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    ARTIFICIAL NEURAL CANAL
    42.
    发明公开
    ARTIFICIAL NEURAL CANAL 失效
    KÜNSTLICHERNEURALER KANAL

    公开(公告)号：EP0945145A1

    公开(公告)日：1999-09-29

    申请号：EP97912504.4

    申请日：1997-11-19

    申请人： Tapic International Co., Ltd. ,  SHIMIZU, Yasuhiko

    发明人： SHIMIZU, Yasuhiko

    IPC分类号： A61L27/00 ,  A61F2/04

    CPC分类号： A61B17/1128 ,  A61F2/04 ,  A61L27/34 ,  A61L27/58 ,  A61L31/041 ,  A61L31/047 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2300/608 ,  A61L2430/32 ,  C08L89/06 ,  A61L31/044 ,  C08L5/10 ,  A61L31/148 ,  C08L67/04

    摘要： The present invention offers an artificial tube for nerve which can remain in the body until the nerve regenerates while does not remain as a foreign body in the body following nerve regeneration, and which induces axons regenerated from severed nerve stumps, can promote infiltration of blood capillaries from the body and regeneration of nerve tissue. The present invention comprises a tube 10 or 20 having coating layers 12, 13 or 22, 23 composed of gelatin or collagen on the inner and outer surfaces of a tube 11 or 21 composed of a material being biodegradable and absorbable in vivo, and a collagen body 30 or 40 having cavities 32, 33 or 41 which pass through said tube so as to be substantially parallel to the axis of said tube; wherein, said cavities are filled with a matrix gel.

    摘要翻译： 本发明提供一种人造神经管，其可以保留在体内，直到神经再生，而在神经再生后不会留在身体中的异物，并且引起从断开的神经根再生的轴突，可以促进毛细血管的渗透 从身体和神经组织的再生。 本发明包括管10或20，其具有由管11或21的内表面和外表面上的由明胶或胶原组成的涂层12,13或22,23，其由可生物降解和体内吸收的材料构成，并且胶原 主体30或40具有通过所述管的空腔32,33或41，以便基本上平行于所述管的轴线; 其中，所述空腔填充有基质凝胶。

    Cyclic peptides bearing a tail designed for subsequent chemical coupling and process for preparing same
    44.
    发明公开
    Cyclic peptides bearing a tail designed for subsequent chemical coupling and process for preparing same 失效
    带有为后续化学偶联而设计的尾巴的环状肽及其制备方法

    公开(公告)号：EP0844252A3

    公开(公告)日：1998-07-08

    申请号：EP97870182.9

    申请日：1997-11-14

    申请人： Remacle, José

    发明人： Remacle, José ,  Delforge, Dominique

    IPC分类号： C07K7/64 ,  C07K17/00

    CPC分类号： C12N5/0068 ,  A61L27/227 ,  A61L27/38 ,  A61L31/047 ,  C07K7/56 ,  C07K7/64 ,  C12N2533/50

    摘要： The present invention relates to a cyclic peptide comprising a dicarboxylic amino acid, said cyclic peptide bearing at least one tail for subsequent coupling on a solid support, on a high molecular weight compound, on a marker, or on one or more other similar or different cyclic peptides. The present invention is also related to the preparation process of said cyclic peptide and to a biomaterial comprising said cyclic peptide.

    摘要翻译： 本发明涉及包含二羧酸氨基酸的环肽，所述环肽带有至少一个用于随后在固体载体上偶联，在高分子量化合物上，在标记物上或在一个或多个其它相似或不同的化合物上偶联的尾部 环肽。 本发明还涉及所述环肽的制备方法和包含所述环肽的生物材料。