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    2-AMINOQUINAZOLINE DERIVATIVES
    12.
    发明公开
    2-AMINOQUINAZOLINE DERIVATIVES 审中-公开
    2- AMINOCHINAZOLINDERIVATE

    公开(公告)号：EP1878727A1

    公开(公告)日：2008-01-16

    申请号：EP06745859.6

    申请日：2006-04-28

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： KISHIKAWA, Kuniyuki ,  IMASE, Hidetomo ,  KASHIMA, Hajime ,  MORI, Kiyotoshi ,  IKEMURA, Toshihide ,  NAKASATO, Yoshisuke ,  TOMURO, Misato

    IPC分类号： C07D239/84 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P1/04 ,  A61P1/18 ,  A61P3/10 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/06 ,  A61P19/10 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00

    CPC分类号： C07D405/12 ,  C07D239/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04

    摘要： The present invention provides 2-aminoquinazoline derivatives represented by formula (I):

    wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like;
    X represents a bond or CR 7a R 7b wherein R 7a and R 7b may be the same or different and each represents a hydrogen atom, and the like;
    when X is a bond, R 3 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group;
    when X is CR 7a R 7b wherein R 7a and R 7b have the same meanings as defined above, respectively, R 3 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, and the like;
    R 4 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, and the like; and
    R 5 represents a hydrogen atom, substituted or unsubstituted aryl, and the like, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供由式（I）表示的2-氨基喹唑啉衍生物：其中R 1和R 2可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; X表示键或CR 7a R 7b，其中R 7a和R 7b可以相同或不同，各自表示氢原子等; 当X为键时，R 3为取代或未取代的芳基或取代或未取代的芳族杂环基; 当X为CR 7a R 7b，其中R 7a和R 7b分别具有与上述相同的含义时，R 3表示取代或未取代的低级烷氧基，取代或未取代的芳基等; R 4表示氢原子，羟基，取代或未取代的低级烷氧基等; R 5表示氢原子，取代或未取代的芳基等，或其药学上可接受的盐。

    INDUSTRIALLY USEFUL MICROORGANISM
    15.
    发明公开
    INDUSTRIALLY USEFUL MICROORGANISM 审中-公开
    工业上有用的微生物

    公开(公告)号：EP1829965A1

    公开(公告)日：2007-09-05

    申请号：EP05809612.4

    申请日：2005-11-25

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： MIZOGUCHI, Hiroshi ,  HARA, Kiyotaka ,  MORI, Hideo

    IPC分类号： C12N15/09 ,  C12N1/20 ,  C12N1/21 ,  C12P7/64 ,  C12P13/00 ,  C12P13/04 ,  C12P17/00 ,  C12P19/00 ,  C12P19/30 ,  C12P19/38 ,  C12P21/02

    CPC分类号： C12P13/08 ,  C12N1/20 ,  C12R1/185

    摘要： According to the present invention, the E . coli mutant strain having chromosomal DNA that is at least 470 kbp shorter than that of a wild-type E . coli strain exhibits such a property that the number of the cells after a certain period of culture is greater than a wild-type strain. Thus, by culturing the mutant strain in a medium so as to generate and accumulate a useful substance in the culture, a useful substance such as proteins, peptides, amino acids, nucleic acids, vitamins, saccharides, organic acids, and lipids can be efficiently produced.

    摘要翻译： 根据本发明，具有比野生型大肠杆菌菌株短至少470kbp的染色体DNA的大肠杆菌突变株显示出这样的性质，即培养一段时间后的细胞数目是 大于野生型菌株。 因此，通过在培养基中培养突变菌株以在培养物中产生并积累有用物质，可以有效地使蛋白质，肽，氨基酸，核酸，维生素，糖类，有机酸和脂质等有用物质 产生的。

    INDUSTRIALLY USEFUL MICROORGANISM
    19.
    发明公开
    INDUSTRIALLY USEFUL MICROORGANISM 有权
    GROSSTECHNISCH GEEIGNETER MIKROORGANISMUS

    公开(公告)号：EP1788075A1

    公开(公告)日：2007-05-23

    申请号：EP05776635.4

    申请日：2005-09-01

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： KATO, Makiko ,  MORI, Hideo ,  KATO, Jun-ichi

    IPC分类号： C12N1/21 ,  C07G13/00 ,  C12N15/09 ,  C12P7/40 ,  C12P7/64 ,  C12P13/00 ,  C12P13/04 ,  C12P19/00 ,  C12P19/28

    CPC分类号： C12P13/24 ,  C12P13/14

    摘要： The present invention provides a microorganism which comprises a chromosomal DNA lacking a part or entire of the gene encoding a protein having the amino acid sequence as shown in SEQ ID NO: 1 or 2, or the gene encoding a protein having 80% or more homology with the amino acid sequence as shown in SEQ ID NO: 1 or 2, and has the ability to produce a useful substance; a process for producing a useful substance using said strain; especially a process for producing a useful substance which is selected from the group consisting of proteins, peptides, amino acids, nucleic acids, vitamins, saccharides, organic acids, and lipids.

    摘要翻译： 本发明提供一种微生物，其含有缺乏编码具有SEQ ID NO：1或2所示的氨基酸序列的蛋白质的基因的一部分或全部的染色体DNA，或编码具有80％以上同源性的蛋白质的基因 具有SEQ ID NO：1或2所示的氨基酸序列，并具有产生有用物质的能力; 使用所述菌株生产有用物质的方法; 尤其是用于生产选自蛋白质，肽，氨基酸，核酸，维生素，糖类，有机酸和脂质的有用物质的方法。

    PROCESS FOR PRODUCING DIPEPTIDES OR DIPEPTIDE DERIVATIVES
    20.
    发明公开
    PROCESS FOR PRODUCING DIPEPTIDES OR DIPEPTIDE DERIVATIVES 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON DIPEPTIDEN ODER DIPEPTIDDERIVATEN

    公开(公告)号：EP1767628A1

    公开(公告)日：2007-03-28

    申请号：EP05765118.4

    申请日：2005-06-24

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： HASHIMOTO, Shin-ichi c/o Technical Research Lab ,  IKEDA, Hajime C/O Technical Research Lab. ,  TABATA, Kazuhiko c/o Technical Research Lab.

    IPC分类号： C12N15/09 ,  C12P21/02 ,  C12N9/48 ,  C12R1/19

    CPC分类号： C12P21/02

    摘要： The present invention provides a process for producing a dipeptide or a dipeptide derivative by using a protein having the activity to form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture as a enzyme source, which comprise; allowing the enzyme sorce, one or more kinds of amino acids or amino acid derivatives and ATP to be present in an aqueous medium;
    allowing the dipeptide or dipeptide derivative to form and accumulate in the medium; and
    recovering the dipeptide or dipeptide derivative from the medium.

    摘要翻译： 本发明提供了通过使用具有从一种或多种氨基酸或氨基酸衍生物形成二肽或二肽衍生物的活性的蛋白质或具有以下能力的细胞培养物来生产二肽或二肽衍生物的方法： 产生作为酶源的培养物的蛋白质或处理物质，其包含： 允许酶吸收，一种或多种氨基酸或氨基酸衍生物和ATP存在于水性介质中; 允许二肽或二肽衍生物在培养基中形成和积累; 并从培养基中回收二肽或二肽衍生物。