公开(公告)号：EP0637989B1

公开(公告)日：2004-04-14

申请号：EP93904972.2

申请日：1993-02-08

申请人： HEMOCLEANSE, INC.

发明人： ASH, Stephen, R.

IPC分类号： A61M1/30 ,  B01D61/24 ,  B01D65/08

CPC分类号： B01D65/08 ,  A61M1/1005 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/1627 ,  A61M1/1643 ,  A61M1/1649 ,  A61M1/1692 ,  A61M1/1696 ,  A61M1/26 ,  A61M1/267 ,  A61M1/30 ,  A61M1/304 ,  A61M1/308 ,  A61M1/3417 ,  A61M1/3427 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3472 ,  A61M1/3475 ,  A61M1/3493 ,  A61M2205/12 ,  A61M2205/7563 ,  B01D61/00 ,  B01D61/145 ,  B01D61/243 ,  B01D61/58 ,  B01D63/16 ,  B01D2321/2083 ,  Y10T436/255

摘要： Method and device for extracorporeal treatment of blood to effectively remove toxins therefrom and from patients are disclosed. The method includes the steps of passing the blood and dialysate through a plate dialyzer (30) comprising a blood inlet (39), a blood outlet (40) and a dialysate inlet (29), a dialysate outlet (35) and the blood side is separated from the dialysate side by dialyzer membranes. The method also includes passing a sorbent suspension through dialysate side and applying alternating negative pressure and positive pressure on the dialysate side of the dialyzer via an accumulateur (22) to expand and contract dialyzer membranes and agitate the sorbent suspension to prevent settling and mix it to maintain chemical gradients across the membrane. A positive pressure gradient is maintained throughout the cycle from the blood side to the dialysate side of the dialyzer.

摘要翻译： 公开了优选的装置和方法，其提供血液的体外治疗以有效且一致地从其中长时间地从患者中去除毒素。

公开(公告)号：EP1389140A1

公开(公告)日：2004-02-18

申请号：EP02771647.1

申请日：2002-05-16

申请人： Plasma Select AG

发明人： SCHIMMELPFENNIG, Winfried ,  LANTOW, Holger

IPC分类号： A61M1/30 ,  A61M1/34 ,  A61M5/142 ,  A61M1/16 ,  F04B23/04

CPC分类号： F04B43/1253 ,  A61M1/16 ,  A61M1/1607 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/307 ,  A61M1/308 ,  A61M1/3444 ,  A61M1/3448 ,  A61M2205/123 ,  A61M2205/3331 ,  F04B23/04 ,  F04B49/22 ,  F04B2205/09

摘要： The invention relates to a method for balancing the amount of two liquids and a disposable based thereon for balanced conveyance of a filtrate and a substituent for a medical treatment device, consisting of two volumetric conveying units (roller pumps), which are alternately crossflown by the media to be balanced in a time symmetrical manner by means of appropriate control elements. The cyclic time symmetry makes it possible to totally eliminate all flow differences in both conduits in the sum. Both conveyed amounts are equal. In order to supress systematic errors, the pressure in the inlets and outlets of the volumetric conveying units is kept constant. A special switching regime Umschaltregime (mirror method) makes it possible to also eliminate time parameter changes in pump output as a balance error.

公开(公告)号：EP1184046B1

公开(公告)日：2003-11-12

申请号：EP01120380.9

申请日：2001-08-25

申请人： Fresenius Medical Care Deutschland GmbH

发明人： Scheunert, Peter ,  Lauer, Martin ,  Weis, Manfred, Dr. ,  Beden, Josef ,  Herlotz, Martin ,  Manke, Joachim, Dr. ,  Hahmann, Uwe

IPC分类号： A61M1/16 ,  A61M1/30

CPC分类号： A61M1/3621 ,  A61M1/16 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M2205/128

公开(公告)号：EP0784496B1

公开(公告)日：2003-08-27

申请号：EP96916645.3

申请日：1996-05-22

申请人： BAXTER INTERNATIONAL INC.

发明人： DENIEGA, Jose, C. ,  DUFF, Daniel, H.

IPC分类号： B01D21/26 ,  B01D21/28 ,  B01D21/30 ,  B01D33/00 ,  B01D33/06 ,  B01D61/00 ,  B01D61/14 ,  B01D61/18 ,  B01D61/22 ,  B01D63/06 ,  A61M1/30

CPC分类号： A61M1/30 ,  A61M1/265 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M2205/3393 ,  A61M2209/082

公开(公告)号：EP1064960A3

公开(公告)日：2002-05-15

申请号：EP00113483.2

申请日：2000-06-26

申请人： DENCO, INC.

发明人： Spencer, Dudley W.C.

IPC分类号： A61M1/34 ,  A61M1/36 ,  A61M1/30 ,  A61M1/02

摘要： A hemodialysis system and method of operation includes providing a plasma separator (36), such as a centrifuge in a process control (34) to remove the plasma fluid from the red and white blood cells so that only the plasma fluid is subjected to the contaminant removal in a downstream dialyzer (48). This shortened by half the time required to perform a hemodialysis treatment a compared to conventional systems.

摘要翻译： 血液透析系统和操作方法包括在过程控制（34）中提供诸如离心机的血浆分离器（36）以从红血球和白血球除去血浆流体，使得只有血浆流体经受污染物 在下游透析器（48）中移除。 与常规系统相比，这缩短了进行血液透析治疗所需时间的一半。

公开(公告)号：EP1058563A4

公开(公告)日：2002-03-20

申请号：EP98957791

申请日：1998-11-11

申请人： BAXTER INT

发明人： BISCHOF DANIEL F ,  LIKENS MATTHEW E ,  GOLDHABER RICHARD P ,  DENIEGA JOSE C ,  DUFF DANIEL H

IPC分类号： A61M1/34 ,  A61K35/14 ,  A61M1/02 ,  A61M1/26 ,  A61M1/30 ,  B01D17/02 ,  B01D21/00 ,  B01D21/24 ,  B01D21/26 ,  B01D21/28 ,  B01D21/30 ,  B01D61/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D61/08 ,  B01D61/22

CPC分类号： B01D21/2405 ,  A61M1/265 ,  A61M1/30 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3496 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2209/082 ,  B01D17/0217 ,  B01D17/085 ,  B01D21/0012 ,  B01D21/26 ,  B01D2221/10

摘要： Blood separation systems and methods draw whole blood from a blood donor selected from a population of blood donors. The whole blood of the selected blood donor has a known hematocrit value that varies within the population of blood donors according to morphology of the selected blood donor. The systems and methods operate a pump in the inlet line to convey a volume of whole blood from the donor at a commanded flow rate for processing into plasma constituent and concentrated red blood cells. The systems and methods set the commanded flow rate to vary the volume of whole blood conveyed over time as a function of the known hematocrit value of the selected donor. The systems and methods obtain, after processing the whole blood volume, a targeted volume of concentrated red blood cells, which is substantially constant for the population of blood donors despite variances in known hematocrit values among the donors.

公开(公告)号：EP0784496A4

公开(公告)日：2000-07-26

申请号：EP96916645

申请日：1996-05-22

申请人： BAXTER TRAVENOL LAB

发明人： DENIEGA JOSE C ,  DUFF DANIEL H

IPC分类号： A61M1/34 ,  A61M1/26 ,  A61M1/30 ,  B01D21/28 ,  B01D21/30 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D21/26 ,  B01D33/00 ,  B01D33/06 ,  B01D61/00 ,  B01D61/22

CPC分类号： A61M1/30 ,  A61M1/265 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M2205/3393 ,  A61M2209/082

摘要： Blood separation systems and methods utilize a membrane separation device (52) comprising a gap (60) between a microporous membrane (64) and a surface (56) facing the microporous membrane (64), one of the microporous membranes (64) and the surface (56) being rotatable relative to the other to cause separation of whole blood in the gap (60) into plasma and concentrated red blood cells. The systems and methods include an inlet pump element (20) and a drive element (46) coupled to the membrane separation device (52) and the steps of commanding the inlet pump element (20) and the drive element (46) as a function of the known beginning hematocrit value to obtain concentrated red blood cells having a high end hematocrit value that remains substantially constant despite variances in the known beginning hematocrit value.

公开(公告)号：EP0775007A4

公开(公告)日：1998-03-25

申请号：EP96916681

申请日：1996-05-22

申请人： BAXTER INT

发明人： BROWN RICHARD I ,  FOLEY JOHN T ,  ELLIS DALE R

IPC分类号： G01N33/48 ,  A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B1/06 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

CPC分类号： A61M1/0209 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/003 ,  B01D21/0087 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  B04B2005/045 ,  A61M2202/0071

摘要： A chamber for rotation about a rotational axis to separate blood components includes first and second spaced apart side walls forming a separation zone. Blood conveyed into the separation zone separates into a first region of cellular components, a second region of plasma, and an interface region between the first and second regions. An outlet conveys the second region of plasma from the separation zone. An interior wall extends into the separation zone to permit passage of the second region of plasma to the outlet while retarding passage of the interface region and the first region of cellular components to the outlet. The tapered second surface has a major axis that is oriented at a non-parallel angle with respect to the axis of the outlet. Due to this orientation, the boundary between the interface region and the other two regions is held uniform along the tapered surface. The boundary does not bulge to spill materials in the first interface region or interface region over the first surface and into the constricted passage. As a result, the second region of plasma is kept essentially free of other materials.

公开(公告)号：EP0637989A4

公开(公告)日：1997-06-11

申请号：EP93904972

申请日：1993-02-08

申请人： HEMOCLEANSE INC

发明人： ASH STEPHEN R

IPC分类号： A61M1/14 ,  A61M1/10 ,  A61M1/16 ,  A61M1/26 ,  A61M1/30 ,  A61M1/34 ,  B01D61/00 ,  B01D61/14 ,  B01D61/24 ,  B01D61/26 ,  B01D61/58 ,  B01D63/16 ,  B01D65/08

CPC分类号： B01D65/08 ,  A61M1/1005 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/1627 ,  A61M1/1643 ,  A61M1/1649 ,  A61M1/1692 ,  A61M1/1696 ,  A61M1/26 ,  A61M1/267 ,  A61M1/30 ,  A61M1/304 ,  A61M1/308 ,  A61M1/3417 ,  A61M1/3427 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3472 ,  A61M1/3475 ,  A61M1/3493 ,  A61M2205/12 ,  A61M2205/7563 ,  B01D61/00 ,  B01D61/145 ,  B01D61/243 ,  B01D61/58 ,  B01D63/16 ,  B01D2321/2083 ,  Y10T436/255

摘要： Method and device for extracorporeal treatment of blood to effectively remove toxins therefrom and from patients are disclosed. The method includes the steps of passing the blood and dialysate through a plate dialyzer (30) comprising a blood inlet (39), a blood outlet (40) and a dialysate inlet (29), a dialysate outlet (35) and the blood side is separated from the dialysate side by dialyzer membranes. The method also includes passing a sorbent suspension through dialysate side and applying alternating negative pressure and positive pressure on the dialysate side of the dialyzer via an accumulateur (22) to expand and contract dialyzer membranes and agitate the sorbent suspension to prevent settling and mix it to maintain chemical gradients across the membrane. A positive pressure gradient is maintained throughout the cycle from the blood side to the dialysate side of the dialyzer.

公开(公告)号：EP0662857A4

公开(公告)日：1997-04-23

申请号：EP94913269

申请日：1994-02-14

申请人： BAXTER INT

发明人： BROWN RICHARD I

IPC分类号： A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D21/26 ,  B01D37/00 ,  B01D61/00 ,  B04B5/00 ,  B04B5/04 ,  A61M1/00 ,  B01D36/00 ,  B04B15/00

CPC分类号： B01D21/302 ,  A61M1/0218 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  B01D21/262 ,  B01D2221/08 ,  B01D2221/10 ,  B04B5/0442 ,  A61M2202/0071

摘要： Systems and methods are provided for reducing the number of leukocytes in cellular products like platelets collected in an on-line or continuous blood separation processes. The systems include first separation element (12) for separating blood into a suspension of platelets, second separation element (14) for reducing the number of leukocytes in a suspension of platelets, third separation element (16) for separating a suspension of platelets into a platelet-rich concentrate and a control means for operating separation elements (12, 14, 16) in various modes. The methods for obtaining a high quality blood product suited for therapeutic use are disclosed.