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91.发明公开FLUORINATED PHENYL-NAPHTHALENYL-UREA COMPOUNDS AS INHIBITORS OF CYTOKINES INVOLVED IN INFLAMMATORY PROCESSES 审中-公开氟化苯基萘基脲衍生物的细胞因子的INHHIBITOREN在炎症过程中
公开(公告)号：EP1549621A1
公开(公告)日：2005-07-06
申请号：EP03784873.6
申请日：2003-08-01
发明人： Cirillo, Pier Fco,Boehringer Ingelheim Pharm Inc. , Hammach, A.,Boehringer Ingelheim Pharm Inc. , Kamhi, Victor,Boehringer Ingelheim Pharm. Inc. , Moss, Neil,Boehringer Ingelheim Pharm., Inc. , Riska, Paul S.,Boehringer Ingelheim Pharm. Inc. , Pargellis, C.,Boehringer Ingelheim Pharm. Inc.
IPC分类号： C07D239/34 , C07D239/46 , C07D403/12 , A61K31/505 , A61K31/506
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D239/34 , C07D239/47 , C07D239/52 , C07D401/12 , C07D405/12
摘要： Disclosed are compounds of formula (I) wherein R1, R2, W and X of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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92.发明公开
公开(公告)号：EP1545514A1
公开(公告)日：2005-06-29
申请号：EP03788293.3
申请日：2003-07-30
IPC分类号： A61K31/415 , A61P7/02
CPC分类号： A61K31/5377 , A61K31/00
摘要： Disclosed are methods for treating a disease or conditions relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
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公开(公告)号：EP1539708A1
公开(公告)日：2005-06-15
申请号：EP03795649.7
申请日：2003-09-04
发明人： BARBOSA, Antonio J.M.,Jr , GOLDBERG, Daniel R. , HAMMACH, Abdelhakim , LIU, Pingrong , MOSS, Neil , RALPH, Mark Stephen , ROTH, Gregory Paul , SARKO, Christopher Ronald , SOLEYMANZADEH, Fariba , WHITE, Andre
IPC分类号： C07D235/26 , C07D401/06 , C07D409/06 , C07D403/06 , C07D405/06 , C07D401/04 , C07D405/04 , C07D401/14 , C07D417/14 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , A61K31/4184 , A61K31/497
CPC分类号： C07D231/12 , C07D233/56 , C07D235/26 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D417/04 , C07D471/10 , C07D491/10
摘要： Disclosed are benzimidazolone compounds of formulas (II) wherein X is O, S or NR5. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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94.发明公开METHOD FOR IMPROVING THE ABILITY OF PATIENTS SUFFERING FROM LUNG DISEASES TO PARTICIPATE IN AND BENEFIT FROM PULMONARY REHABILITATION PROGRAMS 审中-公开患者改造中FûHIGKEIT在肺部疾病方法受苦，参与并肺康复程序的使用
公开(公告)号：EP1539162A1
公开(公告)日：2005-06-15
申请号：EP03794983.1
申请日：2003-09-03
发明人： DISSE, Bernd , KESTEN, Steven , WITEK, Theodore
IPC分类号： A61K31/46
CPC分类号： A61K31/439
摘要： The invention relates to a method for improving the ability of patients suffering from lung diseases to participate in and benefit from pulmonary rehabilitation programs said method comprising the administration of a therapeutically effective amount of (1 ,2 ,4 ,5 ,7 )-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4] nonane salts.
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公开(公告)号：EP1497278A1
公开(公告)日：2005-01-19
申请号：EP03721619.9
申请日：2003-04-10
发明人： GAO, D. A.,Boehringer Ingelheim Pharma. Inc. , GOLDBERG, D. R.,Boehringer Ingelheim Pharma. Inc. , HAMMACH, A.,Boehringer Ingelheim Pharma. Inc. , HAO, M.-H.,Boehringer Ingelheim Pharma. Inc. , MOSS, N.,Boehringer Ingelheim Pharma. Inc. , QIAN, K. C.,Boehringer Ingelheim Pharma. Inc. , ROTH, G. P.,Boehringer Ingelheim Pharma. Inc. , SARKO, C. R.,Boehringer Ingelheim Pharma Inc. , SWINAMER, A. D.,Boehringer Ingelheim Pharma. Inc. , XIONG, Z.,Boehringer Ingelheim Pharma. Inc. , KAMHI, V. M.,Boehringer Ingelheim Pharma. Inc.
IPC分类号： C07D333/70 , C07D209/42 , C07D307/85 , C07C311/08 , C07D409/12 , C07D401/12 , C07D403/12 , C07D417/12 , A61K31/381 , A61K31/343 , A61K31/404 , A61P29/00
CPC分类号： C07D401/12 , C07C311/08 , C07D209/42 , C07D307/85 , C07D333/70 , C07D403/12 , C07D409/12 , C07D417/12
摘要： Disclosed are amide compounds of formula (I) wherein Ar1, Q, Y and R3-R6 of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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96.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开糖皮质激素模拟物，用于生产含有它们的药物组合物，并且使用
公开(公告)号：EP1490317A1
公开(公告)日：2004-12-29
申请号：EP03723790.6
申请日：2003-03-21
发明人： BEKKALI, Y.,Boehringer Ingelheim Pharm., Inc. , CARDOZO, Mario, G. , KIRRANE, T. M.,Boehringer Ingelheim Pharm., Inc. , KUZMICH, D.,Boehringer Ingelheim Pharm., Inc. , PROUDFOOT, J.R.,Boehringer Ingelheim Pharm., Inc. , TAKAHASHI, H.,Boehringer Ingelheim Pharm., Inc. , THOMSON, D.,Boehringer Ingelheim Pharm., Inc. , WANG, J.,Boehringer Ingelheim Pharm., Inc. , ZINDELL, R.,Boehringer Ingelheim Pharm., Inc. , HARCKEN,C.H.J.J.,Boehringer Ingelheim Pharm., Inc. , RAZAVI, H.,Boehringer Ingelheim Pharm., Inc.
IPC分类号： C07C43/23 , A61K31/085 , A61P29/00 , A61P27/14 , C07C255/54 , C07C233/65 , C07D307/79 , C07D213/30
CPC分类号： C07C323/18 , C07C37/055 , C07C39/367 , C07C39/373 , C07C43/23 , C07C45/004 , C07C45/30 , C07C45/44 , C07C45/45 , C07C45/63 , C07C45/673 , C07C45/68 , C07C45/69 , C07C47/575 , C07C49/233 , C07C49/255 , C07C49/577 , C07C49/83 , C07C49/84 , C07C59/56 , C07C65/24 , C07C235/42 , C07C251/48 , C07C255/53 , C07C255/54 , C07C317/22 , C07C2601/02
摘要： Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate,or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA）和式（IB）worinř 1 ，R 2 ，R 3 ，R 4 ，R 5 和R 6 是如对式（IA）或式（IB），或其互变异构体，前药，溶剂化物，或其盐; 药物组合物含有受试化合物，并调节糖皮质激素受体功能的方法和治疗疾病状态或由糖皮质激素受体功能中使用这些化合物的患者介导的或特征为炎性，过敏性或增生性过程病症的方法。
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公开(公告)号：EP1474172A1
公开(公告)日：2004-11-10
申请号：EP03707713.8
申请日：2003-02-05
CPC分类号： A61K31/4709 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/145 , A61K9/146 , A61K9/4866 , A61K47/18 , A61K2300/00
摘要： Disclosed are pharmaceutical compositions of hepatitis C viral protease inhibitors having improved bioavailability, and methods of using these compositions for inhibiting the replication of the hepatitis C virus (HCV) and for the treatment of an HCV infection. These compositions include co-solvent systems, lipid based systems, solid dispersions and granulations, and all comprise the hepatitis C viral protease inhibitor, at least one pharmaceutically acceptable amine and optionally one or more additional ingredients.
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98.发明公开NUCLEIC ACID CONSTRUCTS USEFUL FOR GLUCOSE REGULATED PRODUCTION OF HUMAN INSULIN IN SOMATIC CELL LINES 有权葡萄糖调控人胰岛素生产体细胞系SUITABLE NUCLEIC构建体
公开(公告)号：EP1458240A2
公开(公告)日：2004-09-22
申请号：EP02741943.1
申请日：2002-06-10
发明人： TATAKE, Revati J.,Boehringer Ingelheim Corp. , SCHNEIDERMAN, Richard,Boehringer Ingelheim Corp. , BARTON, Randall Wilber,Boehringer Ingelheim, Corp
IPC分类号： A01N63/00 , A61K48/00 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/85 , C12N15/87
CPC分类号： C07K14/62 , A61K35/12 , A61K48/00 , C12N2510/02
摘要： Unique multifunctional nucleotide expression cassettes comprising a nucleotide sequence encoding a human protease driven by a glucose-regulatable promoter, a nucleotide sequence encoding human proinsulin having sites at its B-C and C-A junctions altered to permit cleavage by the human protease, and a CMV promoter driving the transcription of the nucleotide sequence encoding the human proinsulin, such cassettes optionally having polyadenylation sequences after each structural gene and the nucleotide sequence encoding human proinsulin optionally carrying an H10D variant, and cells transformed thereby.
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公开(公告)号：EP1408950A2
公开(公告)日：2004-04-21
申请号：EP02746764.6
申请日：2002-07-01
IPC分类号： A61K31/216
CPC分类号： A61K31/5377 , A61K31/216 , A61K31/415 , A61K31/435
摘要： Disclosed are methods of treating certain cytokine mediated diseases or conditionsusing novel aromatic heterocyclic compounds of the formula (I) wherein Ar1, Ar2, L, Q and X are described herein.
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100.发明授权SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE 有权合成3-氨基-2-氯-4-甲基吡啶OFF丙二腈和丙酮
公开(公告)号：EP1064265B1
公开(公告)日：2004-04-14
申请号：EP00902349.0
申请日：2000-01-06
发明人： GROZINGER, Karl
IPC分类号： C07D213/73 , C07D213/12
CPC分类号： C07D213/73
摘要： A method for making 3-amino-2-chloro-4-methylpyridine from molononitrile, as depicted in reaction scheme (I).
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