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81.发明公开ALPHA 1,4-N-ACETYLGALACTOSAMINE TRANSFERASE GENE AND PROCESS FOR PRODUCING THIS ENZYME AND N-ACETYLGALACTOSAMINE-CONTAINING COMPLEX CARBOHYDRATE 审中-公开ALPHA 1,4-N-乙酰半乳糖胺转移酶和用于生产这种酶和N-乙酰含有复合糖类
公开(公告)号：EP1275721A1
公开(公告)日：2003-01-15
申请号：EP01919887.8
申请日：2001-04-11
发明人： ENDO, Tetsuo, Tokyo Research Lab. , KAKITA, Shingo, Tokyo Research Lab. , KOIZUMI, Satoshi, Tokyo Research Lab. , OZAKI, Akio, Technical Research Lab.
CPC分类号： C12P19/26 , C12N9/1051 , C12P19/28
摘要： According to the present invention, α1,4-GalNAc transferase can be produced in a large amount by using a microorganism. Also, a GalNAc-containing complex carbohydrate can be economically produced in a large amount by contacting a microorganism expressing the transferase, UDP-GalNAc and an acceptor complex carbohydrate in an aqueous medium.
摘要翻译： 。根据本发明，α-1,4-半乳糖胺转移酶可以在大量使用微生物产生。 所以，含半乳糖胺的复合糖类可经济地大量通过接触微生物表达的转移酶，UDP-的GalNAc产生并在wässrige介质与受体复合糖类英寸
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公开(公告)号：EP1270642A1
公开(公告)日：2003-01-02
申请号：EP00985846.5
申请日：2000-12-22
发明人： YAMASAKI, Motoo, c/o Tokyo Research Laboratories , SUZAWA, Toshiyuki, c/o Tokyo Research Laboratories , MURAKAMI, Tatsuya, c/o Tokyo Research Laboratories , SAKURAI, Noriko, c/o Tokyo Research Laboratories , YAMASHITA, Kinya, Pharm. Res. Inst., Kyowa Hakko , MUKAI, Mayumi, Pharm. Res. Inst., Kyowa Hakko , KUWABARA, Takashi, Pharm. Res. Inst., Kyowa Hakko , OHTA, So, c/o Pharm. Res. Inst., Kyowa Hakko , MIKI, Ichiro, Pharm. Res. Inst., Kyowa Hakko
IPC分类号： C08G65/337 , A61K38/21 , A61K47/48 , A61P21/00
CPC分类号： C08G65/329 , A61K38/215 , A61K47/60 , A61K47/65 , A61K47/6889 , C08L2203/02
摘要： The present invention provides branched polyalkylene glycols useful as a chemically modifying agent for physiologically active polypeptides, wherein two single-chain polyalkylene glycols are linked to a group having a cyclic structure other than a plane structure, and wherein a group having reactivity with an amino acid side chain, an N-terminal amino group or a C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity is linked to the group having a structure other than a plane structure.
摘要翻译： 本发明提供可用作生理活性多肽的化学改性剂的支链聚亚烷基二醇，其中两个单链聚亚烷基二醇与除了平面结构之外的环状结构的基团连接，并且其中与氨基酸具有反应性的基团 侧链，多肽中的N-末端氨基或C-末端羧基或可转化成具有反应性的基团的基团与具有除了平面结构以外的结构的基团连接。
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公开(公告)号：EP0725081B1
公开(公告)日：2003-01-02
申请号：EP95927989.4
申请日：1995-08-08
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/4718
摘要： A monoclonal antibody that recognizes each of the epitopes present at the 10th to 220th, 221st to 297th and 469th to 662nd positions from the N-terminal amino acid of human Mx protein MxA and reacts specifically with the Mx protein by western blotting, immunoprecipitation or immunocyte staining; and a hydbridoma that produces the antibody. This antibody is useful for diagnosing viral infection.
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公开(公告)号：EP0786462B1
公开(公告)日：2002-09-18
申请号：EP96917696.5
申请日：1996-06-14
发明人： KANDA, Yutaka , SAITOH, Yutaka , SAITO, Hiromitsu , ASHIZAWA, Tadashi , SUGIYAMA, Kazuyo , GOMI, Katsushige , KAKITA, Shingo , TAKAHASHI, Yuichi , MURAKATA, Chikara
IPC分类号： C07D513/08 , C07D513/10 , A61K35/70 , A61K31/425
CPC分类号： C07D513/08
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85.发明公开TRANSGENIC NON-HUMAN MAMMALS FOR MONITORING CHANGE IN CALCIUM ION CONCENTRATION IN CELLS 审中-公开用于监视内钙离子浓度的变化而细胞的转基因非人类动物
公开(公告)号：EP1226752A1
公开(公告)日：2002-07-31
申请号：EP00971708.3
申请日：2000-11-01
发明人： MORI, Katsuhiro, Kyowa Hakko Kogyo Ltd , SATO, Mitsuo, Kyowa Hakko Kogyo Ltd , SEKINE, Susumu, Kyowa Hakko Kogyo Ltd
CPC分类号： A01K67/0275 , A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C07K14/43595 , C12N15/8509 , C12N2800/30
摘要： The present invention provides a transgenic non-human mammal which has DNA encoding a foreign reporter protein for monitoring changes in intracellular calcium ion concentration and expresses the reporter protein in one or more types of non-neuronal cells; a method for producing the above transgenic non-human mammal; a method for detecting changes in intracellular calcium ion concentration using the above transgenic non-human mammal; DNA having promoter activity which is used for production of the transgenic non-human mammal; and the method of use of the DNA. The non-human mammal of the present invention expresses the DNA in one or more tissues or organs selected from the group consisting of epithelial tissue, connective tissue, adipose tissue, cartilage tissue, bone tissue, muscle tissue, intraoral tissue, blood tissue, bone marrow, cardiovascular organ, lymphatic organ, teeth, digestive tractl, liver, gallbladder, pancreas, respiratory organ, urinary organ, genital organ, endocrine organ, sense organ and nail, and can be used for evaluation of pharmacological effect and activity of physiologically active substances (for example, drug), novel gene products having unknown functions and the like in these tissues or organs.
摘要翻译： 本发明提供一种转基因非人哺乳动物其中有DNA编码外源报告蛋白用于监测细胞内钙离子浓度和在一个或多个类型的非神经元细胞的快车报告蛋白的变化; 生产上述的转基因非人类哺乳动物的方法; 为了检测使用上述转基因非人类哺乳动物的细胞内钙离子浓度的变化的方法; 具有启动子活性的所有其用于生产转基因的非人哺乳动物的DNA; 和使用DNA的方法。 本发明的非人类哺乳动物快车的DNA在选自上皮组织，结缔组织，脂肪组织，软骨组织，骨组织，肌肉组织，口腔内组织，血液组织，骨中选择的一个或多个组织或器官 骨髓，心血管器官，淋巴器官，牙齿，消化道tractl，肝，胆，胰，呼吸器官，泌尿器官，生殖器官，内分泌器官，感觉器官和指甲，以及可用于生理活性的药理作用和活性评价 物质（例如，药物），新颖的基因产物具有未知功能和在论文组织或器官等。
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公开(公告)号：EP1210426A2
公开(公告)日：2002-06-05
申请号：EP00958842.7
申请日：2000-09-08
发明人： HASEGAWA, KazuhideKyowa Hakko Kogyo Co. Ltd. , KIKUCHI, YasuhiroKyowa Hakko Kogyo Co. Ltd. , NAKANO, HirofumiKyowa Hakko Kogyo Co. Ltd. , MOLLOY, Helen , CHIANO, Mathias
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Methods and means are described for diagnosing a disease or a predisposition to disease by genotyping a klotho gene from an individual and identifying the presence of one or more risk polymorphisms. These risk polymorphisms are associated either directly or indirectly with predisposition to a range of chronic diseases including osteoporosis, skin disorders, age-related disease, lung dysfunction and metabolic syndrome. Methods of treatment, kits for diagnostic purposes and an isolated klotho gene including all or some of a range of polymorphisms are also described as well as methods of isolating molecules that modulate a klotho gene.
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公开(公告)号：EP0974583B1
公开(公告)日：2002-05-29
申请号：EP96930358.5
申请日：1996-09-11
发明人： KUMAZAWA, Toshiaki , KOSHIMURA, Hirokazu , AONO, Shigeru , ICHIKAWA, Shunji , KITAMURA, Shigeto
IPC分类号： C07D211/44 , C07D401/04 , C07D405/04 , C07D409/04 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/445 , A61K31/55
CPC分类号： C07D401/04 , C07D211/52 , C07D405/04 , C07D491/04
摘要： Phenylpiperidine derivative represented by general formula (I) or pharmacologically acceptable salts thereof and an analgetic agent containing the compound, wherein X represents CH or N: Y-Z represents CH2-O, CH2-S, CH2-CH2, CH=CH or CONR5 (wherein R5 represents hydrogen or lower alkyl); R1 represents hydrogen, lower alkyl, halogeno, lower alkoxy or trifluoromethyl; and R?2, R3 and R4¿ are the same or different and each represents hydrogen, lower alkyl or QR6 (wherein Q represents a single bond or lower alkylene; and R6 represents hydroxy, lower alkoxyalkoxy, lower alkoxy, lower alkylthio, nitro, halogeno, lower alkanoyloxy, lower alkoxycarbonyl, lower alkanoyl or carboxy.
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公开(公告)号：EP1204664A1
公开(公告)日：2002-05-15
申请号：EP00952317.6
申请日：2000-07-28
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , SONE, Hiroki , KOTERA, Osamu , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G.
IPC分类号： C07D491/04 , C07D495/04 , C07D401/06 , C07D451/06 , C07D519/00 , C07D471/04 , A61K31/4353 , A61K31/436 , A61K31/4365 , A61K31/55 , A61P37/00
CPC分类号： C07D401/06 , C07D471/04 , C07D491/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by (1) or Z-Y-(CH2)n -X-NR50R5 and physiologically acceptable salts thereof.
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公开(公告)号：EP0628311B1
公开(公告)日：2002-04-24
申请号：EP93914963.9
申请日：1993-07-07
发明人： SUZUKI, Fumio , SHIMADA, Junichi , ISHII, Akio , NAKAMURA, Joji , ICHIKAWA, Shunji , KITAMURA, Shigeto , KOIKE, Nobuaki
IPC分类号： A61K31/52
CPC分类号： A61K31/52 , C07D473/06 , C07D473/08 , F16B37/048
摘要： An antidepressant containing an active ingredient comprising a xanthine derivative represented by general formule (I) or a pharmacologically acceptable salt thereof, wherein R?1, R2 and R3¿ may be the same or different from one another and each represents hydrogen, lower alkyl, alkyl or propargyl; R4 represents cycloalkyl, -(CH¿2)n-R?5 (wherein R5 represents optionally substituted aryl or optionally substituted heterocyclic group, and n represents an integer of 0 to 4) of group (A) wherein Y?1 and Y2¿ may be the same or different from each other and each represents hydrogen, fluorine or methyl, and Z represents optionally substituted aryl, group (B) (wherein R6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro or amino, and m represents an integer of 1 to 3), or optionally substituted heterocyclic group; and X?1 and X2¿ may be the same or different from each other and each represents O or S.
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公开(公告)号：EP0755928B1
公开(公告)日：2002-04-10
申请号：EP96901492.7
申请日：1996-01-31
发明人： AKAMA, Tsutomu , IKEDA, Shun-ichi , ISHIDA, Hiroyuki Oakwood Apartments D205 , KIMURA, Uichiro , GOMI, Katsushige , SAITO, Hiromitsu
IPC分类号： C07D311/30 , A61K31/35
CPC分类号： C07D311/30
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