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31.发明公开GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS 有权GAMBOGISCHE ACID，模拟和衍生物CASPASENAKTIVATOREN和凋亡的归纳
公开(公告)号：EP1180991A4
公开(公告)日：2005-10-12
申请号：EP00905839
申请日：2000-02-01
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , ZHANG HAN-ZHONG , WANG YAN , TSENG BEN , KASIBHATLA SHAILAJA , DREWE JOHN A
IPC分类号： A61K31/352 , A61K31/4025 , A61K31/4178 , A61K31/4188 , A61K31/4433 , A61K31/453 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/5513 , C07D493/20 , C07D493/22 , C07D519/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06
CPC分类号： C07D493/20 , A61K31/352 , A61K31/4025 , A61K31/4178 , A61K31/4188 , A61K31/4433 , A61K31/453 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/5513 , C07D493/22 , C07D519/00
摘要： The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by general Formulae (I-III) wherein R1-R5 are defined herein. The present invention also relates to the discovery that compounds having Formulae (I-III) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled cell growth and spread of abnormal cells occurs.
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32.发明公开CASPASE INHIBITORS FOR THE TREATMENT OF DISEASES AND CONDITIONS CAUSED BY EXPOSURE TO RADIONUCLIDES, BIOLOGICAL AGENTS, OR CHEMICAL AGENTS 审中-公开蛋白酶抑制剂疾病和条件通过与放射性核素，生物制剂或化学药剂接触处理导致
公开(公告)号：EP1494700A2
公开(公告)日：2005-01-12
申请号：EP03754361.8
申请日：2003-04-07
申请人： Cytovia, Inc.
发明人： CAI, Sui, Xiong , TSENG, Ben, Y.
IPC分类号： A61K38/00 , A61K31/535 , A61K31/44 , A61K31/35 , A61K31/27 , A61K31/19 , A61K31/195
CPC分类号： A61K31/16 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/27 , A61K31/35 , A61K31/44 , A61K31/535 , A61K38/05 , A61K38/55 , A61K51/12 , Y02A50/406 , Y02A50/471
摘要： The use of caspase inhibitors for treating cell death induced by radionuclides, biological agents, or chemical agents is disclosed. In particular, treatment of diseases or conditions caused by exposure to radionuclides, biological agents, or chemical agents, spread of radionuclides, biological agents, or chemical agents, explosion of radionuclides, biological agents, or chemical agents by terrorists or accidental exposure to radionuclides, biological agents, or chemical agents from a nuclear power plant, manufacturing or processing plant, research facility, or hospital is disclosed.
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公开(公告)号：EP1392283A4
公开(公告)日：2004-10-20
申请号：EP02731803
申请日：2002-05-16
申请人： CYTOVIA INC , SHIRE BIOCHEM INC
发明人： CAI SUI XIONG , ZHANG HONG , KEMNITZER WILLIAM E , JIANG SONGCHUN , DREWE JOHN A , STORER RICHARD
IPC分类号： A61K31/35 , A61K31/385 , A61K31/47 , C07D215/54 , C07D221/10 , C07D311/16 , C07D311/58 , C07D335/06 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04 , A61P35/00 , C07D215/16 , C07D215/20 , C07D311/04 , C07D335/04
CPC分类号： C07D335/06 , A61K31/35 , A61K31/385 , A61K31/47 , C07D215/54 , C07D221/10 , C07D311/16 , C07D311/58 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
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34.发明公开4-SUBSTITUTED-1-(ARYLMETHYLIDENE)THIOSEMICARBAZIDE, 4-SUBSTITUTED-1-(ARYLCARBONYL)THIOSEMICARBAZIDE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开4-取代的1-（亚苄基）氨基硫脲，4-取代的1-（芳基羰基）氨基硫脲和类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导剂及其用途
公开(公告)号：EP1399159A1
公开(公告)日：2004-03-24
申请号：EP02734605.5
申请日：2002-05-31
申请人： Cytovia, Inc.
发明人： CAI, Sui, Xiong , NGUYEN, Bao Ngoc , DREWE, John , REDDY, P., Sanjeeva , KASIBHATLA, Shailaja , PERVIN, Azra
IPC分类号： A61K31/435
CPC分类号： C07D207/335 , A61K31/175 , A61K31/435 , A61K31/44 , A61K31/4965 , C07C281/14 , C07C337/08 , C07C2602/42 , C07D213/53 , C07D213/61 , C07D213/84 , C07D213/86 , C07D231/16 , C07D233/64 , C07D277/28 , C07D277/56 , C07D285/06 , C07D295/135 , C07D307/52 , C07D307/76 , C07D333/22 , C07D333/44 , A61K2300/00
摘要： The present invention is directed to optionally substituted 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs thereof, represented by the Formulae (I) and (II), wherein A1, A2, Q and R1-R3 are defined herein. The present invention also relates to the discovery that compounds having Formulae (I) and (II) are activators o f caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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35.发明公开
公开(公告)号：EP1165490A4
公开(公告)日：2002-09-18
申请号：EP00917859
申请日：2000-03-15
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , WANG YAN , WEBER ECKARD , MILLS GORDON B , GREEN DOUGLAS R
IPC分类号： C12N9/99 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/22 , A61K31/27 , A61K31/381 , A61K38/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P7/00 , A61P7/06 , A61P9/00 , A61P13/10 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/14 , A61P17/16 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/32 , A61P27/02 , A61P29/00 , A61P37/00 , A61P39/00 , A61P43/00 , C07C271/22 , C07C271/24 , C07C271/28 , C07D333/38 , C07D333/40 , C07K5/023 , C07K7/02 , C12N5/04 , C12N5/06 , C07C229/00 , A01N37/00 , A01N37/10 , A01N37/12 , C07C69/74 , C07C205/00
CPC分类号： C07D333/38 , C07C271/22 , C07C271/24 , C07C271/28 , C07C2601/08 , C07C2601/14
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36.发明公开SUBSTITUTED 4H-CHROMENE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 有权取代-4H-色和类似化合物AS KASPASIS激活剂和细胞凋亡的电感器和它们的用途
公开(公告)号：EP1230232A2
公开(公告)日：2002-08-14
申请号：EP00976912.6
申请日：2000-11-03
申请人： Cytovia, Inc.
发明人： DREWE, John, A. , CAI, Sui, Xiong , WANG, Yan
IPC分类号： C07D311/58 , C07D491/04 , C07D405/04 , C07D407/04 , C07D409/04 , A61K31/352 , C07D311/92 , A61P35/00
CPC分类号： C07D311/58 , C07D311/92 , C07D405/04 , C07D407/04 , C07D409/04 , C07D491/04
摘要： The present invention is directed to substituted 4H-chromene and analogs thereof, represented by general Formula (I), wherein A, B, X, Y, Z and R5 are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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37.发明公开NOVEL FLUORESCENT REPORTER MOLECULES AND THEIR APPLICATIONS INCLUDING ASSAYS FOR CASPASES 审中-公开荧光显示MOLOKÜLE和应用，包括CASPASEDOSIERUNG
公开(公告)号：EP1026988A1
公开(公告)日：2000-08-16
申请号：EP98953317.9
申请日：1998-10-09
申请人： Cytovia, Inc.
CPC分类号： C07K5/06026 , C07K5/06052 , C07K5/0806 , C07K5/0808 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C12Q1/68 , G01N15/1456 , G01N33/533 , G01N2015/1006 , G01N2015/1488 , Y02P20/55
摘要： The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and tissue samples derived from any living organism or organ. The reporter molecules and assay processes can be used in drug screening procedures to identify compounds which act as inhibitors or inducers of the caspase cascade in whole cells or tissues. The reagents and assays described herein are also useful for determining the chemosensitivity of human cancer cells to treatment with chemotherapeutic drugs. The present invention also relates to novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of type 2 methionine aminopeptidase, dipeptidyl peptidase IV, calpain, aminopeptidase, HIV protease, adenovirus protease, HSV-1 protease, HCMV protease and HCV protease.
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公开(公告)号：EP1833482A4
公开(公告)日：2011-02-16
申请号：EP06717281
申请日：2006-01-03
申请人： MYRIAD GENETICS INC , CYTOVIA INC
发明人： CAI SUI XIONG , ANDERSON MARK B , WILLARDSEN ADAM , SIRISOMA NILANTHA SUDATH , ZHANG HONG , SUZUKI KAZUYUKI
IPC分类号： A61K31/517 , C07D239/72 , C07D239/94 , C07D403/12
CPC分类号： C07D239/94 , C07D239/72 , C07D403/12
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39.发明公开SUBSTITUTED 4-ARYL-CHROMENE AS ACTIVATOR OF CASPASES AND INDUCER OF APOPTOSIS AND AS ANTIVASCULAR AGENT AND THE USE THEREOF 审中-公开取代的4-芳基 - 色烯ALS胱天蛋白酶激活剂，细胞凋亡INDUCTOR和抗血管AGENTS AND USE
公开(公告)号：EP2049101A4
公开(公告)日：2010-09-15
申请号：EP07810283
申请日：2007-07-06
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , DREWE JOHN A , KASIBHATLA SHAILAJA , KEMNITZER WILLIAM E , TSENG BEN Y , LABRECQUE DENIS , BLAIS CHARLES , GOURDEAU HENRIETTE
IPC分类号： A61K31/353 , C07D311/58
CPC分类号： C07D405/12 , C07D311/58
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40.发明公开PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开作为资产GATES胱天蛋白酶的药物化合物凋亡及使用电感器
公开(公告)号：EP1833803A4
公开(公告)日：2009-08-05
申请号：EP06733603
申请日：2006-01-03
申请人： MYRIAD GENETICS INC , CYTOVIA INC
发明人： CAI SUI XIONG , ANDERSON MARK B , WILLARDSEN ADAM , JIANG SONGCHUN , HALTER ROBERT J , SLADE RACHEL , KLIMOVA YEVGENIYA
IPC分类号： C07D253/08 , A61K31/472 , A61K31/502 , A61K31/53 , A61P35/00 , C07D217/22 , C07D237/28 , C07D237/30
CPC分类号： C07D237/34 , C07D253/08
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