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公开(公告)号：EP4389145A3
公开(公告)日：2024-08-21
申请号：EP23217647.9
申请日：2019-09-11
申请人： Ambrx, Inc.
IPC分类号： A61K45/00
摘要： The present invention provides methods for targeting interleukin-2 receptor-expressing cells, and,in particular, inhibiting the growth of such cells by using an interleukin-2 (IL-2) variant conjugated to a biologically active molecule that will affect cells expressing the interleukin-2 receptor.
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公开(公告)号：EP1675620B1
公开(公告)日：2019-05-08
申请号：EP04794581.1
申请日：2004-10-07
申请人： AMBRX, INC.
发明人： WILSON, Troy, E.
IPC分类号： A61K47/50
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公开(公告)号：EP2714684B1
公开(公告)日：2018-09-05
申请号：EP12793246.5
申请日：2012-05-24
申请人： Ambrx, Inc.
发明人： MIAO, Zhenwei , ATKINSON, Kyle, C. , BIROC, Sandra , BUSS, Timothy , COOK, Melissa , KRAYNOV, Vadim , MARSDEN, Robin , PINKSTAFF, Jason , SKIDMORE, Lillian , SUN, Ying , SZYDLIK, Angieszka , LOPEZ DE VALENTA, Delia Ianina
IPC分类号： C07D417/12 , C07D207/08 , C07D401/12 , A61K31/427 , A61P35/00 , C07K5/02 , C07K16/30
CPC分类号： C07K5/101 , A61K38/07 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6855 , A61K47/6861 , C07D207/08 , C07D401/12 , C07D417/12 , C07K5/0205 , C07K5/06043
摘要： Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
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4.发明授权
公开(公告)号：EP2337846B1
公开(公告)日：2018-01-17
申请号：EP09817017.8
申请日：2009-09-28
申请人： Ambrx, Inc.
发明人： TIAN, Feng , HEHLI, Brad
IPC分类号： C12N1/36 , C12P21/00 , C12N9/00 , A61K39/108 , C12N15/70
CPC分类号： C12N15/70 , A61K39/0258 , C12N1/36 , C12N9/93
摘要： Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.
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公开(公告)号：EP3125943A4
公开(公告)日：2017-12-06
申请号：EP15773458
申请日：2015-03-30
申请人： MERCK SHARP & DOHME , AMBRX INC
发明人： GARBACCIO ROBERT M , KERN JEFFREY , BRANDISH PHILIP E , SHAH SANJIV , LIANG LINDA , SUN YING , WANG JIANING , KNUDSEN NICK , BECK ANDREW , MANIBUSAN ANTHONY , GATELY DENNIS
CPC分类号： A61K47/48715 , A61K47/48384 , A61K47/48561 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6889 , A61K51/1045 , C07F9/091 , C07F9/098 , C07F9/12 , C07F9/2458 , C07F9/5721 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07H19/10 , C07K16/2866
摘要： Phosphate-based linkers with tunable stability for intracellular delivery of drug conjugates are described. The phosphate-based linkers comprise a monophosphate, diphosphate, triphosphate, or tetraphosphate group (phosphate group) and a linker arm comprising a tuning element and optionally a spacer. A payload is covalently linked to the phosphate group at the distal end of the linker arm and the functional group at the proximal end of the linker arm is covalently linked to a cell-specific targeting ligand such as an antibody. These phosphate-based linkers have a differentiated and tunable stability in blood vs. an intracellular environment (e.g. lysosomal compartment).
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公开(公告)号：EP2318029B1
公开(公告)日：2017-11-01
申请号：EP09800931.9
申请日：2009-07-22
申请人： Ambrx, Inc. , Eli Lilly & Company
发明人： HAYS PUTNAM, Anna-Maria A. , KNUDSEN, Nick , NORMAN, Thea , KODER, Alan , KRAYNOV, Vadim , HO, Lillian , CANNING, Peter C.
IPC分类号： A61K38/00
CPC分类号： C07K14/535 , A61K38/193
摘要： Modified bovine G-CSF polypeptides and uses thereof are provided.
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公开(公告)号：EP3225248A1
公开(公告)日：2017-10-04
申请号：EP17161531.3
申请日：2009-07-22
申请人： Ambrx, Inc. , Eli Lilly & Company
发明人： HAYS PUTNAM, Ana-Maria A , KNUDSEN, Nick , NORMAN, Thea , KODER, Alan , KRAYNOV, Vadim , HO, Lillian , CANNING, Peter C
IPC分类号： A61K38/00
CPC分类号： C07K14/535 , A61K38/193
摘要： Modified bovine G-CSF polypeptides and uses thereof are provided.
摘要翻译： 提供了修饰的牛G-CSF多肽及其用途。
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公开(公告)号：EP3216800A1
公开(公告)日：2017-09-13
申请号：EP17161398.7
申请日：2009-09-25
申请人： Ambrx, Inc. , Eli Lilly & Company
发明人： Tian, Feng , Hays Putnam, Anna-Maria A , Song, Frank , Chu, Stephanie , Sheffer, Joseph , Barnett, Richard S , Siladi, Marc , Atkinson, Kyle , Lee, Darin , Canning, Peter C
CPC分类号： C07K14/505 , A61K38/00 , A61K38/1816 , A61K47/60 , C12N15/102
摘要： Modified animal erythropoietin polypeptides and uses thereof are provided.
摘要翻译： 提供了修饰的动物促红细胞生成素多肽及其用途。
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公开(公告)号：EP3103880A1
公开(公告)日：2016-12-14
申请号：EP16163920.8
申请日：2009-02-05
申请人： Ambrx, Inc.
发明人： KRAYNOV, Vadim , PUTNAM, Anna-Maria, A., Hays , KNUDSEN, Nick , PINKSTAFF, Jason , MYLER, Heather , SULLIVAN, Lorraine
IPC分类号： C12P21/00 , C07K14/00 , C07H21/04 , C07K14/575
CPC分类号： C07K14/5759
摘要： Modified human leptin polypeptides and uses thereof are provided.
摘要翻译： 修饰的人瘦素多肽和其用途被提供。
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公开(公告)号：EP2970424A2
公开(公告)日：2016-01-20
申请号：EP14722420.8
申请日：2014-03-12
申请人： Eli Lilly and Company , Ambrx, Inc.
IPC分类号： C07K14/575
CPC分类号： A61K47/48215 , A61K38/2264 , A61K47/60 , C07K14/5759
摘要： Modified canine leptin polypeptides and formulations and uses thereof, are provided including polyethylene glycol (PEG) modified canine leptin polypeptides, wherein the PEG moiety is covalently attached to a para-acetyl-phenylalanine (pAF) residue of the polypeptide, and related compositions and methods useful in treating companion animal obesity and other leptin-related disorders.
摘要翻译： 提供了修饰的犬瘦素多肽及其制剂和用途，包括聚乙二醇（PEG）修饰的犬瘦素多肽，其中PEG部分共价连接到多肽的对 - 乙酰基 - 苯丙氨酸（pAF）残基，以及相关组合物和方法 可用于治疗伴侣动物肥胖症和其他瘦素相关疾病。
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