公开(公告)号：EP2021798B1

公开(公告)日：2013-04-24

申请号：EP07762333.8

申请日：2007-05-25

申请人： The Queen's Medical Center

发明人： PENNER, Reinhold ,  FLEIG, Andrea

IPC分类号： G01N33/50 ,  G01N33/68

CPC分类号： G01N33/507 ,  G01N33/6872 ,  G01N2333/62 ,  G01N2333/705 ,  G01N2800/042

公开(公告)号：EP2518084A1

公开(公告)日：2012-10-31

申请号：EP10839612.8

申请日：2010-12-27

申请人： Sekisui Medical Co., Ltd.

发明人： SHIMIZU, Tomo ,  KONDOU, Junichi ,  NAKAMURA, Yasushi ,  YAMAMOTO, Mitsuaki

IPC分类号： C07K16/26 ,  G01N33/53 ,  G01N33/543 ,  G01N33/545 ,  G01N33/577 ,  C12P21/08

CPC分类号： G01N33/74 ,  C07K16/26 ,  C07K2317/33 ,  C07K2317/34 ,  G01N2333/62

摘要： A problem of the present invention is to provide an antibody specific to human insulin and an assay and an assay reagent using the antibody capable of accurately assaying human insulin without being affected by porcine insulin. The present invention provides an assay and an assay reagent capable of specifically assaying human insulin by combining a monoclonal antibody specifically reactive with human insulin and nonreactive with porcine insulin and a different anti-human insulin antibody.

摘要翻译： 本发明的一个问题是提供一种对人胰岛素有特异性的抗体，以及使用能够精确测定人胰岛素而不受猪胰岛素影响的抗体的测定法和测定试剂。 本发明提供能够通过将与胰岛素特异性反应的单克隆抗体与猪胰岛素和不同抗人胰岛素抗体反应的单克隆抗体结合来特异性测定人胰岛素的测定法和测定试剂。

公开(公告)号：EP2419512A1

公开(公告)日：2012-02-22

申请号：EP10764280.3

申请日：2010-04-15

申请人： Kobe University ,  JCR Pharmaceuticals CO., LTD.

发明人： SEINO, Susumu ,  ZHANG, Chang-Liang ,  KATO, Megumi ,  SHIBAZAKI, Tadao

IPC分类号： C12N15/09 ,  C07K14/47 ,  C07K19/00 ,  C12N5/10 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50

CPC分类号： C07K14/4702 ,  G01N33/5308 ,  G01N33/542 ,  G01N2333/62 ,  G01N2500/10

摘要： Disclosed are a novel method of screening for insulin secretion-potentiating agents as well as means for performing such screening. The means include a DNA encoding fluorescent-labeled Epac2 comprising two different DNAs encoding two different fluorescent proteins which emit fluorescent light with wavelength differing from each other and a DNA encoding Epac2 which are fused together in-frame, and the cells transformed with the DNA. Also disclosed is a method of screening insulin secretion-potentiating agents comprising bringing a candidate compound into contact with cells transformed with the said DNA, and detecting whether the compound binds to Epac2.

公开(公告)号：EP2021798A4

公开(公告)日：2010-06-09

申请号：EP07762333

申请日：2007-05-25

申请人： QUEENS MEDICAL CT

发明人： PENNER REINHOLD ,  FLEIG ANDREA

IPC分类号： G01N33/68

CPC分类号： G01N33/507 ,  G01N33/6872 ,  G01N2333/62 ,  G01N2333/705 ,  G01N2800/042

公开(公告)号：EP1198589B9

公开(公告)日：2009-08-12

申请号：EP00911657.5

申请日：2000-01-28

申请人： GILEAD SCIENCES, INC.

发明人： HICKE, Brian ,  WARREN, Stephen ,  PARMA, David ,  GOLD, Larry

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12N15/115 ,  A61K38/00 ,  A61K47/54 ,  A61K47/547 ,  A61K47/549 ,  A61K2123/00 ,  B82Y5/00 ,  C07H19/06 ,  C07H19/10 ,  C07H21/00 ,  C07K14/001 ,  C12N9/1276 ,  C12N15/1048 ,  C12N2310/13 ,  C12N2310/317 ,  C12N2310/3183 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3517 ,  C12N2310/53 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2541/101 ,  C12Q2600/158 ,  C40B40/00 ,  F02B2075/027 ,  G01N33/531 ,  G01N33/532 ,  G01N33/535 ,  G01N33/56988 ,  G01N33/68 ,  G01N33/76 ,  G01N2333/16 ,  G01N2333/163 ,  G01N2333/503 ,  G01N2333/575 ,  G01N2333/62 ,  G01N2333/8125 ,  G01N2333/96433 ,  G01N2333/96455 ,  G01N2333/966 ,  G01N2333/9726 ,  G01N2333/974 ,  G01N2333/976 ,  C12N2310/3521

摘要： Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin-C is expressed.

公开(公告)号：EP2011503A2

公开(公告)日：2009-01-07

申请号：EP08010881.4

申请日：1996-06-04

申请人： Gilead Sciences, Inc.

发明人： Tasset, Diane ,  Pagratis, Nikos ,  Jayasena, Sumedha ,  Gold, Larry

IPC分类号： A61K31/7088 ,  C12N15/11

CPC分类号： C07H19/10 ,  A61K47/547 ,  A61K47/549 ,  B82Y5/00 ,  C07H19/06 ,  C07H21/00 ,  C07K14/001 ,  C07K14/47 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/52 ,  C12N9/1276 ,  C12N15/1048 ,  C12N15/115 ,  C12N2310/13 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/53 ,  C12Q1/37 ,  C12Q1/6804 ,  C12Q1/6811 ,  C12Q1/6876 ,  C12Q1/70 ,  C12Q1/703 ,  C40B40/00 ,  F02B2075/027 ,  G01N33/531 ,  G01N33/532 ,  G01N33/535 ,  G01N33/56988 ,  G01N33/68 ,  G01N33/76 ,  G01N2333/16 ,  G01N2333/163 ,  G01N2333/503 ,  G01N2333/575 ,  G01N2333/62 ,  G01N2333/8125 ,  G01N2333/96433 ,  G01N2333/96436 ,  G01N2333/96455 ,  G01N2333/96486 ,  G01N2333/966 ,  G01N2333/9726 ,  G01N2333/974 ,  G01N2333/976 ,  C12Q2525/101

摘要： Methods for identifying and preparing high affinity nucleic acid ligands to cytokines and the ligands obtained thereby are disclosed.

摘要翻译： 公开了鉴定和制备细胞因子高亲和力核酸配体的方法和由此获得的配体。

公开(公告)号：EP1817050A2

公开(公告)日：2007-08-15

申请号：EP05826021.7

申请日：2005-12-05

申请人： RHODE ISLAND HOSPITAL

发明人： DE LA MONTE, Suzanne, Marie ,  WANDS, Jack, Raymond

IPC分类号： A61K38/30 ,  C12N5/06

CPC分类号： G01N33/74 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2333/62 ,  G01N2500/00 ,  G01N2800/2821

摘要： This invention relates to methods for diagnosing Alzheimer's Disease (AD) by determining the level or function of insulin, insulin-like growth factors, their receptors and/or their downstream signaling molecules. The invention further relates to methods for the treatment of AD by administering an insulin agonist and an insulin-like growth factor agonist. The invention additionally provides an animal model of AD and methods of screening for agents useful in the treatment, amelioration, or prevention of AD.

公开(公告)号：EP1599732B1

公开(公告)日：2007-05-09

申请号：EP04717456.0

申请日：2004-03-04

申请人： Metabolex Inc.

发明人： JOHNSON, Jeffrey, D. ,  ZHOU, Yun-Ping

IPC分类号： G01N33/68 ,  G01N33/74 ,  A61K48/00

CPC分类号： C07K14/705 ,  A61K48/00 ,  G01N33/507 ,  G01N33/5088 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/62

摘要： Expression of beta-TRP is enriched in islet cells. Introduction of expression cassettes encoding beta-TRP into diabetic islet cells improved glucose-stimulated insulin production. Therefore, the invention provides methods of identifying beta-TRP modulators for treating diabetic individuals and introducing beta-TRP into islet cells.

公开(公告)号：EP0782580B1

公开(公告)日：2007-01-10

申请号：EP95934468.0

申请日：1995-09-19

申请人： EC Technology LLC

发明人： EATON, Bruce ,  GOLD, Larry

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12P19/34 ,  C12Q1/68 ,  C12N15/10

CPC分类号： C07H21/00 ,  A61K47/547 ,  A61K47/549 ,  B82Y5/00 ,  C07H19/06 ,  C07H19/10 ,  C07K14/001 ,  C12N9/1276 ,  C12N15/1048 ,  C12N15/115 ,  C12N2310/13 ,  C12N2310/322 ,  C12N2310/53 ,  C12Q1/37 ,  C12Q1/6811 ,  C40B40/00 ,  F02B2075/027 ,  G01N33/531 ,  G01N33/532 ,  G01N33/535 ,  G01N33/56988 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/76 ,  G01N2333/16 ,  G01N2333/163 ,  G01N2333/503 ,  G01N2333/575 ,  G01N2333/62 ,  G01N2333/8125 ,  G01N2333/96433 ,  G01N2333/96436 ,  G01N2333/96455 ,  G01N2333/96486 ,  G01N2333/966 ,  G01N2333/9726 ,  G01N2333/974 ,  G01N2333/976 ,  C12Q2541/101 ,  C12Q2525/101 ,  C12Q2525/205 ,  C12Q2525/113

摘要： This invention discloses a method for coevolving products from two or more reactants, along with the nucleic acid that can facilitate the reaction for making the products. The invention further discloses the products and facilitating nucleic acids produced by said method.

公开(公告)号：EP1695978A1

公开(公告)日：2006-08-30

申请号：EP05027853.0

申请日：1991-06-10

申请人： GILEAD SCIENCES, INC.

发明人： Gold, Larry ,  Tuerk, Craig

IPC分类号： C07H21/00 ,  C12Q1/68 ,  C12P19/34

CPC分类号： C12N15/115 ,  A61K47/547 ,  A61K47/549 ,  B82Y5/00 ,  C07H19/06 ,  C07H19/10 ,  C07H21/00 ,  C07K14/001 ,  C12N9/1276 ,  C12N15/1048 ,  C12N2310/13 ,  C12N2310/322 ,  C12N2310/53 ,  C12Q1/37 ,  C12Q1/6804 ,  C12Q1/6811 ,  C12Q1/70 ,  C40B40/00 ,  F02B2075/027 ,  G01N33/531 ,  G01N33/532 ,  G01N33/535 ,  G01N33/56988 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/76 ,  G01N2333/16 ,  G01N2333/163 ,  G01N2333/503 ,  G01N2333/575 ,  G01N2333/62 ,  G01N2333/8125 ,  G01N2333/96433 ,  G01N2333/96436 ,  G01N2333/96455 ,  G01N2333/96486 ,  G01N2333/966 ,  G01N2333/9726 ,  G01N2333/974 ,  G01N2333/976 ,  C12Q2525/301 ,  C12Q2525/101 ,  C12Q2541/101

摘要： A new class of nucleic acid compounds, referred to as nucleic acid antibodies, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the ligand components of the nucleic acid antibodies are identified by the method of the invention referred to as the Systematic Evolution of Ligands by Exponential Enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.

摘要翻译： 已经显示存在对三维分子靶具有特异性结合亲和力的新类型的核酸化合物（称为核酸抗体）。 在优选的实施方案中，核酸抗体的配体组分通过本发明的方法鉴定，称为通过指数富集（SELEX）的配体的系统演化，其中核酸的候选混合物迭代富集高亲和力核酸 并放大以进一步分配。