公开(公告)号：EP2074101A2

公开(公告)日：2009-07-01

申请号：EP07871162.9

申请日：2007-10-15

申请人： Siemens Healthcare Diagnostics Inc. ,  Jiang, Qingping ,  Sharpe, David

发明人： JIANG, Qingping ,  SHARPE, David ,  NATRAJAN, Anand

IPC分类号： C07D219/04 ,  G01N33/532

CPC分类号： C07D219/04 ,  Y10T436/13 ,  Y10T436/143333 ,  Y10T436/21

摘要： Chemiluminescent acridinium esters are provided which are fast light emitting and hydrolytically stable. The chemiluminescent acridinium esters are useful labels in assays for detecting or quantifying analytes.

公开(公告)号：EP1946108A2

公开(公告)日：2008-07-23

申请号：EP06771782.7

申请日：2006-06-01

申请人： Bayer Healthcare LLC

发明人： NATRAJAN, Anand ,  JIANG, Quingping ,  SHARPE, David ,  COSTELLO, James

IPC分类号： G01N33/532

CPC分类号： G01N33/533 ,  B82Y15/00 ,  C07D219/04 ,  C07D219/06 ,  G01N33/542 ,  G01N33/582 ,  G01N33/588 ,  Y10S435/968 ,  Y10S436/80 ,  Y10S436/805

摘要： The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium compound when its chemiluminescence is triggered by alkaline peroxide. More specifically, it has been found that the placement of one or two hydrophilic, alkoxy groups at the C-2 and/or C-7 position of the acridinium ring system of acridinium compounds increases their quantum yield and enhances the aqueous solubility of these compounds. The present hydrophilic, high quantum yield, acridinium compounds are useful chemiluminescent labels for improving the sensitivity of immunoassays.

公开(公告)号：EP1203091B1

公开(公告)日：2005-03-16

申请号：EP00950764.1

申请日：2000-07-27

申请人： Bayer Corporation

发明人： JIANG, Qingping ,  NATRAJAN, Anand ,  SHARPE, David, J. ,  WONG, Wen-Jee ,  LAW, Say-Jong

IPC分类号： C12Q1/42 ,  C07D219/06

CPC分类号： C07D491/10 ,  C07D219/04 ,  C07F9/64 ,  C12Q1/42 ,  C12Q2334/00

公开(公告)号：EP1353908A4

公开(公告)日：2004-01-28

申请号：EP01995974

申请日：2001-12-07

申请人： LUMIGEN INC

发明人： AKHAVAN-TAFTI HASHEM ,  EICKHOLT ROBERT A ,  HANDLEY RICHARD S

IPC分类号： C07B61/00 ,  C07D219/02 ,  C07D219/04 ,  C07D219/06 ,  C07D219/08 ,  C07D401/04 ,  C07D417/04

CPC分类号： C07D417/04 ,  C07D219/04 ,  C07D219/06

摘要： Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-aryl substituted intermendiates by formation of a bond between the nitrogen atom of the acridan ring and a carbon atom of another aromatic or heteroaromatic ring compound. The arylation reaction is catalyzed by a palladium catalyst. The N-arylacridan-carboxylic acid derivatives are useful in methods for producing light and in assays for peroxidase enzymes and enzyme inhibitors and in assays employing enzyme-labeled specific binding pairs.

公开(公告)号：EP1292573A2

公开(公告)日：2003-03-19

申请号：EP01937424.8

申请日：2001-05-16

申请人： CEPHALON, INC. ,  Miller, Matthew, S.

发明人： BACON, Edward, R. ,  CHATTERJEE, Sankar ,  DUNN, Derek ,  MALLAMO, John, P. ,  VAUGHT, Jeffry, L. ,  MILLER, Matthew, S.

IPC分类号： C07C323/60 ,  C07C317/44 ,  C07D333/18 ,  C07D277/26 ,  C07D417/06 ,  C07D231/54 ,  A61K31/165 ,  A61K31/381 ,  A61K31/416 ,  A61K31/427 ,  A61P1/14 ,  A61P9/10 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28

CPC分类号： C07D495/04 ,  C07C317/44 ,  C07C323/60 ,  C07C2603/18 ,  C07D207/16 ,  C07D207/416 ,  C07D211/88 ,  C07D213/34 ,  C07D219/04 ,  C07D231/54 ,  C07D233/64 ,  C07D261/08 ,  C07D263/16 ,  C07D263/32 ,  C07D263/34 ,  C07D275/02 ,  C07D277/26 ,  C07D277/56 ,  C07D307/68 ,  C07D311/84 ,  C07D333/18 ,  C07D335/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06

摘要： The present application is directed to chemical compounds of formula (I-A) or formula (II-A) (in which the variables are as defined in the claims), compositions containing them and uses of the compositions for treating sleepiness, tiredness Parkinson's disease, cerebral ischaemia, stroke, sleep apneas, eating disorders, attention deficit hyperactivity disorder, cognitive dysfunction or fatigue, for the promotion of wakefulness, stimulation of appetite or weight gain or for the treatment of disorders associated with hypofunctionality of the cerebral cortex such as depression, schizophrenia and chronic fatigue syndrome.

摘要翻译： 本发明涉及式（I）的取代的硫代乙酰胺：其中Ar 1，Ar 2，R 1 -R 4和n如权利要求中所定义，其制备方法和硫代乙酰胺用于治疗嗜睡，疲劳，帕金森氏症 疾病，脑缺血，中风，睡眠呼吸暂停，进食障碍，注意缺陷多动障碍，认知功能障碍或疲劳; 用于促进觉醒，刺激食欲或体重增加或用于治疗与大脑皮质功能低下相关的疾病，例如抑郁症，精神分裂症和慢性疲劳综合征。 。

公开(公告)号：EP0679641B1

公开(公告)日：2002-10-02

申请号：EP94921819.2

申请日：1994-07-26

申请人： Eisai Co., Ltd.

发明人： YOSHINO, Hiroshi ,  UEDA, Norihiro 1077-140, Yatabe ,  NIIJIMA, Jun 14-10-B-202, Matsuhiro 1-chome ,  HANEDA, Toru 9-24-1003, Chuo 2-chome ,  KOTAKE, Yoshihiko ,  YOSHIMATSU, Kentaro ,  WATANABE, Tatsuo ,  NAGASU, Takeshi 852-13, Nagakuni ,  TSUKAHARA, Naoko 796-2-101, Shibazaki ,  KOYANAGI, Nozomu 10-15, Toukoudai 1-chome ,  KITOH, Kyosuke 10-8, Toukoudai 1-chome

IPC分类号： C07D209/88 ,  C07D219/08 ,  C07D223/22 ,  C07D241/46 ,  C07D243/38 ,  C07D253/06 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/14 ,  C07D279/20 ,  C07D221/12 ,  C07D281/14 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D219/04 ,  C07C211/55 ,  C07C229/58 ,  C07C311/29 ,  C07D209/88 ,  C07D219/06 ,  C07D219/08 ,  C07D221/12 ,  C07D223/22 ,  C07D243/38 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/20 ,  C07D281/14 ,  C07D413/12 ,  C07D513/04 ,  C07F7/1856

公开(公告)号：EP0647628B1

公开(公告)日：2002-09-11

申请号：EP94119395.5

申请日：1987-08-19

申请人： Dade Behring Marburg GmbH

发明人： Molz, Peter, Dr. ,  Skrzipczyk, Heinz-Jürgen, Dr. ,  Lübbers, Henning, Dr. ,  Strecker, Helmut, Dr. ,  Schnorr, Gerd, Dr. ,  Kinkel, Tonio, Dr.

IPC分类号： C07D219/04 ,  G01N33/533 ,  C07D401/12 ,  G01N33/68

CPC分类号： C07D401/12 ,  C07D219/04 ,  G01N33/533 ,  G01N33/582

公开(公告)号：EP0361817B1

公开(公告)日：2002-08-28

申请号：EP89309705.5

申请日：1989-09-25

申请人： Bayer Corporation

发明人： Chang, Steve Chin-Shen ,  Klukas, Carol K. ,  Law, Say-Jong ,  Vitkauskas, Christine Anne

IPC分类号： C07D219/04 ,  G01N33/533 ,  G01N33/82 ,  G01N33/74 ,  G01N33/88

CPC分类号： C07H23/00 ,  C07D219/04 ,  C07J41/0016 ,  C07J43/003 ,  C07J51/00 ,  G01N33/533 ,  G01N33/743 ,  G01N33/82 ,  G01N33/86 ,  G01N33/88

公开(公告)号：EP1159261A2

公开(公告)日：2001-12-05

申请号：EP00913365.3

申请日：2000-02-04

申请人： ORIDIGM CORPORATION ,  Vermeulin, Nicolaas M. J. ,  Burns, Mark R. ,  Webb, Heather K.

发明人： VERMEULIN, Nicolaas, M., J. ,  BURNS, Mark, R. ,  WEBB, Heather, K.

IPC分类号： C07C279/00

CPC分类号： C07D307/91 ,  C07C211/14 ,  C07C211/15 ,  C07C211/27 ,  C07C211/53 ,  C07C211/54 ,  C07C215/58 ,  C07C233/36 ,  C07C233/37 ,  C07C237/10 ,  C07C251/38 ,  C07C279/12 ,  C07C279/26 ,  C07C2601/02 ,  C07C2603/74 ,  C07D211/26 ,  C07D213/36 ,  C07D219/04 ,  C07D233/16 ,  C07D233/52 ,  C07D295/13 ,  C07D333/34 ,  C07D417/04

摘要： The present invention is directed to agmatine and polyamine analogs and their use as drugs, as well as agricultural or environmentally useful agents. As drugs, the analogs decrease cellular polyamine levels, possibly by inducing antizyme, and can be used to treat disorders of undesired cell proliferation, including cancer, viral infections and bacterial infections. The analogs may be utilized in pharmaceutical compositions either alone or in combination with other agents, particularly other inhibitors of polyamine synthesis or transport, but including other inhibitors of cell proliferation. The analogs are not necessarily metabolized to contribute to the polyamine pool and are designed to enter cells by pathways independent of polyamine transport. The invention further defines structural elements/motifs within these analogs that are key to their induction of antizyme.

摘要翻译： 本发明涉及胍丁胺和多胺类似物及其作为药物的用途，以及农业或环境有用的药剂。 作为药物，类似物可能通过诱导抗酶来降低细胞多胺的水平，并且可用于治疗不希望的细胞增殖的疾病，包括癌症，病毒感染和细菌感染。 类似物可以单独或与其他药剂组合使用在药物组合物中，特别是其他多胺合成或转运抑制剂，但包括其他细胞增殖抑制剂。 类似物不一定被代谢以促成多胺库，并且被设计为通过独立于多胺转运的途径进入细胞。 本发明进一步定义了这些类似物内的结构元件/基序，这些类似物是它们诱导抗酶的关键。

公开(公告)号：EP0938677A1

公开(公告)日：1999-09-01

申请号：EP97913856.0

申请日：1997-11-07

申请人： LUMIGEN, INC.

发明人： AKHAVAN-TAFTI, Hashem ,  SUGIOKA, Katsuaki ,  SUGIOKA, Yumiko ,  REDDY, Lekkala, V.

IPC分类号： G01N33 ,  C07D219 ,  C09B15 ,  C09K11 ,  C12Q1 ,  G01N21

CPC分类号： C07D219/02 ,  C07D219/04 ,  C07D219/06 ,  C09B15/00 ,  C12Q1/28 ,  G01N33/581 ,  G01N33/582

摘要： Methods of detecting analytes or target species using two enzyme-labeled specific binding partners where the two enzymes function in concert to produce a detectable chemiluminescent signal are disclosed. The methods use a specific binding partner labeled with a hydrolytic enzyme to produce a phenolic enhancer in close proximity to a peroxidase-labeled second specific binding partner. The method is useful to detect and quantitate with improved specificity various biological molecules including antigens and antibodies by the technique of immunoassay, proteins by Western blotting, DNA by Southern blotting, RNA by Northern blotting. The method may also be used to detect DNA mutations and juxtaposed gene segments in chromosomal translocations and particularly to unambiguously identify heterozygous genotypes in a single test.