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21.发明授权
公开(公告)号：EP1059883B1
公开(公告)日：2008-02-06
申请号：EP99911191.7
申请日：1999-03-05
CPC分类号： A61B5/15134 , A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150229 , A61B5/150358 , A61B5/15136 , A61B5/157 , A61B2010/008 , A61B2017/00172 , A61B2562/12 , A61K41/0047
摘要： An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum corneum. In one embodiment, the photosensitizing assembly comprises photosensitizing material combined with a carrier, such as, for example, an adhesive or an ink, and the resulting combination is applied to a substrate, such as, for example, an inert polymeric substrate to form a photosensitizing assembly. In another embodiment, the photosensitizing assembly comprises photosensitizing material incorporated into a film-forming polymeric material.
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公开(公告)号：EP1059882B1
公开(公告)日：2007-10-17
申请号：EP99911184.2
申请日：1999-03-05
CPC分类号： A61B5/15134 , A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150229 , A61B5/150358 , A61B5/15136 , A61B5/157 , A61B2010/008 , A61B2017/00172 , A61B2562/12 , A61K41/0047
摘要： An integrated device (100, 200, 300, 400, 600, 1000) for harvesting a biological fluid from the tissue and analysis of the biological fluid. The device comprises a layer having a porating element disposed thereon to form at least one opening in the tissue. Biological fluid is harvested from the opening of the tissue and placed in contact with a sensor incorporated in the integrated device. The sensor is responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. The porating element may comprise one or more heat conducting elements that are either optically or electrically heated, or one or more mechanical porating elements.
摘要翻译： 一种用于从组织收集生物流体并分析生物流体的集成装置（100,200,300,400,600,1000）。 该装置包括具有设置在其上的临时元件以在组织中形成至少一个开口的层。 从组织的开口收集生物流体并放置成与集成装置中包含的传感器接触。 传感器响应于生物流体以提供生物流体特性的指示，诸如组织间液中分析物的浓度。 该接地元件可以包括一个或多个导热元件，该导热元件可以是光学或电加热的，或者是一个或多个机械定位元件。
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公开(公告)号：EP1689483A2
公开(公告)日：2006-08-16
申请号：EP04795823.6
申请日：2004-10-21
IPC分类号： A61M31/00
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0046 , A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/0412 , A61N1/30 , A61N1/327
摘要： A method for delivering permeant substances transdermally into a membrane of an animal includes forming a least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
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24.发明公开TRANSDERMAL DRUG DELIVERY PATCH SYSTEM, METHOD OF MAKING SAME AND METHOD OF USING SAME 审中-公开透皮药物充电系统补丁，方法用于生产和使用方法的THEREOF
公开(公告)号：EP1483019A2
公开(公告)日：2004-12-08
申请号：EP03744634.1
申请日：2003-03-11
发明人： EPPSTEIN, Jonathan , MCRAE, Stuart , SMITH, Alan
IPC分类号： A61N1/30
CPC分类号： A61M37/0015 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61M2205/33 , A61M2205/3303 , A61M2210/04 , A61M2230/20 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/325 , A61N1/326 , A61N1/327
摘要： The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator (100) comprising: i) an outer body defining a top of the actuator, the outer body containing a cavity; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) a reservoir patach attached to the an extention tub, the reservoir patch being applied to the microporated area of a tissue membrane after poration.
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25.发明公开Method for transdermal delivery of permeant substances 审中-公开Verfahren zur transdermalen Verabreichung von durchdringenden Substanzen
公开(公告)号：EP2314282A2
公开(公告)日：2011-04-27
申请号：EP10185373.7
申请日：2004-10-21
IPC分类号： A61K9/00
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0046 , A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/0412 , A61N1/30 , A61N1/327
摘要： A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
摘要翻译： 一种用于将渗透物输送到生物膜中的系统，其中所述系统包括用于在生物膜的区域中轰击至少一个输送开口的微孔系统和用于将渗透物输送穿过所述区域的贴片，其中所述至少一个输送开口 平均开口深度在约40至约90微米之间。
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26.发明公开Apparatus for microporation of biological membranes using thin film tissue interface devices 审中-公开使用薄膜组织界面装置用于生物膜的微操作的装置
公开(公告)号：EP2168497A3
公开(公告)日：2010-12-01
申请号：EP09015859.3
申请日：2000-06-08
CPC分类号： A61N1/30 , A61B10/0045 , A61B17/205 , A61B2010/008 , A61B2017/00761 , A61K41/0047 , A61M37/0015 , A61M2005/3022 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0053 , A61N1/0424 , A61N1/044 , A61N1/0452 , A61N1/0456 , A61N1/0476 , A61N1/306 , A61N1/327
摘要： The invention provides for improved devices and methods for forming openings in a biological membrane for delivering substances into an animal through the biological membrane for treatment applications, or extracting substances from the animal through the biological membrane for monitoring or other diagnosis applications and for increased transmembrane flux.
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27.发明公开Apparatus for microporation of biological membranes using thin film tissue interface devices 审中-公开使用薄膜组织界面装置用于生物膜的微操作的装置
公开(公告)号：EP2168497A2
公开(公告)日：2010-03-31
申请号：EP09015859.3
申请日：2000-06-08
CPC分类号： A61N1/30 , A61B10/0045 , A61B17/205 , A61B2010/008 , A61B2017/00761 , A61K41/0047 , A61M37/0015 , A61M2005/3022 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0053 , A61N1/0424 , A61N1/044 , A61N1/0452 , A61N1/0456 , A61N1/0476 , A61N1/306 , A61N1/327
摘要： The invention provides for improved devices and methods for forming openings in a biological membrane for delivering substances into an animal through the biological membrane for treatment applications, or extracting substances from the animal through the biological membrane for monitoring or other diagnosis applications and for increased transmembrane flux.
摘要翻译： 本发明提供了改进的装置和用于形成生物膜的开口，用于通过生物膜处理的应用程序从该动物通过用于监视或其它诊断应用的生物膜递送的物质到动物，或提取物质的方法和用于增加跨膜通量 ，
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公开(公告)号：EP2120825A1
公开(公告)日：2009-11-25
申请号：EP08728054.1
申请日：2008-01-22
发明人： MCRAE, Stuart , BOWERMAN, Wendy, E. , BRAUN, Steven, Wilson , SPIEHL, Regina , MESSIER, Bernadette , FARQUHAR, David , KOCH, Erin, Melissa , O'LEARY, Jeremiah, Peter , FISHER, Mark, James , KASCAK, Uros , LANTZ, Loren, J. , NOVAKOVIC, Zoran , EPPSTEIN, Jonathan, A.
IPC分类号： A61F13/02
CPC分类号： A61N1/325 , A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61N1/0412 , A61N1/0428 , A61N1/0476 , A61N1/327
摘要： A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
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29.发明授权CONTROLLED REMOVAL OF BIOLOGICAL MEMBRANE BY PYROTECHNIC CHARGE FOR TRANSMEMBRANE TRANSPORT 有权透皮搬运装置生物膜BY烟火火药受控清除
公开(公告)号：EP1124607B1
公开(公告)日：2008-11-12
申请号：EP99934045.8
申请日：1999-07-14
IPC分类号： A61M37/00
CPC分类号： A61N1/30 , A61B10/0045 , A61B17/205 , A61B2010/008 , A61B2017/00761 , A61K41/0047 , A61M5/2046 , A61M37/00 , A61M2037/0007
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30.发明公开Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport 审中-公开用于通过烟火装药受控去除生物膜的透皮传送装置
公开(公告)号：EP1987854A1
公开(公告)日：2008-11-05
申请号：EP08014701.0
申请日：1999-07-14
IPC分类号： A61M37/00
CPC分类号： A61N1/30 , A61B10/0045 , A61B17/205 , A61B2010/008 , A61B2017/00761 , A61K41/0047 , A61M5/2046 , A61M37/00 , A61M2037/0007
摘要： A device for forming at least one opening in a select area of a biological membrane for transmembrane transport, comprising:
a) a substrate having an upper surface and a lower surface;
b) a pyrotechnic element disposed on either the upper or lower surface of said substrate, the pyrotechnic element having an explosive potential sufficient to form such artificial opening; and
c) a trigger device coupled to said pyrotechnic element, wherein said pyrotechnic element is combined with a permeant and/or an enhancer.摘要翻译： 一种用于形成用于跨膜转运生物膜的选择区域的至少一个开口的装置，包括：a）具有上表面和下表面上的基板; b）关于任一设置在所述基片的上或下表面烟火元件，具有爆炸的潜在危险足以形成寻求人造开口的烟火元件; 和c）耦合到所述烟火元件的触发装置，worin所述烟火元件与透膜物和/或增强剂的组合。
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