公开(公告)号：EP1679121A3

公开(公告)日：2006-07-26

申请号：EP06075717.6

申请日：2001-11-30

申请人： Fluidigm Corporation

发明人： The designation of the inventor has not yet been filed

IPC分类号： B01L3/00 ,  F15C5/00

CPC分类号： F15C1/143 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0005 ,  F16K99/0007 ,  F16K99/0034 ,  F16K99/0057 ,  F16K99/0059 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094

摘要： The present invention provides microfabricated fluidic systems. Microfabricated fluidic devices of the present invention include switches (50,70,80,90) that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupled together to perform logic functions and Boolean algebra, such as inverters, AND gates, NAND, gates, NOR gates, and OR gates. The logic gates may be coupled together to form flip-flops that latch signals.

公开(公告)号：EP1567796A2

公开(公告)日：2005-08-31

申请号：EP03790346.5

申请日：2003-12-04

申请人： Spinx, Inc.

发明人： ZUCCHELLI, Piero ,  VAN DE VYVER, Bart

IPC分类号： F16K17/14 ,  G01N9/30

CPC分类号： F16K99/0001 ,  B01F11/0002 ,  B01F13/0059 ,  B01F13/0809 ,  B01F15/0205 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0683 ,  B81B2201/058 ,  B81C1/00119 ,  B81C2201/019 ,  F16K99/003 ,  F16K99/0034 ,  F16K99/004 ,  F16K2099/0073 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N21/01 ,  G01N35/00069 ,  G01N2001/2886 ,  G01N2035/00247 ,  Y10T137/1624 ,  Y10T137/1632 ,  Y10T436/2575

摘要： The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components. Other aspects of this invention include an apparatus and method to perform volumetric quantitation of fluids, an apparatus to program arbitrary connections between a set of input capillaries and a set of output capillaries, and a method to transport fluid in centripetal device from a larger to a smaller radius. In addition, the present invention also is directed to a method to determine the radial and polar position of a pickup in the reference frame of a rotating device.

公开(公告)号：EP1490601A1

公开(公告)日：2004-12-29

申请号：EP03710004.7

申请日：2003-03-21

申请人： Starbridge Systems Limited

发明人： SMITH, Kevin ,  CEFAI, Joseph ,  SHAPLEY, Julian ,  MARTINAU, Peter

IPC分类号： F15C5/00

CPC分类号： F16K99/0001 ,  F15B2015/208 ,  F15C5/00 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0036 ,  F16K99/004 ,  F16K2099/008

摘要： An actuator for a component such as a valve or pump comprises a chamber or capsule (30) of a flexible material, which chamber or capsule (30) is mounted on a substrate (18). Within the capsule (30) is a quantity of thermopneumatic material (32) (i.e. material which expands in volume upon heating). Also disposed within the capsule (30) is an infrared radiation absorbing layer (16). In use, infrared radiation is applied to the capsule (30) at or close to the location of the infrared radiation absorbing layer (16), thereby causing the thermopneumatic material (32) within the capsule (30) to be heated. As the thermopneumatic material (32) is heated, it expands in volume and causes movement of the flexible material forming the capsule (30), i.e. it causes mechanical movement thereof. As the thermopneumatic material (32) cools, it returns to its original volume and the flexible material of the capsule returns to its original position accordingly.

公开(公告)号：EP1313955A4

公开(公告)日：2004-03-24

申请号：EP01965858

申请日：2001-08-06

申请人： BIOMICRO SYSTEMS INC

发明人： MCNEELY MICHAEL ,  SPUTE MARK

IPC分类号： F15C4/00 ,  B01L3/00 ,  B81B1/00 ,  F15C1/14 ,  F15C5/00 ,  F16K99/00

CPC分类号： F15C1/146 ,  B01L3/502738 ,  B01L2200/146 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0694 ,  B81B1/00 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/0084 ,  Y10T137/0396 ,  Y10T137/2071 ,  Y10T137/2076 ,  Y10T137/218 ,  Y10T137/2224

摘要： A method of controlling fluid flow within a microfluidic circuit (10) using external valves and pumps connected to the circuit (10) is disclosed. The external valves and pumps, which are not a part of the microfluidic substrate (11), control fluid pumping pressure and the displacement of air (17) out of the fluid circuit (10) as fluid enters into the circuit (10). If a valve is closed, air (17) cannot be displaced out of circuit, which creates a pneumatic barrier (18) that prevents fluid from advancing within the circuit (under normal operating pressures).

公开(公告)号：EP1296067A3

公开(公告)日：2004-02-11

申请号：EP02256397.7

申请日：2002-09-16

申请人： Randox Laboratories Ltd.

发明人： Gamble, Harold Samuel ,  Mitchell, Samuel John Neil ,  Bien, Daniel Chia Sheng ,  Fitzgerald, Stephen Peter, Randox Lab. Ltd.

IPC分类号： F15C5/00 ,  F04B43/04

CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0094

摘要： A passive microvalve comprises a substrate (1) having a first aperture (2). An upper plate (7a) is mounted on the substrate and has a second aperture (7b) opening into a space defined between the substrate and the upper plate. A closure member (4) is mounted in the space and is movable between a first position in which it allows fluid flow between the first and second apertures and a second position in which it closes the second aperture.

公开(公告)号：EP1350029A2

公开(公告)日：2003-10-08

申请号：EP02705689.4

申请日：2002-01-08

申请人： President And Fellows of Harvard College

发明人： JEON, Noo Li ,  CHIU, Daniel T. ,  WARGO, Christopher J. ,  CHOI, Insung S. ,  WU, Hongkai ,  ANDERSON, Janelle R. ,  WHITESIDES, George M. ,  MCDONALD, J. Cooper ,  METALLO, Steven J. ,  STONE, Howard A.

IPC分类号： F04B39/10

CPC分类号： B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/0611 ,  B01L2400/0638 ,  B01L2400/0677 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0007 ,  F16K99/0015 ,  F16K99/003 ,  F16K99/0034 ,  F16K99/0048 ,  F16K99/0057 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0094 ,  Y10T137/0497 ,  Y10T137/7891 ,  Y10T137/7895 ,  Y10T137/791 ,  Y10T137/87917

摘要： The present invention relates to microfluidic systems, including valves (12) and pumps for microfluidic systems. The valves of the invention include check valves (30) such as diaphragm valves and flap valves. Other valves of the invention include one-use valves (12). The pumps of the present invention include a reservoir (40) and at least two check valves (30, 31). The reservoir (40) may be a variable volume. The present invention also relates to a flexible microfluidic system (10). The present invention additionally relates to a method of making microfluidic systems (10) including those of the present invention. The method includes forming a microfluidic system on a master (100), connecting a support (110) to the microfluidic system (10) and removing the microfluidic system (10) from the master (100). The support (110) may remain connected to the microfluidic system (10) or the microfluidic system (10) may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system. This method includes initiating fluid flow in a first direction (50) and inhibiting fluid flow in a second direction (50) and may be practiced with the valves (12) of the present invention.

公开(公告)号：EP1345697A2

公开(公告)日：2003-09-24

申请号：EP01997351.0

申请日：2001-11-22

申请人： Nextgen Sciences Ltd

发明人： RYAN, Paul Thomas ,  AUTON, Kevin Andrew ,  SCHUROV, Sergei Mikhailovich ,  WIGLEY, David John

IPC分类号： B01L3/00

CPC分类号： F16K99/0001 ,  B01F11/0071 ,  B01F13/0059 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00389 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/50273 ,  B01L3/502738 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2300/1838 ,  B01L2300/1844 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  F16K7/12 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0059 ,  F16K2099/0084 ,  G01F1/708 ,  G01F1/7086 ,  G01F1/7088 ,  G01F11/086 ,  G01P13/0006 ,  Y10T436/117497

摘要： An assay device in which to carry out a fluid-phase chemical assay, comprising means for supporting a test substrate, a sample chamber for receiving a fluid sample and at least one fluid control device for controlling the movement of fluid into and/or out of the sample chamber, wherein the fluid control device comprises a fluid outlet chamber in fluid communication with the sample chamber, and a displaceable flexible diaphragm the displacement of which alters the volume of the outlet chamber so as to allow and/or restrict fluid flow between the outlet and sample chambers. The invention also provides assay apparatus incorporating such a device, an assay station for use as part of such apparatus, a fluid control unit for use as part of the assay device and a method of conducting an assay which may involve the use of such apparatus and devices.

公开(公告)号：EP1129739A3

公开(公告)日：2003-05-02

申请号：EP01113022.6

申请日：1994-10-03

申请人： RESEARCH INTERNATIONAL, INC.

发明人： Saaski, Elric, W. ,  Lawrence, Dale, M.

IPC分类号： A61M5/165 ,  A61M5/168 ,  F15C5/00

CPC分类号： B01D71/025 ,  A61M5/14276 ,  A61M5/16881 ,  A61M2205/0244 ,  A61M2205/0294 ,  B01D61/18 ,  B01D67/0058 ,  B01D67/0065 ,  B01D69/02 ,  B01D71/02 ,  F04B43/043 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/0088 ,  G05D7/0694 ,  Y10S366/03 ,  Y10T29/49409 ,  Y10T29/49412 ,  Y10T29/49417 ,  Y10T29/49419 ,  Y10T29/49826 ,  Y10T137/0491 ,  Y10T137/2607 ,  Y10T137/7788 ,  Y10T137/7791 ,  Y10T137/7792

摘要： The fluid filters are capable of accurately handling substantially continuous fluid flow rates as low as about 0.01 cc/day. The filters are so miniaturized, corrosion-resistant and non-toxic that they are suitable for being implanted in the human body; and are capable of being mass produced at costs so low, by using micromachining techniques, such as etching, that they may be considered to be disposable. The filters are passive devices which consume no electrical energy at all. The filters are reliable because they may have as few as only two parts, only one which is a moving part; and because they may handle fluids at very low pressures

公开(公告)号：EP1205670A2

公开(公告)日：2002-05-15

申请号：EP01126695.4

申请日：2001-11-08

申请人： Bartels Mikrotechnik GmbH

发明人： Bartels, Frank, Dr. ,  Tahhan, Nader Mark Isam

IPC分类号： F15C5/00 ,  B81B1/00 ,  B01J19/00

CPC分类号： F16K99/0001 ,  B01F5/0604 ,  B01F13/0059 ,  B01F2215/0037 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0406 ,  F16K99/003 ,  F16K99/0034 ,  F16K99/004 ,  F16K2099/008 ,  F16K2099/0084

摘要： Die Erfindung stellt eine Verteilerplatte (2) für Flüssigkeiten und/oder Gase bereit, die aus wenigstens einer Schicht (21) besteht, wobei in der Schicht oder den Schichten eine Vielzahl von ersten länglichen Kanälen (211) mit einer ersten geometrischen Ausbildung im wesentlichen in einer ersten Richtung (X) ausgebildet ist, und außerdem eine Vielzahl von zweiten länglichen Kanälen (212) mit einer zweiten geometrischen Ausbildung im wesentlichen in einer zweiten Richtung (Y) ausgebildet ist. Derartige Schichten können insbesondere wenn sie sehr kleine Abmessungen haben und dementsprechend miniaturisiert ausgebildete Kanäle haben auf einfache Weise und kostensparend beispielsweise aus Kunststoff mittels Abformung oder Spritzguß in großer Stückzahl vorgefertigt werden und gelagert werden. Im Bedarfsfall kann in einer derartigen Schicht auf einfache Weise mittels geeigneter Bohrungen in Zwischenräume zwischen nebeneinander angeordneter Kanäle (211,212) mindestens ein erster und zweiter Kanal miteinander verbunden werden, wobei entsprechende Vorgaben durch den bestimmungsgemäßen Einsatz der Verteilerplatte auf ebenso einfache Weise berücksichtigt werden können.

摘要翻译： 分配器板包括具有多个纵向通道（211）的层（21），其在方向（X）上具有几何形状; 以及在方向（Y）上具有第二几何形状的多个第二纵向通道（212）。 A通道通过相邻通道之间的中间室中的孔连接在一起，使得液体可以从第一通道流动到第二通道。 还包括独立索赔：生产分销板的过程; 以及使用该板耦合模块化系统的部件的过程。 优选特征：第一方向（X）和第二方向（Y）形成大约90度或60度的角度。

公开(公告)号：EP1194696A1

公开(公告)日：2002-04-10

申请号：EP00945858.9

申请日：2000-06-30

申请人： Gyros AB

发明人： DERAND, Helene ,  ANDERSSON, Per ,  LARSSON, Anders

IPC分类号： F15C5/00 ,  F16K13/10

CPC分类号： F16K99/0001 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00891 ,  B01L3/502738 ,  B01L2200/12 ,  B01L2300/0806 ,  B01L2300/1861 ,  B01L2400/0661 ,  F15C5/00 ,  F16K13/10 ,  F16K99/0019 ,  F16K99/0034 ,  F16K99/0036

摘要： The invention relates to a method of controlling flow of liquids in a micro channel structure. It comprises providing in said micro channel structure plugs (34) of polymer material in said structure, said polymer material in a first state blocking said channel from liquid flow, and in a second state providing a free path-way (32) for liquid flow. Energy is selectively applied so as to cause said polymer to enter a desired one of said first or second states. It also relates to a micro channel valve system, comprising a plurality of such plugs (34). Additionally it comprises a chemical reactor, comprising a plurality of micro chambers interconnected by micro channels, having a valve system according to the invention.