公开(公告)号：EP3714276B1

公开(公告)日：2024-10-09

申请号：EP18815865.3

申请日：2018-11-14

IPC分类号： G01N33/72 ,  A61B5/145 ,  A61B5/1486

CPC分类号： A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1486 ,  G01N33/721 ,  G01N33/723 ,  G01N33/726 ,  A61B2562/029520130101

公开(公告)号：EP3407069A1

公开(公告)日：2018-11-28

申请号：EP17172749.8

申请日：2017-05-24

申请人： Koninklijke Philips N.V.

发明人： KOOIJMAN, Gerben ,  VAN HARTSKAMP, Michael Alex ,  DE JAGER, Marinus Karel Johannes ,  RMAILE, Amir Hussein ,  PRESHAW, Philip ,  TAYLOR, John

IPC分类号： G01N33/68 ,  G01N33/72

CPC分类号： G01N33/6893 ,  G01N33/721 ,  G01N33/726 ,  G01N2333/4737 ,  G01N2333/4753 ,  G01N2333/545 ,  G01N2333/805 ,  G01N2800/18

摘要： Disclosed is an in vitro method for assessing the presence of gingivitis in a human subject. The method is based on the insight to determine a selection of three biomarker proteins. Accordingly, in a saliva sample of the subject the concentrations are measured of the proteins Hepatocyte growth factor (HGF) and Interleukin-1β (IL1β), and at least one of C reactive protein (CRP) and Haemoglobin. Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with the absence of gingivitis or periodontitis. The comparison allows to assessing whether the testing value is indicative of the presence of gingivitis in said subject Thereby, typically, a testing value reflecting a joint concentration above the joint concentration reflected by the threshold, is indicative of the presence of gingivitis.

公开(公告)号：EP3052022B1

公开(公告)日：2018-09-12

申请号：EP14777068.9

申请日：2014-09-26

申请人： APD Advanced Perfusion Diagnostics

发明人： BEUTE, Jan ,  BONIDAL, Rémi

IPC分类号： A61B5/1455 ,  G01N33/72 ,  A61B5/00 ,  A61B5/1495

CPC分类号： A61B5/14552 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/1495 ,  G01N33/721 ,  G01N33/726

公开(公告)号：EP2175278B1

公开(公告)日：2018-05-09

申请号：EP08776882.6

申请日：2008-07-25

申请人： Panasonic Healthcare Holdings Co., Ltd.

发明人： HIROSHI, Saiki

IPC分类号： G01N35/00 ,  B01J19/00 ,  G01N33/48 ,  G01N35/08 ,  G01N37/00

CPC分类号： B01L3/502 ,  B01L2200/10 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2400/0409 ,  G01N33/726 ,  G01N35/00069 ,  G01N35/08 ,  G01N2035/00495 ,  Y10T436/111666 ,  Y10T436/25625 ,  Y10T436/2575

摘要： A device for analysis used for transferring a solution to a measurement spot 38 by a centrifugal force and reading in which a reaction liquid located at the measurement spot 38 is optically accessed. An operation cavity 30 and a receiving cavity 32 are arranged from the upstream side to the downstream side of the transfer. The operation cavity 30 and the receiving cavity 32 communicate with each other via a connection section 59 to transfer the solution of the operation cavity 30 to the receiving cavity 32. The connection section 59 is located inside the liquid level of a diluted solution retained in the operation cavity 30, relative to a rotation axis 102.

公开(公告)号：EP2366107B1

公开(公告)日：2018-01-24

申请号：EP09774689.5

申请日：2009-11-12

申请人： Oxford MEStar Limited

发明人： BENOIT, Vincent

IPC分类号： G01N33/72 ,  G01N33/487 ,  G01N27/30

CPC分类号： G01N33/725 ,  G01N27/3271 ,  G01N33/726

摘要： A method for amperometric detection of proteins, especially haemoglobin in faeces, using an electrochemical sensor. The electrochemical sensor includes: a working electrode having an electrically conductive matrix holding a first reagent and/or a second reagent, the second reagent being an oxidizing agent, or a precursor thereof, for the first reagent; a counter electrode and optionally a reference electrode; wherein a reaction between the first reagent and the oxidizing agent is catalyzed by the protein to provide a detectable signal at the working electrode. The electrically conductive matrix is an electrically conductive carbon- or graphite-containing matrix or an electrically conductive porous matrix.

公开(公告)号：EP3201624A4

公开(公告)日：2017-08-30

申请号：EP15846601

申请日：2015-09-29

申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC

发明人： BAXTER ANDREW JOHN ,  COTTON PAUL WILLIAM

IPC分类号： G01N33/49

CPC分类号： G01N33/721 ,  A61M1/34 ,  G01N33/483 ,  G01N33/49 ,  G01N33/491 ,  G01N33/4925 ,  G01N33/50 ,  G01N33/72 ,  G01N33/726 ,  G01N33/80 ,  G01N33/84 ,  G01N2015/055

摘要： Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.

摘要翻译： 本发明的方面涉及能够快速和可靠地检测样品中溶血的装置，系统和方法，使得显示不可接受水平的溶血的样品可以在相关的诊断测试中被标记或忽略。

公开(公告)号：EP3155430A4

公开(公告)日：2017-04-19

申请号：EP15807510

申请日：2015-06-08

申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC

发明人： LEDDEN DAVID J ,  COX JANINE A ,  JASPERSE JEFFREY R

IPC分类号： G01N33/558 ,  G01N33/72

CPC分类号： G01N33/725 ,  G01N33/558 ,  G01N33/721 ,  G01N33/726

摘要： In one aspect, the inventive concepts disclosed herein are directed to a chromatographic assay device for detecting the presence of free hemoglobin in a whole blood sample. The device comprising a chromatographic detection pad with a sample application site and a detection side. The chromatographic detection pad defines a path for capillary fluid flow. The chromatographic detection pad has a pore size. The sample application site on the chromatographic detection pad is for application of a portion of the whole blood sample. The detection site on the chromatographic detection pad is spaced apart from the application site and is downstream of the sample application site. The chromatographic detection pad is devoid of a compound located downstream of the application site that is reactive to the whole blood sample.

摘要翻译： 在一个方面，本文公开的发明概念涉及用于检测全血样品中游离血红蛋白的存在的色谱测定装置。 该装置包括具有样品施加位点和检测侧的色谱检测垫。 色谱检测垫确定毛细管流体流动的路径。 色谱检测垫具有孔径。 色谱检测垫上的样品施加位置用于施加全血样品的一部分。 色谱检测垫上的检测位置与施用位点间隔开，位于样品施用位点的下游。 色谱检测垫没有位于施用位点下游的对全血样品具有反应性的化合物。

公开(公告)号：EP3124606A1

公开(公告)日：2017-02-01

申请号：EP14887202.1

申请日：2014-12-27

申请人： Kyocera Corporation

发明人： KURIOKA, Hideharu ,  TANAKA, Hiroyasu

IPC分类号： C12N15/00 ,  C12M1/00 ,  C12N15/115 ,  G01N33/53 ,  G01N33/566

CPC分类号： G01N33/726 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/3517 ,  C12N2310/3519

摘要： An RNA aptamer (130) is provided with a sequence (S) of linkage order of UAUUAGGACCA.

摘要翻译： RNA适体（130）具有UAUUAGGACCA的序列（S）序列。

公开(公告)号：EP2400034B1

公开(公告)日：2016-08-24

申请号：EP11171086.9

申请日：2011-06-22

申请人： ARKRAY, Inc. ,  Sekisui Medical Co., Ltd.

发明人： TAKAGI, Takeshi ,  SAKAI, Toshikatsu ,  MIYAMOTO, Chiaki ,  ASAMI, Takeshi ,  KAMATA, Tatsuo ,  YOTANI, Takuya ,  OKA, Takayuki

IPC分类号： C12Q1/54 ,  G01N33/72 ,  C12Q1/00 ,  G01N33/66

CPC分类号： C12Q1/006 ,  G01N33/66 ,  G01N33/723 ,  G01N33/726

公开(公告)号：EP3052022A1

公开(公告)日：2016-08-10

申请号：EP14777068.9

申请日：2014-09-26

申请人： APD Advanced Perfusion Diagnostics

发明人： BEUTE, Jan ,  BONIDAL, Rémi

IPC分类号： A61B5/1455 ,  G01N33/72 ,  A61B5/00 ,  A61B5/1495

CPC分类号： A61B5/14552 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/1495 ,  G01N33/721 ,  G01N33/726

摘要： The invention relates to a method for estimating a local metabolic parameter of an area of tissue of a patient, said method comprising: receiving (10) light intensities from the area of tissue in question for at least three different wavelengths selected according to the absorptive power of different types of haemoglobin; on the basis of the absorbancy values calculated using the light intensities measured for the three wavelengths, determining (40) a oxyhaemoglobin concentration and a deoxyhaemoglobin concentration; and estimating (50) at least one local metabolic parameter on the basis of the calculated oxyhaemoglobin and deoxyhaemoglobin concentrations.