公开(公告)号：EP1210411A1

公开(公告)日：2002-06-05

申请号：EP00959455.7

申请日：2000-08-25

申请人： Immunex CorporatioN

发明人： MORRIS, Arvia, E. ,  REDDY, Pranhitha

IPC分类号： C12N5/06 ,  C12N5/10 ,  C12N15/67 ,  C07K14/52 ,  C07K14/475 ,  C07K14/705 ,  C12N15/12 ,  C12N1/38 ,  C12N15/54 ,  C12N9/12

CPC分类号： C12P21/02 ,  C12N5/0043 ,  C12N5/005 ,  C12N2501/105 ,  C12N2501/70 ,  C12N2510/02

摘要： The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics.

公开(公告)号：EP1208194A2

公开(公告)日：2002-05-29

申请号：EP00955333.0

申请日：2000-08-02

申请人： Genaissance Pharmaceuticals, Inc.

发明人： CHEW, Anne ,  DENTON, R., Rex ,  DUDA, Amy ,  KLIEM, Stefanie, E. ,  LANZ, Elizabeth, M. ,  NANDABALAN, Krishnan ,  STEPHENS, Joel, Claiborne

IPC分类号： C12N15/00 ,  C12N15/02 ,  C12N15/13 ,  C07H21/04 ,  C12Q1/70

CPC分类号： C07K14/70535 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： Polynucleotides comprising one or more of 22 novel single nucleotide polymorphisms in the human Immunoglobulin E Receptor I Alpha Subunit (IGERA) gene are described. Compositions and methods for detecting one or more of these polymorphisms are also disclosed. In addition, various genotypes and haplotypes for IGERA gene that exist in the population are described.

公开(公告)号：EP1199362A2

公开(公告)日：2002-04-24

申请号：EP01130678.4

申请日：2000-05-12

申请人： IMMUNEX CORPORATION

发明人： Cosman, David, J. ,  Anderson, Dirk, M. ,  Borges, Luis

IPC分类号： C12N15/12 ,  C12N15/62 ,  C07K14/705 ,  C07K19/00 ,  C07K16/28

CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K14/70503 ,  C07K2319/00

摘要： A family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.

摘要翻译： 免疫球蛋白超家族的免疫受体分子家族，（LIR）多肽进行说明。 公开了编码LIR家族成员及其推导的氨基酸序列的序列，通过DNA编码的多肽没有杂交到所定义的核苷酸序列，用于产生LIR家族的多肽处理，和特异性抗体针对LIR多肽。 LIR家族成员可用于治疗与免疫功能抑制相关的自身免疫性疾病和疾病状态。

公开(公告)号：EP1198589A1

公开(公告)日：2002-04-24

申请号：EP00911657.5

申请日：2000-01-28

申请人： GILEAD SCIENCES, INC.

发明人： HICKE, Brian ,  WARREN, Stephen ,  PARMA, David ,  GOLD, Larry

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12N15/115 ,  A61K38/00 ,  A61K47/54 ,  A61K47/547 ,  A61K47/549 ,  A61K2123/00 ,  B82Y5/00 ,  C07H19/06 ,  C07H19/10 ,  C07H21/00 ,  C07K14/001 ,  C12N9/1276 ,  C12N15/1048 ,  C12N2310/13 ,  C12N2310/317 ,  C12N2310/3183 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3517 ,  C12N2310/53 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2541/101 ,  C12Q2600/158 ,  C40B40/00 ,  F02B2075/027 ,  G01N33/531 ,  G01N33/532 ,  G01N33/535 ,  G01N33/56988 ,  G01N33/68 ,  G01N33/76 ,  G01N2333/16 ,  G01N2333/163 ,  G01N2333/503 ,  G01N2333/575 ,  G01N2333/62 ,  G01N2333/8125 ,  G01N2333/96433 ,  G01N2333/96455 ,  G01N2333/966 ,  G01N2333/9726 ,  G01N2333/974 ,  G01N2333/976 ,  C12N2310/3521

摘要： Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin-C is expressed.

公开(公告)号：EP1181374A1

公开(公告)日：2002-02-27

申请号：EP00939378.6

申请日：2000-05-26

申请人： IMMUNEX CORPORATION

发明人： BIRD, Timothy, A. ,  VIRCA, G., Duke ,  MARTIN, Unja ,  ANDERSON, Dirk, M.

IPC分类号： C12N15/54 ,  C12N15/11 ,  C12N15/63 ,  C12N9/12 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C07K16/40 ,  C12Q1/48

CPC分类号： C12N9/1205 ,  C12Q1/48 ,  C12Q1/485 ,  G01N2500/04

摘要： The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.

公开(公告)号：EP1181065A1

公开(公告)日：2002-02-27

申请号：EP99922157.5

申请日：1999-05-03

申请人： Becton Dickinson Medizintechnik Gmbh & Co.KG

发明人： ZECHENDORF, Klaus ,  MACHT, Wolfgang ,  KIRSCHNER, Gerhard ,  HUBER, Antje

IPC分类号： A61M5/14 ,  A61M5/38

CPC分类号： A61M5/38

摘要： An infusion apparatus comprising a tube leading from an outlet end of a drip chamber (11), with the tube being closeable by a tube clamp (14), a lancing part (15) mounted at the inlet end of the drip chamber (11) and having a lance (12) encompassing a liquid passage (16) and also an air passage (18) alongside the liquid passage (16) and preferably provided with an air filter (17), so that air can flow from the outside into the infusion bottle when liquid flows into the drip chamber (11), wherein a fine pored liquid filter (19) is inserted into the path of the infusion solution from the lance (12) to the tube (13), wherein means are provided for the at least partial venting and filling of the drip chamber (11) with the infusion solution prior to the start of an infusion and wherein the entry of air into the tube is prevented after an infusion bottle has run empty and on exchange of the latter for a full one, whereby the liquid filter (19) is arranged above the base (20) of the drip chamber (11) at a space from the latter.

公开(公告)号：EP1181053A2

公开(公告)日：2002-02-27

申请号：EP00930437.9

申请日：2000-05-05

申请人： GENETICS INSTITUTE, INC.

发明人： STURMHOEFEL, Knut ,  WOLF, Stanley, F. ,  O'TOOLE, Margot

IPC分类号： A61K39/39 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/145 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5152 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55566 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2760/16134

摘要： Methods of enhancing immune responses in which soluble forms of costimulatory molecules, e.g., B7 molecules, are administered to augment immune responses to antigens, e.g., to tumor cells and infectious agents are provided. The subject methods are useful for both prophylactic and therapeutic immunization of subjects.

公开(公告)号：EP1171166A1

公开(公告)日：2002-01-16

申请号：EP00922207.6

申请日：2000-04-14

申请人： Diatide, Inc. ,  GENENTECH, INC.

发明人： DEAN, Richard, T. ,  LISTER-JAMES, John ,  VENUTI, Michael, C. ,  SOMERS, Todd, C.

IPC分类号： A61K51/04 ,  C07D243/24

CPC分类号： A61K51/0497 ,  A61K51/047 ,  A61K51/0478

摘要： The invention provides compounds comprising glycoprotein IIb/IIIa receptor-binding benzodiazepine derivatives covalently linked to metal ion chelators. The compounds of the invention may be labeled with a radionuclide such as 99mTc and used to image thrombi.

公开(公告)号：EP1073416A1

公开(公告)日：2001-02-07

申请号：EP98953702.2

申请日：1998-10-19

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： ZAPOL, Warren, M. ,  BLOCH, Kenneth, D. ,  ROSENZWEIG, Anthony

IPC分类号： A61K9/12 ,  A61K9/72 ,  A61K31/155 ,  A61K31/195 ,  A61K31/27 ,  A61K31/52 ,  A61K33/00 ,  A61K33/08

CPC分类号： A61K33/00

摘要： A method for lessening or preventing non-pulmonary ischemia-reperfusion injury or inflammation in a mammal by identifying a mammal which has ischemia-reperfusion or is at risk for developing ischemia-reperfusion in a non-pulmonary tissue; and causing the mammal to inhale a therapeutically effective amount of gaseous nitric oxide sufficient to diminish the ability of leukocytes or platelets to become activated in a manner that contributes to an inflammatory process at the site of the ischemia-reperfusion or inflammation in the non-pulmonary tissue, thereby lessening or preventing non-pulmonary ischemia-reperfusion injury in the mammal.

公开(公告)号：EP0720621B1

公开(公告)日：2001-02-07

申请号：EP94920076.0

申请日：1994-06-03

申请人： Diatide, Inc.

发明人： DEAN, Richard T. ,  McBRIDE, William ,  LISTER-JAMES, John

IPC分类号： C07K14/655 ,  A61K51/08 ,  A61K38/31

CPC分类号： C07K14/6555 ,  A61K38/00 ,  A61K51/083 ,  A61K51/088 ,  A61K2121/00 ,  A61K2123/00