-
1.发明公开
公开(公告)号：EP3394326A1
公开(公告)日：2018-10-31
申请号：EP16877036.0
申请日：2016-12-21
发明人： FALCONER, Ester , HANSEN, Carl Lars Genghis , LECAULT, Veronique , LISAINGO, Kathleen , HEYRIES, Kevin Albert
IPC分类号： C40B30/04 , C12N5/078 , C12Q1/02 , C12Q1/68 , C40B20/00 , C40B40/02 , C40B50/06 , G01N33/543 , G01N33/566 , G01N33/574 , G01N33/68
CPC分类号： C40B40/02 , C12N15/1034 , C12N15/1037 , C12Q1/68 , C40B50/06 , G01N33/566 , G01N33/6845 , G01N33/6854
摘要： The present invention relates to methods for isolating the sequences of an antibody that reacts with a disease related antigen, e.g., an autoantigen, without knowing the identity of the antigen (sequence or structural epitope) a priori. The methods can also be used to identify an antigen that mediates a disease state, e.g., an autoantigen implicated in an autoimmune disorder or a tumor response.
-
2.发明授权NUCLEIC ACID-CONTAINING LIPID PARTICLES AND RELATED METHODS 有权NUKLEINSÄUREHALTIGEFETTPARTIKEL UND ENTSPRECHENDE VERFAHREN
公开(公告)号：EP2496700B1
公开(公告)日：2017-03-01
申请号：EP10851175.9
申请日：2010-11-04
发明人： CULLIS, Pieter, R. , BELLIVEAU, Nathan, M. , HANSEN, Carl Lars Genghis , HUFT, Jens , TAYLOR, James , WILD, Andre , MALCOM, Stuart , HAFEZ, Ismail , LEUNG, Alex , WALKER, David
IPC分类号： C12N15/87 , A61K47/22 , A61K47/24 , A61K47/34 , C12N15/00 , C12N15/10 , A61K31/7088 , C07H21/00 , C12N15/113 , C12N15/88 , A61K9/14
CPC分类号： C12N15/113 , A61K9/1272 , A61K9/145 , A61K9/146 , A61K31/7088 , A61K47/22 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
摘要翻译： 含有核酸的脂质颗粒，用于制备脂质颗粒的装置和方法，以及使用脂质颗粒的方法。
-
公开(公告)号：EP3517625A1
公开(公告)日：2019-07-31
申请号：EP19152969.2
申请日：2015-05-22
发明人： HANSEN, Carl Lars Genghis , MEWIS, Georgia Elizabeth , HEYRIES, Kevin Albert , VANINSBERGHE, Michael Andrew , DA COSTA, Daniel Jay , RICICOVA, Marketa
摘要： Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs.
-
公开(公告)号：EP3253911A1
公开(公告)日：2017-12-13
申请号：EP16746018.7
申请日：2016-02-04
发明人： HANSEN, Carl Lars Genghis , ZAHN, Hans , HUFT, Jens , VAN LOENHOUT, Marinus Theodorus Johannes , LEUNG, Kaston , LIN, Bill Kengli , KLAUS, Anders , APARICIO, Samuel Alves Jana Rodrigues , SHAH, Sohrab Prakash , STEIF, Adi
IPC分类号： C40B50/06 , B81B1/00 , B81B7/04 , C12M1/34 , C12N15/00 , C12P19/34 , C12Q1/00 , C12Q1/68 , C40B20/00 , C40B30/00 , C40B40/06 , G01N33/48 , G01N33/50 , G01N33/53 , G06F19/10
CPC分类号： C12Q1/6869 , B01L3/502761 , B01L3/505 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , C12N15/1093 , C12Q1/6806 , C12Q1/686 , C12Q2531/119 , C12Q2563/149 , C12Q2565/629 , C12Q2525/191 , C12Q2531/113
摘要： Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for reimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.
-
公开(公告)号：EP2496700A1
公开(公告)日：2012-09-12
申请号：EP10851175.9
申请日：2010-11-04
发明人： CULLIS, Pieter, R. , BELLIVEAU, Nathan, M. , HANSEN, Carl Lars Genghis , HUFT, Jens , TAYLOR, James , WILD, Andre , MALCOM, Stuart , HAFEZ, Ismail , LEUNG, Alex , WALKER, David
IPC分类号： C12N15/87 , A61K47/22 , A61K47/24 , A61K47/34 , C12N15/00 , C12N15/10 , A61K31/7088 , C07H21/00 , C12N15/113 , C12N15/88 , A61K9/14
CPC分类号： C12N15/113 , A61K9/1272 , A61K9/145 , A61K9/146 , A61K31/7088 , A61K47/22 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
-
6.发明公开
公开(公告)号：EP4190951A1
公开(公告)日：2023-06-07
申请号：EP22194954.8
申请日：2016-12-21
发明人： FALCONER, Ester , HANSEN, Carl Lars Genghis , LECAULT, Veronique , LISAINGO, Kathleen , HEYRIES, Kevin Albert
IPC分类号： C40B30/04 , C12N5/078 , C12Q1/02 , C12Q1/68 , C40B20/00 , C40B40/02 , C40B50/06 , G01N33/543 , G01N33/566 , G01N33/574 , G01N33/68
摘要： The present invention relates to methods for isolating the sequences of an antibody that reacts with a disease related antigen, e.g., an autoantigen, without knowing the identity of the antigen (sequence or structural epitope) a priori. The methods can also be used to identify an antigen that mediates a disease state, e.g., an autoantigen implicated in an autoimmune disorder or a tumor response.
-
公开(公告)号：EP3872191A1
公开(公告)日：2021-09-01
申请号：EP21151890.7
申请日：2015-05-22
发明人： HANSEN, Carl Lars Genghis , MEWIS, Georgia Elizabeth , HEYRIES, Kevin Albert , VANINSBERGHE, Michael Andrew , DA COSTA, Daniel Jay , RICICOVA, Marketa
IPC分类号： C12Q1/6876 , G16B40/00 , C40B20/00 , G01N33/68
摘要： Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs.
-
公开(公告)号：EP3792378A1
公开(公告)日：2021-03-17
申请号：EP20197858.2
申请日：2016-02-04
发明人： HANSEN, Carl Lars Genghis , ZAHN, Hans , HUFT, Jens , VAN LOENHOUT, Marinus Theodorus Johannes , LEUNG, Kaston , LIN, Bill Kengli , KLAUS, Anders , APARICIO, Samuel Alves Jana Rodrigues , SHAH, Sohrab Prakash , STEIF, Adi
IPC分类号： C40B50/06 , B81B1/00 , B81B7/04 , C12M1/34 , C12N15/00 , C12P19/34 , C12Q1/00 , C12Q1/68 , C40B20/00 , C40B30/00 , C40B40/06 , G01N33/48 , G01N33/50 , G01N33/53 , B01L3/00 , C12Q1/686 , C12Q1/6869 , C12N15/10 , C12Q1/6806
摘要： Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for preimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.
-
公开(公告)号：EP3146079B1
公开(公告)日：2019-01-30
申请号：EP15796244.0
申请日：2015-05-22
-
10.发明公开
公开(公告)号：EP2714884A1
公开(公告)日：2014-04-09
申请号：EP11867040.5
申请日：2011-05-27
发明人： HANSEN, Carl Lars Genghis , VANINSBERGHE, Michael , WHITE, Adam , PETRIV, Oleh , LEAVER, Tim , SINGHAL, Anupam , BOWDEN, William , LECAULT, Veronique , DA COSTA, Dan , WU, Leo , RUSSELL, Georgia , SIKORSKI, Darek
CPC分类号： C12Q1/6806 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L2200/0668 , B01L2300/0816 , B01L2400/086 , C12M23/16 , C12Q1/6844 , G01N1/34 , G01N33/5005 , G01N33/54366 , G01N33/569
摘要： Microfluidic devices are provided for trapping, isolating, and processing single cells. The microfluidic devices include a cell capture chamber having a cell funnel positioned within the cell capture chamber to direct a cell passing through the cell capture chamber towards one or more a cell traps positioned downstream of the funnel to receive a cell flowing. The devices may further include auxiliary chambers integrated with the cell capture chamber for subsequent processing and assaying of the contents of a captured cell. Methods for cell capture and preparation are also provided that include flowing cells through a chamber, funneling the cells towards a cell trap, capturing a predefined number of the cells within the trap, interrupting the flow of cells, flowing a wash solution through the chamber to remove contaminants from the chamber, and sealing the predefined number of cells in the chamber.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.021 秒)
