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101.发明公开CORRELATION OF DISEASE ACTIVITY WITH CLONAL EXPANSIONS OF HUMAN PAPILLOMAVIRUS 16-SPECIFIC CD8+ T-CELLS IN PATIENTS WITH SEVERE EROSIVE ORAL LICHEN PLANUS 审中-公开WITH人类克隆性疾病活性的相关性展开式患者乳头瘤病毒16特异性CD8 + T细胞与HEAVY糜烂口腔扁平苔藓
公开(公告)号：EP3156797A1
公开(公告)日：2017-04-19
申请号：EP16191854.5
申请日：2014-08-08
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Université Paris Diderot - Paris 7 , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
IPC分类号： G01N33/50
CPC分类号： G01N33/56983 , A61K31/675 , A61K39/099 , A61K39/12 , A61K45/06 , A61K2039/545 , A61K2039/572 , A61K2039/575 , A61N5/0613 , C07K14/005 , C07K14/235 , C07K2319/55 , C12N7/00 , C12N2710/20034 , C12Q1/04 , C12Q1/6869 , C12Q1/708 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , G01N33/56972 , G01N2333/025 , G01N2333/7051 , G01N2800/18 , G01N2800/52
摘要： A massive clonal expansion of activated CD8 + T-cells with increased frequency of HPV 16-specific CD8 + T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.
摘要翻译： 活化的CD8 + T细胞的一个巨大的克隆扩增与HPV 16特异性CD8 + T细胞的频率增加，其发现是口腔扁平苔藓（OLP）指示HPV感染和dysimmune过程之间的因果关系的特性。 本发明涉及一种用于OLP患者的诊断和治疗的组合物和方法。
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102.发明公开IMIDAZOL- OR 1,2,4-TRIAZOL-DERIVATIVES AND THEIR USE 审中-公开IMIDAZOL-ODER 1,2,4-TRIAZOLDERIVATE UND DEREN VERWENDUNG
公开(公告)号：EP3154634A1
公开(公告)日：2017-04-19
申请号：EP15728001.7
申请日：2015-06-11
申请人： Université de Lille 2 Droit et Santé , INSTITUT PASTEUR DE LILLE , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： CHARTON, Julie , DEPREZ, Benoit , LEROUX, Florence , STAELS, Bart , MUHR-TAILLEUX, Anne , HENNUYER, Nathalie , LESTAVEL, Sophie , LASSALLE, Manuel , DUBANCHET, Barbara
CPC分类号： C07D401/12 , C07D233/88 , C07D249/14 , C07D403/12
摘要： The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
摘要翻译： 本发明涉及新的式（I）化合物，其药学上可接受的盐或溶剂合物及其用途。
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103.发明授权RAPID DETECTION OF THE HIGH-VIRULENT ST-17 CLONE OF GROUP B STREPTOCOCCUS 有权从B组链球菌“很毒” ST-17的克隆快速检测
公开(公告)号：EP1977008B1
公开(公告)日：2017-04-19
申请号：EP06848761.0
申请日：2006-12-20
申请人： INSTITUT PASTEUR , UNIVERSITE RENE DESCARTES (PARIS V) , Centre National de la Recherche Scientifique
发明人： POYART, Claire , LAMY, Marie-Cécile , DRAMSI, Shaynoor , COUVE, Elisabeth , GLASER, Philippe , TRIEU-CUOT, Patrick
IPC分类号： C12Q1/68
CPC分类号： G01N33/56944 , C07K16/1275 , C12Q1/6883 , C12Q1/689 , G01N2333/315
摘要： The present invention relates to polynucleotides enabling the rapid, simple and specific detection of Group B Streptococcus highly-virulent ST-17 clones. The present invention also relates to the polypeptides encoded by the polynucleotides, as well as to antibodies directed or raised against the polypeptides. The present invention also relates to kits and methods for the specific detection of Group B Streptococcus highly-virulent ST-17 clones, using the polynucleotides, the polypeptides or the antibodies according to the invention.
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104.发明公开IMMUNOLOGICAL SIGNATURES AND PARAMETERS PREDICTING THERAPEUTIC RESPONSES TO ANTI-TNF THERAPY 审中-公开免疫组织化学免疫组织免疫细胞化学参数
公开(公告)号：EP3150716A1
公开(公告)日：2017-04-05
申请号：EP15306536.2
申请日：2015-09-29
申请人： INSTITUT PASTEUR
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6863 , G01N2333/52 , G01N2800/102
摘要： The invention relates to a method of predicting therapeutic responses to anti-TNF blockers before anti-TNF therapy comprising analyzing immune parameters to selected stimuli in patients before therapy and its use for anti-TNF therapy. The invention relates also to a method of determining a predictive biomarker of response to anti-TNF therapy and to the use of the predictive biomarker obtained by the method.
摘要翻译： 本发明涉及一种在抗TNF治疗之前预测抗TNF阻断剂的治疗反应的方法，包括分析治疗前患者选择的刺激物的免疫参数及其用于抗TNF治疗的方法。 本发明还涉及确定对抗TNF治疗的反应的预测生物标志物的方法以及通过该方法获得的预测性生物标志物的使用。
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105.发明授权
公开(公告)号：EP2686019B1
公开(公告)日：2017-03-01
申请号：EP12710480.0
申请日：2012-03-16
申请人： Institut Pasteur , Centre National de la Recherche Scientifique (C.N.R.S.) , Université Paris Sud XI
IPC分类号： A61K47/64 , C07K14/705 , A61P31/18
CPC分类号： A61K47/48276 , A61K38/16 , A61K38/177 , A61K38/195 , A61K47/6425 , C07K14/70514 , C07K14/70539 , C07K17/02 , C07K2319/00
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106.发明公开
公开(公告)号：EP3131890A1
公开(公告)日：2017-02-22
申请号：EP15715776.9
申请日：2015-04-17
发明人： WINDISCH, Marc P. , KIM, Hee-Young , YANG, Jaewon , HWANG, Jong Yeon , JO, Suyeon , KWON, Jeongjin , PARK, Dongsik , CHOI, Jihyun , LEE, Jaeheon
IPC分类号： C07D333/68 , C07D401/04 , C07D401/06 , C07D401/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D487/04 , C07D495/04 , C07D211/14 , C07D211/44 , C07D295/12 , C07D211/58 , A61K31/381 , A61K31/435
CPC分类号： C07D495/04 , A61K31/4365 , A61K45/06 , C07D211/14 , C07D211/44 , C07D211/58 , C07D295/12 , C07D333/68 , C07D401/04 , C07D401/06 , C07D401/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D487/04
摘要： The present invention relates to small molecule compounds and their use in the treatment of diseases, in particular viral diseases, in particular hepatitis C virus (HCV).
摘要翻译： 本发明涉及小分子化合物及其用于治疗疾病，特别是病毒性疾病，特别是丙型肝炎病毒（HCV）的用途。
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107.发明公开PREDICTIVE VALUE OF CLOSTRIDIUM DIFFICILE-SPECIFIC IMMUNE RESPONSE FOR RECURRENCE AND DISEASE OUTCOME 审中-公开复发疾病及产量的艰难梭菌特异性免疫应答预测值
公开(公告)号：EP3126840A1
公开(公告)日：2017-02-08
申请号：EP15712982.6
申请日：2015-04-01
申请人： Institut Pasteur , Universite Paris-Sud , Centre Hospitalier de Versailles , Assistance Publique Hôpitaux de Paris
IPC分类号： G01N33/569
摘要： The present invention relates to the field of Clostridium difficile infections. Methods of diagnosing, treating and preventing Clostridium difficile-associated disease and recurrent CDAD are disclosed herein.
摘要翻译： 本发明涉及梭状芽孢杆菌difficileinfections的领域。 诊断，治疗和预防艰难梭菌相关性疾病和复发CDAD的方法是在光盘游离缺失。
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公开(公告)号：EP3115466A1
公开(公告)日：2017-01-11
申请号：EP15306154.4
申请日：2015-07-10
发明人： CHENAL-FRANCISQUE, Viviane , MAURY, Mylène , LAVINA, Morgane , TOUCHON, Marie , LECLERCQ, Alexandre , LECUIT, Marc , BRISSE, Sylvain
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689
摘要： The application relates to Listerin monocytogenes, more particularly to the determination of the clone to which a L. monocytogenes isolate belongs. The means of the application involve primers and/or probes, more particularly multiplex primers. The means of the application are notably useful to assess the invasivity that said L. monocytogenes isolate might show in a human being.
摘要翻译： 本申请涉及单核细胞增生利斯特氏菌（Listerin monocytogenes），更具体地涉及单核细胞增生李斯特菌分离株所属的克隆的测定。 应用的手段包括引物和/或探针，更具体地说是多重引物。 应用的方法对于评估所述单核细胞增生李斯特氏菌分离株在人体中可能显示的侵袭性是显着有用的。
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109.发明公开METHOD AND DEVICE FOR CONSERVING VIABLE AND FUNCTIONAL HUMAN POLYMORPHONUCLEAR NEUTROPHILS 审中-公开方法和设备为维护可行的和功能性的人多形
公开(公告)号：EP3114216A1
公开(公告)日：2017-01-11
申请号：EP15714027.8
申请日：2015-03-09
IPC分类号： C12N5/0787
CPC分类号： C12N5/0642 , C12N2500/02 , C12N2500/34 , C12N2501/73
摘要： A method for keeping leukocytes alive
ex vivo or in vitro , comprising maintaining the leukocytes in a medium comprising from 3 to 10 mM of glucose, in hypoxic conditions with P(02) ≤ 10 mM Hg.摘要翻译： 一种用于保活白细胞离体或在体外，包括在包含3至葡萄糖，在缺氧条件下用P（O 2）‰¤10毫米汞柱10mM的介质维护白细胞的方法。
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公开(公告)号：EP2561081B1
公开(公告)日：2016-12-28
申请号：EP09707059.3
申请日：2009-01-30
发明人： MILED, Chaouki , TANGY, Frédéric , JACOB, Yves
IPC分类号： A61K39/165 , C12N7/00 , A61K39/00 , A61K39/12 , C07K14/005 , C12N15/81
CPC分类号： A61K39/165 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N15/81 , C12N2760/00051 , C12N2760/18434 , C12N2760/18451 , C12N2770/24134
摘要： The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA viruses in yeast, especially in budding yeast. Accordingly, the patent application relates to a recombinant yeast strain suitable for the rescue of infectious non-segmented negative-strand RNA virus particles or infectious virus-like particles. The invention also relates to the use of the recombinant yeast to prepare vaccine seed and to the use of the produced RNPs or RNPs-like to prepare vaccine formulations. It also concerns the use of the recombinant yeast for the screening of libraries of DNA.
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