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    VECTOR WITH MODIFIED PROTEASE-DEPENDENT TROPISM
    22.
    发明公开
    VECTOR WITH MODIFIED PROTEASE-DEPENDENT TROPISM 有权
    US EN EN EN EN EN US US US US US US US US US US US US US US

    公开(公告)号：EP1505154A1

    公开(公告)日：2005-02-09

    申请号：EP03728016.1

    申请日：2003-04-30

    申请人： Dnavec Research Inc.

    发明人： Kinoh, Hiroaki ,  Inoue, Makoto ,  Ueda, Yasuji ,  Iida, Akihiro ,  Hasagawa, Mamoru ,  Kobayashi, Masanori

    IPC分类号： C12N15/45 ,  C07K14/115 ,  A61K48/00 ,  A61K35/76 ,  A61K45/00 ,  A61P35/00

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/50 ,  C12N15/86 ,  C12N2760/18022 ,  C12N2760/18822 ,  C12N2760/18843 ,  C12N2800/30

    摘要： The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo .

    摘要翻译： 本发明提供具有复制能力的细胞融合载体，其蛋白酶依赖性向性已被修饰。 产生编码修饰的F蛋白的M基因缺陷型病毒载体，其中修复了由不同蛋白酶切割的副粘病毒的F蛋白的切割位点。 在用这些载体转染的细胞中，载体中存在的基因组RNA被复制，并且细胞融合感染根据其它蛋白酶的存在扩散到相邻细胞; 然而，没有病毒颗粒被释放。 编码由活性在癌症中增强的蛋白酶切割的F蛋白的本发明的载体在体内显示出癌症生长抑制作用。

    POLYPEPTIDES AND THEIR USE IN TREATING METAPNEUMOVIRUS (MPV) INFECTION
    30.
    发明公开
    POLYPEPTIDES AND THEIR USE IN TREATING METAPNEUMOVIRUS (MPV) INFECTION 审中-公开
    多肽及其用于治疗金属髓核病毒（MPV）感染的用途

    公开(公告)号：EP2833901A1

    公开(公告)日：2015-02-11

    申请号：EP13772650.1

    申请日：2013-04-04

    申请人： The Scripps Research Institute

    发明人： SCHIEF, William, R.

    IPC分类号： A61K38/08

    CPC分类号： A61K39/385 ,  A61K38/00 ,  A61K2039/6068 ,  A61K2039/64 ,  C07K14/00 ,  C07K14/005 ,  C07K2319/35 ,  C12N7/00 ,  C12N2760/18022 ,  C12N2760/18023 ,  C12N2760/18034 ,  G01N33/6854

    摘要： Polypeptides and compositions thereof are provided for treating or limiting metapneumovinjs (MPV) infection, as well as methods for designing such polypeptides. In further aspects, methods of using said isolated polypeptides, VLPs or pharmaceutical compositions are provided, which include methods for treating a metapneumovirus (MPV) infection, methods for limiting development of an MPV infection, methods for generating an immune response in a subject, methods for monitoring an MPV-induced disease in a subject and/or monitoring response of the subject to immunization by an MPV vaccine, methods for detecting MPV binding antibodies, methods for producing MPV antibodies, and methods of preventing an MPV infection.

    摘要翻译： 提供用于治疗或限制偏肺病毒（MPV）感染的多肽及其组合物，以及用于设计此类多肽的方法。 在进一步的方面，提供了使用所述分离的多肽，VLP或药物组合物的方法，其包括治疗偏肺病毒（MPV）感染的方法，限制MPV感染发展的方法，用于在受试者中产生免疫应答的方法，方法 用于监测受试者中MPV诱导的疾病和/或监测受试者对MPV疫苗免疫接种的反应，检测MPV结合抗体的方法，产生MPV抗体的方法以及预防MPV感染的方法。