公开(公告)号：EP3099782A4

公开(公告)日：2017-06-28

申请号：EP15743916

申请日：2015-01-28

申请人： DSM IP ASSETS BV

发明人： METZ JAMES GEORGE ,  KUNER JERRY M ,  MCCASKILL DAVID GLEN ,  FOSTER MENDY LOUISE

IPC分类号： C12N1/20 ,  A23L33/115 ,  A61K31/202 ,  C07K14/00 ,  C07K14/405 ,  C12N1/28 ,  C12N9/16 ,  C12N9/20 ,  C12N15/79 ,  C12P7/64

CPC分类号： C12N9/20 ,  A23L33/115 ,  A23V2002/00 ,  A61K31/202 ,  C07K14/00 ,  C07K14/405 ,  C12N9/16 ,  C12N15/79 ,  C12P7/6427 ,  C12Y301/01

摘要： Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.

摘要翻译： PUFA合成酶衍生的多不饱和脂肪酸（PUFA）的产生和积累的因素摘要公开了PUFA合酶系统的新型增强因子蛋白，编码其的核酸分子，重组核酸分子和包含此类核酸分子的重组宿主细胞 ，包含其的基因修饰的微生物，以及制备和使用微生物的方法。 还公开了遗传修饰的微生物，其已经被遗传修饰以表达用于生产PUFA的PUFA合酶系统，其中微生物已经被修饰以表达PUFA合酶系统的新增强因子蛋白。

公开(公告)号：EP3102290A1

公开(公告)日：2016-12-14

申请号：EP15750840.9

申请日：2015-02-06

申请人： Massachusetts Institute Of Technology ,  The Governors of the University of Alberta ,  President and Fellows of Harvard College

发明人： KLAPOETKE, Nathan ,  BOYDEN, Edward ,  CHO, Yongku ,  CHOW, Brian Y. ,  WONG, Gane K.S. ,  COHEN, Adam, E. ,  HOCHBAUM, Daniel R.

IPC分类号： A61N5/06 ,  C07K14/405

CPC分类号： C07K14/405 ,  A61B3/0008 ,  A61B3/10 ,  A61K35/30 ,  A61K35/34 ,  A61K36/05 ,  A61K38/00 ,  A61K41/00 ,  A61K41/0057 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0663 ,  G01N33/5023

摘要： The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.

摘要翻译： 本发明在一些方面涉及光激活离子通道多肽和编码核酸，并且还部分涉及包含光活化离子通道多肽的组合物和使用光活化离子通道多肽来改变细胞活性和功能的方法。

公开(公告)号：EP3003388A1

公开(公告)日：2016-04-13

申请号：EP14736527.4

申请日：2014-06-05

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： O'KEEFE, Barry, R. ,  WLODAWER, Alexander ,  MOULAEI, Tinoush

IPC分类号： A61K47/48 ,  A61K38/16 ,  C07K14/405 ,  A61P31/18

CPC分类号： C07K14/405 ,  A61K38/00 ,  A61K47/55 ,  A61K47/59 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  A61K47/643 ,  A61K47/65 ,  C07K2319/00

摘要： The invention provides a construct containing two or more monomeric griffithsin molecules, optionally joined by a linker, as well as conjugate comprising the construct, a nucleic acid encoding the construct or conjugate, vectors, and cells. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.

摘要翻译： 本发明提供了含有两个或多个单体Griffithsin分子的构建体，任选地通过接头连接，以及包含构建体，编码构建体或缀合物的核酸，载体和细胞的缀合物。 还提供了编码多肽或融合蛋白的核酸，以及包含该多肽，融合蛋白或核酸的组合物或细胞。

公开(公告)号：EP2814944A4

公开(公告)日：2016-02-17

申请号：EP13749526

申请日：2013-02-14

申请人： SAPPHIRE ENERGY INC

发明人： YOHN CHRISTOPHER ,  LEE PHILIP

IPC分类号： C12N1/13 ,  C07K14/405 ,  C07K14/415 ,  C12N1/21 ,  C12N9/12 ,  C12N9/14 ,  C12N15/29 ,  C12N15/31 ,  C12N15/52 ,  C12N15/54 ,  C12N15/55 ,  C12N15/82

CPC分类号： C12N15/8242 ,  C07K14/405 ,  C07K14/415 ,  C12N1/12 ,  C12N9/12 ,  C12N9/14 ,  C12N15/8216 ,  C12N15/8261 ,  Y02A40/146

摘要： The present disclosure provides several novel genes that have been shown to increase the biomass yield or biomass of a photosynthetic organism. The disclosure also provides methods of using the novel genes and organisms transformed with the novel genes.

公开(公告)号：EP2895604A1

公开(公告)日：2015-07-22

申请号：EP13773313.5

申请日：2013-09-16

申请人： Aberystwyth University

发明人： PRIVÉ, Florence ,  NEWBOLD, Charles Jamie ,  HUWS, Sharon ,  SCOLLEN, Nigel

IPC分类号： C12N9/20 ,  C12N9/18 ,  C07K16/12 ,  C12P7/64 ,  G01N33/48 ,  G01N33/50 ,  A61K38/46 ,  C12P41/00 ,  C07K14/405

CPC分类号： C12N9/20 ,  A61K38/465 ,  A61K39/3955 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/76 ,  C12N9/18 ,  C12P7/64 ,  C12Y301/01003 ,  Y02E50/13

摘要： A lipase comprising a polypeptide or peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-19 and the polynucleotides encoding the lipases is disclosed. The lipases and nucleic acid sequences encoding these lipases can be used in the preparation of polymers, in formulations which may comprise detergents, as catalysts, in the preparation of bioplastics, as part of diagnostic kits, in the preparation of biofuels and for the prevention and/or treatment of a disease.

公开(公告)号：EP2764017A2

公开(公告)日：2014-08-13

申请号：EP12838474.0

申请日：2012-10-04

申请人： Ben Gurion University of The Negev Research and Development Authority

发明人： GRUNDMAN, Omer ,  KHOZIN-GOLDBERG, Inna ,  HACOHEN, Zvi ,  SHAPIRA, Michal ,  RAVEH, Dina ,  BOUSSIBA, Sammy ,  ZORIN, Boris

IPC分类号： C07K14/405 ,  C12P13/06 ,  C12P13/08 ,  C12N1/13 ,  C12N15/54 ,  C12N15/82 ,  C12N15/63

CPC分类号： C12N9/93 ,  C12N9/0071 ,  C12N9/1022 ,  C12N15/52 ,  C12N15/8251 ,  C12N15/8274 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472 ,  C12Y202/01006

摘要： The present invention provides a protein, specifically Parietochloris incisa acetohydroxyacid synthase, and methods for producing branched-chain amino acid in a cell. The present invention further provides polypeptides and polynucleotides useful for conferring herbicide resistance in a cell or an organism. In particular, the present invention discloses a mutated acetohydroxyacid synthase which is resistant to herbicides.

公开(公告)号：EP2721161A2

公开(公告)日：2014-04-23

申请号：EP12731824.4

申请日：2012-06-15

申请人： Invista Technologies S.à.r.l.

发明人： PEARLMAN, Paul, S. ,  CHEN, Changlin ,  BOTES, Adriana, L.

IPC分类号： C12P7/04 ,  C12P7/42 ,  C12P7/46 ,  C12P13/02 ,  C12P13/00 ,  C12P5/02 ,  C07K14/195 ,  C07K14/37 ,  C07K14/405 ,  C07K14/415 ,  C12N1/32 ,  C12N9/10 ,  C12N9/78 ,  C12N9/88 ,  C12N9/00

CPC分类号： C12P13/005 ,  C07K14/195 ,  C07K14/37 ,  C12N1/32 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1022 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/78 ,  C12N9/88 ,  C12N15/52 ,  C12P5/02 ,  C12P5/026 ,  C12P7/04 ,  C12P7/18 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P13/001 ,  C12P13/02 ,  C12P17/10 ,  C12Y101/01004 ,  C12Y101/01157 ,  C12Y202/01006 ,  C12Y203/01009 ,  C12Y401/01005

摘要： Embodiments of the invention relate to the enzymatic conversion of bioderived feedstocks to commercially valuable chemicals. The enzymatic conversions of the embodiments of the invention offer the potential for lower cost routes to these value-added chemicals. Some of the chemicals that are useful include nylon intermediates such as caprolactam, adipic acid, 1,6-hexamethylene diamine; butanediols such as 1,4-butanediol, 1,3-butanediol, and 2,3-butanediol; butanols such as 1-butanol, and 2-butanol; succinic acid, butadiene, isoprene, and 3-hydroxypropanoic acid.

摘要翻译： 本发明的实施方案涉及将生物活性原料酶催化转化成商业上有价值的化学品。 本发明实施方案的酶促转化提供了对这些增值化学品的较低成本路线的潜力。 一些有用的化学品包括尼龙中间体如己内酰胺，己二酸，1,6-六亚甲基二胺; 丁二醇如1,4-丁二醇，1,3-丁二醇和2,3-丁二醇; 丁醇如1-丁醇和2-丁醇; 琥珀酸，丁二烯，异戊二烯和3-羟基丙酸。

公开(公告)号：EP2465931A4

公开(公告)日：2013-01-09

申请号：EP10808264

申请日：2010-08-10

申请人： UNIV TOHOKU

发明人： TOMITA HIROSHI ,  SUGANO ERIKO

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  A61P27/02 ,  C07K14/405 ,  C07K19/00 ,  C12N5/10

CPC分类号： C07K14/405 ,  A61K38/00 ,  A61K48/005 ,  C07K2319/035 ,  C12N2799/025

公开(公告)号：EP2333071A1

公开(公告)日：2011-06-15

申请号：EP10010708.5

申请日：2000-01-14

申请人： Martek Biosciences Corporation

发明人： Facciotti, Daniel ,  Metz, James George ,  Lassner, Michael

IPC分类号： C12N15/52 ,  C12N15/82 ,  C12N5/10 ,  C12N1/21 ,  C12P7/64 ,  C11C1/00 ,  C07K14/405 ,  C07K14/28 ,  A01H5/00

CPC分类号： C12N15/8247 ,  C07K14/21 ,  C07K14/28 ,  C07K14/405 ,  C12N15/52 ,  C12P7/6427 ,  C12P7/6472

摘要： The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes requires for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain poly-unsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexonoic acid for modification of the fatty acid profile of plants, plants parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plats oils and products.

公开(公告)号：EP2076530A1

公开(公告)日：2009-07-08

申请号：EP07839423.6

申请日：2007-10-10

申请人： Synageva BioPharma Corp. ,  University of Georgia Research Foundation, Inc.

发明人： IVARIE, Robert D. ,  LIU, Guodong ,  RAPP, Jeffrey C. ,  MORRIS, Julie A. ,  HARVEY, Alex J.

IPC分类号： C07K14/405

CPC分类号： C07K14/505

摘要： Erythropoietin obtained from eggs laid by transgenic avians having avian N- linked and O-linked glycosylation patterns.