公开(公告)号：EP3175220A2

公开(公告)日：2017-06-07

申请号：EP15745743.3

申请日：2015-07-27

Applicant: Nanometrics Incorporated

Inventor： KLASSEN, Andrew S. ,  HAZELTON, Andrew J. ,  BARADA, Andrew H. ,  PETIT, Todd M. ,  TU, Chuan Sheng

IPC: G01N21/15 ,  G03F7/20

CPC classification number: G01N21/4785 ,  G01N21/01 ,  G01N21/15 ,  G01N2021/151 ,  G01N2201/02 ,  G01N2201/068 ,  G03F7/70933

Abstract: An integrated metrology module includes a chuck for holding a sample and positioning the sample with respect to an optical metrology device, a reference chip for the optical metrology device, the reference chip being movable to various positions with respect to the optical metrology device, and a reference chip purge device provides a flow of purge gas or air over the reference chip while the reference chip is in the various positions. The reference chip purge device may be static or movable with the reference chip.

Abstract translation: 集成度量模块包括用于保持样本并相对于光学度量装置定位样本的卡盘，用于光学度量装置的参考芯片，参考芯片可相对于光学度量装置移动到各种位置，以及 参考芯片吹扫装置在参考芯片处于不同位置时提供吹扫气体或空气在参考芯片上的流动。 参考芯片清除装置可以是静态的或者可以与参考芯片一起移动。

公开(公告)号：EP3158320A1

公开(公告)日：2017-04-26

申请号：EP15729676.5

申请日：2015-06-01

Applicant: ExxonMobil Upstream Research Company

Inventor： ZENG, Yousheng ,  MORRIS, Jonathan M. ,  ABDELMOATI, Hazem M.

IPC: G01N21/3504 ,  G01J3/28 ,  G01M3/38 ,  G01N21/31 ,  G06K9/00

CPC classification number: G06T7/32 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/36 ,  G01J3/42 ,  G01M3/04 ,  G01M3/38 ,  G01N21/274 ,  G01N21/314 ,  G01N21/3504 ,  G01N2021/3177 ,  G01N2021/3531 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/129 ,  G01S5/021 ,  G01S5/0236 ,  G02B5/208 ,  G02B27/106 ,  G06K9/40 ,  G06K9/6201 ,  G06K9/6289 ,  G06T2207/20224

Abstract: Methods and systems for detecting at least one chemical species including obtaining a first image from a first electromagnetic radiation detector and obtaining a second image from a second electromagnetic radiation detector. The first image includes a first plurality of pixels and the second image includes a second plurality of pixels, each pixel having an associated intensity value. A first resultant image is generated. The first resultant image includes a plurality of resultant pixels, each pixel having an associated intensity value. One or more regions of interest are determined. The correlation between the first image, the second image, and the first resultant image is determined for the one or more regions of interest using a correlation coefficient algorithm to calculate a first correlation coefficient and a second correlation coefficient. The presence of the chemical species is determined based, at least in part, on the first correlation coefficient and the second correlation coefficient.

Abstract translation: 用于检测至少一种化学物质的方法和系统，包括从第一电磁辐射检测器获得第一图像并且从第二电磁辐射检测器获得第二图像。 第一图像包括第一多个像素，并且第二图像包括第二多个像素，每个像素具有相关联的强度值。 生成第一个结果图像。 第一合成图像包括多个合成像素，每个像素具有相关联的强度值。 一个或多个感兴趣的区域被确定。 使用相关系数算法为一个或多个感兴趣区域确定第一图像，第二图像和第一合成图像之间的相关性，以计算第一相关系数和第二相关系数。 化学物质的存在至少部分基于第一相关系数和第二相关系数来确定。

公开(公告)号：EP3034580A4

公开(公告)日：2017-04-12

申请号：EP14836571

申请日：2014-08-13

Applicant: DAINIPPON INK & CHEMICALS ,  NAT UNIV CORP KOCHI UNIV

Inventor： SAKURAI NAOTO ,  SAKURAI YOSHINOBU ,  WATANABE YASUYUKI ,  IKEDA TAKEO ,  SATO TAKAYUKI

IPC: C09K11/02 ,  A61L27/00 ,  A61L27/50 ,  A61L29/00 ,  A61L29/14 ,  A61L29/18 ,  A61L31/00 ,  A61L31/14 ,  A61L31/18 ,  C08K3/00 ,  C08K5/55 ,  C09K11/00 ,  C09K11/06

CPC classification number: C09K11/025 ,  A61B6/12 ,  A61B6/485 ,  A61B90/39 ,  A61B2090/3966 ,  A61L27/50 ,  A61L29/14 ,  A61L29/18 ,  A61L31/14 ,  A61L31/18 ,  C08K3/013 ,  C08K5/55 ,  C09K11/02 ,  C09K11/06 ,  C09K2211/1048 ,  C09K2211/1055 ,  C09K2211/1081 ,  C09K2211/1085 ,  G01N21/64 ,  G01N2201/068 ,  G07D7/0046

Abstract: An object of the present invention is to provide a resin composition which can be detected both by X-ray radiation and by fluorescence or phosphorescence, and a molded article obtained from the resin composition. The present invention provides a resin composition containing a light-emitting substance and a radiopaque substance; in which the light-emitting substance is a near-infrared fluorescent material or a phosphorescent material. a radiopaque substance of the resin composition is any one of barium sulfate, bismuth oxide, bismuth subcarbonate, calcium carbonate, aluminum hydroxide, tungsten, zinc oxide, zirconium oxide, zirconium, titanium, platinum, bismuth subnitrate, and bismuth.A molded article can be obtained by processing any one of the resin compositions described above.

公开(公告)号：EP3150992A1

公开(公告)日：2017-04-05

申请号：EP15798968.2

申请日：2015-05-27

Applicant: Japan Science and Technology Agency

Inventor： YOSHIDA, Hiroyuki

IPC: G01N21/62 ,  H01J37/06 ,  H01J37/244 ,  H01J37/252

CPC classification number: G01N21/71 ,  G01J3/0208 ,  G01J3/443 ,  G01N21/62 ,  G01N23/2254 ,  G01N2201/0638 ,  G01N2201/068 ,  G01N2223/6116 ,  H01J3/02 ,  H01J3/18 ,  H01J37/244 ,  H01J37/252 ,  H01J2237/06308 ,  H01J2237/06375 ,  H01J2237/2445

Abstract: An inverse photoemission spectroscopy apparatus is configured to detect a light generated by the relaxation of electrons to an unoccupied state of a sample.The apparatus includes an electron source for generating electrons with which a sample is irradiated, a wavelength selector for extracting a light having a certain wavelength from the light generated in the sample, a photodetector for detecting the light extracted by the wavelength selector; and a focusing optics disposed between the sample and the photodetector. The electron source contains yttrium oxide as a thermionic emission material.

Abstract translation: 反射光电子发射光谱装置被配置为检测由电子弛豫产生的光到样品的未占据状态。该装置包括用于产生照射样品的电子的电子源，用于提取具有 从样品中产生的光的一定波长，用于检测由波长选择器提取的光的光电检测器; 以及设置在样品和光电检测器之间的聚焦光学元件。 电子源包含氧化钇作为热离子发射材料。

公开(公告)号：EP3147651A1

公开(公告)日：2017-03-29

申请号：EP16189737.6

申请日：2016-09-20

Applicant: Universität Stuttgart

Inventor： Bogner, Martin ,  Frenner, Karsten ,  Sägebarth, Joachim

IPC: G01N21/64 ,  G02B1/00

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2201/068 ,  G02B1/007

Abstract: Die Erfindung betrifft ein Sensorelement (11) für Photolumineszenz-Messungen, mit einer optisch durchlässigen Trägerstruktur (19), auf der eine Lumineszenzstruktur (21) angeordnet ist, die eingerichtet ist zur Intensivierung und zur Weiterleitung von Lumineszenzlicht an die Trägerstruktur (19), wobei die Lumineszenzstruktur eine der Trägerstruktur (19) abgewandte, nanostrukturierte Oberfläche (25) aufweist.

Abstract translation: 该申请涉及到的传感器元件（11），用于光致发光测量，对所有这一切都被放置在发光结构（21）构造成用于增强和发射冷光到载体结构（19），worin在光学透明的载体结构（19） 发光结构具有从所述载架结构（19）面向离开纳米结构化表面（25）。

公开(公告)号：EP3028033A4

公开(公告)日：2017-03-29

申请号：EP14835171

申请日：2014-06-10

Applicant: PHOTONICSYS LTD

Inventor： ABDULHALIM IBRAHIM

IPC: G01N21/552 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/41 ,  G01N21/64 ,  G01N21/65 ,  G01N21/77 ,  G01N29/02 ,  G01N29/24 ,  G01N33/483

CPC classification number: G01N21/554 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/648 ,  G01N21/658 ,  G01N21/7703 ,  G01N29/022 ,  G01N29/2418 ,  G01N2021/7709 ,  G01N2021/7776 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/0633 ,  G01N2201/068 ,  Y10S977/954

Abstract: The invention is a SPR sensor that comprises a multi-layered plasmonic structure on a substrate for sensing. The SPR sensor has an enhanced figure of merit and lower limit of detection (system noise divided by the sensitivity) by at least two orders of magnitude than prior art SPR sensors. The plasmonic structure of the invention comprises a Nanostructured Porous Metal Layer (NPML) and at least one of: (a) buried dielectric layer under the nano-porous metal layer; (b) a nano-dimensional high index layer on top of the metal layer; and (c) a molecular layer for bio-functionalization adjacent to an analyte layer. The invention also encompasses many embodiments of measuring systems that comprise the SPR sensors of the invention with improved signal to noise ratio.

公开(公告)号：EP3111216A2

公开(公告)日：2017-01-04

申请号：EP15755889.1

申请日：2015-02-27

Applicant: NUEON, INC.

Inventor： MESSERSCHMIDT, Robert, G. ,  JONES, Howland, D.T.

IPC: G01N33/53

CPC classification number: G01N21/27 ,  A61B5/0075 ,  A61B5/02 ,  A61B5/4833 ,  G01N21/59 ,  G01N33/492 ,  G01N2201/06113 ,  G01N2201/068

Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.

Abstract translation: 高血压的生物标志物被测量，以确定基于一个或多个生物标志物的受试者的高血压。 在许多实施例中，生物标志的血压响应中发生了至少一个小时的过程中，寻求DASS死高血压识别基于所述受试者的生理在一段时间的累积效应。 的方法和识别高血压与生物标志物的装置具有提供改善的受治疗者的治疗，作为鉴定的生物标记可以在关于该主题的高血压的效果有关的优点，检查作为生物标志物相应于中央的血压 ， 样品可经受在一个或更多的增加的压力或温度，和​​变化的血液样品来测量超时。

公开(公告)号：EP2986597A4

公开(公告)日：2016-11-16

申请号：EP14785208

申请日：2014-04-21

Applicant: AGENCY SCIENCE TECH & RES

Inventor： BRENNER SYDNEY ,  TEO YIN NAH ,  TAN PEE MEI

IPC: C07D311/80 ,  C07D209/08 ,  C07D493/10 ,  C07H21/04 ,  C12Q1/68

CPC classification number: C12Q1/6818 ,  C07D207/46 ,  C07D493/10 ,  C07F7/12 ,  C07F7/184 ,  C07F9/1651 ,  C07F9/2408 ,  C07F9/65522 ,  C07F9/6561 ,  C07F9/65616 ,  C07H21/04 ,  C09B11/08 ,  C09B23/06 ,  C09B29/0003 ,  G01N21/6428 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/068

Abstract: The invention relates to cleavable chemistry in general, and in particular, to tunable fluorescence using cleavable linkers present in fluorochrome-quencher conjugates.

公开(公告)号：EP3087372A1

公开(公告)日：2016-11-02

申请号：EP14816202.7

申请日：2014-12-12

Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften

Inventor： HELL, Stefan W.

IPC: G01N21/64 ,  G02B21/00

CPC classification number: G01N21/6458 ,  G01B11/14 ,  G01N2201/068 ,  G01N2201/10 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/16 ,  G02B21/367 ,  G02B27/58

Abstract: In order to determine the location (X
M ) of individual molecules of a substance in a sample, wherein the individual molecules of the substance are in a fluorescent state in which they are excitable with excitation light for emission of fluorescent light, and wherein distances between the individual molecules of the substance in a region of interest in the sample comply with a minimum value d = λ/(2nsinα √(1 + l/ls)), the individual molecules of the substance are excited with the excitation light for emission of fluorescent light, wherein an intensity distribution of the excitation light has at least one zero. The fluorescent light from the excited individual molecules of the substance is registered for different positions (X
N ) of the at least one zero of the intensity distribution of the excitation light in the region of interest in the sample. In this case, distances between closest adjacent positions (X
N ) of the at least one zero of the intensity distribution of the excitation light in which the fluorescent light from the excited individual molecules of the substance is registered are not greater than half the minimum value d. The locations (X
M ) of the individual molecules of the substance are then derived from the profile of the intensity (I) of the fluorescent light from the respective molecule against the positions (X
N ) of the at least one zero of the intensity distribution of the excitation light in the region of interest in the sample.

Abstract translation: 为了确定样品中单个荧光分子的位置，其保持相对于彼此的最小距离，单个分子被激发以通过激发光发射荧光。 荧光被记录在激发光的强度分布的零点的不同位置。 这些位置之间的距离至少是荧光分子最小距离的一半。 荧光分子的位置来源于激发光的零点位置上的荧光强度的过程。

公开(公告)号：EP3081154A1

公开(公告)日：2016-10-19

申请号：EP16164398.6

申请日：2016-04-08

Applicant: Hill-Rom Services, Inc.

Inventor： FU, Yongi ,  AGDEPPA, Eric D. ,  RIBBLE, David

IPC: A61B5/00 ,  G01N21/21 ,  G01N21/45 ,  G01B9/02

CPC classification number: G01N33/4833 ,  A61B5/0066 ,  A61B5/445 ,  G01B9/02088 ,  G01B9/02091 ,  G01N21/47 ,  G01N21/4795 ,  G01N2201/06113 ,  G01N2201/068

Abstract: A method of assessing a tissue sample includes the steps of::
1) splitting source electromagnetic radiation into:
a) sample arm radiation directed in a Z direction toward a sample thereby illuminating the sample at a first selected XY coordinate pair of the sample, and
b) reflector arm radiation directed toward a reflector so that the reflector arm radiation travels a path length;

2) interfering sample-scattered electromagnetic radiation with reflector-reflected electromagnetic radiation thereby establishing an interference pattern associated with the sample;
3) comparing the sample interference pattern to a reference interference pattern; and
4) reaching a conclusion about the sample based on the comparison.

Abstract translation: assesing组织样品的方法包括的:: 1）分割源的电磁辐射到所述步骤：a）针对在Z方向上朝向一个样品从而照亮在第一选定XY坐标对样本的样本样品臂辐射，并 b）中朝向反射器定向差反射器辐射所以做了反射器臂辐射行进的路径长度; 2）干扰与反射器反射的电磁辐射，从而建立与样本相关联的干涉图案的样品散射的电磁辐射; 3）比较样品干涉图案与参考干涉图案; 和4）达到约基于该比较样品的结论。