公开(公告)号：EP4385570A2

公开(公告)日：2024-06-19

申请号：EP24169784.6

申请日：2011-09-21

申请人： Altor BioScience, LLC

发明人： WONG, Hing C. ,  RHODE, Peter ,  LIU, Bai ,  ZHU, Xiaoyun ,  HAN, Kai-ping

IPC分类号： A61P35/00

CPC分类号： C07K2319/2120130101 ,  C07K2319/2220130101 ,  C07K2319/3020130101 ,  A61K38/00 ,  A61K38/1793 ,  A61K45/06 ,  C07K16/2887 ,  C07K2317/62220130101 ,  C07K2317/73220130101 ,  C12N15/62 ,  C12N15/09 ,  C07K14/5443 ,  C07K14/7155 ,  A61K38/2086 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  A61P37/04 ,  A61P43/00

摘要： The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.

公开(公告)号：EP4382105A2

公开(公告)日：2024-06-12

申请号：EP24158412.7

申请日：2018-08-16

申请人： Gilead Sciences, Inc.

发明人： HOUSTON, Travis, Lee ,  SHI, Bing

IPC分类号： A61K31/454

CPC分类号： C07D401/14 ,  A61P31/18 ,  A61K31/454

摘要： The present disclosure relates to choline salts, and crystalline forms thereof, of a compound which is N-((S)-1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide, which is useful in the treatment and prevention of a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：EP3482769B1

公开(公告)日：2024-05-29

申请号：EP18213706.7

申请日：2009-12-17

IPC分类号： A61K39/00 ,  C07K16/44 ,  C07K16/32 ,  C07K16/28

CPC分类号： A61K2039/50520130101 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/283 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/5620130101 ,  C07K2317/62620130101 ,  C07K2317/7320130101 ,  C07K2317/9220130101 ,  C07K2319/0020130101 ,  C07K2317/3420130101 ,  C07K2317/5220130101 ,  C07K2317/6420130101 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/08 ,  A61P21/04 ,  A61P25/00 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P33/02 ,  A61P33/06 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/02 ,  A61P43/00 ,  A61P5/14 ,  A61P5/38 ,  A61P7/06 ,  A61P9/08 ,  A61P3/10

公开(公告)号：EP3939985B1

公开(公告)日：2024-05-08

申请号：EP21178364.2

申请日：2015-12-16

IPC分类号： C07H19/067 ,  C07H19/073 ,  C07H19/10 ,  C07H19/11 ,  A61K31/7068 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P35/00

CPC分类号： C07H19/067 ,  C07H19/10 ,  C07H19/11 ,  C07H19/073 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P35/00 ,  Y02A50/30

公开(公告)号：EP4351647A1

公开(公告)日：2024-04-17

申请号：EP22821089.4

申请日：2022-06-10

申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. ,  Centre Hospitalier de l'Université de Montréal

发明人： PAZGIER, Marzena ,  TOLBERT, William D. ,  NGUYEN, Dung N. ,  FINZI, Andrés ,  RICHARD, Jonathan

IPC分类号： A61K39/42

CPC分类号： C07K16/1045 ,  C07K2317/73220130101 ,  A61P31/18 ,  C07K2317/62220130101 ,  C07K2317/2220130101

公开(公告)号：EP3127908B1

公开(公告)日：2018-11-28

申请号：EP16190894.2

申请日：2011-08-04

申请人： SHIONOGI & CO., LTD

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14

CPC分类号： C07D498/14 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00 ,  C07B2200/13 ,  C07D211/94 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].

公开(公告)号：EP3383866A1

公开(公告)日：2018-10-10

申请号：EP16806295.8

申请日：2016-12-01

申请人： ViiV Healthcare UK Limited

发明人： JOHNS, Brian Alvin ,  VELTHUISEN, Emile Johann ,  WEATHERHEAD, Jason Gordon

IPC分类号： C07D405/14 ,  C07D217/04 ,  C07D217/06 ,  C07D217/08 ,  C07D217/24 ,  C07D401/06 ,  C07D405/04 ,  C07D413/04 ,  A61K31/472 ,  A61P31/18

CPC分类号： C07D217/04 ,  A61P31/18 ,  C07D217/06 ,  C07D217/08 ,  C07D217/24 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14

摘要： Compounds of Formula (I) are disclosed and methods of treating viral infections with compositions comprising such compounds.

公开(公告)号：EP3383864A1

公开(公告)日：2018-10-10

申请号：EP16808815.1

申请日：2016-12-01

申请人： ViiV Healthcare UK Limited

发明人： JOHNS, Brian Alvin ,  VELTHUISEN, Emile Johann ,  WEATHERHEAD, Jason Gordon

IPC分类号： C07D405/06 ,  C07D209/44 ,  A61K31/4035 ,  A61P31/18

CPC分类号： C07D209/44 ,  A61P31/18 ,  C07D405/06

摘要： Compounds of Formula (I) are disclosed and methods of treating viral infections with compositions comprising such compounds.

公开(公告)号：EP3186239B1

公开(公告)日：2018-10-10

申请号：EP15759599.2

申请日：2015-08-26

申请人： Gilead Sciences, Inc.

发明人： BRIZGYS, Gediminas ,  CANALES, Eda ,  HALCOMB, Randall, L. ,  HU, Yunfeng, Eric ,  KATO, Darryl ,  LINK, John, O. ,  LIU, Qi ,  SAITO, Roland, D. ,  TSE, Winston, C. ,  ZHANG, Jennifer, R.

IPC分类号： C07D401/14 ,  C07D471/04 ,  C07D403/14 ,  C07D405/14 ,  C07D493/04 ,  C07D413/14 ,  C07D498/04 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/437 ,  A61P31/18

CPC分类号： C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  A61P31/18 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D493/04 ,  C07D498/04 ,  C07D519/00

摘要： Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：EP3331546A1

公开(公告)日：2018-06-13

申请号：EP16751668.1

申请日：2016-08-02

申请人： Biokine Therapeutics Ltd. ,  BIOLINERX LTD.

发明人： PELED, Amnon ,  PEREG, Yaron ,  ABRAHAM, Michal ,  KLEIN SILBERMAN, Shiri

IPC分类号： A61K38/12 ,  A61K31/497 ,  A61P35/00 ,  A61P25/28 ,  G01N33/566 ,  A61K38/19 ,  C12Q1/68 ,  A61K38/16

CPC分类号： A61K31/635 ,  A61K31/497 ,  A61K38/12 ,  A61K38/16 ,  A61K38/162 ,  A61K38/195 ,  A61K45/06 ,  A61P31/18 ,  A61P35/00 ,  C12N15/1132 ,  C12N2310/141 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/57484 ,  G01N33/6863 ,  G01N2333/7158 ,  G01N2500/10 ,  G01N2800/28 ,  A61K2300/00

摘要： A method of treating cancer in a subject is disclosed. The method comprises administering to the subject: (i) a therapeutically effective amount of an inhibitory agent that down-regulates an amount of a polypeptide selected from the group consisting of BCL-2, MCL-1 and cyclin D1; and (ii) a therapeutically effective amount of a CXCR4 binding agent that increases the expression of mi R-15a and/or 16-1, thereby treating the cancer.