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11.发明授权IMMUNOGENIC POLYPEPTIDES ENCODED BY MAGE MINIGENES AND USES THEREOF 有权BY GENE MAGE MINI CODED免疫多肽和用途
公开(公告)号：EP1282702B1
公开(公告)日：2006-11-29
申请号：EP01931269.3
申请日：2001-05-07
发明人： BERINSTEIN, Neil , TARTAGLIA, Jim , TINE, John, A. , MOINGEON, Philippe , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre
IPC分类号： C12N15/12 , C07K14/47 , A61K39/00 , A61K38/17 , C12N15/863 , C12N15/861 , A61K31/7088 , A61K48/00
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/4748 , C12N15/62 , C12N2799/021 , C12N2799/023
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12.发明授权
公开(公告)号：EP0789591B1
公开(公告)日：2003-04-16
申请号：EP95913476.8
申请日：1995-01-26
发明人： VAN DER BRUGGEN, Pierre , SZIKORA, Jean-Pierre , COULIE, Pierre , WILDMANN, Claude , BOEL, Pascale , BOON-FALLEUR, Thierry
IPC分类号： C12N15/12 , A61K48/00 , C12Q1/68 , C07K7/06 , C07K14/705
CPC分类号： G01N33/5011 , A61K35/17 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/70539 , G01N2333/70539 , G01N2800/52
摘要： This invention relates to MAGE-1 derived nonapeptides. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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公开(公告)号：EP1117679A2
公开(公告)日：2001-07-25
申请号：EP99970091.7
申请日：1999-09-15
发明人： CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
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公开(公告)号：EP1012283A1
公开(公告)日：2000-06-28
申请号：EP98945923.5
申请日：1998-09-04
发明人： THIELEMANS, Kris , HEIRMAN, Carlo , CORTHALS, Jurgen , CHAUX, Pascal , STROOBANT, Vincent , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , LUITEN, Rosalie
IPC分类号： C12N15/12 , C07K14/705 , C07K19/00 , G01N33/53 , G01N33/68 , A61K38/17 , A61K35/26 , C07K16/30 , C12N5/08
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+T lymphocytes. Methods and products are also provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
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15.发明公开MONOCLONAL ANBIBODIES WHICH BIND TO TUMOR REJECTION ANTIGEN PRECURSOR MAGE-1, RECOMBINANT MAGE-1, AND MAGE-1 DERIVED IMMUNOGENIC PEPTIDES 失效单克隆抗体在预DES TUMORABSTOSSANTIGEN MAGE-1参与结合的，重组的MAGE-1，MAGE-1和ABGEBIETETEIMMUNOGENE PEPTIDE
公开(公告)号：EP0752876A1
公开(公告)日：1997-01-15
申请号：EP95907978.0
申请日：1995-01-05
发明人： CHEN, Yao-Tseng , STOCKERT, Elisabeth , CHEN, Yachi , GARIN-CHESA, Pilar , RETTIG, Wolfgang J. , VAN DER BRUGGEN, Pierre , BOON-FALLEUR, Thierry , OLD, Lloyd J.
IPC分类号： C07K , C12N15 , A61K38 , A61K39 , A61P35 , C07H21 , C07K7 , C07K14 , C07K16 , C12N5 , C12P21 , G01N33 , C12R1
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to monoclonal antibodies which specifically bind to the tumor rejection antigen precursor molecule MAGE-1, hybridomas which produce these monoclonal antibodies, and their use. Also described is a recombinant form of MAGE-1, peptides which are useful as immunogens, and immunogenic compositions containing the peptides and an adjuvant.
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公开(公告)号：EP1224216B1
公开(公告)日：2009-12-30
申请号：EP00942795.6
申请日：2000-06-14
发明人： VAN SNICK, Jacques , LETHE, Bernard , CHAUX, Pascal , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre
IPC分类号： C07K14/47 , C07K14/705 , C07K7/08 , C12N15/62 , A61K38/17 , G01N33/53 , C07K16/18 , A61K35/14 , C12N5/06
CPC分类号： C07K14/4748 , A61K38/00 , C07K2319/00 , Y10S514/885 , Y10S530/806 , Y10S530/828
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17.发明授权TUMOR REJECTION ANTIGEN PRECURSORS, TUMOR REJECTION ANTIGENS AND USES THEREOF 失效负责任TUMORABSTOSSUNG抗原，抗原和PRE及其用途
公开(公告)号：EP0595838B1
公开(公告)日：2004-10-13
申请号：EP92913925.1
申请日：1992-05-22
发明人： BOON, Thierry , VAN DER BRUGGEN, Pierre , VAN DEN EYNDE, Benoit , VAN PEL, Aline , DE PLAEN, Etienne , LURQUIN, Christophe , CHOMEZ, Patrick , TRAVERSARI, Catia
IPC分类号： C12N15/12 , C07K14/00 , A61K39/00 , A61K39/395 , A61K38/00 , G01N33/574 , C12Q1/68 , C12N1/20
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.
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18.发明公开IMMUNOGENIC POLYPEPTIDES ENCODED BY MAGE MINIGENES AND USES THEREOF 有权BY GENE MAGE MINI CODED免疫多肽和用途
公开(公告)号：EP1282702A2
公开(公告)日：2003-02-12
申请号：EP01931269.3
申请日：2001-05-07
发明人： BERINSTEIN, Neil , TARTAGLIA, Jim , TINE, John, A. , MOINGEON, Philippe , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre
IPC分类号： C12N15/12 , C07K14/47 , A61K39/00 , A61K38/17 , C12N15/863 , C12N15/861 , A61K31/7088 , A61K48/00
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/4748 , C12N15/62 , C12N2799/021 , C12N2799/023
摘要： The invention discloses immunogenic polypeptides comprising several MAGE-specific antigen epitopes selected from different (i.e. discrete) members of the MAGE protein family, nucleic acids coding therefor, recombinant viruses and/or cells comprising said nucleic acids, and compositions thereof. Methods for eliciting or inducing MAGE-specific immune responses utilizing the aforementioned immunogenic agents are also disclosed.
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19.发明授权ISOLATED TUMOR REJECTION ANTIGEN PRECURSOR MAGE-2 DERIVED PEPTIDES, AND USES THEREOF 失效分离的肿瘤排斥抗原PRE MAGE-2的肽及其用途
公开(公告)号：EP0810870B1
公开(公告)日：2001-05-16
申请号：EP95914792.7
申请日：1995-03-21
发明人： MELIEF, Cornelis, J., M. , VISSEREN, M., W. , KAST, W., M. , VAN DER BRUGGEN, Pierre , BOON-FALLEUR, Thierry
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5158 , C07K14/705 , Y10S530/828 , Y10S530/868
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20.发明公开TUMOR REJECTION ANTIGENS PRESENTED BY HLA-B44 MOLECULES, AND USES THEREOF 失效由HLA-B44分子提呈肿瘤ABSTOSSUNGSANTIGENE和用途
公开(公告)号：EP0876397A1
公开(公告)日：1998-11-11
申请号：EP97906894.0
申请日：1997-02-05
发明人： HERMAN, Jean , COULIE, Pierre , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , LUESCHER, Immanuel
CPC分类号： C12Q1/6881 , A61K39/00 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , C12Q2600/136 , G01N33/56977 , G01N33/57492
摘要： Tumor rejection antigens presented by HLA-B44 molecules are described. These peptides are useful in diagnostic and therapeutic methodologies. The tumor rejection antigens are derived from MAGE tumor rejection antigen precursors.
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