公开(公告)号：EP1250340A1

公开(公告)日：2002-10-23

申请号：EP00986242.6

申请日：2000-12-11

申请人： ELI LILLY AND COMPANY ,  Wang, Qiuping

发明人： BONJOUKLIAN, Rosanne ,  COHEN, Jeffrey, Daniel ,  GRUBER, Joseph, Michael ,  JOHNSON, Douglas, Webb ,  JUNGHEIM, Louis, Nickolaus ,  KROIN, Julian, Stanley ,  LANDER, Peter, Ambrose ,  LIN, Ho-Shen ,  LOHMAN, Mark, Christopher ,  MUEHL, Brian, Stephen ,  NORMAN, Bryan, Hurst ,  PATEL, Vinod, Francis ,  RICHETT, Michael, Enrico ,  THRASHER, Kenneth, Jeff ,  VEPACHEDU, Sreenivasarao ,  WHITE, Wesley, Todd ,  XIE, Yongping ,  YORK, Jeremy Schulenburg ,  PARKHURST, Brandon, Lee ,  WANG, Quiping

IPC分类号： C07D498/04 ,  A61K31/47 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D471/04

摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).

公开(公告)号：EP1392701A1

公开(公告)日：2004-03-03

申请号：EP02723331.1

申请日：2002-03-27

申请人： ELI LILLY AND COMPANY

发明人： COHEN, Jeffrey, Daniel ,  JUNGHEIM, Louis, Nickolaus ,  MUEHL, Brian, Stephen ,  THRASHER, Kenneth, Jeff

IPC分类号： C07D498/14 ,  A61K31/435

CPC分类号： C07D498/04

摘要： The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

公开(公告)号：EP2358698A1

公开(公告)日：2011-08-24

申请号：EP09752059.7

申请日：2009-11-05

申请人： Eli Lilly and Company

发明人： BASTIAN, Jolie, Anne ,  CLAY, Julia, Marie ,  COHEN, Jeffrey, Daniel ,  HIPSKIND, Philip, Arthur ,  LOBB, Karen, Lynn ,  SALL, Daniel, Jon ,  WILSON (NEE TAKAKUWA), Takako ,  THOMPSON, Michelle, Lee

IPC分类号： C07D401/04 ,  A61K31/501 ,  C07D401/14 ,  C07D417/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D417/14

摘要： The present invention provides novel tetrasubstituted pyridine hedgehog pathway antagonists of the following formula I (I) or a pharmaceutically acceptable salt thereof, wherein: X is C-R
1 or N; R
1 is hydrogen, fluoro or cyano; R
2 is formula II (II), piperidinyl, or gem di-F-substituted cyclohexyl; R
3 is methyl or trifluoromethyl; R
4 is pyrrolidinyl, morpholinyl or pyridyl, amino or dimethylamino; R
5 is trifluoromethyl or methylsulfonyl; R
6 is hydrogen or methyl; and R
7 , R
8 , R
9 , R
10 and R
11 are independently hydrogen fluoro, cyano, chloro, methyl, trifluoromethyl, trifluoromethoxy or methylsulfonyl, provided that al least two of R
7 , R
8 , R
9 , R
10 and R
11 are hydrogen useful in the treatment of cancer.

公开(公告)号：EP2358698B1

公开(公告)日：2012-09-05

申请号：EP09752059.7

申请日：2009-11-05

申请人： Eli Lilly and Company

发明人： BASTIAN, Jolie, Anne ,  CLAY, Julia, Marie ,  COHEN, Jeffrey, Daniel ,  HIPSKIND, Philip, Arthur ,  LOBB, Karen, Lynn ,  SALL, Daniel, Jon ,  WILSON (NEE TAKAKUWA), Takako ,  THOMPSON, Michelle, Lee

IPC分类号： C07D401/04 ,  A61K31/501 ,  C07D401/14 ,  C07D417/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D417/14

公开(公告)号：EP1250340B1

公开(公告)日：2004-11-17

申请号：EP00986242.6

申请日：2000-12-11

申请人： ELI LILLY AND COMPANY

发明人： BONJOUKLIAN, Rosanne ,  COHEN, Jeffrey, Daniel ,  GRUBER, Joseph, Michael ,  JOHNSON, Douglas, Webb ,  JUNGHEIM, Louis, Nickolaus ,  KROIN, Julian, Stanley ,  LANDER, Peter, Ambrose ,  LIN, Ho-Shen ,  LOHMAN, Mark, Christopher ,  MUEHL, Brian, Stephen ,  NORMAN, Bryan, Hurst ,  PATEL, Vinod, Francis ,  RICHETT, Michael, Enrico ,  THRASHER, Kenneth, Jeff ,  VEPACHEDU, Sreenivasarao ,  WHITE, Wesley, Todd ,  XIE, Yongping ,  YORK, Jeremy Schulenburg ,  PARKHURST, Brandon, Lee ,  WANG, Quiping

IPC分类号： C07D498/04 ,  A61K31/47 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D471/04

摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).