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21.发明公开FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY 审中-公开稠合三环IMIDAZOLENDERIVATE AS TNF活性的调节
公开(公告)号：EP3080114A1
公开(公告)日：2016-10-19
申请号：EP14808659.8
申请日：2014-12-08
申请人： UCB Biopharma SPRL
发明人： ALEXANDER, Rikki Peter , BROWN, Julien Alistair , DELIGNY, Michael , HEER, Jag Paul , JACKSON, Victoria Elizabeth , JADOT, Sophie , KROEPLIEN, Boris , MAC COSS, Malcolm , SABNIS, Yogesh Anil , SWINNEN, Dominique Louis Léon , VAN HOUTVIN, Nathalie , ZHU, Zhaoning
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , C07D471/14 , C07D491/14
CPC分类号： C07D491/147 , C07D471/04 , C07D471/14 , C07D491/14
摘要： A series of substituted fused tricyclic imidazole derivatives, in particular dihydro-1H-pyrano[4′,3′:4,5]imidazo[1,2-a]pyridine, 1,2,3,4-tetrahydroimidazo[1,2-a:5,4-c′]dipyridine, dihydro-1H-pyrano[3′,4′:4,5]imidazo[1,2-a]pyridine and tetrahydro-6H-cyclohepta[4,5]imidazo[1,2-a]pyridine, and analogs thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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22.发明公开
公开(公告)号：EP3080085A1
公开(公告)日：2016-10-19
申请号：EP14811828.4
申请日：2014-12-08
申请人： UCB Biopharma SPRL
发明人： ALEXANDER, Rikki Peter , FOULKES, Gregory , HUTCHINGS, Martin Clive , JACKSON, Victoria Elizabeth , KROEPLIEN, Boris , REUBERSON, James Thomas , ROOK, Sarah Margaret , ZHU, Zhaoning
IPC分类号： C07D215/06 , C07D237/28 , C07D237/32 , C07D239/74 , C07D241/44 , A61K31/47 , A61K31/502 , A61K31/517
CPC分类号： C07D239/74 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/502 , A61K31/506 , A61K31/517 , A61K45/06 , C07D215/06 , C07D215/14 , C07D217/16 , C07D237/28 , C07D237/32 , C07D241/42 , C07D241/44 , C07D403/04 , A61K2300/00
摘要： A series of substituted heteroaromatic compounds containing two fused six-membered rings, tivity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：EP3080114B1
公开(公告)日：2019-10-02
申请号：EP14808659.8
申请日：2014-12-08
申请人： UCB Biopharma SPRL
发明人： ALEXANDER, Rikki Peter , BROWN, Julien Alistair , DELIGNY, Michael , HEER, Jag Paul , JACKSON, Victoria Elizabeth , JADOT, Sophie , KROEPLIEN, Boris , MAC COSS, Malcolm , SABNIS, Yogesh Anil , SWINNEN, Dominique Louis Léon , VAN HOUTVIN, Nathalie , ZHU, Zhaoning
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , C07D471/14 , C07D491/14
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公开(公告)号：EP3080091B1
公开(公告)日：2019-08-21
申请号：EP14808650.7
申请日：2014-12-08
申请人： UCB Biopharma SPRL
发明人： HEER, Jag Paul , JACKSON, Victoria Elizabeth , KROEPLIEN, Boris , LECOMTE, Fabien Claude , PORTER, John Robert
IPC分类号： C07D235/12 , A61K31/4184 , A61P29/00
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公开(公告)号：EP3080116B1
公开(公告)日：2019-05-08
申请号：EP14809834.6
申请日：2014-12-08
申请人： UCB Biopharma SPRL
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00
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公开(公告)号：EP2872508B1
公开(公告)日：2018-08-29
申请号：EP13739376.5
申请日：2013-07-05
申请人： UCB Biopharma SPRL
发明人： BENTLEY, Jonathan Mark , BROOKINGS, Daniel Christopher , BROWN, Julien Alistair , CAIN, Thomas Paul , CHOVATIA, Praful Tulshi , FOLEY, Anne Marie , GALLIMORE, Ellen Olivia , GLEAVE, Laura Jane , HEIFETZ, Alexander , HORSLEY, Helen Tracey , HUTCHINGS, Martin Clive , JACKSON, Victoria Elizabeth , JOHNSON, James Andrew , JOHNSTONE, Craig , KROEPLIEN, Boris , LECOMTE, Fabien Claude , LEIGH, Deborah , LOWE, Martin Alexander , MADDEN, James , PORTER, John Robert , QUINCEY, Joanna Rachel , REED, Laura Claire , REUBERSON, James Thomas , RICHARDSON, Anthony John , RICHARDSON, Sarah Emily , SELBY, Matthew Duncan , SHAW, Michael Alan , ZHU, Zhaoning
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K31/554 , C07D491/107 , C07D519/00
摘要： A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：EP3303298A1
公开(公告)日：2018-04-11
申请号：EP16727502.3
申请日：2016-06-07
申请人： UCB Biopharma SPRL
发明人： CHOVATIA, Prafulkumar Tulshibhai , HUTCHINGS, Martin Clive , KROEPLIEN, Boris , REUBERSON, James Thomas
IPC分类号： C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14 , A61K31/506 , A61K31/538 , A61K31/416 , A61P39/00 , A61P25/00 , A61P35/00 , A61P9/00 , A61P3/00 , A61P27/02
CPC分类号： C07D231/56 , A61K31/416 , A61K31/506 , C07D403/04 , C07D403/14 , C07D413/14
摘要： A series of substituted indazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：EP3080126A1
公开(公告)日：2016-10-19
申请号：EP14809008.7
申请日：2014-12-08
申请人： UCB Biopharma SPRL
IPC分类号： C07D473/32 , A61K31/52 , A61P29/00
CPC分类号： C07D473/00 , A61K31/5377 , C07D473/32
摘要： A series of substituted purine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：EP3080123A1
公开(公告)日：2016-10-19
申请号：EP14825109.3
申请日：2014-12-08
申请人： UCB Biopharma SPRL
发明人： DELIGNY, Michaël Louis Robert , HEER, Jag Paul , JACKSON, Victoria Elizabeth , KROEPLIEN, Boris , LECOMTE, Fabien Claude , PORTER, John Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506
摘要： A series of substituted 3H imidazo[4,5-b]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 式（I）的一系列取代的3H咪唑并[4,5-b]吡啶衍生物是人TNFα活性的有效调节剂，因此在治疗和/或预防各种人类疾病中是有益的，所述疾病包括自身免疫疾病和炎性疾病 ; 神经和神经退行性疾病; 疼痛和伤害性疼痛; 心血管疾病; 代谢紊乱; 眼病; 和肿瘤疾病。
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公开(公告)号：EP3080113A1
公开(公告)日：2016-10-19
申请号：EP14808658.0
申请日：2014-12-08
申请人： UCB Biopharma SPRL
发明人： ALEXANDER, Rikki Peter , BRACE, Gareth Neil , BROWN, Julien Alistair , CALMIANO, Mark Daniel , CHOVATIA, Praful Tulshi , DELIGNY, Michael , GALLIMORE, Ellen Olivia , HEER, Jag, Paul , JACKSON, Victoria Elizabeth , KROEPLIEN, Boris , MAC COSS, Malcolm , QUINCEY, Joanna, Rachel , SABNIS, Yogesh, Anil , SWINNEN, Dominique, Louis, Léon , ZHU, Zhaoning , WEHNER, Volkmar , HEINELT, Uwe
IPC分类号： C07D471/04 , A61K31/437 , C07D519/00
摘要： A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 因此，一系列稠合的三环咪唑衍生物，特别是二氢-1H-环戊[4,5]咪唑并[1,2-a]吡啶衍生物及其类似物是人TNFα活性的有效调节剂， 和/或预防各种人类疾病，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疼痛; 心血管疾病; 代谢紊乱; 眼病; 和肿瘤疾病。
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