公开(公告)号：EP2593550A1

公开(公告)日：2013-05-22

申请号：EP11806184.5

申请日：2011-07-18

申请人： University of Saskatchewan

发明人： HARDING, John Clare Samuel ,  HILL, Janet Elizabeth ,  CHIRINO, Manuel ,  RUBIN, Joseph

IPC分类号： C12N15/61 ,  C07K14/20 ,  C07K16/12 ,  C07K16/40 ,  C12N1/20 ,  C12N15/31 ,  C12N15/53 ,  C12N15/54 ,  C12N15/55 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/90 ,  C12Q1/68 ,  G01N33/569 ,  G01N33/573 ,  G01N33/68 ,  C40B30/04

CPC分类号： C07K14/195 ,  C12Q1/6883 ,  C12Q1/689 ,  C12Q2600/158 ,  G01N33/56911 ,  G01N2333/20 ,  G01N2800/067

摘要： A method of screening for, diagnosing or detecting the presence of Brachyspira sp. Sask30446 and/or colitis in a subject comprising detecting a Brachyspira sp. Sask30446 polynucleotide or polypeptide in a sample of the subject, wherein detection of the Brachyspira sp. Sask30446 polynucleotide or polypeptide is indicative of the presence Brachyspira sp. Sask30446 and/or that the subject has colitis or has an increased risk of developing colitis.

公开(公告)号：EP1940439B1

公开(公告)日：2010-10-27

申请号：EP06775098.4

申请日：2006-08-11

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： OBAYAN, Adebola O.E.

IPC分类号： A61K38/05 ,  A61K9/06 ,  A61L27/54 ,  A61L31/16 ,  A61M31/00

CPC分类号： A61L31/16 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/12 ,  A61K31/198 ,  A61K38/05 ,  A61L31/047 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  A61L2300/214 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/424

摘要： Intraperitoneal administration of glutamine reduces post-operative adhesion formation.

公开(公告)号：EP2106446A1

公开(公告)日：2009-10-07

申请号：EP08700513.8

申请日：2008-01-10

申请人： University of Saskatchewan

发明人： GEYER, Ronald, C.

IPC分类号： C12N15/62 ,  C07K16/00 ,  C07K16/46 ,  C07K19/00 ,  C07K7/64 ,  C12N15/11 ,  C12N15/13 ,  C12N15/52 ,  C12N9/00 ,  C12P21/00 ,  C12P21/04 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07K16/00 ,  C07K2317/565 ,  C07K2317/622 ,  G01N33/5008

摘要： In various aspects, the invention provides methods for cyclizing proteins, including methods for enhancing the stability of cyclized proteins under cytosolic conditions. The invention also provides various methods for using the cyclized proteins. For example, cyclized proteins of the invention may be used in screening assays analogous to the yeast two hybrid assay. Selected embodiments of the invention provide cyclized single chain variable fragment (ScFv) molecules, including molecules in the form of an immunoglobulin fold.

公开(公告)号：EP1960358A1

公开(公告)日：2008-08-27

申请号：EP06817653.6

申请日：2006-11-22

申请人： University of Saskatchewan

发明人： DIMMOCK, Jonathan R. ,  DAS, Umashankar

IPC分类号： C07D211/44 ,  A61K31/45 ,  A61P35/00

CPC分类号： C07D409/14 ,  C07D213/68

摘要： The present invention relates to 4-piperidone derivatives represented by the following formula (I) and the acid addition salts thereof. The method of preparation and antineoplastic activity of the said compounds are disclosed. A number of the compounds possess submicromolar IC50 and CC50 values and have a selective toxicity for colon cancers and leukemic cells. In addition, many of the compounds are able to reverse multidrug resistance.

公开(公告)号：EP1937831A1

公开(公告)日：2008-07-02

申请号：EP06817642.9

申请日：2006-09-26

申请人： University of Saskatchewan

发明人： SHARMA, Rajendra, Kumar ,  SHRIVASTAV, Anuraag

IPC分类号： C12Q1/48 ,  C12Q1/04 ,  G01N33/573 ,  G01N33/574

CPC分类号： G01N33/57419 ,  C12Q1/48 ,  G01N2333/91057

摘要： A diagnostic method and kit are disclosed for detection of cancer. Detection of elevated levels of N-myristoyltransferase (NMT) or NMT activity in blood or bone marrow, and specifically in peripheral blood mononuclear cells, can be used as a marker for cancer. The use of this method for detection of adenocarcinoma, such as colorectal cancer, is exemplified.

公开(公告)号：EP1386617B1

公开(公告)日：2008-03-05

申请号：EP03016998.1

申请日：1998-10-01

申请人： MERIAL ,  THE QUEENS'S UNIVERSITY OF BELFAST ,  The University of Saskatchewan

发明人： Allan, Gordon ,  Meehan, Brian ,  Clark, Edward ,  Ellis, John ,  Haines, Deborah ,  Hassard, Lori ,  Harding, John ,  Charreyre, Catherine Elisabeth ,  Chappuis Gilles Emile ,  Mc Neilly, Francis

IPC分类号： A61K39/12 ,  A61K39/42 ,  C07K16/08 ,  C07K14/01 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C07K14/005 ,  A23C19/0321 ,  A23C19/0323 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/51 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N2750/10021 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10043

公开(公告)号：EP1292327B1

公开(公告)日：2007-03-21

申请号：EP01944804.2

申请日：2001-06-11

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： POTTER, Andrew, A. ,  BOLTON, Alexandra, J. ,  SONG, Xin, Ming

IPC分类号： A61K39/09 ,  A61K48/00

CPC分类号： C07K14/315 ,  A61K39/00

摘要： The Mig protein gene of Streptococcus dysgalactiae, and the corresponding amino acid sequence, is described, as is the use of the Mig protein in vaccine compositions to prevent and treat bacterial infections in general, and mastitis in particular.

公开(公告)号：EP1734050A2

公开(公告)日：2006-12-20

申请号：EP06019067.5

申请日：2001-06-11

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： Bolton, Alexandra J. ,  Perez-Casal, Jose ,  Fontaine, Michael ,  Potter, Andrew A.

IPC分类号： C07K14/315 ,  C12N15/31 ,  C12N15/70 ,  C12N1/21 ,  A61K39/09 ,  C07K16/12 ,  A61P31/04 ,  A61K31/7088 ,  G01N33/569 ,  G01N33/577 ,  G01N33/68

CPC分类号： C07K14/315 ,  A61K39/00 ,  A61K2039/53

摘要： The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S. iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.

公开(公告)号：EP1082002B1

公开(公告)日：2006-09-20

申请号：EP99924612.7

申请日：1999-06-03

申请人： University of Saskatchewan Technologies Inc.

发明人： ATTREE, Stephen, M.

IPC分类号： A01H4/00

CPC分类号： A01H4/005

公开(公告)号：EP1689444A1

公开(公告)日：2006-08-16

申请号：EP04789777.2

申请日：2004-10-25

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： FOLDVARI, Marianna ,  VERRALL, Ronald, E. ,  BADEA, Ildiko

IPC分类号： A61K48/00 ,  A61K47/44 ,  A61K9/06 ,  A61K38/21 ,  A61P17/00 ,  A61K31/7088

CPC分类号： A61K9/1272 ,  A61K9/0014 ,  A61K9/1075 ,  A61K31/7088 ,  A61K38/217 ,  A61K48/0033 ,  A61K48/0075 ,  C12N15/88

摘要： The invention provides a delivery system for a biologically active agent comprising a gemini surfactant in admixture with the biologically active agent in a topical formulation for treatment of skin disorders or metabolic diseases. The invention also provides pharmaceutical compositions in topical formulations comprising the delivery system as set out above, in admixture with pharmaceutically acceptable carriers, diluents, excipients, or supplements suitable for application to the skin or mucosal membrane. Methods of preparation and use are also described.