公开(公告)号：EP3068758B1

公开(公告)日：2021-09-08

申请号：EP14861658.4

申请日：2014-11-14

发明人： MESSICK, Troy E. ,  SMITH, Garry R. ,  REITZ, Allen B. ,  LIEBERMAN, Paul M. ,  MCDONNELL, Mark E. ,  ZHANG, Yan ,  VELVADAPU, Venkata

IPC分类号： C07C229/56

公开(公告)号：EP2760841B1

公开(公告)日：2016-08-24

申请号：EP12761636.5

申请日：2012-09-24

申请人： SANOFI

发明人： BENAZET, Alexandre ,  DUCLOS, Olivier ,  GUILLO, Nathalie ,  LASSALLE, Gilbert ,  MACARY, Karim ,  VIN, Valérie

IPC分类号： C07D215/22 ,  C07D215/227 ,  C07C229/56 ,  C07C229/62 ,  C07C237/30 ,  C07D471/04 ,  C07D231/14 ,  C07C255/58

CPC分类号： C07D231/14 ,  C07C229/56 ,  C07C229/62 ,  C07C237/30 ,  C07C255/58 ,  C07D215/22 ,  C07D215/227 ,  C07D471/04

公开(公告)号：EP2912009A1

公开(公告)日：2015-09-02

申请号：EP13786397.3

申请日：2013-10-25

申请人： The Procter & Gamble Company

发明人： GARDLIK, John, Michael ,  PATTEN, Monica, Jo ,  GARRETT, Garry, Steven ,  MURPHY, Bryan, Patrick

IPC分类号： C07C205/19 ,  C07C209/10 ,  C07C209/32 ,  C07C213/02 ,  C07C217/84 ,  C07C229/56

CPC分类号： C07C213/02 ,  C07C213/00 ,  C07C213/06 ,  C07C215/68 ,  C07C217/76

摘要： A process has been developed for preparing 2-methoxymethyl-1,4-benzenediamine (IV-a), other compounds of formula (IV), and the salts thereof, all of which may be used as primary intermediates in compositions for dyeing keratin fibers.

公开(公告)号：EP2463268B1

公开(公告)日：2013-08-28

申请号：EP12156735.8

申请日：2005-12-01

申请人： Daiichi Sankyo Company, Limited

发明人： Muto, Tsuyoshi ,  Tanaka, Taisaku ,  Maruoka, Hiroshi ,  Imajo, Seiichi ,  Tomimori, Yoshiaki

IPC分类号： C07C229/38 ,  C07C229/56 ,  C07D307/68 ,  C07D333/40 ,  C07D213/79 ,  C07D213/80

CPC分类号： C07D243/08 ,  C07C233/47 ,  C07C271/22 ,  C07D213/79 ,  C07D213/80 ,  C07D243/10 ,  C07D307/68 ,  C07D333/40 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

公开(公告)号：EP1777215B1

公开(公告)日：2010-11-03

申请号：EP05768520.8

申请日：2005-08-03

申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： YAMADA, Kazuhiro ,  FUSHIMI, Norio, Mitsubishi Gas Chem. Co., Inc.

IPC分类号： C07C227/16 ,  C07C229/56

CPC分类号： C07C227/16 ,  C07C229/56

摘要： Disclosed is a method for producing 2-amino-5-iodobenzoic acid wherein 2-aminobenzoic acid (A) and a molecular iodine (B) are reacted in a liquid phase in the presence of an oxidant. Hydrogen peroxide is preferably used as the oxidant. This method does not require a step for refining 2-amino-5-iodobenzoic acid or a step for recovering iodine, and enables to economically advantageously produce high-quality 2-amino-5-iodobenzoic acid with high yield. The thus-produced 2-amino-5-iodobenzoic acid can be advantageously used as a pharmaceutical intermediate, an agricultural chemical, a raw material for functional chemicals or the like.

公开(公告)号：EP1777215A4

公开(公告)日：2008-09-03

申请号：EP05768520

申请日：2005-08-03

申请人： MITSUBISHI GAS CHEMICAL CO

发明人： YAMADA KAZUHIRO ,  FUSHIMI NORIO

IPC分类号： C07C227/16 ,  C07C229/56

CPC分类号： C07C227/16 ,  C07C229/56

摘要： Disclosed is a method for producing 2-amino-5-iodobenzoic acid wherein 2-aminobenzoic acid (A) and a molecular iodine (B) are reacted in a liquid phase in the presence of an oxidant. Hydrogen peroxide is preferably used as the oxidant. This method does not require a step for refining 2-amino-5-iodobenzoic acid or a step for recovering iodine, and enables to economically advantageously produce high-quality 2-amino-5-iodobenzoic acid with high yield. The thus-produced 2-amino-5-iodobenzoic acid can be advantageously used as a pharmaceutical intermediate, an agricultural chemical, a raw material for functional chemicals or the like.

公开(公告)号：EP1431274B1

公开(公告)日：2007-08-15

申请号：EP03029005.0

申请日：2003-12-16

申请人： Consorzio Interuniversitario Nazionale "La Chimica Per L'Ambiente"

发明人： Selva, Maurizio ,  Tundo, Pietro

IPC分类号： C07C213/08 ,  C07C231/12 ,  C07C227/14 ,  C07C215/76 ,  C07C215/68 ,  C07C237/40 ,  C07C229/60 ,  C07C229/56

CPC分类号： C07C213/08 ,  C07C227/18 ,  C07C231/12 ,  C07C215/68 ,  C07C215/76 ,  C07C229/56 ,  C07C229/60 ,  C07C237/30

公开(公告)号：EP1697301A2

公开(公告)日：2006-09-06

申请号：EP04807850.5

申请日：2004-12-20

申请人： Astellas Pharma Inc.

发明人： HATTORI, Kouji, Astellas Pharma Inc ,  TODA, Susumu, Astellas Pharma Inc. ,  IMANISHI, Masashi, Astellas Pharma Inc. ,  ITO, Shinji, Astellas Pharma Inc. ,  WASHIZUKA, Kenichi, Astellas Pharma Inc. ,  ARAKI, Takanobu, Astellas Pharma Inc. ,  SAKURAI, Minoru, Astellas Pharma Inc. ,  TANABE, Daisuke, Astellas Pharma Inc.

IPC分类号： C07C229/56

CPC分类号： C07C229/56 ,  C07C229/38 ,  C07C271/16 ,  C07C311/51 ,  C07C323/63 ,  Y02P20/55

摘要： The present invention relates to a compound formula (I): wherein (II) is (III) or (IV), X is bond, -CH2-, -O- or -NH-, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl) carbamoyl or lower alkanoylsulfamoyl, R8 is -Y-R9, in which Y is bond, -CH2-, -O-, -S-, etc., and R9 is hydrogen, lower alkyl, cyclo (lower) alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

公开(公告)号：EP1670763A1

公开(公告)日：2006-06-21

申请号：EP04765925.5

申请日：2004-10-06

申请人： GLAXO GROUP LIMITED

发明人： GIBLIN, Gerard Martin Paul, GlaxoSmithKline ,  HALL, Adrian, GlaxoSmithKline ,  HURST, David Nigel, GlaxoSmithKline ,  KILFORD, Ian Reginald, GlaxoSmithKline ,  LEWELL, Xiao Qing, GlaxoSmithKline ,  NAYLOR, Alan, GlaxoSmithKline ,  NOVELLI, Riccardo, GlaxoSmithKline

IPC分类号： C07D213/55 ,  C07D241/24 ,  C07D239/28 ,  C07D237/24 ,  C07D213/64 ,  C07D213/61 ,  C07C63/68 ,  C07C233/54 ,  C07C229/56 ,  C07D401/08 ,  C07D213/00

CPC分类号： C07C65/28 ,  C07C229/56 ,  C07C233/54 ,  C07C2601/10 ,  C07D213/55 ,  C07D213/61 ,  C07D213/64 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D401/08

摘要： Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R1, R2a, R2b, R8, R9, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.

摘要翻译： 式（I）化合物或其药学上可接受的衍生物：其中A，B，Z，R1，R2a，R2b，R8，R9和Rx如说明书中所定义，制备这些化合物的方法，药物组合物 包括这些化合物和这些化合物在医药中的用途。

公开(公告)号：EP1401443A4

公开(公告)日：2005-10-26

申请号：EP02744287

申请日：2002-06-07

申请人： SMITHKLINE BEECHAM CORP

发明人： CHAI DEPING ,  DARCY MICHAEL G ,  DHANAK DASHYANT ,  DUFFY KEVIN J ,  ERICKSON GREG A ,  FITCH DUKE M ,  GATES ADAM T ,  JOHNSTON VICTOR K ,  SARISKY ROBERT T ,  SHARP MATTHEEW J ,  SHAW ANTONY N ,  TEDESCO ROSANNA ,  WIGGALL KENNETH J ,  ZIMMERMAN MICHAEL N

IPC分类号： A61K31/5415 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/00 ,  A61K38/16 ,  A61K38/21 ,  A61K39/00 ,  A61K45/00 ,  A61K48/00 ,  A61P1/16 ,  A61P29/00 ,  A61P31/14 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  C07C229/56 ,  C07C229/64 ,  C07C311/46 ,  C07D215/56 ,  C07D265/26 ,  C07D285/24 ,  C07D413/06 ,  C07D417/04 ,  C07D417/14 ,  C07D491/04 ,  C07D521/00 ,  C07F7/18 ,  A61K31/452 ,  A61P31/12

CPC分类号： C07D417/04 ,  C07C229/56 ,  C07C311/46 ,  C07C2601/02 ,  C07D215/56 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D265/26 ,  C07D285/24 ,  C07D413/06 ,  C07D417/14 ,  C07D491/04 ,  C07F7/1856