公开(公告)号：EP1620723A1

公开(公告)日：2006-02-01

申请号：EP04731860.5

申请日：2004-05-10

申请人： McGill University ,  Chronogen Inc.

发明人： HEKIMI, Siegfried ,  HIHI, Abdelmadjid, K. ,  NADEAU, Guy

IPC分类号： G01N33/50 ,  C12Q1/26 ,  C12N15/00

CPC分类号： G01N33/5014 ,  C12Q1/26 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/502 ,  G01N33/5038

摘要： The present invention provides methods for screening modulators of 2 polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone (DMQ) hydroxylation activity, inhibitors and activators of the activity, and methods of using such compounds. More particularly, this invention relates to modulators of and UbiF and CLK-1 enzyme activity and methods of identifying same.

公开(公告)号：EP1981493A1

公开(公告)日：2008-10-22

申请号：EP07845502.9

申请日：2007-11-13

申请人： Chronogen Inc. ,  Sosei Co. Ltd.

发明人： HEKIMI, Siegfried ,  HIHI, Abdelmadjid K. ,  BRANICKY, Robyn S. ,  JIA, Xihua

IPC分类号： A61K31/357 ,  A61K45/06 ,  A61P43/00

CPC分类号： A61K31/357

摘要： The present invention relates to the use of ACAT inhibitors, {e.g. F-1394, Avasimibe (CI-1011), Pactimibe (CS505), Efluimibe (F12511), Eldacimibe, NTE 122, AS-183, KW-3033, E5324, FY087, FCE27677, CI-976, K-604, TEI6522, Octimibate, FR179254, and S 58-035, or mixtures thereof), compositions comprising the same, and methods for preventing or treating fibrosis, for preventing or reducing collagen deposition in a tissue, and in the prevention and reduction of excessive fibrous connective tissue

公开(公告)号：EP1325124A2

公开(公告)日：2003-07-09

申请号：EP01951254.0

申请日：2001-06-20

申请人： McGILL UNIVERSITY

发明人： HEKIMI, Siegfried ,  B NARD, Claire ,  MCCRIGHT, Brent ,  LAKOWSKI, Bernard ,  HAN, Dong ,  LABBE, Jean-Claude

IPC分类号： C12N15/12 ,  C12N15/19 ,  C07K14/435 ,  C07K14/415 ,  C07K14/47 ,  A01K67/027 ,  G01N33/68 ,  A61K38/17

CPC分类号： C07K14/43545 ,  C07K14/47

摘要： The present invention relates to a clk-2 gene which has a function at the level of cellular physiology involved in developmental rate, telomere length and longevity, wherein clk-2 mutations cause a longer life, an altered cellular metabolism and an altered telomere length relative to the wild type, wherein clk-2 overexpression leads to telomere shortening. The present invention also relates to clk-2 co-expressed gene which comprises a cex-7 gene having the nucleotide sequence set forth in Fig. 33 which codes for a CEX-7 protein having the amino acid sequence set forth in Fig. 34 wherein said gene is located in the clk-2 operon and said cex-7 gene is transcriptionally co-expressed with clk-2 gene present in said operon. The present invention also relates to a coq-4 gene which has a function at the level of cellular physiology involved in the regulation of developmental rate and longevity, wherein coq-4 mutations cause altered cellular metabolism and physiological relative to the wild type, wherein coq-4 gene has the identifying characteristics of nucleotide sequence set forth in Fig. 36.

公开(公告)号：EP1604041A1

公开(公告)日：2005-12-14

申请号：EP04720559.6

申请日：2004-03-15

申请人： McGill University

发明人： HEKIMI, Siegfried ,  Shibata, Yukimasa ,  BRANICKY, Robyn

IPC分类号： C12Q1/68 ,  G01N33/92 ,  C12Q1/26 ,  C07K14/435

CPC分类号： C07K14/43545

摘要： The invention relates to the use of C. elegans as a model for identifying genes that are involved in lipid or lipoprotein metabolism and which can serve as drug targets. The invention also provides a system for screening drugs useful in the treatment and prevention of diseases associated with undesirable or abnormal levels of lipids (e.g., cholesterol) or lipoproteins (e.g., LDL), such as cardiovascular disorders and dyslipidemia.

公开(公告)号：EP1009813B1

公开(公告)日：2007-06-20

申请号：EP98940027.0

申请日：1998-08-20

申请人： McGill University

发明人： HEKIMI, Siegfried ,  LAKOWSKI, Bernard, Genzentrum, Ludwig-Maximillians ,  BARNES, Thomas ,  LEMIEUX, Jason

IPC分类号： C12N9/10 ,  C12Q1/68 ,  A01K67/027

CPC分类号： C12N9/1085 ,  A01K2217/075

摘要： The invention relates to the identification of gro-1 gene and to demonstrate that the gro-1 gene is involved in the control of a central physiological clock. Also disclosed are four other genes located within the same operon as the gro-1 gene.

公开(公告)号：EP1412527A2

公开(公告)日：2004-04-28

申请号：EP02753979.0

申请日：2002-07-26

申请人： McGill University

发明人： FENG, JinLiu ,  BUSSIERE, Frédéric ,  HEKIMI, Siegfried

IPC分类号： C12Q1/68

CPC分类号： C07K14/43536 ,  A61K38/00 ,  C07K14/395 ,  C07K14/415 ,  C07K14/465 ,  C07K14/47 ,  C07K14/80

摘要： The present invention relates to the characterization of mutants in the genes isp-1 and ctb-1, which are genes that have a function at the level of cellular physiology, mitochondrial respiration and electron transport, and resistance to oxidative stress, as well as regulating developmental, behavioral, reproductive and aging rates. Mutations in the genes isp-1 and ctb-1 are also provided. These genes and the protein they encode are used in a perspective of growth and aging control and in a therapeutic perspective for diseases in which mitochondrial function is altered. There is also provided methods of identification of compounds for the manipulation of the function of the isp-1 and ctb-1 genes and their protein products, as well as for the manipulation of the functions of mitochondria.

公开(公告)号：EP1009813A1

公开(公告)日：2000-06-21

申请号：EP98940027.0

申请日：1998-08-20

申请人： McGILL UNIVERSITY

发明人： HEKIMI, Siegfried ,  LAKOWSKI, Bernard,Genzentrum, Ludwig-Maximillians ,  BARNES, Thomas ,  LEMIEUX, Jason

IPC分类号： C12N9/10 ,  C12Q1/68 ,  A01K67/027

CPC分类号： C12N9/1085 ,  A01K2217/075

摘要： The invention relates to the identification of gro-1 gene and to demonstrate that the gro-1 gene is involved in the control of a central physiological clock. Also disclosed are four other genes located within the same operon as the gro-1 gene.

公开(公告)号：EP0932701A1

公开(公告)日：1999-08-04

申请号：EP97944665.0

申请日：1997-10-17

申请人： McGILL UNIVERSITY

发明人： HEKIMI, Siegfried ,  EWBANK, Jonathan ,  BARNES, Thomas ,  LAKOWSKI, Bernard

IPC分类号： A01K67 ,  A61K48 ,  A61P43 ,  C07K14 ,  C12N15 ,  C12Q1

CPC分类号： C07K14/43545 ,  A01K67/0336 ,  A01K2217/075 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/156

摘要： The present invention relates to a clk-1 gene which has a function at the level of cellular physiology involved in developmental rate and longevity, wherein clk-1 mutants have a longer life and a altered cellular metabolism relative to the wild-type. There is also provided a method for the diagnosis and/or prognosis of cancer in a patient, which comprises the steps of: a) obtaining a tissue sample from the patient; b) analyzing DNA of the obtained tissue sample of step a) to determine if the human clk-1 gene is altered, wherein alteration of the human clk-1 gene is indicative of cancer. There is also provided a method of treatment of pathological conditions causing slowdown of physiological rate of tissue and/or organ in a patient.

公开(公告)号：EP3768829A1

公开(公告)日：2021-01-27

申请号：EP19746864.8

申请日：2019-01-31

申请人： The Royal Institution for the Advancement of Learning / McGill University

发明人： HEKIMI, Siegfried ,  WANG, Ying

IPC分类号： C12N5/10 ,  A01K67/027 ,  A61K31/122 ,  A61K31/337 ,  A61K47/34 ,  A61K47/42 ,  A61K9/08 ,  A61K9/107 ,  A61P35/00 ,  A61P39/06 ,  C07C50/28 ,  C07D305/14 ,  C07K7/56 ,  C12N15/53 ,  C12N15/54 ,  C12Q1/02

公开(公告)号：EP1417485A2

公开(公告)日：2004-05-12

申请号：EP02754011.1

申请日：2002-08-07

申请人： McGILL UNIVERSITY ,  Chronogen

发明人： HEKIMI, Siegfried ,  HIHI, Abdelmadjid ,  LEVAVASSEUR, Françoise ,  SHOUBRIDGE, Eric ,  GAO, Yuan ,  PAQUET, Michel ,  BENARD, Claire

IPC分类号： G01N33/50

CPC分类号： A01K67/0276 ,  A01K67/0336 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2227/703 ,  A01K2267/03 ,  A61K49/0008 ,  C12N9/0073 ,  C12N9/1007 ,  C12N15/8509 ,  C12N2800/30 ,  G01N33/5085 ,  G01N33/5088 ,  G01N2500/00

摘要： The present invention relates to a method of screening for a compound allowing survival of clk1 homozygous mutant embryos; a method of screening for a compound suitable for rescue of mutant phenotype of mclk1 homozygous cell line; a method of screening for a compound suitable for partial or complete functional replacement of endogenous ubiquinone; a method for screening a compound capable of inhibiting activity of clk-1 and/or other processes required to make ubiquinone from demethoxyubiquinone; a non-ubiquinone-producer mouse; a DNA construct, which comprises an alteration of mclk1; a non-ubiquinone-producer ES cell line; a coq-3 mutant subject non-ubiquinone producer; a method of screening for a compound suitable for complete or partial functional ubiquinone or demethoxyubiquinone replacement; a method for reducing and/or increasing ubiquinone level in a multicellular subject; a method of screening for a genetic suppressor of clk-1; and a method of screening for a genetic suppressor of coq-3.