公开(公告)号：EP2005128A2

公开(公告)日：2008-12-24

申请号：EP07754032.6

申请日：2007-03-26

Applicant: Chemimage Corporation

Inventor： TUSCHEL, David ,  ZHANG, Jingyun

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/2803 ,  G01J3/2889 ,  G01J2003/4424 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6417 ,  G01N2021/6423

Abstract: A system and method for collecting Raman data sets without the 'contaminating' effect of luminescence emitted photons. Using a fram transfer CCD for time resolved data collection, Raman imaging may be performed without photobleaching the sample. The system may include a light source, a frame transfer CCD, an optical lens and at least one controller. The light source illuminates the sample with a plurality of photons to generate scattered photons from the sample. The frame transfer CCD has an image array and a storage array. The optical lens collects scattered photons and directs the scattered photons to the image array. The controller transfers a Raman data set representative of the scattered photons from the image array to the storage array.

公开(公告)号：EP1996917A2

公开(公告)日：2008-12-03

申请号：EP07867000.7

申请日：2007-02-20

Applicant: Corning Incorporated

Inventor： GOLLIER, Jacques ,  PIECH, Garrett A. ,  WEBB, Michael Brian ,  WU, Qi

IPC: G01N21/27

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/7743

Abstract: An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.

公开(公告)号：EP1992936A1

公开(公告)日：2008-11-19

申请号：EP08008946.9

申请日：2008-05-14

Applicant: Hitachi High-Technologies Corporation

Inventor： Adachi, Sakuichiro

IPC: G01N21/25 ,  G01J3/04 ,  G01J3/42 ,  G01N35/00

CPC classification number: G01N21/253 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/04 ,  G01J3/36 ,  G01J3/42 ,  G01N21/13 ,  G01N21/255 ,  G01N2021/0325 ,  G01N2021/115 ,  G01N2021/3155 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0618

Abstract: A light amount is increased and an analyzing accuracy can be increased in accordance with an enlargement of a load angle.. However, scattered light tends to be loaded into a light receiving element in an analysis accompanied by scattered light, and the dynamic range of a concentration which can be measured becomes narrow. In the invention, light is dispersed by a light dispersing portion (20), a load angle of the received light is changed per wavelength, the load angle is made larger for light of a wavelength having a small light amount, and the load angle is made smaller for light of a wavelength having a large light amount and used for an analysis accompanied by scattered light. Accordingly, it is possible to gain a dynamic range of a concentration which can be measured in the analysis accompanied by scattered light, while increasing the light amount and maintaining the analyzing accuracy.

Abstract translation: 光量增加，并且可以根据负载角度的增大来提高分析精度。然而，散射光倾向于在伴随散射光的分析中被加载到光接收元件中，并且动态范围 可测量的浓度变窄。 在本发明中，光被光分散部分（20）分散，每波长改变接收光的负载角，对于具有小光量的波长的光，负载角度变大，负载角为 对于具有大光量的波长的光而较小，并用于伴随散射光的分析。 因此，在增加光量并保持分析精度的同时，可以获得在伴随散射光的分析中可以测量的浓度的动态范围。

公开(公告)号：EP1991844A2

公开(公告)日：2008-11-19

申请号：EP07757944.9

申请日：2007-03-05

Applicant: Chemimage Corporation

Inventor： GARDNER, Charles, W. ,  MAIER, John, S. ,  NELSON, Matthew, P. ,  SCHWEITZER, Robert, C. ,  TREADO, Partrick, J. ,  VANNI, G., Steven ,  WOLFE, Julianne ,  DEMUTH, Joseph, E. ,  NEISS, Jason, H. ,  WANG, Chenhui

IPC: G01J3/44 ,  G01J3/45

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2823 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2201/0221

Abstract: The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.

公开(公告)号：EP1866631A1

公开(公告)日：2007-12-19

申请号：EP06739657.2

申请日：2006-03-24

Applicant: 3M Innovative Properties Company

Inventor： BEDINGHAM, William ,  LUDOWISE, Peter, D. ,  ROBOLE, Barry, W.

IPC: G01N21/64 ,  C12M1/34 ,  G01J3/44

CPC classification number: G01J3/4406 ,  G01J3/0218 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/024

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system is described that includes a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of optical modules. Each of the optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of optical modules conveys the fluorescent light from the multiple optical modules to a single detector.

公开(公告)号：EP1859239A2

公开(公告)日：2007-11-28

申请号：EP06734493.7

申请日：2006-02-08

Applicant: Northrop Grumman Corporation

Inventor： HAIRSTON, Peter, P. ,  FREIDHOFF, Carl, B.

IPC: G01J1/58

CPC classification number: G01J3/32 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/36 ,  G01J3/427 ,  G01J3/4406 ,  G01J2003/1213 ,  G01J2003/1217 ,  G01N15/1459 ,  G01N15/1463 ,  G01N21/53 ,  G01N21/645 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/85 ,  G01N2015/0088 ,  G01N2015/144 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6467 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2021/8592

Abstract: A multi-spectral aerosol particle measurement system (100) including a long wavelength (e g, UV light, 340 nm) emitter (102) and a short wavelength (e g, UV light, 280 nm) emitter (108), an emitter reflector (114) such as a dichroic filter, that is transparent to long wavelength radiation (104) and reflective to short wavelength radiation (110), a flowing fluid (116) that contains particles (118) that may intersect first direction (106) such that they are sequentially exposed, producing elastic and inelastic emission wavelengths, including fluorescence, a collimating lens (122), and a detector reflector (124) to reflect short wavelength radiation and pass fluorescent radiation through one of a plurality of filters (126a-d) placed in the optical path of a detector (128) The detector reflector (124) reflects light having a wavelength shorter than 300 nm, so elastic scatter is detected by the light scatter detector (190).

公开(公告)号：EP1817570A1

公开(公告)日：2007-08-15

申请号：EP05817972.2

申请日：2005-10-29

Applicant: HUTCHINSON TECHNOLOGY, INC.

Inventor： SCHMITZ, Roger, W. ,  SCHEELE, Bryan, J.

IPC: G01N21/27 ,  G01N21/47 ,  G02B6/26 ,  G02B6/28

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0291 ,  G01J2003/2866 ,  G01N21/274 ,  G01N21/474

Abstract: A spectrophotometric instrument is comprised of a processor, a probe (402) having a tissue engaging surface (404) with an aperture (422) therethrough and a light source producing measurement light signals and optically coupled to the probe via a first optical path (420). A partially reflective first reflecting member (430) is located in the probe and has a generally elliptical profile positioned to reflect a first portion of the measurement light signals to the tissue aperture and to transmit a second portion of the measurement light signals through the first reflecting member. A second reflecting member (456) is located in the probe and has a generally elliptical profile positioned to reflect the measurement light signals transmitted through the first reflecting member. A second optical path (428) has a distal end positioned in the probe to receive to receive light signals transmitted through the tissue sample and a proximal end coupled to the processor.

公开(公告)号：EP1769282A2

公开(公告)日：2007-04-04

申请号：EP05773054.1

申请日：2005-07-20

Applicant: Neptec Optical Solutions Inc.

Inventor： CARBERRY, John ,  TEKIPPE, Vincent ,  GUYNN, Roy

IPC: G02F1/11

CPC classification number: G02B6/3588 ,  G01J3/0218 ,  G01J3/12 ,  G01J3/36 ,  G01J2003/1213 ,  G01J2003/1221 ,  G02B6/29361 ,  G02B6/29395 ,  G02B6/3512 ,  G02B6/352 ,  G02B6/3524 ,  G02B6/3528 ,  G02B6/3532 ,  G02B6/3548 ,  G02B6/3552 ,  G02B6/3558 ,  G02B6/3574 ,  G02B6/3582 ,  G02B6/3598 ,  G02B6/4246

Abstract: An apparatus for directing a light path sequentially between multiple positions. A rotary switch rotates a light beam from a prism relative to a plurality of optical elements arranged radially on a switch body. In one embodiment, a prism rotates in the switch body, causing the light beam to sweep through the optical elements. In another embodiment, the switch body rotates about a prism transmitting the light beam. In various embodiments, the optical elements include a photodetector, a filter and a photodetector pair, a reflector, and a filter and a reflector.

公开(公告)号：EP1685366A1

公开(公告)日：2006-08-02

申请号：EP04788614.8

申请日：2004-09-08

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： YUN, Seok Hyun, Ph. D. ,  BOUMA, Brett Eugene, Ph. D. ,  TEARNEY, Guillermo J., MD, Ph. D. , 

IPC: G01B9/02 ,  A61B5/00

CPC classification number: H01S5/5045 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/02004 ,  G01B9/02043 ,  G01B9/02075 ,  G01B9/02081 ,  G01B9/02083 ,  G01B9/02084 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/453 ,  G01J9/0215 ,  G01N21/4795 ,  G02B6/3604 ,  G02B26/12 ,  G02B27/48 ,  G02F1/093 ,  G02F1/11 ,  H01S3/0071 ,  H01S3/0078 ,  H01S3/08009 ,  H01S3/08063 ,  H01S3/105 ,  H01S3/1068 ,  H01S5/0071 ,  H01S5/0078 ,  H01S5/1025 ,  H01S5/14 ,  H01S5/141 ,  H01S5/146

Abstract: An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond.

公开(公告)号：EP1674844A1

公开(公告)日：2006-06-28

申请号：EP05111891.7

申请日：2005-12-09

Applicant: National Institutes of Natural Sciences

Inventor： IDA, Katsumi ,  IKEDA, Takeshi

IPC: G01J3/18

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/1804

Abstract: [Purpose] The object of the present invention is to provide a spectroscope having both a wavelength resolving power and a spatial resolving power.
[Solving Means] A spectroscope comprises an incident slit 12, a collimator lens type optical system 14 that makes the light rays having passed through the incident slit 12 parallel light rays, a reflection type diffraction grating 16 that receives the parallel light rays and, according to the wavelength, outputs these light rays at different angles, a condenser lens type optical system 14 that condenses the output light from the diffraction grating 16, and two-dimensional light-receiving means 16 having a two-dimensional light-receiving surface that detects the light rays that have been condensed by the condenser lens type optical system. The collimator lens type optical system and the condenser lens type optical system are disposed so that the angle 2γ defined between the optical axis of the collimator lens type optical system and the optical axis of the condenser lens type optical system may be acute; the condenser lens type optical system is disposed so that the distance between itself and the diffraction grating may be shorter than the distance between the collimator lens type optical system and the diffraction grating; and a setting is made so that a normal line vector at the central portion of the reflection surface of the diffraction grating may be directed, from a bisector of the angle defined between the optical axis of the collimator lens type optical system and the optical axis of the condenser lens type optical system, toward a side where the collimator lens type optical system is disposed.

Abstract translation: [目的]本发明的目的是提供一种具有波长分辨能力和空间分辨能力的分光镜。 [解决方案]分光镜包括入射狭缝12，使穿过入射狭缝12的光线平行光的准直透镜型光学系统14，接收平行光线的反射型衍射光栅16， 以不同的角度输出这些光线，会聚来自衍射光栅16的输出光的聚光透镜型光学系统14和具有二维光接收表面的二维光接收装置16，二维光接收装置16检测 由聚光透镜型光学系统聚光的光线。 准直透镜型光学系统和聚光透镜型光学系统被设置为使得准直透镜型光学系统的光轴和聚光透镜型光学系统的光轴之间限定的角度2 3可以是锐角的; 聚光透镜型光学系统被设置为使得其本身与衍射光栅之间的距离可以短于准直透镜型光学系统和衍射光栅之间的距离; 并且进行设置，使得衍射光栅的反射表面的中心部分处的法线向量可以从准直透镜型光学系统的光轴和光轴的光轴之间的角度的二等分线 聚光透镜型光学系统朝向配置准直透镜型光学系统的一侧。