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126 条记录 (耗时 0.024 秒)

    ANTIBIOTIC TKR2999, PROCESS FOR THE PREPARATION THEREOF AND MICROBE
    32.
    发明授权
    ANTIBIOTIC TKR2999, PROCESS FOR THE PREPARATION THEREOF AND MICROBE 有权
    抗生素TKR2999，工艺生产同样和生殖

    公开(公告)号：EP1044983B1

    公开(公告)日：2007-02-14

    申请号：EP98963649.3

    申请日：1998-12-22

    申请人： TAKARA BIO INC.

    发明人： TAKESAKO, Kazutoh ,  AWAZU, Naoyuki ,  UENO, Mitsuhiro ,  ONISHI, Yoshimi ,  KATO, Ikunoshin

    IPC分类号： C07G11/00 ,  C12P1/02 ,  C12N1/14 ,  C07K4/06

    CPC分类号： C12R1/645 ,  A61K38/00 ,  C07K4/06 ,  C12P21/02

    摘要： Antibiotic TKR2999 having the following physicochemical properties: (1) the m/z value ([M+H] ) is 971 as determined by FAB mass spectrometry, (2) the molecular formula is C44H78N10O14 and the m/z value ([M+H] ) is 971.5776 as determined by high-resolution FAB mass spectrometry, (3) the ultraviolet absorption spectrum (as determined in methanol) has a terminal absorption, (4) the main absorption wavenumbers (cm ) of infrared absorption spectrum (as determined by the KBr method) are 3320, 2920, 1680, 1540, 1210, 1140, 840, 800 and 720, (5) aspartic acid, threonine, serine, glycine, alanine, beta -alanine and ornithine are detected in the amino acid analysis based on the ninhydrin reaction, and (6) it is soluble in methanol but difficultly soluble in hexane, chloroform and water; or pharmacologically acceptable salts thereof. These novel substances are useful as remedies for mycosis.

    DNA POLYMERASE-RELATED FACTORS
    34.
    发明授权
    DNA POLYMERASE-RELATED FACTORS 失效
    DNA聚合酶相关因素

    公开(公告)号：EP0997530B1

    公开(公告)日：2006-08-23

    申请号：EP98929687.6

    申请日：1998-06-24

    申请人： TAKARA BIO INC.

    发明人： UEMORI, Takashi ,  SATO, Yoshimi ,  FUJITA, Tomoko ,  MIYAKE, Kazue ,  MUKAI, Hiroyuki ,  ASADA, Kiyozo ,  KATO, Ikunoshin

    IPC分类号： C12N15/54 ,  C12N9/12 ,  C07K14/195 ,  C12Q1/68

    CPC分类号： C12N9/1252

    摘要： A thermostable DNA polymerase-related factor promoting the DNA synthesizing activities of DNA polymerases; a thermostable DNA polymerase-related factor having the activity of binding to DNA polymerases and a process for producing the same; genes encoding the above DNA polymerase-related factors; a method for synthesizing DNAs wherein DNA polymerases are used in the presence of the above DNA polymerase-related factors; and kits containing the above DNA polymerase-related factors. Use of these DNA polymerase-related factors makes it possible to provide DNA synthesis systems and DNA amplification systems in vitro which are superior to the conventional ones.

    PLASMID
    37.
    发明授权
    PLASMID 失效
    质粒

    公开(公告)号：EP0859057B1

    公开(公告)日：2005-06-15

    申请号：EP97905474.9

    申请日：1997-03-10

    申请人： TAKARA BIO INC.

    发明人： SAGAWA, Hiroaki ,  UENO, Harumi ,  OSHIMA, Atsushi ,  KATO, Ikunoshin

    IPC分类号： C12N15/67

    CPC分类号： C12N15/69 ,  C12N9/1007 ,  C12N9/22

    摘要： A plasmid vector characterized by having a promoter sequence that can be recognized by an RNA polymerase which is not inherent in a host and that controls the expression of target genes and a replication origin that increases the number of copies under the induction by foreign factors; methods of expression and isolation of target genes by using the vector; a polypeptide having the activity of an AccIII restriction enzyme; and a DNA encoding the polypeptide. The invention provides for the first time a plasmid vecto r which can introduce a foreign target gene encoding proteins which are fatal or noxious to hosts into said hosts, a method of efficiently expressing the proteins by using the vector, and also a method of permitting a restriction enzyme gene constituting a restriction-modification system to be isolated even in the absence of a modification enzyme gene, which has been difficult according to prior art.

    METHOD OF LABELING NUCLEIC ACIDS
    39.
    发明公开
    METHOD OF LABELING NUCLEIC ACIDS 审中-公开
    VERFAHREN ZUR MARKIERUNG VONNUKLEINSÄUREN

    公开(公告)号：EP1447446A1

    公开(公告)日：2004-08-18

    申请号：EP02788584.7

    申请日：2002-10-22

    申请人： TAKARA BIO INC.

    发明人： YOSHIZAKI, Miwa ,  YOSHIKAWA, Yoshie ,  MINENO, Junichi ,  MUKAI, Hiroyuki ,  ASADA, Kiyozo ,  KATO, Ikunoshin

    IPC分类号： C12N15/09 ,  C12Q1/68

    CPC分类号： C12Q1/6806 ,  C12Q2563/107

    摘要： The present invention relates to a method for labeling a nucleic acid characterized in that a ratio of signal intensities of each of labels of the labeled nucleic acids prepared from the same nucleic acid used as a template is substantially the same, irrelevant to the kinds of nucleic acids used as the template, a labeled nucleic acid prepared by the method, and a kit used for the method.

    摘要翻译： 本发明涉及一种用于标记核酸的方法，其特征在于，用作模板的相同核酸制备的标记核酸的每个标记的信号强度的比例基本上相同，与核酸的种类无关 用作模板的酸，通过该方法制备的标记核酸，以及用于该方法的试剂盒。

    REMEDIES
    40.
    发明公开
    REMEDIES 审中-公开
    补救措施

    公开(公告)号：EP1415658A1

    公开(公告)日：2004-05-06

    申请号：EP02746077.3

    申请日：2002-07-16

    申请人： TAKARA BIO INC.

    发明人： OHNOGI, Hiromu ,  SUGIYAMA, Katsumi ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： A61K35/84 ,  A61P25/28 ,  A61P25/00 ,  A61P43/00 ,  A23L1/30 ,  A23L2/38 ,  A23K1/18

    CPC分类号： A61K36/07 ,  A23K10/30 ,  A23K20/10 ,  A23L7/00 ,  A23L21/00 ,  A23L31/00 ,  A23L33/125 ,  A23V2002/00 ,  A23V2250/208

    摘要： According to the present invention, there is provided a therapeutic agent or prophylactic agent that is effective for a disease requiring enhancement of nerve growth factor production for treatment or prevention, comprising as an effective ingredient an aqueous extract of mushrooms. These agents are usable in the treatment or prevention of a disease requiring enhancement of nerve growth factor production such as dementia or nerve disorder.
    In addition, according to the present invention, there is provided an enhancing agent for growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising the above-mentioned effective ingredient. According to the food or beverage, by taking as a foodstuff on a daily basis, the symptoms of a disease requiring enhancement of nerve growth factor production can be ameliorated or the like. In addition, the feed is useful for maintaining homeostasis of a living body by its enhancing action for nerve growth factor production.

    摘要翻译： 根据本发明，提供了一种治疗剂或预防剂，其对于需要增强神经生长因子产生以用于治疗或预防的疾病是有效的，所述治疗剂或预防剂包含蘑菇水提取物作为有效成分。 这些药剂可用于治疗或预防需要增强神经生长因子产生的疾病，如痴呆或神经紊乱。 此外，根据本发明，提供了一种生长因子产生增强剂或用于促进神经生长因子产生的食物，饮料或饲料，其各自包含上述有效成分。 根据食品或饮料，通过每日服用作为食品，可以改善需要增强神经生长因子产生的疾病的症状等。 此外，饲料通过其对神经生长因子产生的增强作用而用于维持活体的体内平衡。