公开(公告)号：EP1015098B1

公开(公告)日：2002-08-14

申请号：EP98906708.7

申请日：1998-02-25

申请人： MILLIPORE CORPORATION

发明人： KOPACIEWICZ, William ,  SHEER, Donald, G. ,  ARNOLD, Todd, E. ,  GOEL, Vinay

IPC分类号： B01D61/00 ,  B01D61/18 ,  B01D63/00 ,  B01D63/16 ,  B01D69/10 ,  B01D69/14 ,  B01J20/28 ,  B01L3/02

CPC分类号： B01J20/28033 ,  B01D61/00 ,  B01D61/007 ,  B01D61/18 ,  B01D63/16 ,  B01D69/10 ,  B01D69/141 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28026 ,  B01J20/28028 ,  B01J20/2803 ,  B01J2220/64 ,  B01L3/0275 ,  G01N30/466 ,  G01N30/6004 ,  G01N30/6052 ,  G01N30/6065 ,  G01N2030/528 ,  G01N2035/1053 ,  G01N2035/1055

摘要： A method for casting-in-place composite and/or nonfilled structures (11) which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configurationcan be used , and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast-in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the apropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing (12) and can be used for size-based separations wherein the cast structure (11) acts as a semipermeable membrane barrier. The present invention also encompasses these structures as well as housings containing the structures.

公开(公告)号：EP1166840A1

公开(公告)日：2002-01-02

申请号：EP01401608.3

申请日：2001-06-19

申请人： Novasep

发明人： Lehoucq, Sylvie ,  Ludemann-Hombourger, Olivier ,  Nicoud, Roger-Marc ,  Hamende, Michel ,  Cavoy, Emile

IPC分类号： B01D15/02

CPC分类号： G01N30/44 ,  B01D15/1828 ,  B01D15/1842 ,  B01D15/22 ,  B01D2215/023 ,  G01N30/02 ,  G01N30/468 ,  G01N30/6052 ,  G01N2030/522 ,  G01N2030/8877 ,  B01D15/1821

摘要： L'invention concerne un procédé et un dispositif de séparation d'au moins un constituant d'un mélange en lit mobile simulé, dans lequel chacune des colonnes chromatographiques contenant un absorbant présente un rapport L (longueur) sur D (diamètre) compris entre 0,01 et 0,34.
De plus, le rapport L TOT (longueur dans n colonnes) sur D (diamètre) est compris entre 0,06 et 2,3.
On peut appliquer une pression dynamique axiale sur chacune des colonnes supérieures à la perte de la charge de l'ensemble des colonnes.
Application à la séparation d'isomères optiques en pharmacie.

摘要翻译： 从混合物中分离成分（S）中在一个循环中安排了一系列的列色谱仪的使用吸附剂。 将混合物和解吸剂被注入每个和萃余液和​​萃取物在回路中的每一个点（一个或多个）被去除。 每一列具有的长度与0点01直径比（L / D），以0:34和总长度与直径之比（LTOT / D）是12时06 - 02.03。 独立claimsoft包括用于执行以下操作：与系列色谱仪列（a）的装置如以上对于如上述进行指定。 优选的特征：有≤12列与粒度≤100 PI M中，L / 0.1ð - 0.3和1 LTOT / D - 2每一列工作在3-100巴，优选25 - 50巴。

公开(公告)号：EP0954738A4

公开(公告)日：2000-12-13

申请号：EP98903868

申请日：1998-01-27

申请人： UNIV UTAH RES FOUND

发明人： FRAZIER BRUNO A

IPC分类号： B41J2/02 ,  B41J2/16 ,  C25D1/02 ,  F28D9/00 ,  G01N30/60 ,  G01N35/10 ,  F28F3/12 ,  B01L3/00

CPC分类号： F28D9/00 ,  B41J2/02 ,  B41J2/16 ,  B41J2/1625 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1639 ,  B41J2/1642 ,  B41J2/1643 ,  B41J2/1645 ,  B41J2/1646 ,  B41J2202/22 ,  C25D1/02 ,  F28D2021/0022 ,  F28F2260/02 ,  G01N30/6052 ,  G01N30/6095 ,  G01N2035/1041

摘要： The present invention is directed to methods for preparing devices having hollow metallic microchannels (20) on a surface of a planar substrate (10). More specifically, the present invention is directed to methods for preparing devices having surface metallic microchannels with a range of widths and heights selected to provide efficient flow characteristics and having thick and, thus, strong and durable channel walls. In addition, the methods of the present invention are compatible with standard integrated circuit fabrication techniques and, because the microchannels (20) are formed upon the surface of the substrate (10) without degrading the surface planarity, these techniques can be used to incorporate electronic circuitry into the microchannel-containing devices. For purposes of this application, the term 'microchannel' refers to enclosed or partially enclosed channels having heights within the range from about 2 to about 200 micrometers (νm) and widths within the range of about 10 micrometers to about 2 millimeters.

公开(公告)号：EP1054716A1

公开(公告)日：2000-11-29

申请号：EP99914449.6

申请日：1999-02-09

申请人： MERCK PATENT GmbH

发明人： BLASCHKE, Gottfried ,  CHANKVETADZE, Bezhan ,  SCHULTE, Michael ,  GIROD, Marco ,  KRAUSE, Kerstin

IPC分类号： B01D15/08 ,  G01N30/00

CPC分类号： G01N30/6078 ,  B01D15/34 ,  B01D15/3833 ,  B01D15/3885 ,  C07B57/00 ,  G01N30/02 ,  G01N30/6052 ,  G01N2030/562

摘要： The invention relates to capillaries packed with particulate sorbents, having a constant inner diameter along the entire length. The bed of the sorbents is defined by hardened areas generated by thermal treatment. The invention especially refers to capillaries filled with a chiral sorbent. The invention also relates to the methods for producing said capillaries and to their use in the separation of materials.

公开(公告)号：EP1032830A1

公开(公告)日：2000-09-06

申请号：EP98956133.7

申请日：1998-10-21

申请人： ESA, Inc.

发明人： MATSON, Wayne, R.

IPC分类号： G01N30/56

CPC分类号： G01N30/56 ,  C12Q1/6804 ,  G01N30/6052 ,  G01N2030/009 ,  G01N2030/062 ,  G01N2030/484 ,  G01N2030/524 ,  G01N2030/8827 ,  Y10T436/10

摘要： A sample pre-separation and concentration system for detecting low levels of analytes in highly complex mixtures includes a plurality of trapping columns having a high selectivity for classes of compounds of interest, upstream of a standard separation column. The system may be used, for example, to measure urinary 8 hydroxy 2'deoxyguanoisine.

公开(公告)号：EP1015098A4

公开(公告)日：2000-08-09

申请号：EP98906708

申请日：1998-02-25

申请人： MILLIPORE CORP

发明人： KOPACIEWICZ WILLIAM ,  SHEER DONALD G ,  ARNOLD TODD E ,  GOEL VINAY

IPC分类号： G01N1/10 ,  B01D61/00 ,  B01D61/18 ,  B01D63/00 ,  B01D63/16 ,  B01D67/00 ,  B01D69/10 ,  B01D69/14 ,  B01J20/28 ,  B01L3/02 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  G01N1/36 ,  G01N30/46 ,  G01N30/52 ,  G01N30/60 ,  G01N35/10

CPC分类号： B01J20/28033 ,  B01D61/00 ,  B01D61/007 ,  B01D61/18 ,  B01D63/16 ,  B01D69/10 ,  B01D69/141 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28026 ,  B01J20/28028 ,  B01J20/2803 ,  B01J2220/64 ,  B01L3/0275 ,  G01N30/466 ,  G01N30/6004 ,  G01N30/6052 ,  G01N30/6065 ,  G01N2030/528 ,  G01N2035/1053 ,  G01N2035/1055

摘要： A method for casting-in-place composite and/or nonfilled structures (11) which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configurationcan be used , and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast-in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the apropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing (12) and can be used for size-based separations wherein the cast structure (11) acts as a semipermeable membrane barrier. The present invention also encompasses these structures as well as housings containing the structures.

公开(公告)号：EP1018002A2

公开(公告)日：2000-07-12

申请号：EP99919778.3

申请日：1999-04-02

申请人： SYMYX TECHNOLOGIES

发明人： CARLSON, Eric ,  SAFIR, Adam ,  PETRO, Miroslav ,  NIELSEN, Ralph, B. ,  LEE, Thomas, S. ,  FRECHET, Jean, M., J. ,  DALES, G., Cameron ,  KUEBLER, Sigrid, C. ,  BENNETT, James

IPC分类号： G01N30/02 ,  G01N33/44

CPC分类号： G01N35/1097 ,  B01D15/08 ,  B01D15/12 ,  B01D15/14 ,  B01D15/1871 ,  B01D15/26 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01J19/0046 ,  B01J19/26 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00344 ,  B01J2219/00351 ,  B01J2219/00452 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  C40B40/14 ,  C40B40/18 ,  G01N15/0205 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/461 ,  G01N30/466 ,  G01N30/54 ,  G01N30/60 ,  G01N30/6052 ,  G01N30/88 ,  G01N30/90 ,  G01N33/44 ,  G01N35/085 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2030/324 ,  G01N2030/885 ,  G01N2030/8886 ,  G01N2035/1058 ,  Y10T436/11 ,  Y10T436/25

摘要： Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

公开(公告)号：EP0954738A1

公开(公告)日：1999-11-10

申请号：EP98903868.0

申请日：1998-01-27

申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION

发明人： FRAZIER, Bruno, A.

IPC分类号： B41J2 ,  C25D1 ,  F28D9 ,  G01N30 ,  G01N35

CPC分类号： F28D9/00 ,  B41J2/02 ,  B41J2/16 ,  B41J2/1625 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1639 ,  B41J2/1642 ,  B41J2/1643 ,  B41J2/1645 ,  B41J2/1646 ,  B41J2202/22 ,  C25D1/02 ,  F28D2021/0022 ,  F28F2260/02 ,  G01N30/6052 ,  G01N30/6095 ,  G01N2035/1041

摘要： The present invention is directed to methods for preparing devices having hollow metallic microchannels (20) on a surface of a planar substrate (10). More specifically, the present invention is directed to methods for preparing devices having surface metallic microchannels with a range of widths and heights selected to provide efficient flow characteristics and having thick and, thus, strong and durable channel walls. In addition, the methods of the present invention are compatible with standard integrated circuit fabrication techniques and, because the microchannels (20) are formed upon the surface of the substrate (10) without degrading the surface planarity, these techniques can be used to incorporate electronic circuitry into the microchannel-containing devices. For purposes of this application, the term 'microchannel' refers to enclosed or partially enclosed channels having heights within the range from about 2 to about 200 micrometers (νm) and widths within the range of about 10 micrometers to about 2 millimeters.

公开(公告)号：EP0835443B1

公开(公告)日：1999-08-25

申请号：EP96924383.1

申请日：1996-07-10

申请人： THE PERKIN-ELMER CORPORATION

发明人： DEMOREST, David, M. ,  MORING, Stephen, E. ,  CHIESA, Claudia

IPC分类号： G01N27/447

CPC分类号： G01N27/44752 ,  G01N30/6052 ,  G01N2030/285

摘要： Disclosed is a method for increasing the electroosmotic flow rate available for a silica surface. In the method, there is provided an electrophoretic channel which is defined by one or more silica surfaces. The surface(s) are contacted with an alkaline aqueous solution containing a solubilized silicate-monovalent metal complex in an amount effective to increase the acidity of the silica surfaces(s), as evidenced by a reduction in the average bulk pKa of the surface(s). The achieved increase in acidity is greater than would be obtained using an otherwise identical solution lacking said silicate. In one preferred embodiment, the monovalent metal used in the solution is Li , Na , or K . Also disclosed is a method for increasing the acidity of a silica surface, by contacting the surface with an alkaline aqueous solution of the type noted above.

公开(公告)号：EP0763734A3

公开(公告)日：1999-04-21

申请号：EP96114466.4

申请日：1996-09-10

申请人： HITACHI, LTD.

发明人： Fujii, Yoshio ,  Ito, Masahito ,  Satake, Hiroshi

IPC分类号： G01N30/96

CPC分类号： G01N30/96 ,  G01N30/6052 ,  G01N2030/524 ,  G01N2030/8435

摘要： The invention intends to provide a liquid chromatograph and chromatography which can perform analysis at a higher speed with clearer separation between peaks. The liquid chromatograph comprises a separation column (10), a buffer pump (7) for feeding a plurality of buffers 1, 2, 3 and 4 into the separation column (10), a sampler (9) disposed in a flow path between the buffer pump (7) and the separation column (10) for introducing a sample to be analyzed into the flow path, and a reaction coil (14) for mixing and then reacting amino acids separated by the separation column (10) with a ninhydrin reagent. The separation column (10) is sized so that a ratio (L1/R) of its length L1 to its inner diameter R is not more than 10. The particle size of ion exchange resin filled in the separation column (10) is selected to be not more than 4 µm.