公开(公告)号：EP0932412A1

公开(公告)日：1999-08-04

申请号：EP97941435.0

申请日：1997-09-05

申请人： PHYTERA, INC.

发明人： PAZOLES, Christopher, J. ,  SIEGEL, Scott, A.

IPC分类号： A61K38 ,  A61P31 ,  C07K7

CPC分类号： A61K38/12

摘要： A method of inhibiting viral infection with a pharmaceutical composition containing cyclomarin-A.

公开(公告)号：EP0931080A1

公开(公告)日：1999-07-28

申请号：EP97939837.0

申请日：1997-09-08

申请人： PENTECH PHARMACEUTICALS, INC.

发明人： RONSEN, Bruce ,  EL-RASHIDY, Ragab

IPC分类号： C07D405 ,  A61K31 ,  A61P15 ,  C07D401

CPC分类号： C07D401/12 ,  A61K31/4525

摘要： A free-flowing, amorphous paroxetine hydrochloride-ethanol composition suitable as a therapeutic agent for premature ejaculation can be prepared by dissolving paroxetine free base in a hydrochloric acid-ethanol solution followed by drying. In a preferred embodiment, the amount of ethanol present in the amorphous product is in the range of 1 to 4 weight percent based on paroxetine hydrochloride. The amorphous product is stable and substantially non-hygroscopic.

公开(公告)号：EP0920630A2

公开(公告)日：1999-06-09

申请号：EP97927319.0

申请日：1997-05-29

申请人： McGILL UNIVERSITY

发明人： CASHMAN, Neil, R. ,  DODELET, Vincent

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61P25 ,  A61P35 ,  A61P37 ,  C07K14 ,  C07K19 ,  C12Q1 ,  G01N33

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/02

摘要： In general, the invention features prion protein binding proteins (PrPBPs) and diagnostic, therapeutic, and decontamination uses thereof. The invention also features fusion protein reagents for PrPBP isolation.

公开(公告)号：EP0920522A1

公开(公告)日：1999-06-09

申请号：EP97937243.0

申请日：1997-08-14

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： NELSON, Edward, L. ,  NELSON, Peter, J.

IPC分类号： C07K14 ,  C12N15

CPC分类号： C07K14/71 ,  A61K2039/51 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/38 ,  C12N2830/85 ,  C12N2840/203 ,  C12N2840/44 ,  Y02A50/412

摘要： The invention is a "humanized" polynucleotide vector vaccine which uses covalent closed circular plasmid DNA, "naked DNA", to express target antigens. The vector is non-replicating in mammalian cells but is capable of extended stable expression of the target sequences in skeletal muscle and professional antigen presenting cells generating an immune response to the target antigen in immunized individuals. The polynucleotide vector is particularly useful in accommodating monomorphic and polymorphic nucleic acid sequences encoding tumor antigens via PCR technology.

摘要翻译： 本发明是一种'人源化'多核苷酸载体疫苗，其使用共价闭环质粒DNA'裸DNA'来表达靶抗原。 该载体在哺乳动物细胞中不复制，但能够在骨骼肌中延长靶序列的稳定表达，并且能够在免疫个体中产生对靶抗原的免疫应答的专职抗原呈递细胞。 多核苷酸载体特别适用于通过PCR技术调节编码肿瘤抗原的单形和多态核酸序列。

公开(公告)号：EP0918868A2

公开(公告)日：1999-06-02

申请号：EP97937983.0

申请日：1997-07-18

申请人： ARCH DEVELOPMENT CORPORATION ,  MRJ Trust

发明人： McLEOD, Rima, L., W. ,  ROBERTS, Craig, W. ,  ROBERTS, Fiona ,  JOHNSON, Jennifer, J. ,  METS, Laurens

IPC分类号： A61K39 ,  C12N9 ,  G01N33 ,  A61K38

CPC分类号： A61K39/002 ,  A61K38/00 ,  C12N9/88 ,  C12N9/90 ,  G01N33/56905 ,  Y02A50/412 ,  Y02A50/58

摘要： This invention relates to uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

公开(公告)号：EP0914331A1

公开(公告)日：1999-05-12

申请号：EP97927691.0

申请日：1997-05-16

申请人： Neurotherapeutics L.P.

发明人： MOSKAL, Joseph, R. ,  YAMAMOTO, Hirotaka ,  COLLEY, Patricia, A.

IPC分类号： G01N33 ,  A61K31 ,  A61K38 ,  A61P25 ,  C07K5 ,  C07K7 ,  C12P21

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/06165 ,  C07K5/081 ,  C07K5/0823 ,  C07K5/1013 ,  C07K7/08

摘要： Compositions and methods are described for the specific identification of NMDA receptors, and for the specific identification and manipulation of NMDA glycine co-agonist biological activity.

摘要翻译： 描述了用于特定鉴定NMDA受体以及NMDA甘氨酸共激动剂生物学活性的特定鉴定和操作的组合物和方法。

公开(公告)号：EP0910662A1

公开(公告)日：1999-04-28

申请号：EP96907091.0

申请日：1996-02-20

申请人： THE PERKIN ELMER CORPORATION

发明人： JOHNSTON-DOW, Leslie ,  CHADWICK, Robert, B. ,  PARHAM, Peter

IPC分类号： C12N15 ,  C07K14 ,  C12Q1

CPC分类号： C12Q1/6881 ,  C07K14/70539 ,  C12Q2600/156

摘要： A method for typing HLA class I genes. The method entails first contacting a sample DNA with first and second amplification primers, wherein the first and second primers are each at least partially located in an exonic region. Next, using the first and second primers, a target sequence is amplified by the PCR to form an amplicon of the target sequence. Finally, the amplicon is detected with a sequence-specific detection means, e.g., DNA sequencing. The invention also includes specific amplification primers, specific sequencing primers, and kits especially adapted for use with the above HLA typing method.

公开(公告)号：EP0910394A1

公开(公告)日：1999-04-28

申请号：EP97917871.0

申请日：1997-04-04

申请人： DIACRIN, INC.

发明人： HUNTER, Richard ,  EAGAN, E., Michael

IPC分类号： A01K67 ,  A61K35

CPC分类号： A61K35/407 ,  A01K67/027 ,  A61K35/30 ,  A61K35/34 ,  A61K35/36 ,  A61K35/39

摘要： Methods for providing a pathogen-free pig or pig fetus as a donor of tissue, cells and/or organs to a recipient human. Animals are free of zoonotic pathogens. When fetal tissues are used for transplantation, donor animals are free from zoonotic pathogens, pathogens able to cross the placental barrier, and tissue-specific pathogens, e.g., neurotropic pathogens. Tissues, cells and organs from pigs free of the above-listed pathogens are suitable for transplantation into humans, include fetal neuronal cells for treatment of Parkinson's disease and islet cells for treatment of islet insufficiency-related diseases.

公开(公告)号：EP0906069A1

公开(公告)日：1999-04-07

申请号：EP96941344.0

申请日：1996-11-08

申请人： University of Massachusetts

发明人： VACANTI, Charles, A.

IPC分类号： A61K47 ,  A61L27 ,  C12N5

CPC分类号： A61L27/3843 ,  A61K47/10 ,  A61K47/36 ,  A61L27/3813 ,  A61L27/3817 ,  A61L27/3839 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3891 ,  A61L27/52 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/74 ,  C12N2539/10

摘要： The invention provides hydrogel-tissue precursor cell compositions for generating new tissue on a surface, e.g., a surface of damaged or lost tissue, of a tissue structure or organ in a mammal. Liquid hydrogel-cell compositions are applied in a thin layer to the surface and allowed to solidify, thereby forming a matrix that enables the tissue precursor cells to grow and generate new tissue. The surface can be internal, e.g., the internal surface of a blood vessel, or external, e.g., skin.

公开(公告)号：EP0901379A2

公开(公告)日：1999-03-17

申请号：EP97926647.0

申请日：1997-05-21

申请人： UNIVERSITY OF ALBERTA

发明人： McFADDEN, D. Grant ,  LUCAS, Alexandra

IPC分类号： A61K38 ,  A61K31 ,  A61K45 ,  A61P9 ,  A61P11 ,  A61P31 ,  A61P35 ,  A61P37 ,  C07K14 ,  G01N33

CPC分类号： C07K14/005 ,  A61K38/162 ,  C12N2710/24122

摘要： The present invention provides a method of use for a novel chemokine binding protein (type-2 CBP) encoded by poxviruses and having amino acid sequence homology with the Shope fibroma virus T1 family of proteins against disease syndromes associated with acute or chronic dysregulated inflammatory responses.