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    SUBSTITUIERTE N-PHENYLGLUTARIMIDE UND N-PHENYLGLUTARSÄUREAMIDE, DEREN HERSTELLUNG UND VERWENDUNG IN DER LANDWIRTSCHAFT
    91.
    发明授权
    SUBSTITUIERTE N-PHENYLGLUTARIMIDE UND N-PHENYLGLUTARSÄUREAMIDE, DEREN HERSTELLUNG UND VERWENDUNG IN DER LANDWIRTSCHAFT 失效
    取代的N- phenylglutarimide和正PHENYLGLUTARSÄUREAMIDE，生产和使用农业

    公开(公告)号：EP0666848B1

    公开(公告)日：1998-12-30

    申请号：EP94900070.7

    申请日：1993-10-19

    申请人： BASF Aktiengesellschaft

    发明人： KLINTZ, Ralf ,  HAMPRECHT, Gerhard ,  HEISTRACHER, Elisabeth ,  SCHAEFER, Peter ,  KARDORFF, Uwe ,  WESTPHALEN, Karl-Otto ,  GERBER, Matthias ,  WALTER, Helmut

    IPC分类号： C07D211/88 ,  C07D211/86 ,  C07C233/34 ,  C07C233/54 ,  A01N43/40

    CPC分类号： C07C233/54 ,  A01N37/46 ,  C07D211/84 ,  C07D211/88 ,  C07D211/90

    摘要： Substituted N-phenylglutarimides (I), wherein X1, X2 = O, S; R1 = halogen, NO¿2?, CN, CF3; R?2¿ = H, halogen; R?3, R4, R5¿ = H, halogen, CN, alkyl, cycloalkyl, alkenyl, alkinyl, alkyl halide, alkoxy, alkoxy halide, alkyl thio, alkyl thio halide, cyanoalkyl, alkoxy carbonyl, possibly substituted phenyl or benzyl, or 2 substituents of a C atom of the glutarimide ring are linked via a possibly substituted chain, or 2 substituents of adjacent C atoms of the glutarimide ring are linked via a possibly substituted chain; A = CHR6-CHR7-CO-B or CR6=CR8-CO-B; R6 = H, C¿1?-C6-alkyl or C1-C6-alkyl halide; R?7¿ = halogen, alkyl halide, OH, alkoxy or alkyl carbonyl alkoxy; R8 = H, halogen, CN, alkyl, alkyl halide, OH, alkoxy, alkyl carbonyl, alkoxy carbonyl or alkyl carbonyloxy; B = H, alkyl, alkenyl, alkinyl, alkyl halide, cycloalkyl, alkoxy alkyl, dialkoxy alkyl, alkyl thioalkyl, OR?9, SR9, NR10, R11; R9¿ = H, alkyl, alkenyl, alkinyl, cycloalkyl, alkyl halide, cyanoalkyl, alkenyl halide, alkoxy carbonyl alkyl, alkoxyalkyl, alkyl thioalkyl, alkylimino, alkylimino alkyl, possibly substituted phenyl or benzyl; R10, R11 = H, alkyl, alkenyl, alkinyl, cycloalkyl, alkyl halide, alkyl carbonyl, alkoxy carbonyl, alkoxy alkyl, possibly substituted phenyl, or R?10 und R11¿ together with the common N atom = saturated or unsaturated 4- to 7- membered heterocycle with 1-2 other heteroatoms, as well as salts of (I) that are tolerable to plants; their preparation and use as herbicides and desiccants/defoliants, as well as preproducts for preparing the N-phenylglutarimides (I).

    Röntgenopake Dentalmaterialien
    96.
    发明公开
    Röntgenopake Dentalmaterialien 失效
    nt gen ake。。。

    公开(公告)号：EP0685454A1

    公开(公告)日：1995-12-06

    申请号：EP95250125.2

    申请日：1995-05-24

    申请人： IVOCLAR AG

    发明人： Rheinberger, Volker, Dr. ,  Moszner, Norbert, Prof. Dr. ,  Salz, Ulrich, Dr.

    IPC分类号： C07C69/76 ,  A61K6/083 ,  C07C233/54 ,  C08F220/30

    CPC分类号： A61K6/083 ,  C07C69/76 ,  C07C233/54 ,  C08F220/30

    摘要： Röntgenopake Ester oder Amide iodsubstituierter Benzoesäure gemäß Formel I sowie daraus hergestellte Polymere und Dentalmaterialien.


    R¹ = Wasserstoff oder C₁- bis C₃-Alkyl, vorzugsweise H oder CH₃;
    R² = geradkettiges oder verzweigtes C₁- bis C₆-Alkylen, -Oxyalkylen oder -Arylen, vorzugsweise C₂- bis C₄-Alkylen und besonders bevorzugt -CH₂-CH₂- und -CH₂CH(-)CH₂-;
    X = O oder NH, vorzugsweise O;
    R³-R⁷ = mindestens 3 Iodsubstituenten, vorzugsweise in R³-, R⁴- und R⁶-oder R³-, R⁵- und R⁷-Stellung, die übrigen Reste sind Wasserstoff, C1- bis C₆-Alkyl, C₁- bis C₆-Alkoxy, -Cl, -Br, -OH, -NH₂, -N(C₁- bis C₆-Alkyl)₂ oder -NH-CO-(C₁-bis C₆-Alkyl), vorzugsweise sind R³, R⁴, und R⁶ = I und R⁵ und R⁷ = H, oder R³, R⁵ und R⁷ = I und R⁴ und R⁶ = -NH(COCH₃);
    n = 1, 2 oder 3, vorzugsweise 1 oder 2.

    Die erfindungsgemäßen Benzoesäureester und -amide lassen sich radikalisch oder anionisch gut polymerisieren, die Polymere sind in den üblichen Dentalmonomeren gut löslich. Aus den Monomeren oder Polymeren hergestellte Dentalmaterialien zeichnen sich dadurch aus, daß die röntenopake Komponente kovalent in das polymere Matrixmaterial eingebunden und damit nicht auswaschbar ist. Außerdem läßt sich ohne die Verwendung von Füllstoffen eine ausgezeichnete Röntgenopazität erzielen.

    摘要翻译： 式（I）的碘代苯甲酸的不透明的酯或酰胺是新的。 R 1 = H或1-3C烷基; R 2 =直链或支链的1-6C亚烷基，氧化烯或亚芳基; X = O或NH; R 3 -R 7 =至少3个碘取代基，其他gps。 C 1-6烷基或烷氧基，Cl，Br，OH，NH 2，-N（1-6C烷基）2或-NH-CO-（1-6C烷基）; n = 1,2或3.还要求的是不透射线的（甲基）丙烯酸酯聚合物（II）。 （I），不透射线牙科材料（III） （I）和/或（II），和人造牙齿，单板，植入物，冠，桥梁和镶嵌物。 （I）和/或（II）和/或（III）。

    Iodinated aroyloxy esters and their use as contrast agents in X-ray imaging
    99.
    发明公开
    Iodinated aroyloxy esters and their use as contrast agents in X-ray imaging 失效
    Iodierte Aroxy Ester和ivre Verwendung alsRöntgenkontrastmittel。

    公开(公告)号：EP0603922A1

    公开(公告)日：1994-06-29

    申请号：EP93203301.2

    申请日：1993-11-26

    申请人： NanoSystems L.L.C.

    发明人： Bacon, Edward R., Sterling Winthrop Inc. ,  Daum, Sol J., Sterling Winthrop Inc. ,  Spara, Paul P., Sterling Winthrop Inc.

    IPC分类号： C07C233/54 ,  A61K49/04 ,  C07C233/88 ,  C07C233/91

    CPC分类号： A61K49/0433 ,  C07C233/54 ,  C07C233/88 ,  C07C233/91

    摘要： Compounds having the structure

       wherein (Z)̵COO is the residue of an iodinated aromatic acid;
       n is an integer from 1 to 20;
       R¹ and R² are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;
       R³ and R⁴ are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetamidoalkyl, COO-alkyl and cyano;
       R⁵ is alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, alkoxyalkyl or acetamidoalkyl;
       are useful as contrast agents in x-ray imaging compositions and methods for x-ray diagnostic imaging.

    摘要翻译： 具有结构的化合物，其中（Z＆rparstr＆COO是碘化芳族酸的残基; n是1-20的整数; R 1和R 2独立地是H，烷基，氟烷基，环烷基，芳基 芳烷基，烷氧基或芳氧基; R 3和R 4独立地为H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，卤素，羟基，酰氨基，乙酰胺基烷基，COO-烷基和氰基; 5是烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，烷氧基烷基或乙酰氨基烷基;可用作x射线成像组合物和x射线诊断成像方法中的造影剂。

    Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase
    100.
    发明公开
    Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase 失效
    芳族酯，氧化剂如人弹性蛋白酶神经亲水的抑制剂的接受与否。

    公开(公告)号：EP0465802A1

    公开(公告)日：1992-01-15

    申请号：EP91108206.3

    申请日：1991-05-21

    申请人： CORTECH, INC.

    发明人： Kirschenheuter, Gary P. ,  Cheronis, John C. ,  Spruce, Lyle W.

    IPC分类号： C07C323/20 ,  C07C317/22 ,  C07C205/43 ,  C07C309/42 ,  C07C69/612 ,  C07D295/155 ,  C07D211/14 ,  C07D233/60 ,  C07C233/54 ,  C07D209/64 ,  A61K31/215 ,  A61K31/495 ,  A61K31/415 ,  A61K31/535 ,  A61K31/405 ,  C07D207/40 ,  A61K31/40 ,  C07C323/52 ,  C07C317/44

    CPC分类号： C07D295/155 ,  C07C45/46 ,  C07C69/017 ,  C07C69/612 ,  C07C205/43 ,  C07C205/56 ,  C07C309/42 ,  C07C317/22 ,  C07C317/44 ,  C07C323/20 ,  C07C323/52 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07C49/792

    摘要： 2-Phenylalkanoate esters which are useful as inhibitors of human leukocyte elastase are illustrated by the following formula:

    wherein:
    R₁ and R₂, which may be the same or different, are selected from the group consisting of: hydrogen, alkyl, cycloalkyl or together represent a methylene group -(CH₂) n - where n is a whole number of from 1 to 6; R₃ represents one or more substituents up to five selected from the group consisting of:
    hydrogen, halogen, haloalkyl (e.g., CF₃), alkyl, alkoxy, cycloalkyl, alkenyl, mono- or dicyclic aryl (e.g., optionally substituted phenyl or naphthyl),
    -ZR₅ where Z is O, S, S(O)₂ or SO, and R₅ is hydrogen alkyl, cycloalkyl or phenyl;
    -NR₆R₇ wherein R₆ and R₇ may be the same or different and may be hydrogen, alkyl, cycloalkyl, phenyl, alkoxy, acyl of the formula -C(O)R₈ where R₈ is alkyl, cycloalkyl, phenyl, CH₃OC(O)CH₂CH₂-, HOOCCH₂CH₂-, NaO₃SCH₂CH₂NHC(O)CH₂CH₂-, or R₆ and R₇ together represent -C(O)CH₂CH₂C(O)-, -C(O)-C₆H₄-C(O)- or -(CH₂) x -where x is 2, 3, 4, 5 or 6;
    morpholino, imidazolino or piperazino joined to the phenyl ring through a nitrogen atom; or
    R₃ represents the atoms necessary to complete between adjacent ring carbons a further carbocyclic ring of from 1 to 6 carbons or a 5-6 membered heterocyclic ring including one or more O, S or N ring atoms; and R₄ is from one to five substituents selected from hydrogen, halogen, nitro, -C(O)CH₃, S(O) p R₉ where p is 0, 1 or 2 and R₉ is hydroxy, -ONa or optionally substituted alkyl or optionally substituted cycloalkyl including, for example, lower alkyl substituted with halogen (such as trifluoromethyl) or lower alkyl bearing a carboxylic acid group, especially -CH₂C(CH₃)₂CO₂H.

    摘要翻译： 2- Phenylalkanoate酯作为人体白血球弹性蛋白酶抑制剂的下式所示的哪些是有用的： worin：R1和R2可以是相同的或不同的，选自下组由......组成：氢，烷基，环烷基 或一起代表亚甲基基团 - （CH2）n-，其中n是一个整数1至6的; R3 darstellt一个或多个取代多达五个选自的选自：氢，卤素，卤代烷基（例如，CF 3），烷基，烷氧基，环烷基，链烯基，单 - 或二环芳基（例如，苯基或萘基OPTIONALLY substituiertem） -ZR5其中Z是O，S，S（O）2或SO，并且R 5是氢，烷基，环烷基或苯基; -NR6R7 worin R6和R7可以相同或不同，可以是氢，烷基，环烷基，苯基，烷氧基，式-C酰基（O）R8，其中R8是烷基，环烷基，苯基，CH 3 OC（O）CH 2 CH 2 ，HOOCCH2CH2-，NaO3SCH2CH2NHC（O）CH 2 CH 2，或R6和R7一起表示-C（O）CH2CH2C（O） - ， - C（O）-C 6 H 4 C（O） - 或 - （CH 2）x，其中x 为2，3，4，5或6; 吗啉代，imidazolino或哌嗪子接合到通过氮原子的苯基环; 或R 3表示的原子必要在相邻环碳原子之间完成从1至6个碳的再碳环或5-6元杂环包含一个或多个O，S或N的环原子; 且R 4是选自氢，卤素，硝基，-C（O）CH 3，S（O）PR 9，其中p是0，1或2，R 9为羟基，-ONa或任意取代的烷基或任选substituiertem选择的一个至五个取代基 包括环烷基，例如，低级烷基被卤素取代的（颜色：例如三氟甲基）或低级烷基带有羧酸基团，特别是-CH 2 C（CH 3）2 CO 2 H。