公开(公告)号：EP3380876A1

公开(公告)日：2018-10-03

申请号：EP16869282.0

申请日：2016-11-23

申请人： President and Fellows of Harvard College

发明人： DEVLIN, Robert C. ,  KHORASANINEJAD, Mohammadreza ,  CAPASSO, Federico ,  PARK, Hongkun ,  HIGH, Alexander Arthur

IPC分类号： G02B1/00 ,  G02B27/42 ,  G03F1/50 ,  H01L31/02

CPC分类号： G02B13/14 ,  G02B1/002 ,  G02B1/005 ,  G02B1/02 ,  G03F7/0005 ,  G03F7/40 ,  H01L31/02

摘要： A method of fabricating a visible spectrum optical component includes: providing a substrate; forming a resist layer over a surface of the substrate; patterning the resist layer to form a patterned resist layer defining openings exposing portions of the surface of the substrate; performing deposition to form a dielectric film over the patterned resist layer and over the exposed portions of the surface of the substrate, wherein a top surface of the dielectric film is above a top surface of the patterned resist layer; removing a top portion of the dielectric film to expose the top surface of the patterned resist layer and top surfaces of dielectric units within the openings of the patterned resist layer; and removing the patterned resist layer to retain the dielectric units over the substrate.

公开(公告)号：EP3250936A2

公开(公告)日：2017-12-06

申请号：EP16800421.6

申请日：2016-01-29

申请人： President and Fellows of Harvard College

发明人： KOLKOWITZ, Shimon, Jacob ,  SAFIRA, Arthur ,  HIGH, Alexander, A. ,  DEVLIN, Robert, C. ,  CHOI, Soonwon ,  UNTERREITHMEIER, Quirin, P. ,  PATTERSON, David ,  ZIBROV, Alexander, S. ,  MANUCHARYAN, Vladimir, E. ,  LUKIN, Mikhail, D. ,  PARK, Hongkun

IPC分类号： G01R33/60

摘要： A method of making measurements includes providing a sensor with at least one solid state electronic spin; irradiating the sensor with radiation from an electromagnetic radiation source that manipulates the solid state electronic spins to produce spin-dependent fluorescence, wherein the spin-dependent fluorescence decays as a function of relaxation time; providing a target material in the proximity of the sensor, wherein, thermally induced currents (Johnson noise) present in the target material alters the fluorescence decay of the solid state electronic spins as a function of relaxation time; and determining a difference in the solid state spins spin-dependent fluorescence decay in the presence and absence of the target material and correlating the difference with a property of the sensor and/or target material.

公开(公告)号：EP3110971A2

公开(公告)日：2017-01-04

申请号：EP15709048.1

申请日：2015-02-26

申请人： The Broad Institute Inc. ,  The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College ,  Massachusetts Institute of Technology

发明人： KUCHROO, Vijay ,  REGEV, Aviv ,  GAUBLOMME, Jellert ,  LEE, Youjin ,  SHALEK, Alexander, K. ,  WANG, Chao ,  YOSEF, Nir ,  PARK, Hongkun

IPC分类号： C12Q1/68

CPC分类号： G01N33/6863 ,  C07K16/2866 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/75 ,  C07K2317/76 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.

摘要翻译： 本发明一般涉及用于鉴定调节，控制或以其它方式影响T细胞平衡的调节网络的组合物和方法，例如Th17细胞分化，维持和/或功能，以及用于利用调节网络的组合物和方法， 控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡。 本发明还涉及鉴定和利用调节，控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡的靶基因和/或靶基因产物。

公开(公告)号：EP2981795A1

公开(公告)日：2016-02-10

申请号：EP14778267.6

申请日：2014-04-01

申请人： President and Fellows of Harvard College

发明人： MAURER, Peter Christian ,  NOH, Hyun Ji ,  KUCSKO, Georg ,  LUKIN, Mikhail D. ,  PARK, Hongkun ,  KUBO, Minako

IPC分类号： G01K7/32

CPC分类号： G01K7/32 ,  G01K11/20 ,  G01K13/00 ,  G01K2211/00

摘要： An approach to nanoscale thermometry that utilizes coherent manipulation of the electronic spin associated with nitrogen-vacancy (NV) color centers in diamond is disclosed. The methods and apparatus allow for detection of temperature variations down to milli-Kelvin resolution, at nanometer length scales. This biologically compatible approach to thermometry offers superior temperature sensitivity and reproducibility with a reduced measurement time. The disclosed apparatus can be used to study heat-generating intracellular processes.

摘要翻译： 公开了采用与金刚石中氮空位（NV）颜色中心相关联的电子自旋相干操作的纳米级测温方法。 所述方法和装置允许以纳米级的尺度检测温度变化至毫开尔文分辨率。 这种生物相容的温度测量方法提供了出色的温度灵敏度和重复性，同时减少了测量时间。 所公开的装置可用于研究发热细胞内过程。

公开(公告)号：EP2971116A1

公开(公告)日：2016-01-20

申请号：EP14762551.1

申请日：2014-03-17

申请人： The Broad Institute, Inc. ,  President and Fellows of Harvard College ,  Massachusetts Institute of Technology

发明人： REGEV, Aviv ,  SHALEK, Alexander, K. ,  SATIJA, Rahul ,  PARK, Hongkun

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12Q1/02 ,  A61K39/395

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5047 ,  G01N33/6893 ,  G01N2800/24

摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences dendritic cell (DC) response(s), for example, dendritic cell maturation, dendritic cell antiviral response(s) and/or dendritic cell inflammatory response(s), as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences dendritic cell response(s) in a variety of therapeutic and/or diagnostic indications.

公开(公告)号：EP2961849A2

公开(公告)日：2016-01-06

申请号：EP14715725.9

申请日：2014-02-27

申请人： The Broad Institute, Inc. ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： REGEV, Aviv ,  KUCHROO, Vijay ,  PARK, Hongkun ,  YOSEF, Nir ,  SHALEK, Alexander, K. ,  GAUBLOMME, Jellert ,  JOLLER, Nicole C. ,  WU, Chuan ,  ANDERSON, Ana, Carrizosa

IPC分类号： C12Q1/68 ,  A61K39/39 ,  C12N5/0783

CPC分类号： C12N5/0636 ,  A61K31/12 ,  A61K31/198 ,  A61K31/37 ,  A61K31/4745 ,  A61K31/66 ,  A61K31/661 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/739 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K38/1767 ,  A61K38/1866 ,  A61K38/191 ,  A61K38/363 ,  A61K38/4866 ,  A61K48/00 ,  C07K16/28 ,  C07K2317/76 ,  C12N5/0637 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2501/15 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/2323 ,  C12N2501/25 ,  C12N2501/90 ,  C12Q1/6881 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y304/21069 ,  G01N33/56972 ,  G01N2570/00 ,  G01N2800/56

摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.

公开(公告)号：EP2621584A2

公开(公告)日：2013-08-07

申请号：EP11770258.9

申请日：2011-09-28

申请人： President and Fellows of Harvard College

发明人： PARK, Hongkun ,  ROBINSON, Jacob ,  SUTTON, Amy ,  JORGOLLI, Marsela ,  SHALEK, Alexander Kann

IPC分类号： A61N1/32

CPC分类号： G01N27/26 ,  A61B5/6877 ,  A61B2562/0285 ,  A61B2562/046 ,  A61B2562/125 ,  B82Y5/00 ,  B82Y15/00 ,  C12N13/00 ,  G01N33/48728

摘要： A molecular delivery device including a plurality of nanowires (e.g., Si NWs) coated with an electrically conductive layer. Also disclosed are methods for delivering a molecule by nanowire-mediated electroporation.

公开(公告)号：EP2621582A2

公开(公告)日：2013-08-07

申请号：EP11770260.5

申请日：2011-09-28

申请人： President and Fellows of Harvard College

发明人： PARK, Hongkun ,  ROBINSON, Jacob ,  SUTTON, Amy ,  JORGOLLI, Marsela ,  SHALEK, Alexander Kann

IPC分类号： A61N1/04

CPC分类号： G01N27/26 ,  A61B5/6877 ,  A61B2562/0285 ,  A61B2562/046 ,  A61B2562/125 ,  B82Y5/00 ,  B82Y15/00 ,  C12N13/00 ,  G01N33/48728

摘要： A molecular delivery device including a plurality of nanowires (e.g., Si NWs) coated with an electrically conductive layer. Also disclosed are methods for delivering a molecule by nanowire-mediated electroporation.

公开(公告)号：EP1436841A1

公开(公告)日：2004-07-14

申请号：EP02759070.2

申请日：2002-05-20

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  University of Southampton

发明人： LIEBER, Charles, M. ,  DUAN, Xiangfeng ,  CUI, Yi ,  HUANG, Yu ,  GUDIKSEN, Mark S. ,  LAUHON, Lincoln J. ,  WANG, Jiangfang ,  PARK, Hongkun ,  WEI, Quingqiau ,  LIANG, Wenjie ,  SMITH, David C.,Uni. of Southampton ,  WANG, Deli ,  ZHONG, Zhaohui

IPC分类号： H01L29/06

CPC分类号： H01L29/0665 ,  B82Y10/00 ,  B82Y15/00 ,  C30B11/00 ,  C30B25/005 ,  C30B29/605 ,  G01N27/4146 ,  G01N33/54373 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/025 ,  G11C13/04 ,  G11C2213/77 ,  G11C2213/81 ,  H01L23/53276 ,  H01L29/0673 ,  H01L29/068 ,  H01L29/1606 ,  H01L29/207 ,  H01L29/267 ,  H01L33/06 ,  H01L51/0048 ,  H01L2924/0002 ,  H01L2924/12044 ,  H01L2924/3011 ,  Y02E10/549 ,  H01L2924/00

摘要： Published without an