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    METHOD FOR PRODUCING FATTY ACID ALKYL ESTERS USING MICROORGANISMS HAVING OIL-PRODUCING ABILITY
    12.
    发明授权
    METHOD FOR PRODUCING FATTY ACID ALKYL ESTERS USING MICROORGANISMS HAVING OIL-PRODUCING ABILITY 有权

    公开(公告)号：EP2455484B1

    公开(公告)日：2018-12-05

    申请号：EP10800069.6

    申请日：2010-07-19

    申请人： Korea Advanced Institute of Science and Technology

    发明人： LEE, Sang Yup ,  CHOI, Yong Jun

    IPC分类号： C12P7/64 ,  C12N1/21 ,  C12N15/55

    CPC分类号： C12N9/20 ,  C12P7/649 ,  C12Y301/01003 ,  Y02E50/13 ,  Y02P20/52

    摘要： The present invention relates to a method of producing a fatty acid alkyl ester using microorganisms having the ability to produce oil, and more particularly to a method of producing a fatty acid alkyl ester, the method comprising culturing microorganisms having the ability to produce oil, thus accumulating a large amount of oil in the microorganisms, inducing the autolysis of the produced oil in the microorganisms to produce a free fatty acid, and converting the free fatty acid into an alkyl ester. According to the method of the present invention, oil accumulated in microorganisms, such as triacylglycerol that is typical oil produced by microorganisms, can be converted into a fatty acid alkyl ester with high efficiency using a metabolic engineering approach. Thus, the method of the present invention is useful for the industrial production of a fatty acid alkyl ester which has been recently found to be effective as biodiesel.

    RECOMBINANT MICROORGANISM WITH INCREASED BUTANOL PRODUCTION ABILITY, AND PREPARATION METHOD OF BUTANOL USING SAME
    14.
    发明授权
    RECOMBINANT MICROORGANISM WITH INCREASED BUTANOL PRODUCTION ABILITY, AND PREPARATION METHOD OF BUTANOL USING SAME 有权
    重组微生物提高丁醇生产能力，以及使用相同的丁醇制备方法

    公开(公告)号：EP2481793B1

    公开(公告)日：2017-08-30

    申请号：EP10819056.2

    申请日：2010-09-21

    申请人： Korea Advanced Institute of Science and Technology ,  Biofuelchem Co. ,  GS Caltex Corporation

    发明人： LEE, Sang Yup ,  JANG, Yu-Sin ,  LEE, Jin Young ,  LEE, Joung Min ,  PARK, Jin Hwan

    IPC分类号： C12N1/21 ,  C12P7/16 ,  C12N15/52

    CPC分类号： C12P7/16 ,  C12N9/0006 ,  C12N9/1029 ,  C12Y101/01001 ,  C12Y203/01008 ,  C12Y203/01019 ,  Y02E50/10

    摘要： The present invention relates to recombinant microorganisms having an increased ability to produce butanol, and a method of producing butanol using the same. More specifically, the invention relates to recombinant microorganisms whose ability to produce butanol was increased by manipulation of their metabolic networks, and a method of producing butanol using the same. The recombinant microorganisms having an increased ability to produce butanol comprise a deletion of a gene, which encodes an enzyme that converts acetyl CoA to acetate, in host microorganisms having genes that encode enzymes involved in acetyl CoA and butyryl CoA biosynthetic pathway. The recombinant microorganisms obtained by manipulating the metabolic flux of microorganisms are able to selectively produce butanol with high efficiency, and thus are useful as microorganisms for producing industrial solvents and transportation fuels.

    摘要翻译： 本发明涉及具有提高的丁醇生产能力的重组微生物以及使用该微生物生产丁醇的方法。 更具体地说，本发明涉及通过操作其代谢网络来增加丁醇生产能力的重组微生物，以及使用该微生物生产丁醇的方法。 具有增加的丁醇生产能力的重组微生物包括在编码参与乙酰辅酶A和丁酰辅酶A生物合成途径的酶的基因的宿主微生物中缺失编码将乙酰辅酶A转化为乙酸的酶的基因。 通过操作微生物的代谢流而获得的重组微生物能够高效选择性地生产丁醇，因此可用作用于生产工业溶剂和运输燃料的微生物。

    NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL, AND METHOD FOR PREPARING SUCCINIC ACID USING SAME
    16.
    发明公开
    NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL, AND METHOD FOR PREPARING SUCCINIC ACID USING SAME 有权
    NEW突变微生物琥珀酸与琥珀酸的生产，使蔗糖和甘油和方法的同时使用PRODUCTION

    公开(公告)号：EP2612905A2

    公开(公告)日：2013-07-10

    申请号：EP11822105.0

    申请日：2011-08-30

    申请人： Korea Advanced Institute Of Science And Technology

    发明人： LEE, Sang Yup ,  LEE, Jeong Wook ,  CHOI, Sol ,  YI, Jongho

    IPC分类号： C12N1/21 ,  C12N15/52 ,  C12P7/40

    CPC分类号： C12P7/46 ,  C12N1/20 ,  C12N15/52 ,  C12R1/01

    摘要： The present invention relates to a succinic acid-producing mutant microorganism that is able to utilize sucrose and glycerol simultaneously as carbon sources. More particularly, the present invention relates to a succinic acid-producing mutant microorganism that is able to utilize sucrose and glycerol simultaneously for succinic acid production, the mutant organism being obtained by relieving the mechanism of sucrose-mediated catabolite repression of glycerol in a succinic acid-producing microorganism. As described above, when the succinic acid-producing mutant microorganism is cultured, it utilizes sucrose and glycerol simultaneously so that succinic acid can be produced with high productivity in a maximum yield approaching the theoretical yield while the production of byproducts is minimized. In addition, according to the present invention, various reduced chemicals which have been produced in low yields in conventional methods can be more effectively produced.

    摘要翻译： 本发明涉及一种产琥珀酸微生物突变体确实能够利用蔗糖和甘油同时作为碳源。 更具体地，本发明涉及一种产琥珀酸微生物突变体也能够利用蔗糖和甘油同时用于琥珀酸生产，所述突变体有机体由缓和甘油的蔗糖介导的分解代谢物抑制的机制在琥珀酸获得 - 生产微生物。 如上所述，当产生琥珀酸的突变体微生物进行培养时，它利用蔗糖和甘油同时所以也琥珀酸可以以高生产率在最大产率接近理论产率而生产的副产物最小化产生的。 此外，雅鼎在本发明中，已在低产量被生产中的常规方法减少各种化学品可以更有效地生产。

    METHOD FOR PRODUCING FATTY ACID ALKYL ESTERS USING MICROORGANISMS HAVING OIL-PRODUCING ABILITY
    17.
    发明公开
    METHOD FOR PRODUCING FATTY ACID ALKYL ESTERS USING MICROORGANISMS HAVING OIL-PRODUCING ABILITY 审中-公开
    用于生产使用具有OIL生成能力的微生物的脂肪酸烷基酯

    公开(公告)号：EP2455484A2

    公开(公告)日：2012-05-23

    申请号：EP10800069.6

    申请日：2010-07-19

    申请人： Korea Advanced Institute of Science and Technology

    发明人： LEE, Sang Yup ,  CHOI, Yong Jun

    IPC分类号： C12P7/64 ,  C12N1/21 ,  C12N15/55

    CPC分类号： C12N9/20 ,  C12P7/649 ,  C12Y301/01003 ,  Y02E50/13 ,  Y02P20/52

    摘要： The present invention relates to a method of producing a fatty acid alkyl ester using microorganisms having the ability to produce oil, and more particularly to a method of producing a fatty acid alkyl ester, the method comprising culturing microorganisms having the ability to produce oil, thus accumulating a large amount of oil in the microorganisms, inducing the autolysis of the produced oil in the microorganisms to produce a free fatty acid, and converting the free fatty acid into an alkyl ester. According to the method of the present invention, oil accumulated in microorganisms, such as triacylglycerol that is typical oil produced by microorganisms, can be converted into a fatty acid alkyl ester with high efficiency using a metabolic engineering approach. Thus, the method of the present invention is useful for the industrial production of a fatty acid alkyl ester which has been recently found to be effective as biodiesel.

    摘要翻译： 本发明涉及使用微生物具有产生油生产的脂肪酸烷基酯的方法的能力，更具体地，该方法包括具有产生油的能力培养微生物产生的脂肪酸烷基酯的方法，从而 累积大量的油在微生物，诱导所述微生物产生的油的自溶，以产生游离脂肪酸，游离脂肪酸转化成在烷基酯。 。根据本发明的方法中，油积累在微生物中，：如三酰甘油确实是由微生物产生的典型的油，可以被转换成使用代谢工程方法以高效率的脂肪酸烷基酯。 因此，本发明的方法是用于工业生产最近已经发现是有效的作为生物柴油的脂肪酸烷基酯是有用的。