公开(公告)号：EP1661877A1

公开(公告)日：2006-05-31

申请号：EP03818527.8

申请日：2003-08-27

Applicant: IHARA CHEMICAL INDUSTRY CO., LTD.

Inventor： KAWAZOE, Kentaro, Ihara Chemical Industry Co. Ltd.

IPC: C07C47/54 ,  C07C45/30 ,  C07C201/12 ,  C07C205/19 ,  C07C47/575 ,  C07C47/55 ,  C07C47/546 ,  C07C47/542

CPC classification number: C07C201/12 ,  C07C45/30 ,  C07C47/546 ,  C07C47/544 ,  C07C47/54 ,  C07C47/575 ,  C07C47/55 ,  C07C205/44

Abstract: A process for producing an aromatic aldehyde compound represented by a general formula (3):

(wherein R' and n are as defined below), which comprises reacting a benzyl compound represented by a general formula (1):

(wherein R may represents hydrogen atom, n represents an integer of 1 to 6, and R' may be the same or different and represent a hydrogen atom or an alkyl gorup, an alkyl group or a phenyl group which may have a substituent) with an oxy-compound of bromine represented by the formula (2):

        MBrO m      (2)

(wherein M represents a hydrogen atom or a metal atom, and m represents an integer of 1 to 3) in the presence of an acid catalyst. According to this method, an aromatic aldehyde compound can be produced in high selectivity by a simple operation without using an expensive catalyst or transition metal.

Abstract translation: 一种制备由通式（3）表示的芳族醛化合物的方法：（其中R'和n如下所定义），其包括使通式（1）表示的苄基化合物：其中R可以表示氢 原子，n表示1〜6的整数，R'可以相同或不同，表示氢原子或烷基，可以具有取代基的烷基或苯基）与溴的氧化合物 由式（2）表示：€ƒ€ƒ€ƒ€ƒ€ƒ€ƒMBrOƒ€ƒ€ƒ€ƒ（2）（其中M表示氢原子或金属原子， m表示1〜3的整数）。 根据该方法，通过简单的操作，可以高选择性地制备芳族醛化合物，而不使用昂贵的催化剂或过渡金属。

公开(公告)号：EP1097158B1

公开(公告)日：2006-01-25

申请号：EP99933785.0

申请日：1999-07-09

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： BUCHWALD, Stephen ,  OLD, David, W. ,  WOLFE, John, P. ,  PALUCKI, Michael ,  KAMIKAWA, Ken ,  CHIEFFI, Andrew ,  SADIGHI, Joseph, P. ,  SINGER, Robert, A. ,  AHMAN, Jens

IPC: C07F7/18 ,  C07F9/48 ,  C07F9/50 ,  C07F9/572 ,  C07F9/653 ,  C07F9/6547 ,  C07F9/6571 ,  C07F15/00

CPC classification number: C07C17/263 ,  C07B37/04 ,  C07C1/26 ,  C07C29/32 ,  C07C41/16 ,  C07C41/30 ,  C07C45/68 ,  C07C45/71 ,  C07C67/31 ,  C07C67/343 ,  C07C201/12 ,  C07C209/10 ,  C07C209/18 ,  C07C211/59 ,  C07C213/02 ,  C07C213/08 ,  C07C221/00 ,  C07C225/12 ,  C07C227/08 ,  C07C227/18 ,  C07C231/12 ,  C07C249/02 ,  C07C249/16 ,  C07C251/24 ,  C07C253/30 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/08 ,  C07D213/50 ,  C07D213/72 ,  C07D213/74 ,  C07D295/023 ,  C07D295/033 ,  C07D295/096 ,  C07D295/112 ,  C07D295/13 ,  C07D295/155 ,  C07D307/33 ,  C07D317/22 ,  C07D317/26 ,  C07D317/66 ,  C07D333/08 ,  C07D333/66 ,  C07D401/04 ,  C07F7/1892 ,  C07F9/4875 ,  C07F9/5022 ,  C07F9/5027 ,  C07F9/5728 ,  C07F9/653 ,  C07F9/6547 ,  C07F9/65719 ,  C07F15/0066 ,  C07C25/18 ,  C07C33/24 ,  C07C49/67 ,  C07C49/215 ,  C07C49/782 ,  C07C49/755 ,  C07C49/683 ,  C07C49/657 ,  C07C49/245 ,  C07C49/84 ,  C07C47/575 ,  C07C49/213 ,  C07C49/255 ,  C07C69/92 ,  C07C69/612 ,  C07C69/76 ,  C07C211/48 ,  C07C211/55 ,  C07C217/40 ,  C07C217/84 ,  C07C217/92 ,  C07C225/22 ,  C07C229/36 ,  C07C229/60 ,  C07C233/07 ,  C07C235/46 ,  C07C251/86 ,  C07C255/33 ,  C07C255/50 ,  C07C255/54 ,  C07C255/56 ,  C07C255/58 ,  C07C205/04 ,  C07C205/06 ,  C07C43/205 ,  C07C43/225 ,  C07C43/263 ,  C07C43/29 ,  C07C43/275

Abstract: One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject processes provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.

公开(公告)号：EP1459804A4

公开(公告)日：2005-04-06

申请号：EP02791966

申请日：2002-12-05

Applicant: DAICEL CHEM

Inventor： ISHII YASUTAKA ,  HIRAI NARUHISA

IPC: B01J31/02 ,  B01J31/26 ,  C07C29/50 ,  C07C45/36 ,  C07C49/453 ,  C07C49/675 ,  C07C51/265 ,  C07C51/31 ,  C07C67/29 ,  C07C205/05 ,  C07C205/44 ,  C07C205/57 ,  C07C253/30 ,  C07C255/57 ,  C07D251/34

CPC classification number: B01J31/0249 ,  B01J31/26 ,  B01J2231/323 ,  B01J2231/42 ,  C07C29/50 ,  C07C45/36 ,  C07C49/453 ,  C07C49/675 ,  C07C51/265 ,  C07C51/313 ,  C07C67/29 ,  C07C201/08 ,  C07C201/12 ,  C07C253/30 ,  C07C2601/14 ,  C07C2603/74 ,  C07D251/34 ,  Y02P20/55 ,  C07C47/55 ,  C07C47/54 ,  C07C47/542 ,  C07C63/06 ,  C07C63/26 ,  C07C63/313 ,  C07C55/14 ,  C07C255/57 ,  C07C69/157 ,  C07C205/05 ,  C07C205/44 ,  C07C205/57 ,  C07C35/37

Abstract: A catalyst comprising a cyclic acylurea compound having a cyclic acylurea skeleton represented by the general formula (I): (I) [wherein R is hydrogen or a hydroxyl-protecting group; G is carbon or nitrogen; and n is 1 or 2, with the proviso that when n is 2, two G’s may be the same or different]. The catalyst may consist of a combination of the above cyclic acylurea compound and a metal compound. Reaction of (A) a radical-forming compound with (B) a radical-capturing compound in the presence of the above catalyst gives an addition or replacement product of the compound (B) with the compound (A) or derivatives thereof. According to the invention, organic compounds can be produced through addition or replacement reaction under mild conditions at high selectivity and in high yield.

Abstract translation: 在本发明的催化剂包括具有由下式（I）表示的环状酰基脲骨架的环状酰基脲化合物： worin R是氢原子或羟基保护基; n是1或2; G为碳原子或氮原子，其中两个是GS相同或不同，当n是2。催化剂可包括环状酰基脲化合物和组合的金属化合物。 在催化剂（A），其能够形成自由基的化合物的存在下使其与（B）一种自由基清除化合物反应，从而得到化合物（A）和化合物（B）的加成或取代反应产物 或其衍生物。 这种催化剂可以生产至有机化合物具有高选择性高产率作为一个结果，例如，在温和的条件下加成或取代反应。

公开(公告)号：EP0994099B1

公开(公告)日：2005-02-02

申请号：EP98420187.1

申请日：1998-10-13

Applicant: Bayer CropScience S.A.

Inventor： Viauvy, Agnès ,  Casado, Michel

IPC: C07C201/12 ,  C07C205/12

CPC classification number: C07C201/12 ,  C07C253/14 ,  C07C255/50 ,  C07C205/12

公开(公告)号：EP1404324A4

公开(公告)日：2004-12-22

申请号：EP02744314

申请日：2002-06-11

Applicant: XENOPORT INC

Inventor： GALLOP MARK A ,  CUNDY KENNETH C ,  ZHOU CINDY X ,  QIU FAYANG G ,  YAO FENMEI ,  XIANG JIA-NING ,  OLLMAN IAN R

IPC: A61K9/22 ,  A61K9/26 ,  A61K31/19 ,  A61K31/197 ,  A61K31/22 ,  A61K31/27 ,  A61K31/341 ,  A61K45/00 ,  A61K47/48 ,  A61P1/00 ,  A61P1/06 ,  A61P19/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/32 ,  A61P39/02 ,  A61P43/00 ,  C07C205/43 ,  C07C271/22 ,  C07C323/58 ,  C07D213/80 ,  C07D267/06 ,  C07D307/58 ,  C07D317/22 ,  C07D317/32 ,  C07D317/40 ,  A61K31/44 ,  A61K31/195 ,  A61K31/225 ,  A61K31/335 ,  C07C205/00 ,  C07C229/00 ,  C07C261/00 ,  C07C269/00 ,  C07C271/00 ,  C07D213/02 ,  C07D317/00

CPC classification number: C07C201/12 ,  A61K31/19 ,  A61K31/197 ,  A61K31/22 ,  A61K31/27 ,  A61K31/341 ,  A61K47/54 ,  A61K47/555 ,  C07C271/22 ,  C07C323/58 ,  C07C2601/14 ,  C07D213/79 ,  C07D213/80 ,  C07D267/06 ,  C07D307/33 ,  C07D307/58 ,  C07D307/60 ,  C07D317/32 ,  C07D317/40 ,  C07C205/43

公开(公告)号：EP1479667A1

公开(公告)日：2004-11-24

申请号：EP03707123.0

申请日：2003-02-27

Applicant: Sumitomo Chemical Company, Limited ,  ONO PHARMACEUTICAL CO., LTD.

Inventor： HIBINO, Hiroaki ,  OHTSUKA, Susumu ,  MIYAMOTO, Yasunobu ,  YOSHIDA, Tomoyasu ,  OKUMOTO, Itsuo

IPC: C07C201/12 ,  C07C205/37 ,  C07C67/307 ,  C07C69/63 ,  C07D311/24

CPC classification number: C07C205/37 ,  C07C201/12 ,  C07D311/24

Abstract: A process for producing a dicarboxylic acid compound represented by the formula (4):
wherein R 1 and R 2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2):
wherein R 1 , R 2 and the wavy line have the same meanings as the above, and one of X 2 and X 3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3):
in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5):
wherein R 1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.

Abstract translation: 一种由式（4）表示的二羧酸化合物的制备方法：其中R 1和R 2相同或不同，表示低级烷基，波浪线表示该化合物为E - 或Z-异构体或它们的混合物，其特征在于使由式（2）表示的化合物：其中R 1，R 2和波浪线具有与上述相同的含义;和 X 2和X 3之一表示氢，另一个表示卤素，与式（3）表示的硝基苯酚：在碱存在下反应; 一种制备由式（5）表示的硝基色酮化合物的方法：其中R 1具有与上述相同的含义的，其特征在于使二羧酸化合物或其羧酸与酸反应; 制备氨基色酮化合物的方法，其包括还原硝基色酮化合物; 并提供了包括酰化所述氨基色酮化合物的酰氨基色酮化合物的制备方法。

公开(公告)号：EP0853647B1

公开(公告)日：2004-10-13

申请号：EP97922299.9

申请日：1997-04-11

Applicant: Molecular Probes, Inc.

Inventor： GEE, Kyle, R. ,  POOT, Martin ,  KLAUBERT, Dieter, H. ,  SUN, Wei-Chuan ,  HAUGLAND, Richard, P. ,  MAO, Fei

IPC: C09B11/00 ,  C09B11/24 ,  G01N1/30 ,  C07C209/36 ,  C07C245/20 ,  C07C37/00

CPC classification number: C09B11/00 ,  C07C37/055 ,  C07C41/18 ,  C07C201/08 ,  C07C201/12 ,  C07C205/26 ,  C07C205/37 ,  C07C209/10 ,  C07C213/02 ,  C07C213/08 ,  C07C245/20 ,  C07D311/82 ,  C09B11/24 ,  G01N1/30 ,  Y10S430/116 ,  Y10S430/126 ,  C07C39/245 ,  C07C211/52 ,  C07C217/84 ,  C07C215/76 ,  C07C43/225

Abstract: The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.

公开(公告)号：EP1463697A2

公开(公告)日：2004-10-06

申请号：EP02787239.9

申请日：2002-12-04

Applicant: BALLARD POWER SYSTEMS INC.

Inventor： STONE, Charles ,  PECKHAM, Timothy, J. ,  BURTON, Donald, J. ,  RAGHAVANPILLAI, Anilkumar

IPC: C07C17/26 ,  C08F12/20 ,  C07C22/02 ,  C07C22/08

CPC classification number: C07D333/12 ,  C07B37/04 ,  C07C17/093 ,  C07C41/30 ,  C07C43/225 ,  C07C201/12 ,  C07C25/28 ,  C07C25/24 ,  C07C22/08 ,  C07C205/11

Abstract: a,ß,ß-Trifluorostyrene and derivatives thereof synthesized in two steps from 1,1,1,2-tetrafluoroethylene. In the first step, 1,1,1,2-tetrafluoroethylene is reacted with a base, a metal salt such as zinc chloride and an optionally amine to form a trifluorovinyl metal complex. In the second step, the trifluorostyrene or derivative is obtained by reacting the trifluorovinyl metal complex with an aryl transfer agent such as, for example, an aryl triflate or an aryl halide, in the presence of a metal catalyst and optionally a coordinating ligand. Both steps may be carried out in one reactor.

公开(公告)号：EP1459804A1

公开(公告)日：2004-09-22

申请号：EP02791966.1

申请日：2002-12-05

Applicant: Daicel Chemical Industries, Ltd.

Inventor： ISHII, Yasutaka ,  HIRAI, Naruhisa

IPC: B01J31/02 ,  C07D251/34

CPC classification number: B01J31/0249 ,  B01J31/26 ,  B01J2231/323 ,  B01J2231/42 ,  C07C29/50 ,  C07C45/36 ,  C07C49/453 ,  C07C49/675 ,  C07C51/265 ,  C07C51/313 ,  C07C67/29 ,  C07C201/08 ,  C07C201/12 ,  C07C253/30 ,  C07C2601/14 ,  C07C2603/74 ,  C07D251/34 ,  Y02P20/55 ,  C07C47/55 ,  C07C47/54 ,  C07C47/542 ,  C07C63/06 ,  C07C63/26 ,  C07C63/313 ,  C07C55/14 ,  C07C255/57 ,  C07C69/157 ,  C07C205/05 ,  C07C205/44 ,  C07C205/57 ,  C07C35/37

Abstract: A catalyst of the invention includes a cyclic acylurea compound having a cyclic acylurea skeleton represented by following Formula (I):
wherein R is a hydrogen atom or a hydroxyl-protecting group; n is 1 or 2; G is a carbon atom or a nitrogen atom, where two Gs are the same or different when n is 2. The catalyst may include the cyclic acylurea compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.

Abstract translation: 在本发明的催化剂包括具有由下式（I）表示的环状酰基脲骨架的环状酰基脲化合物： worin R是氢原子或羟基保护基; n是1或2; G为碳原子或氮原子，其中两个是GS相同或不同，当n是2。催化剂可包括环状酰基脲化合物和组合的金属化合物。 在催化剂（A），其能够形成自由基的化合物的存在下使其与（B）一种自由基清除化合物反应，从而得到化合物（A）和化合物（B）的加成或取代反应产物 或其衍生物。 这种催化剂可以生产至有机化合物具有高选择性高产率作为一个结果，例如，在温和的条件下加成或取代反应。

公开(公告)号：EP1441010A1

公开(公告)日：2004-07-28

申请号：EP04076071.2

申请日：1997-04-11

Applicant: Molecular Probes, Inc.

Inventor： Gee, Kyle R. ,  Klaubert, Dieter H. ,  Haugland, Richard P. ,  Poot, Martin ,  Sun, Wei-Chuan ,  Mao, Fei

IPC: C09B11/00 ,  C09B11/24 ,  G01N1/30 ,  C07C209/36 ,  C07C245/20 ,  C07C37/00

CPC classification number: C09B11/00 ,  C07C37/055 ,  C07C41/18 ,  C07C201/08 ,  C07C201/12 ,  C07C205/26 ,  C07C205/37 ,  C07C209/10 ,  C07C213/02 ,  C07C213/08 ,  C07C245/20 ,  C07D311/82 ,  C09B11/24 ,  G01N1/30 ,  Y10S430/116 ,  Y10S430/126 ,  C07C39/245 ,  C07C211/52 ,  C07C217/84 ,  C07C215/76 ,  C07C43/225

Abstract: The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.

Abstract translation: 本发明的染料族是在一个或多个芳族碳上被氟直接取代的荧光素和二醇。 与非氟化染料相比，这些氟取代的荧光染料具有更高的光稳定性并且对生理范围内的pH变化具有较低的敏感性，当与物质缀合时表现出较少的淬灭，并且具有额外的优点。 本发明的染料可用作可检测的示踪剂并用于制备有机和无机物质的共轭物。