKOLJ, George , LAPLANTE, Steven , POUPART, Marc-André
CPC分类号： C07K14/005 , C07K2299/00 , C12N9/127 , C12N2770/24222
-
公开(公告)号：EP1984323A1
公开(公告)日：2008-10-29
申请号：EP07701744.0
申请日：2007-02-01
IPC分类号： C07C233/88 , A61K31/196 , A61K31/395 , A61K31/4468 , A61P31/14 , C07D207/04
CPC分类号： C07C311/29 , C07C205/59 , C07C233/63 , C07C235/46 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/14 , C07D209/08 , C07D209/44 , C07D211/10 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/74 , C07D213/75 , C07D231/12 , C07D231/40 , C07D231/56 , C07D233/60 , C07D233/64 , C07D235/06 , C07D239/26 , C07D241/20 , C07D243/08 , C07D249/14 , C07D265/30 , C07D277/46 , C07D279/12 , C07D295/092 , C07D295/155 , C07D295/205 , C07D295/215 , C07D295/26 , C07D309/14
摘要： Compounds of formula (I): wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
摘要翻译： 式I化合物：其中X，R2，R3，R5和R6如本文所定义，可用作丙型肝炎病毒NS5B聚合酶的抑制剂。
-
公开(公告)号：EP2220046A1
公开(公告)日：2010-08-25
申请号：EP08800314.0
申请日：2008-09-11
发明人： TSANTRIZOS, Youla, S. , BAILEY, Murray, D. , BILODEAU, François , CARSON, Rebekah, J. , COULOMBE, René , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , MORIN, Sébastien , PARISIEN, Mathieu , POUPART, Marc-André , SIMONEAU, Bruno
IPC分类号： C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/538 , A61P31/18 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06
CPC分类号： C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/4741 , A61K31/538 , A61K31/5383 , C07D215/18 , C07D221/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06 , C07D498/06
摘要： Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译： 式（I）化合物：其中R 4，R 6和R 7如本文所定义，可用作HIV复制的抑制剂。
-
公开(公告)号：EP2350039A1
公开(公告)日：2011-08-03
申请号：EP09817130.9
申请日：2009-10-01
发明人： BEAULIEU, Pierre , BONNEAU, Pierre , COULOMBE, René , FORGIONE, Pasquale , GILLARD, James , JAKALIAN, Araz , RANCOURT, Jean
IPC分类号： C07D307/91 , A61K31/343 , A61K31/395 , A61P31/14 , C07D405/02 , C07D407/04 , C07D409/12 , C07D413/02 , C07D417/02 , C07D495/04
CPC分类号： C07D307/91 , A61K31/343 , A61K31/395 , C07D405/06 , C07D405/12 , C07D407/04 , C07D413/06 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present application provides compounds of formula I wherein X, Y, R
2 , n, R
5 and R
6 are defined herein, useful as inhibitors of the hepatitis C virus NS5B polymerase The present application also provides pharmaceutical compositions containing said compounds, methods of using said compounds as pharmaceuticals alone or with other antiviral agent in the treatment of a hepatitis C viral infection in a mammal having or at risk of having the infection.-
公开(公告)号：EP1625154A1
公开(公告)日：2006-02-15
申请号：EP04731118.8
申请日：2004-05-05
发明人： COULOMBE, René , BEAULIEU, Pierre, Louis , JOLICOEUR, Eric , KUKOLJ, George , LAPLANTE, Steven , POUPART, Marc-André
CPC分类号： C07K14/005 , C07K2299/00 , C12N9/127 , C12N2770/24222
摘要： The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a confirmation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding pocket defined generally by amino acid residues 392, 393, 395, 396, 399, 424, 425, 428, 429, 492, 493, 494, 495, 496, 500 and 503. This newly exposed binding pocket defines a novel target in the search of further chemical entities which are capable of binding to HCV NS5B and modulating, or preferably inhibiting, the polymerase activity of HCV NS5B.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.016 秒)
