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    ANTIBIOTIC TKR2999, PROCESS FOR THE PREPARATION THEREOF AND MICROBE
    2.
    发明公开
    ANTIBIOTIC TKR2999, PROCESS FOR THE PREPARATION THEREOF AND MICROBE 有权
    抗生素TKR2999，VERFAHREN ZUR HERSTELLUNG DESSELBEN SOWIE MIKROBE

    公开(公告)号：EP1044983A1

    公开(公告)日：2000-10-18

    申请号：EP98963649.3

    申请日：1998-12-22

    申请人： Takara Shuzo Co, Ltd.

    发明人： TAKESAKO, Kazutoh ,  AWAZU, Naoyuki ,  UENO, Mitsuhiro ,  ONISHI, Yoshimi ,  KATO, Ikunoshin

    IPC分类号： C07G11/00 ,  C12P1/02 ,  C12N1/14

    CPC分类号： C12R1/645 ,  A61K38/00 ,  C07K4/06 ,  C12P21/02

    摘要： The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt:
    (1) FAB-MS m/z 971 [M+H] + , (2) the molecular formula: C 44 H 78 N 10 O 14 , and high-resolution FAB-MS m/z 971.5776 [M+H] + , (3) the ultraviolet absorption spectrum in methanol has an end absorption, (4) the infrared absorption spectrum by KBr method shows the major absorption wave numbers at 3320, 2920, 1680, 1540, 1210, 1140, 840, 800, and 720 cm -1 , (5) aspartic acid, threonine, serine, glycine, alanine, β-alanine, and ornithine are detected by the amino acid analysis using ninhydrin reaction, and (6) the solubility is that it is soluble in methanol, and practically insoluble in hexane, chloroform, and water.
    The novel antibiotic is useful as a therapeutic agent for fungal infection diseases.

    摘要翻译： 具有下述物理化学性质的抗生素TKR2999及其药理学上可接受的盐：（1）FAB-MS m / z 971ÄM+HÜ+，（2）分子式：C44H78N10O14和高分辨率FAB-MS m / z 971.5776ÄM+HÜ+，（3）甲醇中的紫外吸收光谱具有终点吸收，（4）通过KBr方法的红外吸收光谱显示了3320,2920,1680,1540,1210,1600,1540,1410,1440,1540,1410,1440,1480,1540,1410,1440,1480,1440,1480,1440,1480,1440,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,14 1140,840,800和720cm -1，（5）通过使用茚三酮反应的氨基酸分析检测天冬氨酸，苏氨酸，丝氨酸，甘氨酸，丙氨酸，β-丙氨酸和鸟氨酸，和（6） 溶解度是溶于甲醇，几乎不溶于己烷，氯仿和水。 新型抗生素可用作真菌感染疾病的治疗剂。

    ANTIGEN PROTEIN AND NUCLEIC ACID CODING FOR SAID PROTEIN
    3.
    发明公开
    ANTIGEN PROTEIN AND NUCLEIC ACID CODING FOR SAID PROTEIN 审中-公开
    抗原蛋白DIEDAFÜRKODIERENDENUKLEINSÄURE

    公开(公告)号：EP1026245A1

    公开(公告)日：2000-08-09

    申请号：EP98944256.1

    申请日：1998-09-28

    申请人： Takara Shuzo Co, Ltd.

    发明人： TAKESAKO, Kazutoh ,  MIZUTANI, Shigetoshi ,  ENDO, Masahiro ,  OGAWA, Junko ,  OKADO, Takashi ,  KATO, Ikunoshin

    IPC分类号： C12N15/31 ,  C07K14/40

    CPC分类号： C07K14/40 ,  A61K38/00 ,  A61K39/00 ,  Y10S530/824

    摘要： To provide a novel antigenic protein and a nucleic acid encoding the antigenic protein, which are useful for prophylaxis, treatment and diagnosis of diseases caused by fungi including Candida albicans . An antigenic protein characterized in that the antigenic protein is recognized by antiserum derived from a mammal having Candida albicans -infection resistance; and a nucleic acid encoding an antigenic protein which is recognized by antiserum derived from a mammal having Candida albicans -infection resistance.

    摘要翻译： 提供新型抗原蛋白和编码抗原蛋白的核酸，其可用于预防，治疗和诊断由真菌引起的疾病，包括白色念珠菌。 一种抗原蛋白，其特征在于抗原蛋白由来自具有白色念珠菌感染抗性的哺乳动物的抗血清识别; 以及编码由来自具有白念珠菌感染抗性的哺乳动物的抗血清识别的抗原性蛋白质的核酸。

    INHIBITION OF IgA PRODUCTION
    5.
    发明公开
    INHIBITION OF IgA PRODUCTION 有权
    IGA PRODUKTIONSINHIBITOREN

    公开(公告)号：EP1080723A1

    公开(公告)日：2001-03-07

    申请号：EP99919525.8

    申请日：1999-05-11

    申请人： Takara Shuzo Co, Ltd.

    发明人： TAKESAKO, Kazutoh ,  SAITO, Hideharu ,  KATO, Ikunoshin

    IPC分类号： A61K31/16

    CPC分类号： A61K31/16

    摘要： The production of IgA is selectively inhibited by orally administering 15-deoxyspergualin or pharmacologically acceptable salts thereof, thus preventing and treating IgA-associated immunological diseases such as IgA nephropathy.

    摘要翻译： 通过口服施用15-脱氧精胍菌素或其药理学上可接受的盐来选择性地抑制IgA的产生，从而预防和治疗IgA相关免疫疾病如IgA肾病。

    SPHINGOSINE DERIVATIVES AND MEDICINAL COMPOSITION
    6.
    发明公开
    SPHINGOSINE DERIVATIVES AND MEDICINAL COMPOSITION 有权
    SPHINGOSINDERIVATE UND MEDIZINISCHE ZUBEREITUNG

    公开(公告)号：EP1020429A1

    公开(公告)日：2000-07-19

    申请号：EP98941825.6

    申请日：1998-09-11

    申请人： Takara Shuzo Co, Ltd.

    发明人： TAKESAKO, Kazutoh ,  KUROME, Toru ,  AWAZU, Naoyuku ,  KATO, Ikunoshin

    IPC分类号： C07C219/06 ,  C07C229/06 ,  C07C235/12 ,  A61K31/16 ,  A61K31/22

    CPC分类号： C07C219/06 ,  C07C229/08 ,  C07C235/12 ,  C07C237/12 ,  C07C237/22

    摘要： Sphingosine derivatives capable of regulating the function of sphingolipids. The sphingosine derivatives are represented by general formula (I) wherein R 1 and R 2 are the same or different and each represents hydrogen, C 1-4 alkyl, or C 2-5 acyl; R 3 and R 4 are the same or different and each represents hydrogen or hydroxyl, or R 3 and R 4 in combination represent a covalent bond; and X 1 represents -(CH 2 ) n -CO-NH-CH(R 5 )-R 6 or-(CH 2 ) m -O-CO-CH(R 7 )-R 8 .

    摘要翻译： 能够调节鞘脂功能的鞘氨醇衍生物。 鞘氨醇衍生物由通式（I）表示，其中R 1和R 2相同或不同，各自表示氢，C 1-4烷基或C 2-5酰基; R 3和R 4相同或不同，各自表示氢或羟基，或者R 3和R 4组合表示共价键; X 1表示 - （CH 2）n -CO-NH-CH（R 5）-R 6或 - （CH 2）m -O-CO-CH（R 7）-R 8。

    SPHINGOSINE ANALOGUES
    7.
    发明公开
    SPHINGOSINE ANALOGUES 失效
    类神经类似物

    公开(公告)号：EP1002790A1

    公开(公告)日：2000-05-24

    申请号：EP98907195.6

    申请日：1998-03-12

    申请人： Takara Shuzo Co, Ltd.

    发明人： TAKESAKO, Kazutoh ,  KUROME, Toru ,  AWAZU, Naoyuki ,  KATO, Ikunoshin

    IPC分类号： C07C215/10 ,  C07C229/22 ,  C07C271/22 ,  C07C215/24 ,  C07C229/30 ,  C07D263/06

    CPC分类号： C07D307/33 ,  C07C215/10 ,  C07C215/24 ,  C07C229/22 ,  C07C229/30 ,  C07C237/08 ,  C07C237/22 ,  C07C251/08 ,  C07C271/22 ,  C07D263/06 ,  Y02P20/55

    摘要： The present invention aims to provide a novel sphingosine analogue, which is useful as an intermediate for syntheses of novel lipid derivatives such as sphingolipid derivatives and the like that can regulate the effects of sphingolipid.
    The present invention relates to a sphingosine analogue represented by the general formula (I) described below.

    In the formula, as for Q 1 , Q 2 and Q 3 , Q 1 and Q 2 , which are the same or different each other, are hydrogen, alkyl groups having 1-4 of carbon atoms, acyl groups having 2-5 of carbon atoms, or protecting groups of the amino group, and Q 3 is a hydrogen or a protecting group of the hydroxyl group; or Q 2 and Q 3 make up an isopropylidene group and Q 1 is a hydrogen or a protecting group of the amino group. Q 4 and Q 5 , which are the same or different each other, are hydroxyl groups, acyl groups having 2-5 of carbon atoms, -O-Q 6 , or hydrogen; or Q 4 and Q 5 make up a covalent bond. Q 6 is a protecting group of the hydroxyl group. X 1 is -COOH, -CONH 2 , -CO-Q 7 , -CH 2 OH, or -CH 2 O-Q 8 . Q 7 is a protecting group of the carboxyl group, and Q 8 is a protecting group of the hydroxyl group.

    摘要翻译： 本发明的目的在于提供一种新型的鞘氨醇类似物，其可用作合成可调节鞘脂类作用的新型脂质衍生物如鞘脂衍生物等的中间体。 本发明涉及由下述通式（I）表示的鞘氨醇类似物。 在式中，对于Q1，Q2和Q3，Q1和Q2彼此相同或不同，为氢，具有1-4个碳原子的烷基，具有2-5个碳原子的酰基或保护 氨基的基团，并且Q 3是氢或羟基的保护基团; 或Q2和Q3构成异亚丙基，Q1是氢或氨基的保护基。 Q4和Q5彼此相同或不同，为羟基，具有2-5个碳原子的酰基，-O-Q6或氢; 或Q4和Q5构成共价键。 Q6是羟基的保护基。 X1是-COOH，-CONH2，-CO-Q7，-CH2OH或-CH2O-Q8。 Q7是羧基的保护基，Q8是羟基的保护基。

    PROMOTERS
    10.
    发明公开
    PROMOTERS 失效
    PROMOTOREN

    公开(公告)号：EP0832979A1

    公开(公告)日：1998-04-01

    申请号：EP96914448.4

    申请日：1996-05-27

    申请人： TAKARA SHUZO CO. LTD.

    发明人： OKADO, Takashi ,  TAKESAKO, Kazutoh ,  KATO, Ikunoshin

    IPC分类号： C12N15/81 ,  C12N1/19 ,  C12P21/02

    CPC分类号： C12N15/81 ,  C07K14/395

    摘要： Promoters originating in yeasts which are usable in a complete nutrition medium and the transcription of which can be controlled by PDR1 gene products. That is, the DNA represented by SEQ ID NO: 1 in the Sequence Listing or a part of the same and having a promoter activity in a yeast; a DNA having the above-mentioned promoter activity the transcription of which can be controlled by PDR1 gene products; and a DNA hybridizable with the above-mentioned DNA and having a promoter activity in a yeast.

    摘要翻译： 起始于酵母的启动子，其可用于完整营养培养基，其转录可由PDR1基因产物控制。 也就是说，由序列表中的SEQ ID NO：1表示的DNA或其一部分，并且在酵母中具有启动子活性; 具有上述启动子活性的DNA，其转录可由PDR1基因产物控制; 以及与上述DNA杂交并在酵母中具有启动子活性的DNA。