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126 条记录 (耗时 0.023 秒)

    REMEDIES
    91.
    发明公开
    REMEDIES 有权
    ARZNEIEN ZUR BEHANDLUNG VON NERVENERKRANKUNGEN

    公开(公告)号：EP1254658A1

    公开(公告)日：2002-11-06

    申请号：EP01946787.7

    申请日：2001-01-26

    申请人： TAKARA BIO INC.

    发明人： OHNOGI, Hiromu ,  SHIRAGA, Masahiro ,  KOBAYASHI, Eiji ,  LI, Tuo-Ping ,  DEGUCHI, Suzu ,  NISHIYAMA, Eiji ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： A61K31/12 ,  A61K31/216 ,  A61K31/352 ,  A61K31/7004 ,  A61P25/00 ,  A61P25/28 ,  A61P9/10 ,  A61P43/00 ,  A23L1/30 ,  C07C49/83 ,  C07C49/255 ,  C07C49/84 ,  C07C49/573 ,  C07C69/12

    CPC分类号： A61K31/7004 ,  A23L33/10 ,  A61K31/12 ,  A61K31/216 ,  A61K31/222 ,  A61K31/352

    摘要： The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.

    摘要翻译： 本发明提供了需要增强神经生长因子产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂或用于增强神经生长因子产生的食品，饮料或饲料，其各自包含作为有效成分 具有增强神经生长因子生成活性的特定化合物或其盐; 一种用于增强神经生长因子产生的方法，包括向哺乳动物施用上述化合物或其盐; 以及上述化合物或其盐在制备需要增强神经生长因子产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂或食品，饮料或饲料中的用途 增强神经生长因子的产生。 此外，本发明提供了具有增强神经生长因子生产活性的新型化合物。

    EFFECT OF TREATMENT WITH 4,5-DIHYDROXY- 2-CYCLOPENTEN-1-ONE (DHCP) ON GENE EXPRESSION AND QUORUM-SENSING IN BACTERIA
    96.
    发明授权
    EFFECT OF TREATMENT WITH 4,5-DIHYDROXY- 2-CYCLOPENTEN-1-ONE (DHCP) ON GENE EXPRESSION AND QUORUM-SENSING IN BACTERIA 有权
    治疗与4,5-二羟基-2-环戊烯-1-酮（DHCP）对基因表达和仲裁测量中的细菌的影响

    公开(公告)号：EP1482793B1

    公开(公告)日：2008-12-31

    申请号：EP03713993.8

    申请日：2003-03-07

    申请人： Takara Bio, Inc.

    发明人： PHADTARE, Sangita ,  KATO, Ikunoshin ,  INOUYE, Masayori, The Colony House

    IPC分类号： A01N37/18 ,  C07K1/00 ,  C07H21/02

    CPC分类号： C12P21/00 ,  C12Q1/6837 ,  C12Q1/689 ,  C12Q2600/158

    摘要： DHCP (4,5-dihydroxy-2-cyclopenten-1-one) has been previously shown to have antibacterial activity against Escherichia coli. Global transcriptional pattern of E. coli was analyzed in response to DHCP by DNA microarray. It is now shown that DHCP has widespread effects in E. coli, affecting genes encoding proteins involved in general metabolism and cell membrane synthesis and functions. In addition, rpoS and RpoS-regulated genes responding to various stresses are upregulated. DHCP is also shown to inhibit AI-2, an autoinducer involved in interspecies quorum-sensing, and the genes comprising quorum-regulated processes such as virulence, motility and outer membrane functions are downregulated by DHCP treatment. In addition, cysK which is a known quorum-sensing gene working in an alternate pathway(s) in E. coli increases considerably in response to DHCP. These results suggest that DHCP regulates the switching on/off of the different quorum-sensing circuits in E. coli.

    Anti aptotosis AGENTS
    100.
    发明授权
    Anti aptotosis AGENTS 有权
    抗凋亡剂

    公开(公告)号：EP1086952B1

    公开(公告)日：2007-08-15

    申请号：EP99923961.9

    申请日：1999-06-08

    申请人： TAKARA BIO INC.

    发明人： ENOKI, Tatsuji ,  TOMONO, Jun ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： C07D493/08

    CPC分类号： A61K31/7004 ,  A23L3/3535 ,  A23L3/3562 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/35 ,  A61K31/351 ,  A61K31/357 ,  A23V2250/60 ,  A23V2250/608 ,  A23V2250/5024 ,  A23V2250/5036

    摘要： Therapeutic or preventive agents for diseases requiring apoptosis induction, cancerous diseases, diseases requiring the inhibition of active oxygen production, those requiring the inhibition of nitrogen monoxide production, those requiring the inhibition of prostaglandin synthesis, those requiring the inhibition of synovial cell proliferation, those requiring the induction of heat shock protein production or those requiring the inhibition of α-glycosidase, which contain as the active ingredient compounds selected from among compounds represented by general formula (I), (wherein X and Y are each H or CH2OH, provided that when X is CH2OH, Y is H, while when X is H, Y is CH2OH), those represented by general formula (II), (wherein R is a residue obtained by freeing a compound having an SH group from the SH group) and salts of both; and foods, drinks, cosmetics and so on, containing compounds selected from among compounds of general formula (I), those of general formula (II) and salts of both.