公开(公告)号：EP1667713A1

公开(公告)日：2006-06-14

申请号：EP04784276.0

申请日：2004-09-15

申请人： ID Biomedical Corporation of Quebec ,  McGill University

发明人： BURT, David, S. ,  WARD, Brian, J. ,  CHABOT, Sophie

IPC分类号： A61K39/165 ,  A61K39/39 ,  A61P31/14

CPC分类号： C07K16/1027 ,  A61K39/12 ,  A61K39/165 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55572 ,  C12N2760/18434

摘要： Compositions and methods for making and using therapeutic formulations of measles virus antigens with a Proteosome-based adjuvant are provided. The measles virus antigens may be derived from a variety of sources, such as from recombinant production or from a split antigen preparation. The measles vaccine formulations may be used, for example, in methods for treating or preventing a measles virus infection and eliciting a protective immune response.

公开(公告)号：EP1658484A2

公开(公告)日：2006-05-24

申请号：EP04786402.0

申请日：2004-08-21

申请人： McGill University

发明人： KOSKI, Kristine, G. ,  BURNS, David, H.

IPC分类号： G01N1/00

CPC分类号： A61B5/1459 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/7275 ,  G06F19/00

摘要： Methods and spectra for monitoring fetal growth and predicting birth weight of an infant prior to birth are provided wherein one or more selected biological markers are measured in a sample of amniotic fluid obtained from a pregnant woman. Levels of the selected biochemical markers and/or spectra correlate with one or more medical conditions, such as fetal growth and birth weight of the infant, and gestational diabetes. A measurement probe for in situ measurement can be used safely and repeatedly. Monitoring and/or treatment of maternal and fetal health is also provided.

公开(公告)号：EP1639098A1

公开(公告)日：2006-03-29

申请号：EP04737935.9

申请日：2004-07-08

申请人： McGill University

发明人： Peterson, Alan Clarke

IPC分类号： C12N5/06 ,  A01K67/027

CPC分类号： C12N15/873 ,  A01K67/027 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2267/0393 ,  C12N2517/00 ,  C12N2517/02

摘要： The present invention provides non-inbred mouse embryonic stem (ES) cells comprising alleles derived from at least two different mouse strains and having high developmental potential. The ES cells optionally comprises a docking site for a transgene. Methods for production of the ES cells are also disclosed. This invention further provides chimeric and transgenic mice derived from the non-inbred ES cells and methods for deriving such mice.

公开(公告)号：EP1620723A1

公开(公告)日：2006-02-01

申请号：EP04731860.5

申请日：2004-05-10

申请人： McGill University ,  Chronogen Inc.

发明人： HEKIMI, Siegfried ,  HIHI, Abdelmadjid, K. ,  NADEAU, Guy

IPC分类号： G01N33/50 ,  C12Q1/26 ,  C12N15/00

CPC分类号： G01N33/5014 ,  C12Q1/26 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/502 ,  G01N33/5038

摘要： The present invention provides methods for screening modulators of 2 polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone (DMQ) hydroxylation activity, inhibitors and activators of the activity, and methods of using such compounds. More particularly, this invention relates to modulators of and UbiF and CLK-1 enzyme activity and methods of identifying same.

公开(公告)号：EP1599573A2

公开(公告)日：2005-11-30

申请号：EP04711868.2

申请日：2004-02-17

申请人： COLD SPRING HARBOR LABORATORY ,  McGill University

发明人： FRIDMAN, Jordan S. ,  LOWE, Scott ,  DE STANCHINA, Elisa ,  WENDEL, Hans G. ,  PELLETIER, Jerry

IPC分类号： C12N1/00

CPC分类号： C12N15/86 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0393 ,  C07K14/82 ,  C12N9/1205 ,  C12N15/8509 ,  C12N2740/14043 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/574 ,  G01N2800/52

摘要： The invention provides the components of in vivo and in vitro systems and methods which use them to study the effects of altered expression of a gene activity, such as the human akt, bcl-2, eIF4E or PTEN activities, on the descendants of stem cells that have been engineered to give rise to hematopoietic tumorigenic or tumor cells, such as lymphomas, with a high frequency. The present invention provides vectors, cells and mammals, and methods which in part depend on such products, useful for understanding tumorigenesis and its treatments, and in particular, for identifying and studying inhibitors and activators associated with tumor cell growth and growth inhibition, cell death through apoptotic pathways, and changes in apoptotic pathway components that affect drug sensitivity and resistance in tumorigenic cells. Methods for identifying molecular targets for drug screening, identifying interacting gene activities, for identifying therapeutic treatments and for identifying candidates for new therapeutic treatments are provided.

公开(公告)号：EP0979089B1

公开(公告)日：2005-11-16

申请号：EP98917538.5

申请日：1998-04-29

申请人： McGill University

发明人： PRICHARD, Roger, K. ,  POULIOT, Jean-François ,  GEORGES, Elias

IPC分类号： A61K31/70 ,  A61K31/475 ,  A61K38/10 ,  A61K38/12 ,  A61K31/365 ,  A61P35/00

CPC分类号： C07D493/22 ,  A61K31/365 ,  A61K31/475 ,  A61K31/70 ,  A61K38/08 ,  A61K38/12 ,  A61K45/06 ,  A61K31/335 ,  A61K31/165 ,  A61K2300/00

摘要： This invention describes methods for increasing the toxicity of a cytostatic hydrophobic chemotherapeutic agent against resistant tumor cells in mammals which comprise administering a multidrug resistant reversing agent to the mammal in connection with the administration of the cytostatic hydrophobic chemotherapeutic agent in an amount effective to increase the toxicity of the chemotherapeutic agent, wherein the multidrug resistant reversing agent is a macrocyclic lactone compound. Examples of the macrocyclic lactone compounds useful in the present invention include, but are not limited to, the LL-F28249 alpha - lambda series of compounds, the 23-oxo or 23-imino derivative thereof, the avermectins, the 22,23-dihydro derivatives thereof and the milbemycins. Compositions comprising the macrocyclic lactone compounds and the chemotherapeutic agents are also described herein.

公开(公告)号：EP1554932A2

公开(公告)日：2005-07-20

申请号：EP05009071.1

申请日：2000-10-06

申请人： McGILL UNIVERSITY

发明人： Smith, Donald L. ,  Prithiviraj, Balakrishnan ,  Zhou, Xiaomin ,  Souleimanov, Alfred

IPC分类号： A01N43/16 ,  A01N63/02 ,  A01N63/00

CPC分类号： A01N43/16 ,  A01N63/00 ,  A01N63/02

摘要： The present invention relates to agriculture. More particularly, the invention relates to a method of increasing photosynthesis of a plant and more particularly of crop plants. The method consists of foliar application of an effective amount of lipo-chitooligosaccharides along with an agriculturally suitable carrier so as to enhance photosynthesis when compared to an untreated plant.

摘要翻译： 本发明涉及农业。 更具体地，本发明涉及增加植物的光合作用，更具体作物植物的方法。 有效量的脂壳寡糖地连同计划未处理农业上合适的载体上的的叶面施用的方法besteht从而提高光合作用相比。

公开(公告)号：EP1554309A2

公开(公告)日：2005-07-20

申请号：EP03769082.3

申请日：2003-10-03

申请人： McGILL UNIVERSITY

发明人： STANNERS, Clifford, P. ,  ILANTZIS, Christian

IPC分类号： C07K14/705 ,  C07K16/30 ,  C07K16/28

CPC分类号： C07K16/3007 ,  A61K2039/505 ,  C07K2317/55

摘要： The present invention relates to differentiation and tumorigenicity. The present invention more particularly relates to ligands which target CEA and CEACAM6 such that the adhesion, differentiation-Inhibitory activities and tumorigenic effects of Ig superfamily members, CEA and CEACAM6, can be reduced or blocked. More particularly, the present invention relates to CEA-binding agents which reverse CEA-mediated tumorigenic effects by declustering CEA and CEACAM6. In one embodiment the invention relates to methods of reducing, preventing or reversing a CEA-mediated tumorigenic effect comprising a use of a CEA-mediated tumorigenic effect reducing CEA-declustering agent. In one embodiment, the invention relates to compositions and use thereof for reversing CEA-mediated tumorigenic effects on human cancer cells and uses thereof. In particular, the application relates to a monovalent CEA binding agent which interfereswith a CEA interaction responsible for a CEA-mediated tumorigenic effects, thereby minimizing or reversing same.

公开(公告)号：EP1173619B1

公开(公告)日：2005-06-29

申请号：EP00926615.6

申请日：2000-05-05

申请人： McGill University

发明人： ROEMER, Terry ,  BUSSEY, Howard ,  DAVISON, John

IPC分类号： C12Q1/68 ,  C07K14/40

CPC分类号： C07K14/40 ,  C12Q1/6895

摘要： The invention relates to the identification and disruption of essential fungal specific genes isolated in the yeast pathogen Candida albicans namely CaKRE5, CaALR1 and CaCDC24 and to the use thereof in antifungal diagnosis and as essential antifungal targets in a fungal species for antifungal drug discovery. More specifically, the invention relates to the CaKRE5, CaALR1 and CaCDC24 genes, to their use to screen for antifungal compounds and to the drugs identified by such.

摘要翻译： 本发明涉及的识别和在酵母病原体白色念珠菌即CaKRE5，CaALR1和CaCDC24并在抗真菌的药物发现的真菌物种中诊断和抗真菌抗真菌靶必要及其使用分离必需真菌特异性基因破坏。 更具体地，本发明涉及到CaKRE5，CaALR1，和CaCDC24基因，它们的用途来筛选抗真菌化合物和所识别BY检查的药物。

公开(公告)号：EP1511857A1

公开(公告)日：2005-03-09

申请号：EP03724756.6

申请日：2003-05-30

申请人： McGill University

发明人： KARAPLIS, Andrew ,  GOLTZMAN, David

IPC分类号： C12Q1/68 ,  A01K67/027 ,  C12N15/11

CPC分类号： A01K67/0275 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N2800/30 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The invention provides a method of diagnosing bone disease and/or a susceptibility thereto, in an individual. The method includes screening a biological sample obtained from the individual for one or more genetic indicators of bone disease in said PTHrP gene of the individual, and diagnosing the individual based on a characterization of the genetic indictor(s) detected. A genetic indicator of the invention preferably includes a genetic segment of a PTHrP gene. More preferably, a genetic segment of a PTHrP gene includes a VNTR containing region. The invention further provides a transgenic non-human mammal for the study of bone disease and/or bone conditions, the mammal having a disruption or inactivation of a PTHrP gene or portion thereof specifically in osteoblast cells.