公开(公告)号：EP2791164A1

公开(公告)日：2014-10-22

申请号：EP12813390.7

申请日：2012-12-13

申请人： Glykos Finland Oy

发明人： SATOMAA, Tero ,  SAARINEN, Juhani ,  NATUNEN, Jari ,  VILKMAN, Anja ,  VIRTANEN, Heidi ,  HILTUNEN, Jukka

IPC分类号： C07K16/00 ,  A61K39/00

CPC分类号： C07K16/2863 ,  A61K47/48092 ,  A61K47/549 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/244 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/72 ,  C07K2317/732

摘要： The invention relates to a composition comprising a glycoprotein comprising the Fc domain of an antibody, or a fragment thereof, comprising an Asn (asparagine) residue and an oligosaccharide structure attached thereto, wherein said oligosaccharide structure has a structure according to formula I; and wherein at least 20% of the oligosaccharide structures attached to glycoprotein inthe composition consist of oligosaccharide structures according to formula (I).

摘要翻译： 本发明涉及包含包含抗体的Fc结构域或其片段的糖蛋白的组合物，其包含Asn（天冬酰胺）残基和与其连接的寡糖结构，其中所述寡糖结构具有根据式I的结构; 并且其中在组合物中与糖蛋白连接的至少20％的寡糖结构由式（I）的寡糖结构组成。

公开(公告)号：EP2370475A4

公开(公告)日：2014-10-22

申请号：EP09832997

申请日：2009-12-18

申请人： GLYKOS FINLAND OY

发明人： SAARINEN JUHANI ,  NIEMELÄ RITVA ,  HELIN JARI ,  NATUNEN JARI ,  HILTUNEN JUKKA

IPC分类号： C08B37/00 ,  A23K1/06 ,  A23L1/09 ,  A61K31/715 ,  A61K36/064 ,  C12N1/16 ,  C12P19/04

CPC分类号： A23L1/09 ,  A23K20/163 ,  A23L2/52 ,  A23L29/30 ,  A23L33/10 ,  A23L33/14 ,  C08B37/0003 ,  C08B37/0087 ,  C12P19/04

摘要： The present invention is directed to a method of production of an immunostimulatory composition having a saccharide fraction, the method including the steps of hydrolyzes of yeast cells and recovering the soluble fraction. The saccharide fraction having composition thus obtained may be incorporated as a food or beverage component or be used as a pharmaceutical for treatment of specific conditions.

公开(公告)号：EP2566486A1

公开(公告)日：2013-03-13

申请号：EP11723491.4

申请日：2011-05-06

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU ,  Glykos Finland Oy

发明人： NYSTEDT, Johanna ,  ANDERSON, Heidi ,  SATOMAA, Tero ,  NATUNEN, Jari ,  HELIN, Jari ,  SAARINEN, Juhani

IPC分类号： A61K31/728 ,  C07K14/535 ,  A61P7/00 ,  A61K31/198 ,  C08B37/00

CPC分类号： A61K31/198 ,  A61K31/728 ,  A61K38/193 ,  C07K14/535 ,  C08B37/0072 ,  C08L5/08 ,  A61K2300/00

摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention relates also to a use of the combination to alter the relative amounts of blood cells and/or the types of blood cells in a subject. Further, the present invention relates to a use of the combination to mobilize stem cells to the bloodstream of a subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.

公开(公告)号：EP1945676A4

公开(公告)日：2012-06-27

申请号：EP06808024

申请日：2006-11-08

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU ,  GLYKOS FINLAND OY

发明人： LAINE JARMO ,  SATOMAA TERO ,  NATUNEN JARI ,  HEISKANEN ANNAMARI ,  BLOMQVIST MARIA ,  OLONEN ANNE ,  SAARINEN JUHANI ,  JAATINEN TAINA ,  IMPOLA ULLA ,  MIKKOLA MILLA

IPC分类号： C08B37/00 ,  C07H13/04 ,  G01N33/50

CPC分类号： G01N33/66 ,  C07H13/04 ,  C08B37/006 ,  G01N2400/10

公开(公告)号：EP1910838B1

公开(公告)日：2012-04-11

申请号：EP06764481.5

申请日：2006-07-20

申请人： Glykos Finland Oy

发明人： SATOMAA, Tero ,  NATUNEN, Jari ,  HEISKANEN, Annamari ,  OLONEN, Anne ,  SAARINEN, Juhani ,  SALOVUORI, Noora ,  HELIN, Jari

IPC分类号： G01N33/574 ,  A61K31/715

CPC分类号： C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  C12Q1/34 ,  G01N33/574 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2400/38 ,  Y10T436/143333

摘要： The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans. The invention is also directed to the use of said glycans and reagents binding to them for the diagnostics of cancer and malignancies. Furthermore, the invention is directed to the use of said glycans and reagents binding to them for the treatment of cancer and malignancies. Moreover, the present invention comprises efficient methods to differentiate between malignant and benign tumors by analyzing glycan structures.

公开(公告)号：EP2091960A2

公开(公告)日：2009-08-26

申请号：EP07823214.7

申请日：2007-10-26

申请人： Glykos Finland Oy

发明人： NATUNEN, Jari ,  HILTUNEN, Jukka ,  NIEMELÄ, Ritva ,  HELIN, Jari ,  AITIO, Olli

IPC分类号： C07K7/06 ,  C07K14/11 ,  A61K38/08 ,  A61K31/7028 ,  C07H15/00 ,  A61P31/16

CPC分类号： A61K39/145 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/64 ,  C07K5/0815 ,  C07K5/0821 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134 ,  G01N33/56983 ,  G01N2333/11 ,  Y10T436/143333

摘要： The invention relates to the method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus. The invention also provides peptide epitopes 5 for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza.

公开(公告)号：EP1531832A1

公开(公告)日：2005-05-25

申请号：EP03761605.9

申请日：2003-06-30

申请人： Glykos Finland Oy

发明人： ANGSTRÖM, Jonas ,  TENEBERG, Susann ,  SAARINEN, Juhani ,  SATOMAA, Tero ,  ROCHE, Niamh ,  NATUNEN, Jari ,  MILLER-PODRAZA, Halina ,  KARLSSON, Karl-Anders ,  ABUL-MILH, Maan

IPC分类号： A61K31/702 ,  A61P1/04 ,  A61P1/12

CPC分类号： G01N33/56922 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/702 ,  A61K45/06 ,  A61K47/61 ,  G01N33/566 ,  G01N33/56905 ,  G01N33/56911 ,  G01N33/56916 ,  Y02A50/473 ,  Y02A50/475 ,  A61K2300/00 ,  A23V2250/28 ,  A23V2200/32

摘要： The invention provides a therapeutical composition comprising purified fractions of compounds being or containing a pathogen-inhibiting oligosaccharide sequence for use as a medicament. The present invention especially describes an oligosaccharide-containing substance or receptor binding to diarrheagenic Escherichia coli and/or zoonotic Helicobacter species, and use thereof in, e.g., pharmaceutical, nutritional and other compositions for prophylaxis and treatment of conditions due to the presence of Escherichia coli and/or zoonotic Helicobacter species. The invention is also directed to the use of the receptors for diagnostics of Escherichia coli and/or zoonotic Helicobacter species.

公开(公告)号：EP3682904A1

公开(公告)日：2020-07-22

申请号：EP20156566.0

申请日：2015-06-26

申请人： Glykos Finland Oy

发明人： Helin, Jari ,  Saarinen, Juhani ,  Satomaa, Tero ,  Ekholm, Filip S.

IPC分类号： A61K47/68 ,  A61K47/54 ,  A61P35/00 ,  A61P35/02

摘要： A molecule comprising a saccharide bound via an O-glycosidic bond to a hydroxyl group of a toxic payload molecule is disclosed. An antibody-drug conjugate comprising an antibody covalently bound to a toxic payload molecule, optionally via a linker group, and a saccharide bound via an O-glycosidic bond to a hydroxyl group of the toxic payload molecule is further disclosed.

公开(公告)号：EP3160513B1

公开(公告)日：2020-02-12

申请号：EP15742047.2

申请日：2015-06-26

申请人： Glykos Finland Oy

发明人： HELIN, Jari ,  SAARINEN, Juhani ,  SATOMAA, Tero ,  EKHOLM, Filip S.

IPC分类号： A61K47/68 ,  A61K47/54 ,  A61P35/00 ,  A61P35/02

公开(公告)号：EP3019621B1

公开(公告)日：2018-11-28

申请号：EP14738496.0

申请日：2014-07-10

申请人： Glykos Finland Oy

发明人： NATUNEN, Jari ,  LANDOWSKI, Christopher ,  SALOHEIMO, Markku ,  OSTERMEIER, Christian ,  SOMMER, Benjamin Patrick ,  WAHL, Ramon

IPC分类号： C12P21/00 ,  C12N9/10 ,  C07K16/00 ,  C12N15/80

CPC分类号： C12P21/005 ,  C07K16/00 ,  C12N9/1051 ,  C12N9/1081 ,  C12N15/80 ,  C12Y204/01

摘要： The present disclosure relates to compositions and methods useful for the production of heterologous proteins with increased N-glycosylation site occupancy in filamentous fungal cells, such as Trichoderma cells. More specifically, the invention provides a filamentous fungal cell comprising i. one or more mutation that reduces or eliminates one or more endogenous protease activity compared to a parental filamentous fungal cell which does not have said mutation(s), ii. a polynucleotide encoding a heterologous catalytic subunit of oligosaccharyl transferase, and iii. a polynucleotide encoding a heterologous glycoprotein, wherein said catalytic subunit of oligosaccharyl transferase is selected from Leishmania oligosaccharyl transferase catalytic subunits.