摘要:
Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要:
A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.
摘要:
The present invention provides systems, methods, and devices for electroporation- based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
摘要:
An apparatus for use in carrying out a prophylactic or treatment procedure on tissue comprises a head piece 1 having a receiver 2 for receiving an instrument such as an endoscope 10 and chamber 3 into which tissue is drawn by vaccum. There are two electrodes 11 within the chamber 2 and two electrodes 25 located on opposite sides of the entrance 5 into the chamber. The voltage applied to the inner and outer electrodes 11, 25 can be varied independently an allows tissue underlying the device to be treated. This is particularly important for colorectal cancers.
摘要:
A new device for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
摘要:
The invention provides for improved devices and methods for forming openings in a biological membrane for delivering substances into an animal through the biological membrane for treatment applications, or extracting substances from the animal through the biological membrane for monitoring or other diagnosis applications and for increased transmembrane flux.
摘要:
The present invention relates to an apparatus and method for improving the delivery of desirable substances across a membrane utilizing a varying electromagnetic energisation profile. More particularly, the invention provides methods for modifying the cellular environment of such membranes and the behaviour of substance molecules during transport across a membrane. In use, the profile will have application in, enhancing transmembrane delivery of substances (such as pharmaceuticals, nutraceuticals, biopharmaceuticals and cosmeceuticals), and/or enhancing or expanding a cellular cohort of membranes and surrounding tissues.
摘要:
The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.
摘要:
Die Erfindung betrifft eine Elektrodenanordnung 20, insbesondere zur Beaufschlagung von adhärenten Zellen mit mindestens einem elektrischen Feld, die mindestens zwei Elektroden 21 umfasst, welche jeweils mindestens eine Fläche 32 aufweisen, die der entsprechenden Fläche 32 der jeweils anderen Elektrode 21 gegenüberliegend angeordnet ist, wobei zwischen den Flächen 32 der Elektroden 21 zumindest teilweise ein elektrisch isolierendes Material 26 angeordnet ist. Durch diese erfindungsgemäße Lösung wird erreicht, dass das elektrische Feld im Bereich der zu behandelnden Zellen konzentriert werden kann, so dass ein Spannungsimpuls bzw. der hierdurch entstandene Strom durch die Zellen fließt, ohne dass ein Hauptteil davon ungenutzt im Elektrolyten über den Zellen abfließt. Die Erfindung betrifft ferner ein Verfahren zur Beaufschlagung von adhärenten Zellen mit mindestens einem elektrischen Feld, bei dem das elektrische Feld durch das Anlegen einer Spannung and mindestens zwei Elektroden erzeugt wird, das elektrische Feld an der den Zellen zugewandten Seite der Elektroden konzentriert und/oder auf den Raum zwischen den Zellen und der den Zellen zugewandten Seite der Elektroden begrenzt wird.
摘要:
The present invention includes methods and devices for providing sustained in-vivo release of an active agent to a subject. In some aspects, such release may be achieved by reacting an active agent in-vivo with a depot forming agent in order to form a sustained release active agent depot inside the subject. The depot can then release the active agent over a sustained period of time.