公开(公告)号：EP1161988B1

公开(公告)日：2004-10-13

申请号：EP01116443.1

申请日：1999-08-12

申请人： Symyx Technologies, Inc.

发明人： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC分类号： B01J19/00 ,  G05D16/00

CPC分类号： B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

公开(公告)号：EP1450942A2

公开(公告)日：2004-09-01

申请号：EP02795121.9

申请日：2002-12-06

申请人： Avantium International B.V.

发明人： NAGY, Anton, John ,  VAN DEN BRINK, Peter, John ,  HARJI, Bashir, Husein

IPC分类号： B01J19/00

CPC分类号： B01J19/0046 ,  B01J2219/00038 ,  B01J2219/00283 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00477 ,  B01J2219/00479 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00698 ,  B01J2219/0072 ,  C40B60/14

摘要： The present invention relates to a batch reaction system (1) for simultaneously conducting reactions in at least two separate reactors (2), the reaction system (1) comprising: at least two batch reactors (2), each reactor (2) containing mixing means (14), a fluid inlet (3) and a gas outlet (4); a fluid feeding common conduit (5) for feeding fluid to the reactors (2), the fluid feeding common conduit (5) being connected to the inlet (3) of each reactor (2) by a fluid inlet conduit (6); a gas discharge conduit (7) for discharging gas from the reactor (2), the gas discharge conduit (7) being connected to teh gas outlet (4) of each reactor (2) by a gas outlet conduit (8); wherein each fluid conduit (6) and each gas outlet conduit (7) comprises a non-return valve (9, 10).

公开(公告)号：EP1444041A2

公开(公告)日：2004-08-11

申请号：EP02777087.4

申请日：2002-09-13

申请人： Solvias AG

发明人： BLATTER, Fritz ,  CRON-ECKHARDT, Brigitte ,  HOFMEIER, Urs, Christoph ,  KOLLER, Peter ,  MARCOLLI, Claudia ,  SZELAGIEWICZ, Martin

IPC分类号： B01L3/00

CPC分类号： G01N21/253 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00389 ,  B01J2219/00484 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00756 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2400/0487 ,  C40B60/14 ,  G01N1/40 ,  G01N21/11 ,  G01N2001/4027 ,  G01N2021/651

摘要： Device consisting of a support (1) and at least two seals (2), which are arranged in a row and are hermetically fitted into cavities, and protrude from the support laterally with respect to inlet and outlet openings, one end of the support being provided with an inlet opening (3) and one end being provided with an outlet opening (4), and the seals being provided with a least one inlet opening and one outlet opening, and the support containing at least one first channel (5) which starts at the inlet opening (3) and is continuous, and is arranged in such a way that it opens into the inlet openings in the side walls of the seals arranged in a row, and one second channel (6) which starts at the outlet opening and is continuous, and is arranged in such a way that it opens into the outlet openings in the side walls of the seals arranged in a row. The system is suitable for simultaneous multiple studies, in particular with the use of microtitration plates, and physical measurements of the results directly in the containers, for example of a microtitration plate. The multiple studies may be used to perform screening processes to discover and develop polymorphic and pseudopolymorphic forms, new formulations and suitable crystallisation conditions.

公开(公告)号：EP1434055A2

公开(公告)日：2004-06-30

申请号：EP04007702.6

申请日：2000-02-15

申请人： Applera Corporation

发明人： Vann, Charles S. ,  Lehto, Dennis

IPC分类号： G01N35/10

CPC分类号： G01N35/1065 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00369 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00545 ,  B01J2219/00549 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/0065 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01L3/021 ,  B01L3/0289 ,  B01L3/563 ,  B01L2200/021 ,  B01L2200/0647 ,  B01L2200/0657 ,  B01L2200/143 ,  B01L2300/0654 ,  B01L2300/0864 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/049 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  C40B70/00 ,  G01N35/10 ,  G01N2035/00574 ,  Y10T436/11 ,  Y10T436/255 ,  Y10T436/2575

摘要： A bead dispensing system is provided for delivering small amounts of substances onto substrates. The system can include, for example, a movable support structure having an array of spaced-apart projections depending from its lower side. An attraction source, such as a vacuum, magnetic, and/or electrostatic force, is operable at each projection end region to attract and retain one bead. The projection array can be aligned with an array of bead-receiving regions of a substrate, e.g., an array of spaced-apart wells of a micro-plate or card. In one embodiment, a plurality of reagent-carrying beads are picked up, retained at respective projection end regions, and moved to a location over a multi-well plate. The beads are then released in a fashion permitting each bead to land in a respective well. The system of the invention is particularly useful for fabricating arrays of reagents.

摘要翻译： 提供珠分配系统用于将少量物质输送到基底上。 该系统可以包括例如可移动的支撑结构，该支撑结构具有从其下侧悬挂的间隔开的突起的阵列。 诸如真空，磁力和/或静电力之类的吸引源可在每个突出端区域处操作以吸引并保持一个珠子。 投影阵列可以与衬底的珠子接收区域的阵列对齐，例如，微板或卡的间隔开的阱阵列。 在一个实施例中，拾取多个携带试剂的珠子，保持在相应的突出端区域，并移动到多孔板上方的位置。 然后以允许每个珠粒落在相应的井中的方式释放珠子。 本发明的系统对于制造试剂阵列特别有用。

公开(公告)号：EP1425577A1

公开(公告)日：2004-06-09

申请号：EP02731970.6

申请日：2002-05-24

申请人： SYMYX TECHNOLOGIES

发明人： CARLSON, Eric, D. ,  CONG, Peijun ,  CHANDLER, William, H., Jr. ,  CHAU, Henry, K. ,  DANIELSON, Earl ,  DESROSIERS, Peter, J. ,  DOOLAN, Robert, D. ,  WU, Luping

IPC分类号： G01N33/48

CPC分类号： B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymporphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system.

公开(公告)号：EP0904841B1

公开(公告)日：2004-01-28

申请号：EP98117824.7

申请日：1998-09-19

申请人： F. HOFFMANN-LA ROCHE AG

发明人： Fattinger, Christof ,  Tschirky, Hansjörg

IPC分类号： B01L9/06

CPC分类号： B01L9/06 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00315 ,  C40B60/14

公开(公告)号：EP1126918B1

公开(公告)日：2003-07-23

申请号：EP99952204.8

申请日：1999-11-03

申请人： Hettlab AG

发明人： DÖBELIN, Werner

IPC分类号： B01L11/00 ,  G01N1/00

CPC分类号： G01N1/40 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00369 ,  B01J2219/00376 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00596 ,  C40B60/14 ,  G01N2001/4027

摘要： The invention relates to a system that feeds gaseous or liquid media into moveable sample vessels or reaction vessels in vacuum centrifuges or reaction chambers that are provided with an integrated shaker. An adapter plate (6) fitted with needles (7) that are allocated to individual vessels is arranged inside the centrifuge or reaction chamber above the sample vessels (5). The adapter plate is provided with a system (9) for the introduction of the gaseous or liquid medium. The height of the adapter plate can be adjusted. This enables the depth at which the needles are introduced into the sample vessels to be chosen at will.

公开(公告)号：EP1322923A1

公开(公告)日：2003-07-02

申请号：EP01969128.6

申请日：2001-10-04

申请人： Chemspeed Ltd.

发明人： GÜLLER, Rolf ,  SCHRÖER, Josef ,  FRANK, Paul ,  METZGER, Franz ,  BACHMANN, Christoph ,  KLOKOW, Gerhard ,  ZAHND, Bernhard

IPC分类号： G01G13/285 ,  G01G17/06

CPC分类号： G01G17/06 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00351 ,  B01J2219/00376 ,  B01J2219/00585 ,  B01J2219/00691 ,  C40B60/14 ,  G01G13/2851 ,  G01N2035/00217 ,  Y10S483/902 ,  Y10T436/11

摘要： The invention relates to a device that comprises a tool holder (1) that can be adjusted in an x axis, an y axis which is perpendicular thereto, and a z axis that is perpendicular both to the x axis and the y axis and that can be pivoted about the z axis. A dispense head (350) for solid material is mounted on the tool holder (1) as the tool. Two scales (369, 374) are disposed on the dispense head (350) for solid material, said scales weighing the material which is or is to be delivered by the dispense head (350) for solid material. The inventive design with two scales directly mounted on the dispense head (350) for solid material allows for weighing of the material without the dispense head (350) for solid material or the material having to be placed on separate scales.

公开(公告)号：EP1069942B1

公开(公告)日：2003-05-28

申请号：EP99942147.2

申请日：1999-08-12

申请人： Symyx Technologies, Inc.

发明人： TURNER, Howard ,  DALES, G., Cameron ,  VAN ERDEN, Lynn ,  VAN BEEK, Johannes, A., M. ,  HAJDUK, Damian, A. ,  NIELSEN, Ralph, B. ,  MANSKY, Paul ,  MATSIEV, Leonid ,  WANG, Pei ,  McFARLAND, Eric

IPC分类号： B01J19/00

CPC分类号： G01N21/253 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01F15/00454 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  Y10T436/11

摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：EP1310297A2

公开(公告)日：2003-05-14

申请号：EP03003215.5

申请日：2001-06-01

申请人： Symyx Technologies, Inc.

发明人： Nielson, Ralph B. ,  Safir, Adam ,  Tiede, Richard ,  McWaid, Thomas Harding ,  Vanerden, Lynn

IPC分类号： B01J19/00

CPC分类号： B01F15/00207 ,  B01F7/00258 ,  B01F7/00266 ,  B01F7/00291 ,  B01F7/00416 ,  B01F7/00575 ,  B01F7/167 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14

摘要： A parallel, semi-continuous or continuous reactor comprising four or more semi-continuous or continuous reaction vessels for containing a liquid reaction mixture, each of the four or more reaction vessels having a volume of not more than about 1 liter, at least four liquid feed lines in selectable fluid communication with each of the four or more reaction vessels, each of the at least four liquid feed lines being in fluid communication with one or more liquid reagent source vessels, each of the at least four liquid feed lines comprising at least a first section and a second section in fluid communication with each other, the second section being releasably connected with the first section and having a distal end positioned within one of the reaction vessels.

摘要翻译： 包含四个或更多个半连续或连续反应容器的平行，半连续或连续反应器，用于容纳液体反应混合物，四个或更多个反应容器中的每一个具有不大于约1升的体积，至少四种液体 与四个或更多个反应容器中的每一个选择性流体连通的进料管线，所述至少四个液体进料管线中的每一个与一个或多个液体试剂源容器流体连通，所述至少四个液体进料管道中的每一个至少包括 第一部分和第二部分彼此流体连通，第二部分可释放地与第一部分连接并且具有位于反应容器内的远端。