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11.发明公开
公开(公告)号：EP0972201A2
公开(公告)日：2000-01-19
申请号：EP98911411.1
申请日：1998-02-25
申请人： CORIXA CORPORATION
发明人： XU, Jiangchun , DILLON, Davin, C.
IPC分类号： G01N33/574 , G01N33/577 , C07K16/30 , A61K39/395 , A61K47/48 , C12Q1/68 , G01N33/543
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/158
摘要： Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
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公开(公告)号：EP0850305A2
公开(公告)日：1998-07-01
申请号：EP96933010.0
申请日：1996-08-30
申请人： CORIXA CORPORATION
发明人： REED, Steven, G. , SKEIKY, Yasir, A., W. , DILLON, Davin, C. , CAMPOS-NETO, Antonio , HOUGHTON, Raymond , VEDVICK, Thomas, H. , TWARDZIK, Daniel, R.
IPC分类号： G01N33 , A61K31 , A61K39 , A61P31 , C07K7 , C07K14 , C07K16 , C07K19 , C12N1 , C12N15 , C12P21 , C12Q1 , C12R1
CPC分类号： C12Q1/689 , C07K14/35 , G01N33/5695
摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis secretory or non-secretory proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
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13.发明授权COMPOUNDS FOR IMMUNOTHERAPY AND DIAGNOSIS OF TUBERCULOSIS AND METHODS OF THEIR USE 失效化合物的免疫治疗和诊断结核病和使用方法的其
公开(公告)号：EP1012293B1
公开(公告)日：2009-01-07
申请号：EP98924827.3
申请日：1998-05-20
申请人： CORIXA CORPORATION
IPC分类号： C12N15/31 , C07K14/35 , A61K39/04 , A61K48/00 , A61K49/00 , C12N15/62 , C07K19/00 , G01N33/50 , G01N33/60 , G01N33/569 , C12N1/19 , C12N1/21 , C12R1/19
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
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14.发明公开
公开(公告)号：EP1363929A2
公开(公告)日：2003-11-26
申请号：EP02723095.2
申请日：2002-02-04
申请人： CORIXA CORPORATION
发明人： DILLON, Davin, C. , DAY, Craig, H. , JIANG, Yuqiu , HOUGHTON, Raymond, L. , MITCHAM, Jennifer, L. , WANG, Tongtong , MCNEILL, Patricia, D. , HARLOCKER, Susan, L. , BENNINGTON, Angela, Ann , ZEHENTNER, Barbara , FANGER, Gary, R. , RETTER, Marc, W.
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C07K14/47 , C07K2319/00 , G01N33/57415
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breastcancer, are disclosed. Illustrative compositions comprise one or more breasttumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breastcancer.
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15.发明公开
公开(公告)号：EP1311673A2
公开(公告)日：2003-05-21
申请号：EP01922786.7
申请日：2001-03-27
申请人： CORIXA CORPORATION
发明人： XU, Jiangchun , DILLON, Davin, C. , MITCHAM, Jennifer, L. , HARLOCKER, Susan, L. , JIANG, Yuqiu , KALOS, Michael, D. , FANGER, Gary, Richard , RETTER, Marc, W. , STOLK, John, A. , DAY, Craig, H. , VEDVICK, Thomas, S. , CARTER, Darrick , LI, Samuel, X. , WANG, Aijun , SKEIKY, Yasir, A., W. , HEPLER, William, T. , HENDERSON, Robert, A.
IPC分类号： C12N15/12 , C07K14/47 , C12N1/21 , C12N5/10 , C07K16/18 , G01N33/68 , C07K19/00 , C12N15/10 , A61K38/17 , A61K31/70 , A61K39/395 , A61K35/14 , C12Q1/68
CPC分类号： C07K14/47
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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16.发明公开
公开(公告)号：EP1230364A2
公开(公告)日：2002-08-14
申请号：EP00979155.9
申请日：2000-11-09
申请人： CORIXA CORPORATION
发明人： XU, Jiangchun , DILLON, Davin, C. , MITCHAM, Jennifer, L. , HARLOCKER, Susan, L. , JIANG, Yuqiu , REED, Steven, G. , KALOS, Michael, D. , RETTER, Marc, W. , STOLK, John, A. , DAY, Craig, H. , SKEIKY, Yasir, A.W. , WANG, Aijun
IPC分类号： C12N15/12 , C12N15/62 , C12N15/11 , C12N1/21 , C12N5/10 , C07K14/47 , C07K16/18 , C07K19/00 , A61K38/17 , A61K31/70 , A61K39/395 , A61K48/00 , G01N33/68 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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17.发明公开COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF BREAST CANCER AND METHODS FOR THEIR USE 有权组合物用于治疗和乳腺癌和利用方式诊断THEREOF
公开(公告)号：EP1183348A2
公开(公告)日：2002-03-06
申请号：EP00919352.5
申请日：2000-02-15
申请人： CORIXA CORPORATION
发明人： YUQIU, Jiang , DILLON, Davin, C. , MITCHAM, Jennifer, Lynn , XU, Jiangchun , HARLOCKER, Susan, L.
IPC分类号： C12N15/12 , C12N15/52 , C07K14/47 , C12N9/00 , C12N5/10 , C12N1/21 , A61K38/17 , A61K39/00 , C07K16/30 , C07K16/32 , C07K16/40 , A61K39/395 , A61K35/12 , C07K19/00 , C12N15/62 , C12N5/00 , G01N33/68 , C12Q1/68 , C12N15/11
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portion thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
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18.发明公开COMPOUNDS FOR IMMUNOTHERAPY AND DIAGNOSIS OF TUBERCULOSIS AND METHODS OF THEIR USE 失效化合物的免疫治疗和诊断结核病和使用方法的其
公开(公告)号：EP1012293A2
公开(公告)日：2000-06-28
申请号：EP98924827.3
申请日：1998-05-20
申请人： CORIXA CORPORATION
IPC分类号： C12N15/31 , C07K14/35 , A61K39/04 , A61K48/00 , A61K49/00 , C12N15/62 , C07K19/00 , G01N33/50 , G01N33/60 , G01N33/569 , C12N1/19 , C12N1/20 , C12N1/21 , C12N5/10
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
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19.发明公开$i(LEISHMANIA) ANTIGENS FOR USE IN THE THERAPY AND DIAGNOSIS OF LEISHMANIASIS 失效利什曼原虫属抗原FOR USE在治疗和诊断利什曼
公开(公告)号：EP0981624A2
公开(公告)日：2000-03-01
申请号：EP98907489.3
申请日：1998-02-12
申请人： CORIXA CORPORATION
发明人： REED, Steven, G. , CAMPOS-NETO, Antonio , WEBB, John, R. , DILLON, Davin, C. , SKEIKY, Yasir, A.
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , A61K2039/51 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
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公开(公告)号：EP0932681A2
公开(公告)日：1999-08-04
申请号：EP97910873.0
申请日：1997-10-07
申请人： CORIXA CORPORATION
发明人： REED, Steven, G. , SKEIKY, Yasir, A., W. , DILLON, Davin, C. , CAMPOS-NETO, Antonio , HOUGHTON, Raymond , VEDVICK, Thomas, S. , TWARDZIK, Daniel, R. , LODES, Michael, J.
IPC分类号： A61K , C07H , C07K , C12N , G01N , G01N33 , A61K39 , A61K48 , A61P31 , C07K14 , C07K19 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1 , A61K38
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
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