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    BRAIN-PROTECTIVE AGENT
    5.
    发明公开
    BRAIN-PROTECTIVE AGENT 失效
    脑保护ACTIVE

    公开(公告)号：EP1008352A4

    公开(公告)日：2005-03-16

    申请号：EP98929828

    申请日：1998-07-03

    申请人： FUJISAWA PHARMACEUTICAL CO

    发明人： ONO SHIGEKI ,  DATE ISAO

    IPC分类号： A61K38/00 ,  C12N15/113 ,  A61K45/00 ,  A61K31/70 ,  C07H21/00 ,  C12N15/11

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/13

    摘要： A brain-protective agent containing an NF-k decoy. In brain diseases, the brain can be particularly effectively protected against brain disorders (for example, cerebrovascular contraction following subarachnoidal bleeding and cerebral nerve cell death in the prognosis of patients with cerebrovascular disorders or serious head injury) caused by the undesired activation of cytokines or cell adhesion factors which are regulated by NF-k by administering the brain-protective agent containing an NF-k decoy, i.e., a compound antagonistic specifically to a nucleic acid to which NF-kB binds.

    NUCLEAR RECEPTOR RXR ALPHA ISOFORMS
    8.
    发明公开
    NUCLEAR RECEPTOR RXR ALPHA ISOFORMS 审中-公开
    ISOFORMEN DESNUKLEÄRENREZEPTORS RXR ALPHA

    公开(公告)号：EP1489094A1

    公开(公告)日：2004-12-22

    申请号：EP03712915.2

    申请日：2003-03-25

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： KOJO, Hitoshi ,  TAJIMA, Kaoru ,  FUKAGAWA, Masao ,  NISHIMURA, Shintaro ,  ISOGAI, Takao

    IPC分类号： C07K14/705 ,  C12N15/12 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  C12P21/02 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： C07K14/70567

    摘要： The present invention relates to the novel isoforms, RXRα2 and RXRα3, of nuclear receptor RXRα. Unlike known isoform RXRα1, the transcriptional activation functions of RXRα2 and RXRα3 are augmented by SRC-1. The present invention provides methods for evaluating the function of regulating augmentation by co-activators of these RXRα isoforms, and screening methods based on these evaluation methods. By controlling the interaction between isoforms and co-activators, transcription-controlling activity can be regulated in an isoform-specific manner.

    摘要翻译： 本发明涉及核受体RXRα的新型异构体RXRα2和RXRα3。 与已知的同种型RXRα1不同，RXRα2和RXRα3的转录激活功能被SRC-1增强。 本发明提供了通过这些RXRα同种型的共激活剂来评价调节功能的方法以及基于这些评价方法的筛选方法。 通过控制同种型和共激活剂之间的相互作用，可以以同种型特异性方式调控转录调控活性。