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730 条记录 (耗时 0.035 秒)

    (3-{3-´(2,4-BIS-TRIFLUORMETHYL-BENZYL)-(5-ETHYL-PYRIMIDIN-2-YL)-AMINO!-PROPOXY}-PHENYL)-ACETIC ACID AND RELATED COMPOUNDS AS MODULATORS OF PPARS AND METHODS OF TREATING METABOLIC DISORDERS
    54.
    发明公开
    (3-{3-´(2,4-BIS-TRIFLUORMETHYL-BENZYL)-(5-ETHYL-PYRIMIDIN-2-YL)-AMINO!-PROPOXY}-PHENYL)-ACETIC ACID AND RELATED COMPOUNDS AS MODULATORS OF PPARS AND METHODS OF TREATING METABOLIC DISORDERS 有权
    （3- {3 - “（2,4-双 - 三氟甲基 - 苄基） - （5-乙基 - 嘧啶-2-基）氨基丙氧基！}苯基）乙酸和相关化合物作为PPARs的AND METHOD的调节剂 代谢疾病的治疗

    公开(公告)号：EP1613326A1

    公开(公告)日：2006-01-11

    申请号：EP04759820.6

    申请日：2004-04-07

    申请人： Kalypsys, Inc.

    发明人： LIU, Kevin ,  ZHAO, Cunxiang

    IPC分类号： A61K31/505 ,  A61K31/4402 ,  A61K31/426 ,  A61K31/421 ,  C07D239/42 ,  C07D213/38 ,  C07D277/82 ,  C07D263/58 ,  A61P3/04

    CPC分类号： C07D239/42 ,  C07D213/38 ,  C07D213/74 ,  C07D263/58 ,  C07D277/82

    摘要： Disclosed are compounds of formula I as modulators of peroxisome proliferator activated receptors (PPARs) for the treatment of metabolic diseases such as obesity: wherein Ar1 is selected from the group consisting of a monocyclic heteroarornatic ring structure and a bicyclic heteroaromatic ring structure; Ar2 is selected from the group consisting of a monocyclic, a bicyclic, and a tricyclic carbocyclic aryl ring structure R1 is selected from the group consisting of alkyl, optionally substituted a five-membered or six-membered heteroarylring or a six-membered aryl ring, optionally substituted R2 is selected from the group consisting of hydrogen; alkyl, optionally substituted a five-membered or six-membered heteroaryl ring or a six-membered aryl ring, optionally substituied cyano; nitro; an amino; an amido; perhaloalkyl; and halogen; R3 is selected from the group consisting of hydrogen; alkyl, optionally substituted and B is a five-membered or six-membered heteroaryl ring, or -(CH2)j-C(O)OR4, wherein j is 0 or I 1 when Ar2 is a bicyclic or tricyclic carbocyclic ring structure and j is 1 when Ar2 is a monocyclic carbocyclic ring structure; and R4 is selected from the group consisting of hydrogen; alkyl, optionally substituted a five-membered or six-membered heteroaryl ring or a six-membered aryl ring, optionally substituted. The obtional substituents are as defined in claim 1.