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公开(公告)号：EP1224216B1
公开(公告)日：2009-12-30
申请号：EP00942795.6
申请日：2000-06-14
发明人： VAN SNICK, Jacques , LETHE, Bernard , CHAUX, Pascal , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre
IPC分类号： C07K14/47 , C07K14/705 , C07K7/08 , C12N15/62 , A61K38/17 , G01N33/53 , C07K16/18 , A61K35/14 , C12N5/06
CPC分类号： C07K14/4748 , A61K38/00 , C07K2319/00 , Y10S514/885 , Y10S530/806 , Y10S530/828
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12.发明授权ISOLATED NUCLEIC ACID MOLECULE CODING FOR TUMOR REJECTION ANTIGEN PRECURSORS MAGE-C1 AND MAGE-C2 AND USES THEREOF 失效包含抗原前体MAGE TUMORABSTOSSUNGS-C1和MAGE-C2及其用途编码的分离的核酸分子
公开(公告)号：EP0979235B1
公开(公告)日：2005-12-21
申请号：EP98918810.7
申请日：1998-04-24
IPC分类号： C07H21/04 , A61K38/00 , A61K39/00 , A61K39/12 , G01N33/574 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which may be recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.
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13.发明公开
公开(公告)号：EP1301624A2
公开(公告)日：2003-04-16
申请号：EP01927400.0
申请日：2001-03-14
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , INSTITUT NATIONAL DE LA SANTE ET DE LARECHERCHE MEDICALE (INSERM) , INSTITUT GUSTAVE ROUSSY
发明人： ECHCHAKIR, Hamid , MAMI-CHOUAIB, Fathia , VERGNON, Isabelle , CHOUAIB, Salem , BAURAIN, Jean FrançoisUni. Catholique de Louvain , COULIE, Pierre G.,Uni. Catholique de Louvain , BOON-FALLEUR, Thierry
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C07K14/585 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to the identification of a tumor rejection antigen precursor. It has been established that preprocalcitonin protein functions as a tumor rejection antigen precursor, and is processed to at least one tumor rejection antigen. Complexes of the tumor rejection antigen and an MHC molecule are recognized by cytolytic T lymphocytes, and lysed.
摘要翻译： 本发明涉及肿瘤排斥抗原前体的鉴定。 已经确定，前降钙素原蛋白作为肿瘤排斥抗原前体起作用，并被加工成至少一种肿瘤排斥抗原。 肿瘤排斥抗原和MHC分子的复合物被细胞溶解性T淋巴细胞识别，并被裂解。
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14.发明公开IMMUNOGENIC POLYPEPTIDES ENCODED BY MAGE MINIGENES AND USES THEREOF 有权BY GENE MAGE MINI CODED免疫多肽和用途
公开(公告)号：EP1282702A2
公开(公告)日：2003-02-12
申请号：EP01931269.3
申请日：2001-05-07
发明人： BERINSTEIN, Neil , TARTAGLIA, Jim , TINE, John, A. , MOINGEON, Philippe , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre
IPC分类号： C12N15/12 , C07K14/47 , A61K39/00 , A61K38/17 , C12N15/863 , C12N15/861 , A61K31/7088 , A61K48/00
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/4748 , C12N15/62 , C12N2799/021 , C12N2799/023
摘要： The invention discloses immunogenic polypeptides comprising several MAGE-specific antigen epitopes selected from different (i.e. discrete) members of the MAGE protein family, nucleic acids coding therefor, recombinant viruses and/or cells comprising said nucleic acids, and compositions thereof. Methods for eliciting or inducing MAGE-specific immune responses utilizing the aforementioned immunogenic agents are also disclosed.
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公开(公告)号：EP1165776A1
公开(公告)日：2002-01-02
申请号：EP00910250.0
申请日：2000-02-18
IPC分类号： C12N15/12 , C07K14/47 , G01N33/566 , A61K38/17 , C07K16/28 , A61K39/395 , C12N15/62
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the EphA3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the EphA3 gene.
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公开(公告)号：EP1123108A1
公开(公告)日：2001-08-16
申请号：EP99950142.2
申请日：1999-10-04
发明人： OOMS, AnnieUniversité de Liège, Sart Tilman , DE GIOVANNI, Gerard,Univ. de Liège, Sart Tilman , MOREL, Sandra , VAN DEN EYNDE, Benoit , BOON-FALLEUR, Thierry
IPC分类号： A61K38/08 , A61K39/00 , A61K39/385 , C12N1/21 , C12N5/10 , C12N15/63 , C12N15/70 , C12N15/85 , C12N15/87 , C12N15/74 , C07K19/00
CPC分类号： C12N9/0059 , A61K38/00 , C07K14/70539
摘要： The invention relates to peptides which bind to HLA-B35 molecules, leading to recognition and lysis of the resulting complexes by cytolytic T cells. Also a part of the invention are nucleic acid molecules which encode these peptides, and uses of each of these. The molecules are derived, in some cases, from tyrosinase, and portions of the tyrosinase molecule and portions of nucleic acid molecules which encode tyrosinase are also a part of the invention.
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17.发明授权ISOLATED TUMOR REJECTION ANTIGEN PRECURSOR MAGE-2 DERIVED PEPTIDES, AND USES THEREOF 失效分离的肿瘤排斥抗原PRE MAGE-2的肽及其用途
公开(公告)号：EP0810870B1
公开(公告)日：2001-05-16
申请号：EP95914792.7
申请日：1995-03-21
发明人： MELIEF, Cornelis, J., M. , VISSEREN, M., W. , KAST, W., M. , VAN DER BRUGGEN, Pierre , BOON-FALLEUR, Thierry
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5158 , C07K14/705 , Y10S530/828 , Y10S530/868
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18.发明公开TUMOR REJECTION ANTIGENS PRESENTED BY HLA-B44 MOLECULES, AND USES THEREOF 失效由HLA-B44分子提呈肿瘤ABSTOSSUNGSANTIGENE和用途
公开(公告)号：EP0876397A1
公开(公告)日：1998-11-11
申请号：EP97906894.0
申请日：1997-02-05
发明人： HERMAN, Jean , COULIE, Pierre , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , LUESCHER, Immanuel
CPC分类号： C12Q1/6881 , A61K39/00 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , C12Q2600/136 , G01N33/56977 , G01N33/57492
摘要： Tumor rejection antigens presented by HLA-B44 molecules are described. These peptides are useful in diagnostic and therapeutic methodologies. The tumor rejection antigens are derived from MAGE tumor rejection antigen precursors.
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19.发明公开
公开(公告)号：EP0871765A1
公开(公告)日：1998-10-21
申请号：EP95912584.0
申请日：1995-02-23
发明人： DE PLAEN, Etienne , BOON-FALLEUR, Thierry , LETHE, Bernard , SZIKORA, Jean-Pierre , DE SMET, Charles , CHOMEZ, Patrick , GAUGLER, Beatrice , VAN DEN EYNDE, Benoit , BRASSEUR, Francis , PATARD, Jean-Jacques, Hôpital Henry Mondor , WEYNANTS, P. , MARCHAND, M. , VAN DER BRUGGEN, Pierre
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/112
摘要： A method for determining cancers is described. The method involves assaying for expression of a gene coding for at least one of MAGE tumor rejection antigen or its precursor expression product.
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20.发明公开ISOLATED NUCLEIC ACID MOLECULES, PEPTIDES WHICH FORM COMPLEXES WITH MHC MOLECULE HLA-A2 AND USES THEREOF 失效分离的核酸分子的肽与HLA-A2分子（MHC）络合物形式，及其用途
公开(公告)号：EP0845032A2
公开(公告)日：1998-06-03
申请号：EP96913954.0
申请日：1996-05-07
发明人： GUILLOUX, Yannick , JOTEREAU, Francine , BOON-FALLEUR, Thierry , LUCAS, Sophie , BRICHARD, Vincent
IPC分类号： G01N33 , A61K35 , A61K38 , A61K39 , A61K45 , A61K48 , A61P35 , A61P37 , A61P43 , C07K14 , C12N1 , C12N5 , C12N15
CPC分类号： C07K14/4748 , A61K38/00
摘要： New tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as NAG tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as NAG coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are discribed.
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